Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi Zhonghua Laodong Weisheng Zhiyebing Zazhi Chinese Journal of Industrial Hygiene and Occupational Diseases, Dec 1, 2012
The past decade has witnessed an exponential growth of biological data including genomic sequence... more The past decade has witnessed an exponential growth of biological data including genomic sequences, gene annotations, expression and regulation, and protein-protein interactions. A key aim in the post-genome era is to systematically catalogue gene networks and pathways in a dynamic living cell and apply them to study diseases and phenotypes. To promote the research in systems biology and its application to disease studies, we organized a workshop focusing on the reconstruction and analysis of gene networks and pathways in any organisms from high-throughput data collected through techniques such as microarray analysis and RNA-Seq.
2008 the 9th International Conference For Young Computer Scientists, 2008
As link rates and traffic volumes of Internet are constantly growing, string matching using the D... more As link rates and traffic volumes of Internet are constantly growing, string matching using the Deterministic Finite Automaton (DFA) will be the performance bottleneck of Deep Packet Inspection (DPI). The recently proposed bit-split string matching algorithm suffers from the unnecessary state transitions problem, limiting the efficiency of DPI. The root cause lies in the fact that each tiny DFA of
International Journal of Computational Biology and Drug Design, 2011
The past decade has witnessed an exponential growth of biological data including genomic sequence... more The past decade has witnessed an exponential growth of biological data including genomic sequences, gene annotations, expression and regulation, and protein-protein interactions. A key aim in the post-genome era is to systematically catalogue gene networks and pathways in a dynamic living cell and apply them to study diseases and phenotypes. To promote the research in systems biology and its application to disease studies, we organized a workshop focusing on the reconstruction and analysis of gene networks and pathways in any organisms from high-throughput data collected through techniques such as microarray analysis and RNA-Seq.
Three-liquid-phase partitioning of Pd(II), Pt(IV) and Rh(III) in systems of S201(diisoamyl sulfid... more Three-liquid-phase partitioning of Pd(II), Pt(IV) and Rh(III) in systems of S201(diisoamyl sulfide)/nonane–EOPO(polyethylene oxide–polypropylene oxide random block copolymer)–Na2SO4–H2O was investigated. Experimental results indicated that the selective enrichment of Pd(II), Pt(IV) and Rh(III) respectively into the S201 organic top phase, EOPO-based middle phase and Na2SO4 bottom phase was achieved by control over the phase behavior of the three-liquid-phase systems (TLPS). The microphase mass transfer behavior of Pt(IV), Pd(II) and Rh(III) was closely related to the micellization of EOPO molecules. A suggested micro-mechanism model and a mass transfer model describe the micellization of EOPO molecules and the effect on mass transfer of platinum ions across the microphase interfaces. The salting-out induced continuous dehydration and ordered arrangement of the hydrophilic PEO segments in amphiphilic EOPO micelle, and these are the main driving forces for mass transfer of platinum metal ions onto the exposed activity sites of the dehydrated PEO segments. The differences in microphase interfacial structure of EOPO micelles are crucial for the efficient separation between Pt(IV), Pd(II) and Rh(III).A mass transfer model describes the anionic exchange process between platinum metal ion complexes and the phase-forming salt anions across the microphase interfaces of copolymer micelles.► The appearance of three liquid phases permits one-step separation of Pd, Pt and Rh. ► The phase behavior has a correlation with three-phase partitioning of Pd, Pt and Rh. ► Microphase interfacial structure is an important factor in mass transfer of metals.
Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 2010
... Single crystal X-ray dif-fraction analysis confirmed that these kinds of functional thiacalix... more ... Single crystal X-ray dif-fraction analysis confirmed that these kinds of functional thiacalixarene and sulfonylcalixarenes exist mainly in 1,3-alternate ... 41, 99105 (2001) 5. Dhir, A., Bhalla, V., Kumar, M.: Ratiometry of monomer/exci-mer emissions of dipyrenyl thiacalix[4]arene for ...
ABSTRACT A self-crosslinking compound with epoxy groups and anhydride groups (GEMA) was successfu... more ABSTRACT A self-crosslinking compound with epoxy groups and anhydride groups (GEMA) was successfully synthesized from tung oil fatty acid by reacting with maleic anhydride via the Diels–Alder reaction. GEMA has very good storage stability and could be cured with trace amounts of tertiary amine. This advantage avoided the nonuniformity, bubbles and insolubility during the mixing procedure of the epoxy resins and curing agents. Compared to commercial Bisphenol A epoxy resins, GEMA has relatively lower mechanical properties and thermal properties. However, in view of its renewable properties, GEMA is still a very promising bio-based epoxy which may replace bisphenol A epoxy resins in some applications.
Guang Pu Xue Yu Guang Pu Fen Xi Guang Pu, Apr 1, 2008
Two-dimensional (2D) correlation spectroscopy is a powerful method to study the intermolecular in... more Two-dimensional (2D) correlation spectroscopy is a powerful method to study the intermolecular interactions between different molecules/functional groups. In the present paper, variable concentrations were selected to construct 2D synchronous spectrum for studying the weak intermolecular interactions in solutions. Mathematical analysis performed on 2D synchronous spectra using variable concentration as an external perturbation shows that the "Orthogonal Sample Design Scheme" is necessary for eliminating the interfering cross peaks in 2D synchronous spectra. The authors prepared four mixed-solutes-solutions whose concentration series satisfy the "Orthogonal Sample Design Scheme" for each chemical system and the consequent 2D synchronous spectrum was calculated from the corresponding four 1D spectra. Thus, by 1D & 2D FTIR spectra together with solid grinding reaction, the intermolecular interactions in two chemical systems (Sodium 2-Aminobenzoate/NdCl3 in aqueous solution, and 2-ethylhexyl phosphonic acid mono 2-ethylhexyl ester (PC88A)/Naphthenic Acid (NA) in heptane solution) were studied, where the intermolecular interactions only induce subtle spectral variations in conventional 1D spectra. First, the cross peaks between f-f transition bands of Nd3+ ion at 521, 574, 741, 795 and 865 nm and pi-pi transition band of Sodium 2-Aminobenzoate at 308 nm in 2D synchronous spectrum confirm the coordination interaction between Sodium 2-Aminobenzoate and Nd3+. Solid grinding reaction between Sodium 2-Aminobenzoate and NdCl3 and FTIR spectra of the product indicate that the vibration bands of amino, carboxyl groups from sodium 2-aminobenzoate show considerable changes. Based on the spectral result above, a conclusion is drawn that Nd3+ can coordinate with Sodium 2-Aminobenzoate by amino and carboxyl groups. Second, the cross peaks between POH stretching band of PC88A at 983 cm(-1) and COOH stretching band of NA at 1 710 cm(-1) in 2D spectra confirm the interaction between PC88A and NA. Subtraction spectrum demonstrates that when PC88A is mixed with NA in heptane solution, and P=O stretching band of PC88A shifts from 1 199 to 1161 cm(-1), and POH stretching band shifts from 983 to 965 cm(-1). Based on the spectral result above, a conclusion was made that PC88A and NA can interact with each other by forming new assemblies with POH and COOH groups.
Journal of the American Society For Information Science and Technology, Aug 1, 2005
Comparative study of knowledge management (KM) promises to lead to more effective knowledge use i... more Comparative study of knowledge management (KM) promises to lead to more effective knowledge use in all cultural environments. This pilot study compares KM priorities, needs, tools, and administrative structure components in large Chinese and American universities. General KM theory and literature related to KM in higher education are analyzed to develop the four components of the study. Comparative differences in KM practice at large Chinese and American universities are analyzed for each component. A correlation matrix reveals statistically significant co-variation among all but one of the study components. Four conclusions related to comparative KM and suggestions for future research are presented.
This paper introduces a new approach named double orthogonal sample design scheme (DOSD) to probe... more This paper introduces a new approach named double orthogonal sample design scheme (DOSD) to probe intermolecular interactions based on a framework of two-dimensional (2D) correlated spectroscopy. In this approach, specifically designed concentration series are selected according to the mathematical analysis on orthogonal vectors to generate useful 2D correlated spectra. As a result, the interfering portion can be completely removed from both synchronous and asynchronous spectra, and complementary information concerning intermolecular interactions can be obtained from the set of 2D spectra. A model system, where intermolecular interactions occur between two solutes in a solution, is used to investigate the behavior of 2D correlated spectra generated by using the DOSD approach. Simulation results demonstrate that the resultant spectral patterns can reflect subtle spectral variation in bandwidths, peak positions, and absorptivities brought about by intermolecular interaction, which are hardly visualized in conventional 1D spectra because of the severe band-overlapping problem. The ability to reveal a subtle variation in a characteristic peak in detail by using the DOSD approach provides a new opportunity to understand the nature of intermolecular interactions from a molecular structural point of view. Intermolecular interactions between iodine and benzene in CCl4 solutions were investigated by using the proposed DOSD approach to prove the applicability of the DOSD method in real chemical systems.
Many papers have reported that salt ions can exert a great influence on the self-assembly behavio... more Many papers have reported that salt ions can exert a great influence on the self-assembly behavior of PEO-PPO copolymers in the aqueous solution. Whereas the mechanism through which salt ions influence the self-assembly behavior of PEO-PPO copolymers is unclear and the dispute is mainly focused on whether the salt ions have a direct interaction with PEO-PPO copolymers. In this paper, the interaction of sodium and potassium ions with PEO-PPO copolymer was investigated by using FTIR, Raman and 23 Na NMR spectroscopy. Experimental results reveal that direct interactions between salt cations and PEO-PPO macromolecular chains indeed occur in appropriate conditions. The present work highlights the role of cations in the self-assembly process of PEO-PPO copolymer.
ABSTRACT In this work, a new liquid thermal stabilizer (LTS) was prepared using rosin and fatty a... more ABSTRACT In this work, a new liquid thermal stabilizer (LTS) was prepared using rosin and fatty acids as feedstock and evaluated for its stabilizing effects on poly(vinyl chloride) (PVC). First, a rosin/oil-based dimer acid (RODA) was prepared by the addition reaction of rosin and industrial fatty acids and then converted into its zinc soap (RODA-Zn) and calcium soap (RODA-Ca). The chemical structures were examined by UV–Vis and Fourier Transform infrared spectroscopies. Liquid form thermal stabilizers (RODA-LTS) were obtained by treating the solid RODA-Zn and RODA-Ca soaps with epoxidized soybean oil, triphenyl phosphite and liquid paraffin at 120 °C for 3 h. Thermal stabilizing effects of the resulting RODA-LTS for PVC were compared with that of two commercial LTSs. Thermal stability of PVC compounds was determined using dehydrochlorination test, thermogravimetric analysis (TGA), Congo red test and torque rheological analysis. Results indicated that RODA-LTS had overall superior thermal stability. Tensile and dynamic mechanical properties of the PVC compounds were also studied, and the results indicated that the PVC compounds stabilized with RODA-LTS and commercial LTSs displayed comparable strength, modulus and glass transition temperatures.
ABSTRACT The present work reports an interesting phenomena that the addition of hydrophobic ionic... more ABSTRACT The present work reports an interesting phenomena that the addition of hydrophobic ionic liquid, [C4mim]PF6, into the oil–water two phase system of diisopentyl sulfide (S201)–nonane organic solutions and hydrochloric acid aqueous solutions containing Pt (IV), Pd (II) and Rh (III) chloric-complexing anions could induce the formation of a stable liquid–liquid–liquid three layered liquids coexisting medium for extraction and one-step separation of platinum, palladium and rhodium. The influences of H+ and Cl− concentrations in equilibrating aqueous solutions, the initial Pt (IV) concentration, the volume ratio of added [C4mim][PF6] to hydrochloric acid aqueous solution and the different salt ions in equilibrating aqueous solutions on the three-liquid-phase partitioning behaviors of three platinum metal ions were evaluated. The transferring of PtCl62- into the [C4mim]PF6 bottom phase in TLPS was proposed to be according with an anion exchange between PtCl62- and PF6- in ionic liquid. Therefore, the separated ionic liquid phase is not the solvent of organic extractants, but provides an extended separation capacity than the literature reported ionic liquid based two-phase extraction systems. The present work indicated that this ionic liquid based three-liquid system can be used to separate multi-metal coexisting solutions.
2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW), 2010
We propose a signal processing approach for detecting enrichment regions from ChIP-seq datasets. ... more We propose a signal processing approach for detecting enrichment regions from ChIP-seq datasets. A wavelet transform of the ChIP-seq data offers a direct visualization for both short- and long-range patterns of the genome-wide mapping profile for protein binding site on DNA. To investigate the location of transcription factor binding site (TFBS) from ChIP-seq data, a wavelet-based peak detection algorithm is proposed. Differing from prior methods exploring the statistics of peaks in whole genome, scalogram of raw data is used. In addition, a SNR-like parameter used to detects the peaks is proposed to instead of raw data for tackling the peak finding problem. Also peak depth, the length of peak regions can be obtained by the measurement of SNR-like parameter with a threshold constrain. Furthermore, in order to eliminate false positives, a filter which sifts out the peaks with sufficient SNR but not deep enough in sequence depth is applied. The effectiveness of our method is demonstrated by applying the STAT1 ChIP-seq data and comparing to the well known published method, PeakSeq. The experimental results show that a large fraction of peaks identified by our method are consistent with the results of PeakSeq algorithm while our results show more consistent motif conservation scores.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi Zhonghua Laodong Weisheng Zhiyebing Zazhi Chinese Journal of Industrial Hygiene and Occupational Diseases, Dec 1, 2012
The past decade has witnessed an exponential growth of biological data including genomic sequence... more The past decade has witnessed an exponential growth of biological data including genomic sequences, gene annotations, expression and regulation, and protein-protein interactions. A key aim in the post-genome era is to systematically catalogue gene networks and pathways in a dynamic living cell and apply them to study diseases and phenotypes. To promote the research in systems biology and its application to disease studies, we organized a workshop focusing on the reconstruction and analysis of gene networks and pathways in any organisms from high-throughput data collected through techniques such as microarray analysis and RNA-Seq.
2008 the 9th International Conference For Young Computer Scientists, 2008
As link rates and traffic volumes of Internet are constantly growing, string matching using the D... more As link rates and traffic volumes of Internet are constantly growing, string matching using the Deterministic Finite Automaton (DFA) will be the performance bottleneck of Deep Packet Inspection (DPI). The recently proposed bit-split string matching algorithm suffers from the unnecessary state transitions problem, limiting the efficiency of DPI. The root cause lies in the fact that each tiny DFA of
International Journal of Computational Biology and Drug Design, 2011
The past decade has witnessed an exponential growth of biological data including genomic sequence... more The past decade has witnessed an exponential growth of biological data including genomic sequences, gene annotations, expression and regulation, and protein-protein interactions. A key aim in the post-genome era is to systematically catalogue gene networks and pathways in a dynamic living cell and apply them to study diseases and phenotypes. To promote the research in systems biology and its application to disease studies, we organized a workshop focusing on the reconstruction and analysis of gene networks and pathways in any organisms from high-throughput data collected through techniques such as microarray analysis and RNA-Seq.
Three-liquid-phase partitioning of Pd(II), Pt(IV) and Rh(III) in systems of S201(diisoamyl sulfid... more Three-liquid-phase partitioning of Pd(II), Pt(IV) and Rh(III) in systems of S201(diisoamyl sulfide)/nonane–EOPO(polyethylene oxide–polypropylene oxide random block copolymer)–Na2SO4–H2O was investigated. Experimental results indicated that the selective enrichment of Pd(II), Pt(IV) and Rh(III) respectively into the S201 organic top phase, EOPO-based middle phase and Na2SO4 bottom phase was achieved by control over the phase behavior of the three-liquid-phase systems (TLPS). The microphase mass transfer behavior of Pt(IV), Pd(II) and Rh(III) was closely related to the micellization of EOPO molecules. A suggested micro-mechanism model and a mass transfer model describe the micellization of EOPO molecules and the effect on mass transfer of platinum ions across the microphase interfaces. The salting-out induced continuous dehydration and ordered arrangement of the hydrophilic PEO segments in amphiphilic EOPO micelle, and these are the main driving forces for mass transfer of platinum metal ions onto the exposed activity sites of the dehydrated PEO segments. The differences in microphase interfacial structure of EOPO micelles are crucial for the efficient separation between Pt(IV), Pd(II) and Rh(III).A mass transfer model describes the anionic exchange process between platinum metal ion complexes and the phase-forming salt anions across the microphase interfaces of copolymer micelles.► The appearance of three liquid phases permits one-step separation of Pd, Pt and Rh. ► The phase behavior has a correlation with three-phase partitioning of Pd, Pt and Rh. ► Microphase interfacial structure is an important factor in mass transfer of metals.
Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 2010
... Single crystal X-ray dif-fraction analysis confirmed that these kinds of functional thiacalix... more ... Single crystal X-ray dif-fraction analysis confirmed that these kinds of functional thiacalixarene and sulfonylcalixarenes exist mainly in 1,3-alternate ... 41, 99105 (2001) 5. Dhir, A., Bhalla, V., Kumar, M.: Ratiometry of monomer/exci-mer emissions of dipyrenyl thiacalix[4]arene for ...
ABSTRACT A self-crosslinking compound with epoxy groups and anhydride groups (GEMA) was successfu... more ABSTRACT A self-crosslinking compound with epoxy groups and anhydride groups (GEMA) was successfully synthesized from tung oil fatty acid by reacting with maleic anhydride via the Diels–Alder reaction. GEMA has very good storage stability and could be cured with trace amounts of tertiary amine. This advantage avoided the nonuniformity, bubbles and insolubility during the mixing procedure of the epoxy resins and curing agents. Compared to commercial Bisphenol A epoxy resins, GEMA has relatively lower mechanical properties and thermal properties. However, in view of its renewable properties, GEMA is still a very promising bio-based epoxy which may replace bisphenol A epoxy resins in some applications.
Guang Pu Xue Yu Guang Pu Fen Xi Guang Pu, Apr 1, 2008
Two-dimensional (2D) correlation spectroscopy is a powerful method to study the intermolecular in... more Two-dimensional (2D) correlation spectroscopy is a powerful method to study the intermolecular interactions between different molecules/functional groups. In the present paper, variable concentrations were selected to construct 2D synchronous spectrum for studying the weak intermolecular interactions in solutions. Mathematical analysis performed on 2D synchronous spectra using variable concentration as an external perturbation shows that the "Orthogonal Sample Design Scheme" is necessary for eliminating the interfering cross peaks in 2D synchronous spectra. The authors prepared four mixed-solutes-solutions whose concentration series satisfy the "Orthogonal Sample Design Scheme" for each chemical system and the consequent 2D synchronous spectrum was calculated from the corresponding four 1D spectra. Thus, by 1D & 2D FTIR spectra together with solid grinding reaction, the intermolecular interactions in two chemical systems (Sodium 2-Aminobenzoate/NdCl3 in aqueous solution, and 2-ethylhexyl phosphonic acid mono 2-ethylhexyl ester (PC88A)/Naphthenic Acid (NA) in heptane solution) were studied, where the intermolecular interactions only induce subtle spectral variations in conventional 1D spectra. First, the cross peaks between f-f transition bands of Nd3+ ion at 521, 574, 741, 795 and 865 nm and pi-pi transition band of Sodium 2-Aminobenzoate at 308 nm in 2D synchronous spectrum confirm the coordination interaction between Sodium 2-Aminobenzoate and Nd3+. Solid grinding reaction between Sodium 2-Aminobenzoate and NdCl3 and FTIR spectra of the product indicate that the vibration bands of amino, carboxyl groups from sodium 2-aminobenzoate show considerable changes. Based on the spectral result above, a conclusion is drawn that Nd3+ can coordinate with Sodium 2-Aminobenzoate by amino and carboxyl groups. Second, the cross peaks between POH stretching band of PC88A at 983 cm(-1) and COOH stretching band of NA at 1 710 cm(-1) in 2D spectra confirm the interaction between PC88A and NA. Subtraction spectrum demonstrates that when PC88A is mixed with NA in heptane solution, and P=O stretching band of PC88A shifts from 1 199 to 1161 cm(-1), and POH stretching band shifts from 983 to 965 cm(-1). Based on the spectral result above, a conclusion was made that PC88A and NA can interact with each other by forming new assemblies with POH and COOH groups.
Journal of the American Society For Information Science and Technology, Aug 1, 2005
Comparative study of knowledge management (KM) promises to lead to more effective knowledge use i... more Comparative study of knowledge management (KM) promises to lead to more effective knowledge use in all cultural environments. This pilot study compares KM priorities, needs, tools, and administrative structure components in large Chinese and American universities. General KM theory and literature related to KM in higher education are analyzed to develop the four components of the study. Comparative differences in KM practice at large Chinese and American universities are analyzed for each component. A correlation matrix reveals statistically significant co-variation among all but one of the study components. Four conclusions related to comparative KM and suggestions for future research are presented.
This paper introduces a new approach named double orthogonal sample design scheme (DOSD) to probe... more This paper introduces a new approach named double orthogonal sample design scheme (DOSD) to probe intermolecular interactions based on a framework of two-dimensional (2D) correlated spectroscopy. In this approach, specifically designed concentration series are selected according to the mathematical analysis on orthogonal vectors to generate useful 2D correlated spectra. As a result, the interfering portion can be completely removed from both synchronous and asynchronous spectra, and complementary information concerning intermolecular interactions can be obtained from the set of 2D spectra. A model system, where intermolecular interactions occur between two solutes in a solution, is used to investigate the behavior of 2D correlated spectra generated by using the DOSD approach. Simulation results demonstrate that the resultant spectral patterns can reflect subtle spectral variation in bandwidths, peak positions, and absorptivities brought about by intermolecular interaction, which are hardly visualized in conventional 1D spectra because of the severe band-overlapping problem. The ability to reveal a subtle variation in a characteristic peak in detail by using the DOSD approach provides a new opportunity to understand the nature of intermolecular interactions from a molecular structural point of view. Intermolecular interactions between iodine and benzene in CCl4 solutions were investigated by using the proposed DOSD approach to prove the applicability of the DOSD method in real chemical systems.
Many papers have reported that salt ions can exert a great influence on the self-assembly behavio... more Many papers have reported that salt ions can exert a great influence on the self-assembly behavior of PEO-PPO copolymers in the aqueous solution. Whereas the mechanism through which salt ions influence the self-assembly behavior of PEO-PPO copolymers is unclear and the dispute is mainly focused on whether the salt ions have a direct interaction with PEO-PPO copolymers. In this paper, the interaction of sodium and potassium ions with PEO-PPO copolymer was investigated by using FTIR, Raman and 23 Na NMR spectroscopy. Experimental results reveal that direct interactions between salt cations and PEO-PPO macromolecular chains indeed occur in appropriate conditions. The present work highlights the role of cations in the self-assembly process of PEO-PPO copolymer.
ABSTRACT In this work, a new liquid thermal stabilizer (LTS) was prepared using rosin and fatty a... more ABSTRACT In this work, a new liquid thermal stabilizer (LTS) was prepared using rosin and fatty acids as feedstock and evaluated for its stabilizing effects on poly(vinyl chloride) (PVC). First, a rosin/oil-based dimer acid (RODA) was prepared by the addition reaction of rosin and industrial fatty acids and then converted into its zinc soap (RODA-Zn) and calcium soap (RODA-Ca). The chemical structures were examined by UV–Vis and Fourier Transform infrared spectroscopies. Liquid form thermal stabilizers (RODA-LTS) were obtained by treating the solid RODA-Zn and RODA-Ca soaps with epoxidized soybean oil, triphenyl phosphite and liquid paraffin at 120 °C for 3 h. Thermal stabilizing effects of the resulting RODA-LTS for PVC were compared with that of two commercial LTSs. Thermal stability of PVC compounds was determined using dehydrochlorination test, thermogravimetric analysis (TGA), Congo red test and torque rheological analysis. Results indicated that RODA-LTS had overall superior thermal stability. Tensile and dynamic mechanical properties of the PVC compounds were also studied, and the results indicated that the PVC compounds stabilized with RODA-LTS and commercial LTSs displayed comparable strength, modulus and glass transition temperatures.
ABSTRACT The present work reports an interesting phenomena that the addition of hydrophobic ionic... more ABSTRACT The present work reports an interesting phenomena that the addition of hydrophobic ionic liquid, [C4mim]PF6, into the oil–water two phase system of diisopentyl sulfide (S201)–nonane organic solutions and hydrochloric acid aqueous solutions containing Pt (IV), Pd (II) and Rh (III) chloric-complexing anions could induce the formation of a stable liquid–liquid–liquid three layered liquids coexisting medium for extraction and one-step separation of platinum, palladium and rhodium. The influences of H+ and Cl− concentrations in equilibrating aqueous solutions, the initial Pt (IV) concentration, the volume ratio of added [C4mim][PF6] to hydrochloric acid aqueous solution and the different salt ions in equilibrating aqueous solutions on the three-liquid-phase partitioning behaviors of three platinum metal ions were evaluated. The transferring of PtCl62- into the [C4mim]PF6 bottom phase in TLPS was proposed to be according with an anion exchange between PtCl62- and PF6- in ionic liquid. Therefore, the separated ionic liquid phase is not the solvent of organic extractants, but provides an extended separation capacity than the literature reported ionic liquid based two-phase extraction systems. The present work indicated that this ionic liquid based three-liquid system can be used to separate multi-metal coexisting solutions.
2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW), 2010
We propose a signal processing approach for detecting enrichment regions from ChIP-seq datasets. ... more We propose a signal processing approach for detecting enrichment regions from ChIP-seq datasets. A wavelet transform of the ChIP-seq data offers a direct visualization for both short- and long-range patterns of the genome-wide mapping profile for protein binding site on DNA. To investigate the location of transcription factor binding site (TFBS) from ChIP-seq data, a wavelet-based peak detection algorithm is proposed. Differing from prior methods exploring the statistics of peaks in whole genome, scalogram of raw data is used. In addition, a SNR-like parameter used to detects the peaks is proposed to instead of raw data for tackling the peak finding problem. Also peak depth, the length of peak regions can be obtained by the measurement of SNR-like parameter with a threshold constrain. Furthermore, in order to eliminate false positives, a filter which sifts out the peaks with sufficient SNR but not deep enough in sequence depth is applied. The effectiveness of our method is demonstrated by applying the STAT1 ChIP-seq data and comparing to the well known published method, PeakSeq. The experimental results show that a large fraction of peaks identified by our method are consistent with the results of PeakSeq algorithm while our results show more consistent motif conservation scores.
Uploads
Papers by Kun Huang