Papers by Leticia Barajas-nava
BMJ Open
IntroductionAgeing entails a variety of physiological changes that increase the risk of chronic n... more IntroductionAgeing entails a variety of physiological changes that increase the risk of chronic non-communicable diseases. The prevalence of these diseases leads to an increase in the use of health services. The care models implemented by health systems should provide comprehensive long-term healthcare. We conducted this systematic review to determine whether any model of care for older persons have proven to be effective.MethodsA systematic review of literature was carried out to identify randomised clinical trials that have assessed how effective a care model for older patients with chronic diseases. A searches electronic databases such as MEDLINE, Turning Research Into Practice Database, Cochrane Library and Cochrane Central Register of controlled Trials was conducted from January 1966 to January 2021. Two independent reviewers assessed the eligibility of the studies. Interventions were identified and classified according to the taxonomies developed by the Cochrane Effective Prac...
Additional file 2: of Self-perception and knowledge of evidence based medicine by physicians
Spreadsheet Self-perception and knowledge of EBM. (XLSX 87 kb)
Additional file 1: of BADERI: an online database to coordinate handsearching activities of controlled clinical trials for their potential inclusion in systematic reviews
BADERI subsections. (PDF 541 kb)
Health and quality of life outcomes, Jan 13, 2017
The resilience to face disease is a process of positive adaptation despite the loss of health. It... more The resilience to face disease is a process of positive adaptation despite the loss of health. It involves developing vitality and skills to overcome the negative effects of adversity, risks, and vulnerability caused by disease. In Mexico, the Mexican Resilience Measurement Scale (RESI-M) has been validated with a general population and has a five-factor structure. However, this scale does not allow evaluation of resilience in specific subpopulations, such as caregivers. This study investigated the psychometric properties of RESI-M in 446 family caregivers of children with chronic diseases. A confirmatory factor analysis (CFA) was performed, internal consistency values were calculated using Cronbach's alpha coefficient, and mean comparisons were determined using t-tests. The expected five-factor model showed an adequate fit with the data based on a maximum likelihood test. The internal consistency for each factor ranged from .76 to .93, and the global internal consistency was .9...
C linical guidelines are "statements that include recommendations intended to optimize patient ca... more C linical guidelines are "statements that include recommendations intended to optimize patient care that are informed by systematic reviews of evidence and an assessment of the benefits and harms of alternative care options." 1 As with systematic reviews, guidelines become outdated as new evidence is published and require a periodic reassessment to remain valid. 2-4 Updating clinical guidelines is a complex process that includes identifying new evidence, assessing whether it has an impact on the recommendations and assessing whether an update is required. 5,6 Methodological handbooks include little guidance as to how to review and update guidelines, other than to do so periodically. 5,7-9 Despite scant research, guideline programs endorse 3 to 5 years as a reasonable period after which guidelines should be reviewed. 5,10 This generic guidance is based on a study published more than 10 years ago that investigated how often guidelines needed to be updated. 4 We therefore developed a strategy to assess the validity of recommendations and estimated how long it took before recommendations became out of date. Methods Design We conducted a retrospective cohort study of recommendations from clinical guidelines. We included recommendations from English translations of guidelines developed in the Spanish National Health System clinical guidelines program since 2008. All of the guidelines are available from the GuiaSalud library (www.guiasalud.es/). We stratified guidelines by topic (cancer and palliative care, cardiovascular disease, mental health and metabolic disease) and by year of publication (2008 and 2009). When multiple guidelines per strata were available, we randomly selected one. We classified recommendations according to topic (as stated previously), strength (A, B, C, D, or good practice point as graded using the Scot
Additional file 1: of Self-perception and knowledge of evidence based medicine by physicians
Survey. (PDF 22 kb)
Viral epidemics or pandemics of acute respiratory infections, like influenza or severe acute resp... more Viral epidemics or pandemics of acute respiratory infections, like influenza or severe acute respiratory syndrome pose a global threat. Antiviral drugs and vaccination may be insufficient to prevent their spread. Therefore, a Cochrane systematic review evaluated effectiveness of physical interventions to interrupt or reduce the spread of respiratory viruses.
Boletin medico del Hospital Infantil de Mexico, 2021
Background The coronavirus disease 2019 (COVID-19) pandemic has posed significant challenges glob... more Background The coronavirus disease 2019 (COVID-19) pandemic has posed significant challenges globally. Continuous transmission of the virus is mostly due to insufficient infection control measures and a lack of vaccines. Therefore, this review aimed to identify and describe possible vaccines for the prevention of COVID-19. Methods A systematic review of the scientific literature was performed through electronic searches of the main databases to identify published reports or studies on vaccines under development against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Websites from international organizations, institutes of health and research, Google, and references from identified studies were also reviewed. Studies examining the mechanisms of infection, immunopathology, and genomics were excluded. Results A total of 141 vaccines in development against SARS-CoV-2 were identified. The technologies used include weakened and inactive viruses, viral vectors, nucleic acids,...
Inhibidores de la aromatasa para estatura baja en niños y adolescentes de sexo masculino
Boletín Médico del Hospital Infantil de México
Los inhibidores de la aromatasa son fármacos disponibles por vía oral que inhiben la conversión d... more Los inhibidores de la aromatasa son fármacos disponibles por vía oral que inhiben la conversión de la testosterona en estradiol. Los estrógenos desempeñan un papel esencial en la maduración del cartílago de crecimiento y del cierre epifisario, evento que marca el final del proceso de crecimiento esquelético. Por este motivo, los inhibidores de la aromatasa se han probado como una intervención para mejorar la talla en niños y adolescentes de sexo masculino mediante el retraso en la maduración esquelética al disminuir la concentración de estradiol en la placa de crecimiento. Se resumen los resultados de una revisión sistemática Cochrane en la cual se evaluaron la eficacia y la seguridad de los inhibidores de la aromatasa para el tratamiento de la estatura baja en niños.
miRNAs as biomarkers for diagnosis of type 2 diabetes: A systematic review
Journal of Diabetes
Uso de sildenafil para la hipertensión pulmonar en neonatos
Boletín Médico del Hospital Infantil de México
Boletín Médico del Hospital Infantil de México
promueve el uso de las revisiones sistemáticas para la toma de decisiones en salud. Con ese objet... more promueve el uso de las revisiones sistemáticas para la toma de decisiones en salud. Con ese objetivo, se realizará la publicación periódica de resúmenes de revisiones sistemáticas Cochrane sobre temas relevantes que apoyen la práctica clínica. Palabras clave: Metilfenidato. Niños. Trastorno por déficit de atención con hiperactividad. Use of methylphenidate in attention-deficit hyperactivity disorder Hospital Infantil de México Federico Gómez is affiliated with the Cochrane Collaboration. As part of the activities of the Cochrane Center of the Hospital Infantil de México, the use of systematic reviews in health decision making is promoted. With this objective, summaries of Cochrane systematic reviews on relevant topics will be periodically published to support the clinical practice.
Probiotics for the treatment of irritable bowel syndrome in children
Cochrane Database of Systematic Reviews
Boletín Médico del Hospital Infantil de México (English Edition)
Background: Controlled clinical trials (CCTs) are the study design with the highest accuracy and ... more Background: Controlled clinical trials (CCTs) are the study design with the highest accuracy and evidence level. From its introduction in biomedical research, changes have been implemented in the way of establishing the basis for diagnosis, prognosis, and treatment in clinical practice. Studies to identify published CCTs regarding different medical fields have been carried out. To date, none of them has identified the clinical trials that have been published in the Boletín Médico del Hospital Infantil de México (BMHIM). This study aimed to identify and describe the CCTs published in the BMHIM. Methods: A manual and systematic search was performed in each of the volumes of the BMHIM from 1968 to 2016. CCTs were recorded to obtain their main characteristics. In addtion, their methodological quality was assessed through the "risk of bias" tool. Results are presented in a descriptive, graphical, and time-based manner. Results: In total, 73 issues with 363 volumes were reviewed, and 4925 articles were analyzed. The proportion of CCTs identified in the BMHIM was 1% (67/4925). In general, clinical trials were performed in the national context and at a third-level of medical care. CCTs also presented reduced sample sizes; pharmacological interventions were the most frequent. The methodological quality of the studies was low with a high risk of bias. conclusions: Clinical trials represented 1% of all the original research articles published in the BMHIM. There are still pediatric research fields that require CCTs to be developed to improve clinical practice, as well as to increase the quality of the research.
Boletín Médico del Hospital Infantil de México
Introducción: El ensayo clínico es la manera más rigurosa de conducir los experimentos en seres h... more Introducción: El ensayo clínico es la manera más rigurosa de conducir los experimentos en seres humanos. Desde su introducción en investigación biomédica se han implementado cambios en el modo de establecer las bases para el diagnóstico, pronóstico y la terapéutica en la práctica clínica. Se han realizado estudios para identificar los ensayos clínicos publicados en diferentes áreas médicas, pero hasta el momento ninguno había identificado los ensayos clínicos publicados en el Boletín Médico del Hospital Infantil de México (BMHIM). El objetivo de este trabajo fue identificar y describir los ensayos clínicos controlados (ECC) publicados en el BMHIM. Métodos: Se realizó búsqueda manual y sistemática en cada uno de los números y volúmenes del BMHIM de 1968 a 2016. Se registraron los ECC para obtener sus principales características. Adicionalmente, se evaluó su calidad metodológica mediante la herramienta de riesgo de sesgo. Los resultados se presentan de forma descriptiva, gráfica y temporal. Resultados: Se revisaron 73 números con 363 volúmenes, analizando 4925 artículos. La proporción de ECC identificados en el BMHIM fue del 1% (67/4925). En general, los ensayos clínicos se realizaron en el contexto nacional, en el tercer nivel de atención, con un tamaño de muestra reducido, y las intervenciones farmacológicas fueron las más utilizadas. La calidad metodológica de los estudios fue baja, con alto riesgo de sesgo. Conclusiones: Los ensayos clínicos representan el 1% de todos los artículos de investigación originales publicados en el BMHIM. Aún existen áreas de investigación pediátrica, las cuales requieren del desarrollo de ECC para mejorar la práctica clínica, así como para elevar la calidad de la investigación.
Background: The resilience to face disease is a process of positive adaptation despite the loss o... more Background: The resilience to face disease is a process of positive adaptation despite the loss of health. It involves developing vitality and skills to overcome the negative effects of adversity, risks, and vulnerability caused by disease. In Mexico, the Mexican Resilience Measurement Scale (RESI-M) has been validated with a general population and has a five-factor structure. However, this scale does not allow evaluation of resilience in specific subpopulations, such as caregivers. Method: This study investigated the psychometric properties of RESI-M in 446 family caregivers of children with chronic diseases. A confirmatory factor analysis (CFA) was performed, internal consistency values were calculated using Cronbach’s alpha coefficient, and mean comparisons were determined using t-tests. Results: The expected five-factor model showed an adequate fit with the data based on a maximum likelihood test. The internal consistency for each factor ranged from .76 to .93, and the global in...
Archibald Cochrane: evidencia, efectividad y toma de decisiones en salud
Boletín Médico del Hospital Infantil de México
Trials, Jan 13, 2017
Systematic reviews provide the best evidence on the effect of health care interventions. They rel... more Systematic reviews provide the best evidence on the effect of health care interventions. They rely on comprehensive access to the available scientific literature. Electronic search strategies alone may not suffice, requiring the implementation of a handsearching approach. We have developed a database to provide an Internet-based platform from which handsearching activities can be coordinated, including a procedure to streamline the submission of these references into CENTRAL, the Cochrane Collaboration Central Register of Controlled Trials. We developed a database and a descriptive analysis. Through brainstorming and discussion among stakeholders involved in handsearching projects, we designed a database that met identified needs that had to be addressed in order to ensure the viability of handsearching activities. Three handsearching teams pilot tested the proposed database. Once the final version of the database was approved, we proceeded to train the staff involved in handsearchi...
Medical interventions for cancer treatment-induced symptoms in children: an overview
Boletín Médico del Hospital Infantil de México, 2016
Interventions for preventing keratinocyte cancer in high-risk groups not receiving immunosuppressive therapy
Protocols, 2016
Uploads
Papers by Leticia Barajas-nava