Papers by Lorena Hernandez
clac CÍRCULO clac de lingüística aplicada a la comunica ción 40/2009 © 2009 Lorena Pérez Hernánde... more clac CÍRCULO clac de lingüística aplicada a la comunica ción 40/2009 © 2009 Lorena Pérez Hernández CÍRCULO de Lingüística Aplicada a la Comunicación (clac) 40, 62-92 Universidad Complutense de Madrid. ISSN 1576-4737. http://www.ucm.es/info/circulo ANÁLISIS LÉXICO-CONSTRUCCIONAL DE VERBOS DE HABLA Lorena Pérez Hernández Universidad de La Rioja lorena perez en unirioja es Resumen El presente artículo recoge los resultados del análisis de un grupo de verbos de habla en inglés. El estudio se ha llevado a cabo dentro del marco teórico conocido como Modelo Léxico-Construccional (MLC), propuesto por Ruiz de Mendoza y Mairal (el objetivo de superar las limitaciones de ambas en el estudio de la relación entre significado léxico y sintáctico. Las características semánticas y sintácticas de los verbos de habla objeto de este estudio han sido descritas en las correspondientes plantillas léxicas. Posteriormente, se ha mostrado cómo estas plantillas han de ser constreñidas para poder participar en construcciones gramaticales de alto nivel como las de movimiento causado y movimiento causado con way. La compatibilidad de diferentes subgrupos de los verbos de habla estudiados con las dos construcciones anteriormente mencionadas se ha explicado mediante una serie de principios y restricciones tanto internas como externas, basadas en aspectos cognitivos, semánticos y pragmáticos de los predicados implicados. pérez hernández: verbos de habla 63 clac 40/2009, 62-92 Palabras clave: Verbos de habla, Modelo Léxico-Construccional, semántica, Lingüística Cognitiva. Abstract A Lexical-Constructional Analysis of Verbs of Speech. This paper presents the results of an analysis of a group of English verbs of speech. The study has been carried out within the theoretical framework provided by the Lexical-Constructional Model as developed by Ruiz de Mendoza and Mairal (2007a, 2007b, 2008a, 2008b), and Mairal and Ruiz de Mendoza (2009) which offers a bridge between projectionist theories of language such as Role and Reference Grammar (Van Valin, 1997, 2005) and constructional theories such as those put forward by and . The syntactic and semantic idiosyncrasy of the verbs of speech under scrutiny is captured by means of lexical templates, which are subsumed into the higher-level constructional templates for the caused motion and caused motion with way constructions Levin, 1993). A number of internal and external constraints based on semantic, cognitive, and pragmatic aspects of the meaning of the verbs have been shown to determine the degree of compatibility that exists between different sub categories of verbs of speech and the two aforementioned constructions.
International Journal of Quantum Chemistry, 2007
Breast cancer is the most common cancer among women. Tamoxifen is the preferred drug for estrogen... more Breast cancer is the most common cancer among women. Tamoxifen is the preferred drug for estrogen receptor-positive breast cancer treatment, yet many of these cancers are intrinsically resistant to tamoxifen or acquire resistance during treatment. Therefore, scientists are searching for breast cancer drugs that have different molecular targets. Previous work revealed that 8-mer and cyclic 9-mer peptides inhibit breast cancer in mouse and rat model systems, interacting with an unknown receptor, while peptides smaller than eight amino acids did not inhibit breast cancer. We have shown that the use of replica exchange molecular dynamics predicts structure and dynamics of active peptides, leading to the discovery of smaller peptides with full biological activity. These simulations identified smaller peptide analogs with a conserved turn, a -turn formed in the larger peptides. These analogs inhibit estrogen-dependent cell growth in a mouse uterine growth assay, a test showing reliable correlation with human breast cancer inhibition. We outline the computational methods that were tried and used with the experimental information that led to the successful completion of this research.
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Papers by Lorena Hernandez