Kevin Corcoran

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Suzanne Newcombe

The Open University

Eroica Soans

St Jude Childrens research Hospital

Dominic D'Agostino

University of South Florida

David Vago

Vanderbilt University

Prof. Dr. Rasime Kalkan

European University of Lefke

tiziana crepaldi

Università degli Studi di Torino

Andrea Chiba

University of California, San Diego

Peter Krell

University of Guelph

Henning Schneider

University of Bern, Switzerland

Amita Agarwal

Sanjay Gandhi Postgraduate Institute of Medician Sciences, Lucknow

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Papers by Kevin Corcoran

GABAergic mechanisms regulated by miR-33 encode state-dependent fear

Nature neuroscience, 2015

Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the bra... more Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fear, we used a mouse model of contextual fear conditioning. We found that heightened activity of hippocampal extrasynaptic GABAA receptors, believed to impair fear and memory, actually enabled their state-dependent encoding and retrieval. This effect required protein kinase C-βII and was influenced by miR-33, a microRNA that regulates several GABA-related proteins. In the extended hippocampal circuit, extrasynaptic GABAA receptors promoted subcortical, but impaired cortical, activation during memory encoding of context fear. Moreover, suppression of retrosplenial cortical activity, which normally impairs retrieval, had an enhancing effect on the retrieval of state-depend...

Double Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social Behaviorsm

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Jan 31, 2015

Social interactions in vertebrates are complex phenomena based on affective and cognitive process... more Social interactions in vertebrates are complex phenomena based on affective and cognitive processes. Multiple brain regions and neurotransmitter systems are involved in the expression of social behaviors, but their individual roles in specific aspects of social interactions are not well understood. Here we investigated how Gq-protein coupled metabotropic glutamate receptor 5 (mGluR5) and oxytocin receptor (Oxtr) affect social affiliation and social memory. We used conditional genetic approaches in which the genes coding for these receptors were knocked out in the lateral septum by infusion of recombinant adeno-associated viral vectors containing Cre recombinase (AAV-Cre). Social behavior was assessed two weeks later using a three-chamber paradigm for sociability and preference for social novelty. Septal deletion of mGluR5 abolished sociability while leaving preference for social novelty intact. In contrast, deletion of Oxtr did not affect sociability but significantly impaired prefe...

Hippocampal inactivation disrupts contextual retrieval of fear memory after extinction

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001

Recent studies implicate the hippocampus in contextual memory retrieval. The present experiments ... more Recent studies implicate the hippocampus in contextual memory retrieval. The present experiments explore this possibility by examining the impact of reversible inactivation of the dorsal hippocampus (DH) on the context-specific expression of extinction. In experiment 1, rats were conditioned to fear a tone conditional stimulus (CS) and subsequently extinguished either in the same context as conditioning or in a novel context. A third group of rats underwent fear conditioning but did not receive extinction. After extinction, conditional fear to the tone CS was assessed in the conditioning context by measuring freezing. Rats extinguished in the conditioning context exhibited low levels of freezing, whereas those extinguished in a different context and those that received no extinction showed high levels of freezing. This indicates that the expression of extinction is context-specific. In experiment 2, the context-specific expression of extinction was disrupted by infusion of muscimol,...

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