LUCA CORRADI

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I'm a retirede M.D. , but I'm interested in philosopy. I did a contribute during "Heidegger nel pensiero di Severino" international congress in 2019, that i published in Academi. edu in the acts complete of the congress. I follow other contibution abaut that and abaut "Italian theory". I live in Modena, Italy and I'm 65.

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University of Perugia

Gianpaolo Reboldi

University of Perugia

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Long-term effects of ramipril and nitrendipine on albuminuria in hypertensive patients with type II diabetes and impaired renal function

Journal of Human Hypertension, 1999

The aim of this study was to compare the effects of ramipril and nitrendipine chronic treatment o... more The aim of this study was to compare the effects of ramipril and nitrendipine chronic treatment on urinary albumin excretion (UAE) in hypertensive patients with type II non-insulin-dependent diabetes mellitus (NIDDM) and impaired renal function. A 2-year, prospective, randomised study was conducted on 51 men with a diastolic blood pressure (DBP) у95 and р105 mm Hg, stable NIDDM, serum creatinine between 1.6 and 3.0 mg/dl and persistent UAE Ͼ300 and Ͻ2000 mg/24 h. After a 3month preliminary observation period, during which patients began a low-protein, low-sodium diet, and a subsequent 4-week run-in period on placebo, patients were randomly treated with ramipril 5 mg or nitrendipine 20 mg for 2 years. Both drugs similarly reduced BP without affecting glucose homeostasis. In the ramipril group

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Efficacy and safety of two treatment combinations of hypertension in very elderly patients

Archives of Gerontology and Geriatrics, 2009

The study compared valsartan/amlodipine combination with irbesartan/hydrochlorothiazide (HCTZ) co... more The study compared valsartan/amlodipine combination with irbesartan/hydrochlorothiazide (HCTZ) combination in very elderly hypertensives. After a 4-week placebo period, 94 hypertensives, aged 75-89 years were randomized to valsartan 160 mg/amlodipine 5 mg or irbesartan 300 mg/HCTZ 12.5 mg for 24 weeks according to a prospective, parallel group study. After 4 weeks amlodipine or HCTZ was doubled in non-responders. Patients were checked every 4 weeks. At each visit clinical sitting, lying and standing blood pressure (BP), systolic BP (SBP) and diastolic BP (DBP) were evaluated, and an electrocardiogram was performed. At the end of the placebo period and of the treatment period a non-invasive 24-h ambulatory BP monitoring (ABPM) was performed and electrolytes and uric acid were evaluated. Both combinations significantly reduced ambulatory BP. In the valsartan/amlodipine group the mean reduction (À29.9/À15.6 for 24 h, À28.6/À14.5 mmHg for daytime and À26.2/À17.4 mmHg for nighttime SBP/DBP) was similar to that of the irbesartan/HCTZ group (À29.6/À15.4 for 24 h, À29.3/ À14.9 mmHg for daytime and À25.4/À16.9 mmHg for night-time SBP/DBP). Both combinations significantly reduced clinical sitting and lying BP values with no difference between treatments. BP changes from lying to standing position were significantly greater in the irbesartan/HCTZ group (À17.2/ À9.1 mmHg) than in the valsartan/amlodipine group (À10.1/À1.9 mmHg, p < 0.05 for SBP and p < 0.01 for DBP vs. irbesartan/HCTZ). Potassium significantly decreased and uric acid significantly increased (À0.4 mmol/l, p < 0.05 and +0.5 mg/dl, p < 0.05 vs. baseline, respectively) only in the irbesartan/HCTZ group. In conclusion, both combinations were similarly effective in reducing ambulatory and clinical BP in very elderly hypertensives. However, valsartan/amlodipine offered some advantages in terms of less pronounced BP orthostatic changes and absence of metabolic adverse effects.

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Long-term effects of ramipril and nitrendipine on albuminuria in hypertensive patients with type II diabetes and impaired renal function

Journal of Human Hypertension, 1999

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Efficacy and safety of two treatment combinations of hypertension in very elderly patients

Archives of Gerontology and Geriatrics, 2009

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