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Korany Ali

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Phone: +201006377620
Address: Department of Applied Organic Chemistry, National Research Center, 12622, Dokki, Cairo, Egypt

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School of the Art Institute of Chicago

Dr.Yousery Sherif

Mansoura University

Moscow State University

Hernan Chaimovich

Universidade de São Paulo

azaiez ben akacha

University of Tunis El Manar

Professor Dr. Loutfy H . Madkour

Al-Baha University, Kingdom of Saudi Arabia

Uwamere O Edeghor

University of Calabar, Calabar, Nigeria.

University of Chicago

Fathy Abdelrazek

Cairo University

Kayitesi Eugenie

UNIVERSITY OF JOHANNESBURG

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Papers by Korany Ali

Alginate and carrageenan-nanocellulose composite beads for efficient removal of metal cations

Journal of organic & inorganic chemistry, Sep 27, 2018

New polymeric matrix of polylactic acid/sodium alginate/carbon nanoparticles (PLA/SA/CNP) for efficient removal of methylene blue

Chemical Papers, Jul 19, 2023

For the adsorption of methylene blue (MB), novel bio-polymeric matrices prepared from polylactic ... more For the adsorption of methylene blue (MB), novel bio-polymeric matrices prepared from polylactic acid/sodium alginate (PLA/SA) and polylactic acid/sodium alginate/carbon nanoparticle (PLA/SA/CNP) as green adsorbates were prepared in the form of beads. The developed adsorbent was analyzed using scanning electron microscopes and Fourier transform infrared spectrometers. The percentage of adsorbed dye increased with increasing CNP content, and the optimum ratio was 5% wt. The efficiency of the beads' removal and adsorption capacity were evaluated concerning with (adsorbent dosage, contact time, initial pH, and concentration of adsorbate). After 120 min using 50 mg of PLA/SA/CNP beads, the adsorptive removal process for MB dye was determined to have the maximum rate at pH 9. The models of Langmuir and Freundlich were used to illustrate the experimental data. Langmuir models determined the highest adsorption capacity to be 304.88 mg/g.

ChemInform Abstract: Design, Synthesis and Structure-Activity Relationship Study of Novel Pyrazole-Based Heterocycles as Potential Antitumor Agents

ChemInform, Mar 14, 2011

Design, Synthesis, and Structure-Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-... more Design, Synthesis, and Structure-Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-yl)ethylamino]pyridazine Derivatives as Acetylcholinesterase Inhibitors.-Various analogues of the known inhibitor (I) are prepared. Among all products, derivatives (IIa) and (IIb) are found to be the most representative drugs, more selective than the reference compound (I).-(CONTRERAS, JEAN-MARIE; PARROT, ISABELLE;

Adsorption of Methylene Blue on A Polymeric Matrix of Poly Lactic Acid/Sodium Alginate/Carbon Nanoparticles (PLA/SA/CNP)

Research Square (Research Square), Jun 24, 2022

This study presents the preparation of Poly lactic acid/Sodium alginate (PLA/SA) and PLA/SA/CNP b... more This study presents the preparation of Poly lactic acid/Sodium alginate (PLA/SA) and PLA/SA/CNP beads for the methylene blue (MB) adsorption. A Fourier transform infrared spectrometer (FTIR) characterized the produced adsorbent. The various dosages of CNP content were added to PLA/SA beads. The percentage of adsorbed dye increased with increasing CNP content, so the optimum percentage is 5%wt. The beads' adsorption capacity and removal e ciency was investigated as a function of (adsorbent dosage, contact time, initial pH, and concentration of adsorbate). The highest rate of the adsorptive removal process for MB dye was found at pH 9 after 120 min equilibration time with 50mg of PLA/SA/CNP beads. Langmuir and Freundlich's models were applied for the illustration of experimental data. Langmuir models illustrate that the maximum adsorption capacity equals 304.88mg/g. Dyes have different long-term impacts on organisms depending on the dye content and exposure time 4,5. Dye exposure and indigestion have been linked to several health concerns, including eye burn, cancer, skin irritation, nausea, and dermatitis 6. Because of the dangers of dyes, removing them from water and treating contaminated water has sparked a lot of interest, and a lot of research has been done in this eld of environmental science. Among those methods, membrane ltration, electrochemical, advanced oxidation process, chemical oxidation, biological process, Ion exchange resin is one of the physical dye treatment procedures 7 , photocatalysis 8 , and adsorption that has been interestingly studied because of its bene ts, which include cheap costs, ease of application, ease of design and operation, effectiveness, the ability to reuse and regenerate adsorbents 9-12. Rather than eliminating the pigment, most of these procedures dilute the high dye concentration. As a result, dye is removed from high concentrations using adsorption. Furthermore,

Microwave‐assisted synthesis and heterocyclic functionalization of chromenopyridines on calixarene scaffold

Journal of Heterocyclic Chemistry, Apr 1, 2020

A three‐component one‐pot condensation reaction of chroman‐4‐one with ethyl 2‐cyanoacetate and va... more A three‐component one‐pot condensation reaction of chroman‐4‐one with ethyl 2‐cyanoacetate and various aldehydes in the presence of ammonium acetate afforded a series of 2‐oxo‐4‐phenyl‐1,5‐dihydro‐2H‐chromeno[4,3‐b]pyridine‐3‐carbonitrile. These heterocycles have been converted to chloropyridine derivatives and appended to macrocyclic calix[4]arene scaffold through aromatic nucleophilic substitution under microwave irradiation. In this study, the microwave‐assisted functionalization of the lower rim of calix[4]arene has been considered the only appropriate tool because the conventional heating did not lead to any new product after 72 hours of heating under thermal condition.

Design, Synthesis and In-vivo Anti-inflammatory Activity of New Celecoxib Analogues as NSAID

Mini-reviews in Medicinal Chemistry, Sep 13, 2018

Background: A new series of Celecoxib analogues were easily synthesized via reactions of 4-(2-(1-... more Background: A new series of Celecoxib analogues were easily synthesized via reactions of 4-(2-(1-chloro-2-oxopropylidene)hydrazinyl)benzene sulfonamide (1) with active methylene compounds and dialkyl malonate. In addition, compound 1 was reacted also with thiourea derivatives and thiosemicarbazone derivatives to afford thiazole derivatives 9 and 11, respectively. Furthermore, triazolo pyrimidine derivatives 13 were prepared via reaction of compound 1 with pyrimidine thione derivatives. The structures of the new synthesized compounds were assigned by elemental analysis and spectroscopic data. The new analogues were screened for their in vivo anti-inflammatory activity using carrageenan-induced paw edema method. Conclusion: They showed moderate to good in vivo anti-inflammatory effects. Compounds 1, 6 and 11b were the most active compounds that reduced the paw edema induced by carrageenan by 12.25 %, 12.96 % and 12.97% respectively, as compared to the Indomethacin that inhibited the oedema volume by 7.47 %.

Synthesis and Antimicrobial Evaluation of a New Series of Heterocyclic Systems Bearing a Benzosuberone Scaffold

Molecules, Nov 16, 2015

A series of novel benzosuberone derivatives were synthesized and evaluated as antimicrobial agent... more A series of novel benzosuberone derivatives were synthesized and evaluated as antimicrobial agents by using substituted benzosuberone derivatives 1a,b as starting materials. Treatment of 1a,b with phenyl isothiocyanate in dimethylformamide was followed by treatment with cold HCl solution to afford the thioamides 4a,b, which was reacted with methyl iodide to obtain methylated products 5a,b. Cyclocondensation of 4a,b with chloroacetone 6 and phenacyl chloride 7 gave the corresponding thiophene derivatives 9a-c. Reaction of 4a,b with C-acetyl-N-arylhydrazonoyl chlorides 14a and 14b in boiling EtOH in the presence of triethylamine, afforded the corresponding 1,3,4-thiadiazoline derivatives 16a-d. The thioamides 4a,b were reacted with C-ethoxycarbonyl-N-arylhydrazonoyl chlorides 18a,b which afforded 1,3,4-thiadiazoline derivatives 19a-d. The benzosuberones 1a,b were treated with 3-mercaptopropanoic acid to give compounds 21a,b, which were cyclized to tricyclic thiopyran-4(5H)-one derivatives 22a,b. The latter compounds 22a,b were reacted with 3-mercaptopropanoic acid to give compounds 23a,b, which were cyclized tetracyclic ring systems 24a,b. Finally, compounds 24a,b were oxidized using hydrogen peroxide under reflux conditions to afford the oxidized form of the novel tetracyclic heterogeneous ring systems 25a,b. The newly synthesized compounds were screened for antimicrobial activities. The structures of new compounds were characterized by 1 H-NMR,

Biodegradable grafting cellulose/clay composites for metal ions removal

International Journal of Biological Macromolecules, Oct 1, 2018

Biodegradable bi-functional cellulose derivatives were synthesized to remove widespread undergrou... more Biodegradable bi-functional cellulose derivatives were synthesized to remove widespread underground water cations such as; Ca 2+ , Mg 2+ , Fe 2+ , Pb 2+ , and Cu 2+. Firstly, graft copolymerization of cellulose with binary monomers such as acrylic acid (AA), and 2acrylamido-2-methylpropanesulfonic acid (AMPS) with acrylamide (Am) were achieved using potassium persulfate as initiator. Then, cellulose/clay composites were prepared by graft copolymerization of cellulose using different montmorillonite concentrations such as 3, 6 and 9

Novel alginate carbon nanoparticle composite beads for efficient removal of Pb2+ ions from aqueous solutions

Nanotechnology for environmental engineering, Oct 19, 2022

Anticancer Activity of Some Synthesized of Mn(II), Cu(II), Ni(II), Sn(II) and Ca(II) Complexes Bis(3-phenylpropane-1,3-dione) Derivative as Ligand

Journal of Computational and Theoretical Nanoscience, Aug 1, 2017

ChemInform Abstract: Regioselective Synthesis of Diazaspiro[4.4]nona- and Tetrazaspiro[4,5]deca-2,9-diene-6-one Derivatives

ChemInform, May 13, 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Development of functionalized carrageenan, chitosan and alginate as polymeric chelating ligands for water softening

International Journal of Environmental Science and Technology, Mar 15, 2017

Chitosan, carrageenan and alginate are among the most abundant biopolymers in nature. They were p... more Chitosan, carrageenan and alginate are among the most abundant biopolymers in nature. They were prepared in uniform beads shape with a diameter of 2 mm ± 10%, using the encapsulator for removal of calcium, magnesium and iron cations from hard water. Solutions of 100-500 mg/L were prepared from each cation, and the detection of cations was carried out using atomic absorption spectrometer. Carrageenan and chitosan were able to chelate the three cations without further modification. However, alginate beads succeeded to chelate iron and magnesium and failed to chelate any calcium ions; in contrast, it increased the initial calcium concentration! That could be due to the pre-cross-linking of alginate beads using calcium chloride solution, which may be leaked back to the solution. However, grafting the alginate beads with polyethyleneimine and bromoacetic acid rectified this problem and the new functional group,-COOH, has been proved using the FT-IR. Optimization of the results in terms of beads weight (0.25-3.0 g) and cations concentrations (100-500 mg/L) has shown that most biopolymeric beads can chelate 85-100% of the cations in concentrations up to 500 mg/L. According to our finding, we came up with the recommendation to use chitosan for chelation of calcium and iron as it showed 100% chelation efficiency of both cations, whereas carrageenan is highly recommended for chelation of iron and magnesium, as it showed 100 and 98% chelation efficiency, respectively. Further work can be done on the reusability of the beads and scale up for the industrial use.

Preparations methods of tizanidine (API) and related compounds: A review

Applied chemical engineering, Feb 22, 2023

Tizanidine is an imidazoline derivative with the agonistic activity of central alpha 2 receptors ... more Tizanidine is an imidazoline derivative with the agonistic activity of central alpha 2 receptors at both the spinal and supra-spinal levels. It was prepared for the first time in 1978 and approved for use in 1996. The present review focuses on all methods used for the synthesis of tizanidine, related compounds and intermediates. This review article covers all the methods that have been used in the preparation of tizanidine since its discovery until now. Methods used for the preparation of tizanidine-related compounds are also covered. This review gives those interested in drug synthesis and designs the ability to form a complete picture of the preparation of this drug, as well as providing the opportunity for the synthesis of other drugs developed from this drug to increase activity and/or reduce side effects.

Design and synthesis of novel fused heterocycles using 4-chromanone as synthon

Russian Journal of General Chemistry, Dec 1, 2015

A new series of heterocyclic systems, including azole, azolopyrimidine, and pyridopyrimidine deri... more A new series of heterocyclic systems, including azole, azolopyrimidine, and pyridopyrimidine derivatives, attached to 2H-chromene scaffold, was prepared by a convenient procedure through the reactions of (E)-2-dimethylamino-methylene chromanone with different nitrogen binucleophiles. Various substituted chromeno[4,3-b]pyridine derivatives were also prepared through the reactions of (E)-2-dimethylaminomethylene chromanone with a series of active methylene compounds.

Development of carrageenan modified with nanocellulose-based materials in removing of Cu2+, Pb2+, Ca2+, Mg2+, and Fe2+

International Journal of Environmental Science and Technology, Aug 11, 2018

Different bio-polymeric matrixes of carrageenan and modified carrageenan with cellulosic nonmater... more Different bio-polymeric matrixes of carrageenan and modified carrageenan with cellulosic nonmaterials were prepared in the form of beads. The nanocellulosic materials were prepared from dissolved bagasse pulp and include cellulose nanocrystals, cellulose nanofibers and tricarboxy cellulose nanofibers. The prepared bio-polymeric matrixes were characterized with transmission electron microscopy, FTIR, X-ray diffraction and scanning electron microscope. The capabilities of carrageenan and modified carrageenan beads to chelate with several metal cations were evaluated. Interestingly, the modification of carrageenan with cellulose nanoparticles obtained high efficiency toward removing Cu 2+ , Pb 2+ , Ca 2+ , Mg 2+ , and Fe 2+. The modified carrageenan with tricarboxy cellulose nanofibers which has higher carboxylate content showed high removal efficiency rather than the other modifications.

Synthesis and antimicrobial activity of some heterocyclic 2,6-bis(substituted)-1,3,4-thiadiazolo-, oxadiazolo-, and oxathiazolidino-pyridine derivatives from 2,6-pyridine dicarboxylic acid dihydrazide

Journal of Heterocyclic Chemistry, May 27, 2011

In this work, we report on the synthesis and preliminary biological activity screening of several... more In this work, we report on the synthesis and preliminary biological activity screening of several heterocyclic derivatives 2, 3, 4, 5, 6, 7, 8, 9, 10, 10a, 10b, 11, 11a, 11b, 12, 12a, 12b, 13, 13a, 13b, 14, 15 based on N2′,N6′-diphenylthiosemi-carbazide pyridine-2,6-dicarbohydrazide 2, which has been obtained from the corresponding dihydrazide 1. The biological screening showed that many of these compounds have good antimicrobial activities. The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. J. Heterocyclic Chem., (2011).

Ring closing metathesis and metal-catalyzed cyclopropanation for the preparation of sultone derivatives

Arkivoc, Dec 30, 2018

Ring closing metathesis (RCM) using Grubbs catalyst 2 nd generation as a catalyst was applied to ... more Ring closing metathesis (RCM) using Grubbs catalyst 2 nd generation as a catalyst was applied to prepare series of novel unsaturated sultones with high yields. Many attempts, were applied for the cyclopropanation of the allylic sultones by Simmon-smith cyclopropanation using diethyl zinc/diiodomethane or Zn-Cu/diiodomethane but in each case the corresponding cyclic adduct was not formed. A novel palladium or preferably rhodiumcatalyzed cyclopropanation of unsaturated sultones with ethyl diazoacetate was achieved by the transition metal-catalyzed transfer of a CH-CO2Et unit. The reaction was applied by a portion-wise addition of ethyl diazoacetate over 6h to a mixture of the sultones and palladium(II) acetate or rhodium(II) acetate dimer under low temperature (0-20 o C). The desired products of the cyclopropanation were achieved in each case, as a single diastereomer with 33-37% yield in the allylic sultones and 10% for vinylic sultone.

Synthesis and Antimicrobial Activity of New Thiazolidine-Based Heterocycles as Rhodanine Analogues

Journal of Heterocyclic Chemistry, Jan 11, 2018

A new series of compounds containing thiazole nucleus as Rhodanine analogues have been synthesize... more A new series of compounds containing thiazole nucleus as Rhodanine analogues have been synthesized. The new compounds were prepared from the reactions of the thiosemicarbazones (3a,b) with a series of α-halo carbonyl compounds to give the corresponding Rhodanine analogues. The thiosemicarbazones derivatives (3a,b) were reacted also with hydrazonoyl chlorides to afford the corresponding tri-substituted and tetra-substituted thiazoles. The structures of the newly synthesized compounds were confirmed by elemental analysis and spectral data. The biological activities of the new synthesized Rhodanine analogues' were evaluated for their antimicrobial activities. The results showed that some of these compounds showed excellent activity against two fungal strains, including Aspergillus niger and Aspergillus flavus, in addition to three yeast strains, including Saccharomyces cervesi, Candida albicans NRRL Y-477, and Candida Pathological specimen compared with the ketoconazol, as the reference drug.

Design, Synthesis, and StructureActivity Relationship of Novel Aryl-Substituted Formyl Oxazolidine Derivatives as Herbicide Safeners

Extraction of degradable bio polymer materials from shrimp shell wastes by two different methods

IOP Conference Series: Materials Science and Engineering, 2018

Chitosan is one of the most widespread biopolymer materials available in nature which is extracte... more Chitosan is one of the most widespread biopolymer materials available in nature which is extracted from chitin. The main source of chitosan is the chitin that is extracted from exoskeletons of crustacean, such as shrimp and crabs, which are found in a huge amount of shells waste that produced from seafood companies around the world. The chitosan has several applications such as pharmaceutical, fertilizer and edible coating in food industries. The quality of the chitosan's depends on its extraction method, so in this research work we have studied the effect of grounding shrimp shell waste before the extraction step. The chemical and physical properties of the extracted chitosan were studied by using different techniques such as Fourier transform infrared spectroscopy (FTIR), and Thermogravimetric analysis (TGA). The study showed that the films and powder produced from non-ground samples showed a higher purity of chitosan and better thermal stability than the chitosan produced from ground samples.

Alginate and carrageenan-nanocellulose composite beads for efficient removal of metal cations

Journal of organic & inorganic chemistry, Sep 27, 2018

New polymeric matrix of polylactic acid/sodium alginate/carbon nanoparticles (PLA/SA/CNP) for efficient removal of methylene blue

Chemical Papers, Jul 19, 2023

For the adsorption of methylene blue (MB), novel bio-polymeric matrices prepared from polylactic ... more For the adsorption of methylene blue (MB), novel bio-polymeric matrices prepared from polylactic acid/sodium alginate (PLA/SA) and polylactic acid/sodium alginate/carbon nanoparticle (PLA/SA/CNP) as green adsorbates were prepared in the form of beads. The developed adsorbent was analyzed using scanning electron microscopes and Fourier transform infrared spectrometers. The percentage of adsorbed dye increased with increasing CNP content, and the optimum ratio was 5% wt. The efficiency of the beads' removal and adsorption capacity were evaluated concerning with (adsorbent dosage, contact time, initial pH, and concentration of adsorbate). After 120 min using 50 mg of PLA/SA/CNP beads, the adsorptive removal process for MB dye was determined to have the maximum rate at pH 9. The models of Langmuir and Freundlich were used to illustrate the experimental data. Langmuir models determined the highest adsorption capacity to be 304.88 mg/g.

ChemInform Abstract: Design, Synthesis and Structure-Activity Relationship Study of Novel Pyrazole-Based Heterocycles as Potential Antitumor Agents

ChemInform, Mar 14, 2011

Design, Synthesis, and Structure-Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-... more Design, Synthesis, and Structure-Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-yl)ethylamino]pyridazine Derivatives as Acetylcholinesterase Inhibitors.-Various analogues of the known inhibitor (I) are prepared. Among all products, derivatives (IIa) and (IIb) are found to be the most representative drugs, more selective than the reference compound (I).-(CONTRERAS, JEAN-MARIE; PARROT, ISABELLE;

Adsorption of Methylene Blue on A Polymeric Matrix of Poly Lactic Acid/Sodium Alginate/Carbon Nanoparticles (PLA/SA/CNP)

Research Square (Research Square), Jun 24, 2022

This study presents the preparation of Poly lactic acid/Sodium alginate (PLA/SA) and PLA/SA/CNP b... more This study presents the preparation of Poly lactic acid/Sodium alginate (PLA/SA) and PLA/SA/CNP beads for the methylene blue (MB) adsorption. A Fourier transform infrared spectrometer (FTIR) characterized the produced adsorbent. The various dosages of CNP content were added to PLA/SA beads. The percentage of adsorbed dye increased with increasing CNP content, so the optimum percentage is 5%wt. The beads' adsorption capacity and removal e ciency was investigated as a function of (adsorbent dosage, contact time, initial pH, and concentration of adsorbate). The highest rate of the adsorptive removal process for MB dye was found at pH 9 after 120 min equilibration time with 50mg of PLA/SA/CNP beads. Langmuir and Freundlich's models were applied for the illustration of experimental data. Langmuir models illustrate that the maximum adsorption capacity equals 304.88mg/g. Dyes have different long-term impacts on organisms depending on the dye content and exposure time 4,5. Dye exposure and indigestion have been linked to several health concerns, including eye burn, cancer, skin irritation, nausea, and dermatitis 6. Because of the dangers of dyes, removing them from water and treating contaminated water has sparked a lot of interest, and a lot of research has been done in this eld of environmental science. Among those methods, membrane ltration, electrochemical, advanced oxidation process, chemical oxidation, biological process, Ion exchange resin is one of the physical dye treatment procedures 7 , photocatalysis 8 , and adsorption that has been interestingly studied because of its bene ts, which include cheap costs, ease of application, ease of design and operation, effectiveness, the ability to reuse and regenerate adsorbents 9-12. Rather than eliminating the pigment, most of these procedures dilute the high dye concentration. As a result, dye is removed from high concentrations using adsorption. Furthermore,

Microwave‐assisted synthesis and heterocyclic functionalization of chromenopyridines on calixarene scaffold

Journal of Heterocyclic Chemistry, Apr 1, 2020

A three‐component one‐pot condensation reaction of chroman‐4‐one with ethyl 2‐cyanoacetate and va... more A three‐component one‐pot condensation reaction of chroman‐4‐one with ethyl 2‐cyanoacetate and various aldehydes in the presence of ammonium acetate afforded a series of 2‐oxo‐4‐phenyl‐1,5‐dihydro‐2H‐chromeno[4,3‐b]pyridine‐3‐carbonitrile. These heterocycles have been converted to chloropyridine derivatives and appended to macrocyclic calix[4]arene scaffold through aromatic nucleophilic substitution under microwave irradiation. In this study, the microwave‐assisted functionalization of the lower rim of calix[4]arene has been considered the only appropriate tool because the conventional heating did not lead to any new product after 72 hours of heating under thermal condition.

Design, Synthesis and In-vivo Anti-inflammatory Activity of New Celecoxib Analogues as NSAID

Mini-reviews in Medicinal Chemistry, Sep 13, 2018

Background: A new series of Celecoxib analogues were easily synthesized via reactions of 4-(2-(1-... more Background: A new series of Celecoxib analogues were easily synthesized via reactions of 4-(2-(1-chloro-2-oxopropylidene)hydrazinyl)benzene sulfonamide (1) with active methylene compounds and dialkyl malonate. In addition, compound 1 was reacted also with thiourea derivatives and thiosemicarbazone derivatives to afford thiazole derivatives 9 and 11, respectively. Furthermore, triazolo pyrimidine derivatives 13 were prepared via reaction of compound 1 with pyrimidine thione derivatives. The structures of the new synthesized compounds were assigned by elemental analysis and spectroscopic data. The new analogues were screened for their in vivo anti-inflammatory activity using carrageenan-induced paw edema method. Conclusion: They showed moderate to good in vivo anti-inflammatory effects. Compounds 1, 6 and 11b were the most active compounds that reduced the paw edema induced by carrageenan by 12.25 %, 12.96 % and 12.97% respectively, as compared to the Indomethacin that inhibited the oedema volume by 7.47 %.

Synthesis and Antimicrobial Evaluation of a New Series of Heterocyclic Systems Bearing a Benzosuberone Scaffold

Molecules, Nov 16, 2015

A series of novel benzosuberone derivatives were synthesized and evaluated as antimicrobial agent... more A series of novel benzosuberone derivatives were synthesized and evaluated as antimicrobial agents by using substituted benzosuberone derivatives 1a,b as starting materials. Treatment of 1a,b with phenyl isothiocyanate in dimethylformamide was followed by treatment with cold HCl solution to afford the thioamides 4a,b, which was reacted with methyl iodide to obtain methylated products 5a,b. Cyclocondensation of 4a,b with chloroacetone 6 and phenacyl chloride 7 gave the corresponding thiophene derivatives 9a-c. Reaction of 4a,b with C-acetyl-N-arylhydrazonoyl chlorides 14a and 14b in boiling EtOH in the presence of triethylamine, afforded the corresponding 1,3,4-thiadiazoline derivatives 16a-d. The thioamides 4a,b were reacted with C-ethoxycarbonyl-N-arylhydrazonoyl chlorides 18a,b which afforded 1,3,4-thiadiazoline derivatives 19a-d. The benzosuberones 1a,b were treated with 3-mercaptopropanoic acid to give compounds 21a,b, which were cyclized to tricyclic thiopyran-4(5H)-one derivatives 22a,b. The latter compounds 22a,b were reacted with 3-mercaptopropanoic acid to give compounds 23a,b, which were cyclized tetracyclic ring systems 24a,b. Finally, compounds 24a,b were oxidized using hydrogen peroxide under reflux conditions to afford the oxidized form of the novel tetracyclic heterogeneous ring systems 25a,b. The newly synthesized compounds were screened for antimicrobial activities. The structures of new compounds were characterized by 1 H-NMR,

Biodegradable grafting cellulose/clay composites for metal ions removal

International Journal of Biological Macromolecules, Oct 1, 2018

Biodegradable bi-functional cellulose derivatives were synthesized to remove widespread undergrou... more Biodegradable bi-functional cellulose derivatives were synthesized to remove widespread underground water cations such as; Ca 2+ , Mg 2+ , Fe 2+ , Pb 2+ , and Cu 2+. Firstly, graft copolymerization of cellulose with binary monomers such as acrylic acid (AA), and 2acrylamido-2-methylpropanesulfonic acid (AMPS) with acrylamide (Am) were achieved using potassium persulfate as initiator. Then, cellulose/clay composites were prepared by graft copolymerization of cellulose using different montmorillonite concentrations such as 3, 6 and 9

Novel alginate carbon nanoparticle composite beads for efficient removal of Pb2+ ions from aqueous solutions

Nanotechnology for environmental engineering, Oct 19, 2022

Anticancer Activity of Some Synthesized of Mn(II), Cu(II), Ni(II), Sn(II) and Ca(II) Complexes Bis(3-phenylpropane-1,3-dione) Derivative as Ligand

Journal of Computational and Theoretical Nanoscience, Aug 1, 2017

ChemInform Abstract: Regioselective Synthesis of Diazaspiro[4.4]nona- and Tetrazaspiro[4,5]deca-2,9-diene-6-one Derivatives

ChemInform, May 13, 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Development of functionalized carrageenan, chitosan and alginate as polymeric chelating ligands for water softening

International Journal of Environmental Science and Technology, Mar 15, 2017

Chitosan, carrageenan and alginate are among the most abundant biopolymers in nature. They were p... more Chitosan, carrageenan and alginate are among the most abundant biopolymers in nature. They were prepared in uniform beads shape with a diameter of 2 mm ± 10%, using the encapsulator for removal of calcium, magnesium and iron cations from hard water. Solutions of 100-500 mg/L were prepared from each cation, and the detection of cations was carried out using atomic absorption spectrometer. Carrageenan and chitosan were able to chelate the three cations without further modification. However, alginate beads succeeded to chelate iron and magnesium and failed to chelate any calcium ions; in contrast, it increased the initial calcium concentration! That could be due to the pre-cross-linking of alginate beads using calcium chloride solution, which may be leaked back to the solution. However, grafting the alginate beads with polyethyleneimine and bromoacetic acid rectified this problem and the new functional group,-COOH, has been proved using the FT-IR. Optimization of the results in terms of beads weight (0.25-3.0 g) and cations concentrations (100-500 mg/L) has shown that most biopolymeric beads can chelate 85-100% of the cations in concentrations up to 500 mg/L. According to our finding, we came up with the recommendation to use chitosan for chelation of calcium and iron as it showed 100% chelation efficiency of both cations, whereas carrageenan is highly recommended for chelation of iron and magnesium, as it showed 100 and 98% chelation efficiency, respectively. Further work can be done on the reusability of the beads and scale up for the industrial use.

Preparations methods of tizanidine (API) and related compounds: A review

Applied chemical engineering, Feb 22, 2023

Tizanidine is an imidazoline derivative with the agonistic activity of central alpha 2 receptors ... more Tizanidine is an imidazoline derivative with the agonistic activity of central alpha 2 receptors at both the spinal and supra-spinal levels. It was prepared for the first time in 1978 and approved for use in 1996. The present review focuses on all methods used for the synthesis of tizanidine, related compounds and intermediates. This review article covers all the methods that have been used in the preparation of tizanidine since its discovery until now. Methods used for the preparation of tizanidine-related compounds are also covered. This review gives those interested in drug synthesis and designs the ability to form a complete picture of the preparation of this drug, as well as providing the opportunity for the synthesis of other drugs developed from this drug to increase activity and/or reduce side effects.

Design and synthesis of novel fused heterocycles using 4-chromanone as synthon

Russian Journal of General Chemistry, Dec 1, 2015

A new series of heterocyclic systems, including azole, azolopyrimidine, and pyridopyrimidine deri... more A new series of heterocyclic systems, including azole, azolopyrimidine, and pyridopyrimidine derivatives, attached to 2H-chromene scaffold, was prepared by a convenient procedure through the reactions of (E)-2-dimethylamino-methylene chromanone with different nitrogen binucleophiles. Various substituted chromeno[4,3-b]pyridine derivatives were also prepared through the reactions of (E)-2-dimethylaminomethylene chromanone with a series of active methylene compounds.

Development of carrageenan modified with nanocellulose-based materials in removing of Cu2+, Pb2+, Ca2+, Mg2+, and Fe2+

International Journal of Environmental Science and Technology, Aug 11, 2018

Different bio-polymeric matrixes of carrageenan and modified carrageenan with cellulosic nonmater... more Different bio-polymeric matrixes of carrageenan and modified carrageenan with cellulosic nonmaterials were prepared in the form of beads. The nanocellulosic materials were prepared from dissolved bagasse pulp and include cellulose nanocrystals, cellulose nanofibers and tricarboxy cellulose nanofibers. The prepared bio-polymeric matrixes were characterized with transmission electron microscopy, FTIR, X-ray diffraction and scanning electron microscope. The capabilities of carrageenan and modified carrageenan beads to chelate with several metal cations were evaluated. Interestingly, the modification of carrageenan with cellulose nanoparticles obtained high efficiency toward removing Cu 2+ , Pb 2+ , Ca 2+ , Mg 2+ , and Fe 2+. The modified carrageenan with tricarboxy cellulose nanofibers which has higher carboxylate content showed high removal efficiency rather than the other modifications.

Synthesis and antimicrobial activity of some heterocyclic 2,6-bis(substituted)-1,3,4-thiadiazolo-, oxadiazolo-, and oxathiazolidino-pyridine derivatives from 2,6-pyridine dicarboxylic acid dihydrazide

Journal of Heterocyclic Chemistry, May 27, 2011

In this work, we report on the synthesis and preliminary biological activity screening of several... more In this work, we report on the synthesis and preliminary biological activity screening of several heterocyclic derivatives 2, 3, 4, 5, 6, 7, 8, 9, 10, 10a, 10b, 11, 11a, 11b, 12, 12a, 12b, 13, 13a, 13b, 14, 15 based on N2′,N6′-diphenylthiosemi-carbazide pyridine-2,6-dicarbohydrazide 2, which has been obtained from the corresponding dihydrazide 1. The biological screening showed that many of these compounds have good antimicrobial activities. The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. J. Heterocyclic Chem., (2011).

Ring closing metathesis and metal-catalyzed cyclopropanation for the preparation of sultone derivatives

Arkivoc, Dec 30, 2018

Ring closing metathesis (RCM) using Grubbs catalyst 2 nd generation as a catalyst was applied to ... more Ring closing metathesis (RCM) using Grubbs catalyst 2 nd generation as a catalyst was applied to prepare series of novel unsaturated sultones with high yields. Many attempts, were applied for the cyclopropanation of the allylic sultones by Simmon-smith cyclopropanation using diethyl zinc/diiodomethane or Zn-Cu/diiodomethane but in each case the corresponding cyclic adduct was not formed. A novel palladium or preferably rhodiumcatalyzed cyclopropanation of unsaturated sultones with ethyl diazoacetate was achieved by the transition metal-catalyzed transfer of a CH-CO2Et unit. The reaction was applied by a portion-wise addition of ethyl diazoacetate over 6h to a mixture of the sultones and palladium(II) acetate or rhodium(II) acetate dimer under low temperature (0-20 o C). The desired products of the cyclopropanation were achieved in each case, as a single diastereomer with 33-37% yield in the allylic sultones and 10% for vinylic sultone.

Synthesis and Antimicrobial Activity of New Thiazolidine-Based Heterocycles as Rhodanine Analogues

Journal of Heterocyclic Chemistry, Jan 11, 2018

A new series of compounds containing thiazole nucleus as Rhodanine analogues have been synthesize... more A new series of compounds containing thiazole nucleus as Rhodanine analogues have been synthesized. The new compounds were prepared from the reactions of the thiosemicarbazones (3a,b) with a series of α-halo carbonyl compounds to give the corresponding Rhodanine analogues. The thiosemicarbazones derivatives (3a,b) were reacted also with hydrazonoyl chlorides to afford the corresponding tri-substituted and tetra-substituted thiazoles. The structures of the newly synthesized compounds were confirmed by elemental analysis and spectral data. The biological activities of the new synthesized Rhodanine analogues' were evaluated for their antimicrobial activities. The results showed that some of these compounds showed excellent activity against two fungal strains, including Aspergillus niger and Aspergillus flavus, in addition to three yeast strains, including Saccharomyces cervesi, Candida albicans NRRL Y-477, and Candida Pathological specimen compared with the ketoconazol, as the reference drug.

Design, Synthesis, and StructureActivity Relationship of Novel Aryl-Substituted Formyl Oxazolidine Derivatives as Herbicide Safeners

Extraction of degradable bio polymer materials from shrimp shell wastes by two different methods

IOP Conference Series: Materials Science and Engineering, 2018

Chitosan is one of the most widespread biopolymer materials available in nature which is extracte... more Chitosan is one of the most widespread biopolymer materials available in nature which is extracted from chitin. The main source of chitosan is the chitin that is extracted from exoskeletons of crustacean, such as shrimp and crabs, which are found in a huge amount of shells waste that produced from seafood companies around the world. The chitosan has several applications such as pharmaceutical, fertilizer and edible coating in food industries. The quality of the chitosan's depends on its extraction method, so in this research work we have studied the effect of grounding shrimp shell waste before the extraction step. The chemical and physical properties of the extracted chitosan were studied by using different techniques such as Fourier transform infrared spectroscopy (FTIR), and Thermogravimetric analysis (TGA). The study showed that the films and powder produced from non-ground samples showed a higher purity of chitosan and better thermal stability than the chitosan produced from ground samples.