Seven individuals with deletions of the distal long arm of chromosome 18 were evaluated at the cl... more Seven individuals with deletions of the distal long arm of chromosome 18 were evaluated at the clinical, cytogenetic, and molecular levels. The patients had varying degrees of typical clinical findings associated with the 18q- syndrome. Cytogenetic analysis revealed deletions from 18q21.3 or 18q22.2 to qter. Somatic cell hybrids derived from the patients were molecularly characterized using ordered groups of probes isolated from a chromosome 18-specific library. In general, the size of the deletion could be correlated with the severity of the phenotype. Based on the clinical pictures of these seven patients, a preliminary phenotypic map for the clinical features associated with deletions of the distal portion of the long arm has been generated. Furthermore, genes previously localized to 18q21 were mapped relative to the chromosome breakpoints present in these patients.
In a Distributed System with N sites, the precise detection of causal relationships between event... more In a Distributed System with N sites, the precise detection of causal relationships between events can only be done with vector clocks of size N. This gives rise to scalability and efficiency problems for logical clocks that can be used to order events accurately. In this paper we propose a class of logical clocks called plausible clocks that can be implemented with a number of components not affected by the size of the system and yet they provide good ordering accuracy. We develop rules to combine plausible clocks to produce more accurate clocks. Several examples of plausible clocks and their combination are presented. Using a simulation model, we evaluate the performance of these clocks. We also present examples of applications where constant size clocks can be used.
La materia pretende lograr que el estudiante aprenda las bases conceptuales utilizadas en la Eval... more La materia pretende lograr que el estudiante aprenda las bases conceptuales utilizadas en la Evaluación Financiera y Económica de Proyectos. Se realizará especial énfasis en la comprensión e interpretación de los conceptos involucrados en la temática del curso, para lograr una correcta aplicación a los problemas relacionados con la toma de decisiones de inversión, en una sociedad cuya principal característica es la "escasez de recursos".
Seven individuals with deletions of the distal long arm of chromosome 18 were evaluated at the cl... more Seven individuals with deletions of the distal long arm of chromosome 18 were evaluated at the clinical, cytogenetic, and molecular levels. The patients had varying degrees of typical clinical findings associated with the 18q- syndrome. Cytogenetic analysis revealed deletions from 18q21.3 or 18q22.2 to qter. Somatic cell hybrids derived from the patients were molecularly characterized using ordered groups of probes isolated from a chromosome 18-specific library. In general, the size of the deletion could be correlated with the severity of the phenotype. Based on the clinical pictures of these seven patients, a preliminary phenotypic map for the clinical features associated with deletions of the distal portion of the long arm has been generated. Furthermore, genes previously localized to 18q21 were mapped relative to the chromosome breakpoints present in these patients.
In a Distributed System with N sites, the precise detection of causal relationships between event... more In a Distributed System with N sites, the precise detection of causal relationships between events can only be done with vector clocks of size N. This gives rise to scalability and efficiency problems for logical clocks that can be used to order events accurately. In this paper we propose a class of logical clocks called plausible clocks that can be implemented with a number of components not affected by the size of the system and yet they provide good ordering accuracy. We develop rules to combine plausible clocks to produce more accurate clocks. Several examples of plausible clocks and their combination are presented. Using a simulation model, we evaluate the performance of these clocks. We also present examples of applications where constant size clocks can be used.
La materia pretende lograr que el estudiante aprenda las bases conceptuales utilizadas en la Eval... more La materia pretende lograr que el estudiante aprenda las bases conceptuales utilizadas en la Evaluación Financiera y Económica de Proyectos. Se realizará especial énfasis en la comprensión e interpretación de los conceptos involucrados en la temática del curso, para lograr una correcta aplicación a los problemas relacionados con la toma de decisiones de inversión, en una sociedad cuya principal característica es la "escasez de recursos".
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