Journal of Psychiatric and Mental Health Nursing, 2000
... Nursing and extrapyramidal symptoms: a critical commentary. Liam Clarke. Article first publis... more ... Nursing and extrapyramidal symptoms: a critical commentary. Liam Clarke. Article first published online: 25 DEC 2001. DOI: 10.1046/j.1365-2850.2000.355.1.x. Issue. ... More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 2001
To avoid molecular damage of biomolecules due to oxidation, all cells have evolved constitutive a... more To avoid molecular damage of biomolecules due to oxidation, all cells have evolved constitutive and responsive systems to mitigate and repair chemical modifications. Archaea have adapted to some of the most extreme environments known to support life, including highly oxidizing conditions. However, in comparison to bacteria and eukaryotes, relatively little is known about the biology and biochemistry of archaea in response to changing conditions and repair of oxidative damage. In this study transcriptome, proteome, and chemical reactivity analyses of hydrogen peroxide (H 2 O 2 ) induced oxidative stress in Sulfolobus solfataricus (P2) were conducted. Microarray analysis of mRNA expression showed that 102 transcripts were regulated by at least 1.5 fold, 30 minutes after exposure to 30 mM H 2 O 2 . Parallel proteomic analyses using two-dimensional differential gel electrophoresis (2D-DIGE), monitored more than 800 proteins 30 and 105 minutes after exposure and found that 18 had significant changes in abundance. A recently characterized ferritin-like antioxidant protein, DPSL, was the most highly regulated species of mRNA and protein, in addition to being post-translationally modified. As expected, a number of antioxidant related mRNAs and proteins were differentially regulated. Three of these, DPSL, superoxide dismutase, and peroxiredoxin were shown to interact and likely form a novel supramolecular complex for mitigating oxidative damage. A scheme for the ability of this complex to perform multi-step reactions is presented. Despite the central role played by DPSL, cells maintained a lower level of protection after disruption of the dpsl gene, indicating a level of redundancy in the oxidative stress pathways of S. solfataricus. This work provides the first ''omics'' scale assessment of the oxidative stress response for an archeal organism and together with a network analysis using data from previous studies on bacteria and eukaryotes reveals evolutionarily conserved pathways where complex and overlapping defense mechanisms protect against oxygen toxicity.
Journal of Psychiatric and Mental Health Nursing, 1994
The study reported here was conducted following claims made by a forensic psychiatric unit (calle... more The study reported here was conducted following claims made by a forensic psychiatric unit (called Ambrose Unit) that, in effect, it functioned as a therapeutic community. The study aimed to compare this claim with findings from the Attitude to Treatment Questionnaire (ATQ) that was administered to the staff of the unit. For the purposes of the exercise, the unit was matched with another similar unit that had not claimed to function therapeutically. It was hypothesized that, in keeping with their therapeutic claims, scores for staff from the Ambrose Unit would be more liberal than those for staff from the other unit (called Delphi unit). A series of ANOVA calculations supported this hypothesis and other hypotheses regarding political and social attitudes of staff working in these units. However, the discussion considers in more detail, scores from the ATQ, and questions these results. The nature of therapeutic community research in general is also considered and the validity of results generated from such research is discussed. Finally, the limitations imposed by the difficulty with which terms in this area are defined is acknowledged.
Journal of Psychiatric and Mental Health Nursing, 2000
... Necessary debates: the need for controversy in mental health. Liam Clarke. Article first publ... more ... Necessary debates: the need for controversy in mental health. Liam Clarke. Article first published online: 25 DEC 2001. ... View Full Article (HTML). More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 2001
... Doubts and certainties in the nursing profession: a commentary. Liam Clarke. Article first pu... more ... Doubts and certainties in the nursing profession: a commentary. Liam Clarke. Article first published online: 21 DEC 2001. DOI: 10.1046/j.1365-2850.2003.00597.x-i1. Issue. ... More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 1996
Is postmodernism in many ways the empiricist-liberal tradition at the inevitable end of its intel... more Is postmodernism in many ways the empiricist-liberal tradition at the inevitable end of its intellectual and political tether? Or is postmodernism the ‘laughter of genius’ that art and argument in their traditional forms are dead? Can postmodernism be applied to social and economic issues whilst carrying a denial of the manner by which Western thought has shaped these issues? Can postmodernism provide moral pathways to help us with contemporary ethical issues? How can postmodernist thought encompass the activities of nurses, particularly in the area of psychiatric care? Can nurses afford postmodernist suppositions in the face of suffering and pain? If postmodernism exists, does it exist everywhere (as does nursing) or is it a more localized event?
Journal of Psychiatric and Mental Health Nursing, 2005
The UBR (University of Brighton Repository) is a central institutional repository that records th... more The UBR (University of Brighton Repository) is a central institutional repository that records the work of the University's researchers. It is an open access, organic resource and is freely available via the web to researchers worldwide.
Journal of Psychiatric and Mental Health Nursing, 2000
... Necessary debates: the need for controversy in mental health. Liam Clarke. Article first publ... more ... Necessary debates: the need for controversy in mental health. Liam Clarke. Article first published online: 25 DEC 2001. ... View Full Article (HTML). More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 2001
... Doubts and certainties in the nursing profession: a commentary. Liam Clarke. Article first pu... more ... Doubts and certainties in the nursing profession: a commentary. Liam Clarke. Article first published online: 21 DEC 2001. DOI: 10.1046/j.1365-2850.2003.00597.x-i1. Issue. ... More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 2000
... Nursing and extrapyramidal symptoms: a critical commentary. Liam Clarke. Article first publis... more ... Nursing and extrapyramidal symptoms: a critical commentary. Liam Clarke. Article first published online: 25 DEC 2001. DOI: 10.1046/j.1365-2850.2000.355.1.x. Issue. ... More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 2005
The UBR (University of Brighton Repository) is a central institutional repository that records th... more The UBR (University of Brighton Repository) is a central institutional repository that records the work of the University's researchers. It is an open access, organic resource and is freely available via the web to researchers worldwide.
Journal of Psychiatric and Mental Health Nursing, 2000
... Nursing and extrapyramidal symptoms: a critical commentary. Liam Clarke. Article first publis... more ... Nursing and extrapyramidal symptoms: a critical commentary. Liam Clarke. Article first published online: 25 DEC 2001. DOI: 10.1046/j.1365-2850.2000.355.1.x. Issue. ... More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 2001
To avoid molecular damage of biomolecules due to oxidation, all cells have evolved constitutive a... more To avoid molecular damage of biomolecules due to oxidation, all cells have evolved constitutive and responsive systems to mitigate and repair chemical modifications. Archaea have adapted to some of the most extreme environments known to support life, including highly oxidizing conditions. However, in comparison to bacteria and eukaryotes, relatively little is known about the biology and biochemistry of archaea in response to changing conditions and repair of oxidative damage. In this study transcriptome, proteome, and chemical reactivity analyses of hydrogen peroxide (H 2 O 2 ) induced oxidative stress in Sulfolobus solfataricus (P2) were conducted. Microarray analysis of mRNA expression showed that 102 transcripts were regulated by at least 1.5 fold, 30 minutes after exposure to 30 mM H 2 O 2 . Parallel proteomic analyses using two-dimensional differential gel electrophoresis (2D-DIGE), monitored more than 800 proteins 30 and 105 minutes after exposure and found that 18 had significant changes in abundance. A recently characterized ferritin-like antioxidant protein, DPSL, was the most highly regulated species of mRNA and protein, in addition to being post-translationally modified. As expected, a number of antioxidant related mRNAs and proteins were differentially regulated. Three of these, DPSL, superoxide dismutase, and peroxiredoxin were shown to interact and likely form a novel supramolecular complex for mitigating oxidative damage. A scheme for the ability of this complex to perform multi-step reactions is presented. Despite the central role played by DPSL, cells maintained a lower level of protection after disruption of the dpsl gene, indicating a level of redundancy in the oxidative stress pathways of S. solfataricus. This work provides the first ''omics'' scale assessment of the oxidative stress response for an archeal organism and together with a network analysis using data from previous studies on bacteria and eukaryotes reveals evolutionarily conserved pathways where complex and overlapping defense mechanisms protect against oxygen toxicity.
Journal of Psychiatric and Mental Health Nursing, 1994
The study reported here was conducted following claims made by a forensic psychiatric unit (calle... more The study reported here was conducted following claims made by a forensic psychiatric unit (called Ambrose Unit) that, in effect, it functioned as a therapeutic community. The study aimed to compare this claim with findings from the Attitude to Treatment Questionnaire (ATQ) that was administered to the staff of the unit. For the purposes of the exercise, the unit was matched with another similar unit that had not claimed to function therapeutically. It was hypothesized that, in keeping with their therapeutic claims, scores for staff from the Ambrose Unit would be more liberal than those for staff from the other unit (called Delphi unit). A series of ANOVA calculations supported this hypothesis and other hypotheses regarding political and social attitudes of staff working in these units. However, the discussion considers in more detail, scores from the ATQ, and questions these results. The nature of therapeutic community research in general is also considered and the validity of results generated from such research is discussed. Finally, the limitations imposed by the difficulty with which terms in this area are defined is acknowledged.
Journal of Psychiatric and Mental Health Nursing, 2000
... Necessary debates: the need for controversy in mental health. Liam Clarke. Article first publ... more ... Necessary debates: the need for controversy in mental health. Liam Clarke. Article first published online: 25 DEC 2001. ... View Full Article (HTML). More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 2001
... Doubts and certainties in the nursing profession: a commentary. Liam Clarke. Article first pu... more ... Doubts and certainties in the nursing profession: a commentary. Liam Clarke. Article first published online: 21 DEC 2001. DOI: 10.1046/j.1365-2850.2003.00597.x-i1. Issue. ... More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 1996
Is postmodernism in many ways the empiricist-liberal tradition at the inevitable end of its intel... more Is postmodernism in many ways the empiricist-liberal tradition at the inevitable end of its intellectual and political tether? Or is postmodernism the ‘laughter of genius’ that art and argument in their traditional forms are dead? Can postmodernism be applied to social and economic issues whilst carrying a denial of the manner by which Western thought has shaped these issues? Can postmodernism provide moral pathways to help us with contemporary ethical issues? How can postmodernist thought encompass the activities of nurses, particularly in the area of psychiatric care? Can nurses afford postmodernist suppositions in the face of suffering and pain? If postmodernism exists, does it exist everywhere (as does nursing) or is it a more localized event?
Journal of Psychiatric and Mental Health Nursing, 2005
The UBR (University of Brighton Repository) is a central institutional repository that records th... more The UBR (University of Brighton Repository) is a central institutional repository that records the work of the University's researchers. It is an open access, organic resource and is freely available via the web to researchers worldwide.
Journal of Psychiatric and Mental Health Nursing, 2000
... Necessary debates: the need for controversy in mental health. Liam Clarke. Article first publ... more ... Necessary debates: the need for controversy in mental health. Liam Clarke. Article first published online: 25 DEC 2001. ... View Full Article (HTML). More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 2001
... Doubts and certainties in the nursing profession: a commentary. Liam Clarke. Article first pu... more ... Doubts and certainties in the nursing profession: a commentary. Liam Clarke. Article first published online: 21 DEC 2001. DOI: 10.1046/j.1365-2850.2003.00597.x-i1. Issue. ... More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 2000
... Nursing and extrapyramidal symptoms: a critical commentary. Liam Clarke. Article first publis... more ... Nursing and extrapyramidal symptoms: a critical commentary. Liam Clarke. Article first published online: 25 DEC 2001. DOI: 10.1046/j.1365-2850.2000.355.1.x. Issue. ... More content like this. Find more content: like this article. Find more content written by: Liam Clarke. ...
Journal of Psychiatric and Mental Health Nursing, 2005
The UBR (University of Brighton Repository) is a central institutional repository that records th... more The UBR (University of Brighton Repository) is a central institutional repository that records the work of the University's researchers. It is an open access, organic resource and is freely available via the web to researchers worldwide.
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