Papers by Kürşat Gündoğan
Journal of critical care, Jun 1, 2024
Journal of critical care, Jun 1, 2024
The COVID-19 pandemic remains a significant public health concern despite the new vaccines and th... more The COVID-19 pandemic remains a significant public health concern despite the new vaccines and therapeutics. The clinical course of acute SARS-CoV-2 infection is highly variable and influenced by several factors related to the virus and the host. Numerous genetic studies, including candidate gene, exome, and genome sequencing studies, genome-wide association studies, and other omics efforts, have proposed various Mendelian and non-Mendelian associations with COVID-19 course. In this study, we conducted whole-exome sequencing on 90 unvaccinated patients from Turkey with no known comorbidities associated with severe COVID-19. Of these patients, 30 had severe, 30 had moderate, and 30 had mild/asymptomatic disease. We identified rare variants in genes associated with SARS-CoV-2 susceptibility and pathogenesis, with an emphasis on genes related to the regulation of inflammation, and discussed these in the context of the clinical course of the patients. In addition, we compared the frequencies of common variants between each group. Even though no variant remained statistically significant after correction for multiple testing, we observed that certain previously associated genes and variants showed significant associations before correction. Our study contributes to the existing literature regarding the genetic susceptibility to SARS-CoV-2. Future studies would be beneficial characterizing the host genetic properties in different populations.
Erciyes medical journal, 2020
Objective: The present study aims to evaluate vitamin D (Vit D) level in critically ill patients ... more Objective: The present study aims to evaluate vitamin D (Vit D) level in critically ill patients and to assess its level about morbidity and mortality. Materials and Methods: This study was conducted in an intensive care unit (ICU). Vit D level was measured on admission, third and seventh day. Results: Of the 62 patients, the median Vit D level at baseline and on the third and seventh days was 12.8 mcg/L, 8.35 mcg/L, and 9.30 mcg/L, respectively. Vitamin D level was low (<30 mcg/L) in 92% of patients at baseline and 97% on the third day. 23% of the studied patients developed a new site infection. No statistically difference in the Vit D level at baseline, or on the third or seventh day based on the presence of infection (p=0.556, p=0.404, p=0.439, respectively). The most commonly seen infections were ventilator-associated pneumonia (VAP) and catheter-related bloodstream infection (CRBSI). The growth of Acinetobacter baumannii was the most frequent. Vit D level (p>0.05) might not have a causal role in mortality (ICU, 30-day, and 6-month), and no correlation was found between them. Conclusion: The level of Vit D was low. Our study did not show any relationship between mortality rates and Vit D level, but VAP and CRBSI were observed.
Erciyes medical journal, Dec 23, 2015
Objective: Endotracheal intubation is a frequently performed procedure in the intensive care unit... more Objective: Endotracheal intubation is a frequently performed procedure in the intensive care unit (ICU). Extremely serious complications occur during this procedure. In this study, theoretical and practical training were given to residents who started to work in the medical intensive care unit, and it was aimed to evaluate the complications following training. Materials and Methods: This study was conducted prospectively. Results: A total of 36 patients were included in the study; 16 (45%) were male, and the average age of the patients was 64±16.0 years. The most common indications for admittance to the ICU were shock (50%) and acute respiratory failure (36%). The most common indication for intubation was determined as acute respiratory failure (44%). The intubation was performed as an emergency procedure in 27% of these patients, whereas it was performed semi-urgently in 8% and electively in 65%. Among intubated patients, at least one complication developed in 13 (36%) cases. The drugs most commonly used for sedation were midazolam (76%) and propofol (16.7%). Conclusion: Complications of endotracheal intubation are significant problems in ICUs. A successful procedure of intubation avoids complications. Regular training for endotracheal intubation in the ICU decreases the complications.
Nöropsikiyatri arşivi, 2023
Turkiye Klinikleri Endocrinology - Special Topics, 2008
Clinical nutrition ESPEN, Oct 1, 2022
Dahili ve cerrahi bilimler yoğun bakım dergisi, 2018
Intensive Care Medicine Experimental, Oct 1, 2015
Erciyes tıp dergisi, Jul 22, 2014
The aim of extracorporeal detoxification through plasma exchange therapy is to eliminate protein-... more The aim of extracorporeal detoxification through plasma exchange therapy is to eliminate protein-bound components and to prevent their potential toxic effects. It is thought that hyperbilirubinemia has a direct cytotoxic effect on T lymphocytes and that it thus increases infection and sepsis. The use of bilirubin absorption column reduces bilirubin levels in patients with hepatic insufficiency. For the first time in Turkey, we presented a patient with cardiac cirrhosis and high bilirubin levels who was successfully treated with bilirubin absorption column method.
Aim: This study was designed to analyze demographic, clinical and laboratory characteristics besi... more Aim: This study was designed to analyze demographic, clinical and laboratory characteristics beside risk factors that affect the mortality rate of patients hospitalized in ICUs with diagnosis of CNS infection. Methods: Patients that have been hospitalized at ICU on pre-CNS infection were retrospectively studied. Beside the clinical laboratory characteristics of the patients, mortality rate and risk factors that affect the mortality were recorded to be analyzed later. Results: Following the evaluation of 118 ICU patients who were suspected to have CNS infection, 62 of them, with full diagnosis of CNS infection, were included in the study. Bacterial meningitis was the diagnosis for 40 (66%) of these patients while 18 of the total (30%) was diagnosed with viral encephalitis and 3 of them (4%) was diagnosed with tuberculous meningitis. When these factors were investigated in a multivariable study, age and time from the onset of symptoms to hospital admission were independent risk factors (CI: 1,098(1,031-1,169), 1,614(1,037-1,278). Conclusion: The mortality rate of the patients that were subjects of the study was 52,5%. Age and time from the onset of symptoms to hospital admission were independent risk factors that affect the mortality.
Clinical nutrition ESPEN, Dec 1, 2020
Rural water networks in the developing world are typically branched networks with a single water ... more Rural water networks in the developing world are typically branched networks with a single water source. The main design decision to be made for such networks is the choice of pipe diameters from a discrete set of commercially available pipe diameters. Larger the pipe diameters, better the service (pressure), but higher is the capital cost. In general, each link (connection between two nodes) in the network can consist of several pipe segments of differing diameters. For such networks, existing design tools solve the constrained-optimization problem heuristically [1] [2]. In [3], an ILP formulation is proposed for the special case of one pipe diameter per link. This means that currently one can either get an optimal solution for the special case of one piped segment per link or get a non-optimal solution for the general case of multiple pipe segments per link. In this work, we come up with a model that solves the general formulation while still maintaining optimality. Our model has an LP formulation. It not only manages to optimally solve the general case, it also has a runtime performance that is better than both the heuristic approach to the general problem as well as the optimal approach to the specific problem (one pipe per link). To aid the designers of piped water networks, we have developed an optimization system called JalTantra that implements this model. It also has GIS functionality integrated for ease of providing network details. It is publicly available at http://www.cse.iitb.ac.in/jaltantra/ .
Turkiye Klinikleri Journal of Internal Medical Sciences, 2006
Dahili ve cerrahi bilimler yoğun bakım dergisi, Aug 1, 2011
Aim: We aimed to compare patients who developed complications during endotracheal intubation and ... more Aim: We aimed to compare patients who developed complications during endotracheal intubation and who did not develop any complication in the Medical Intensive Care Unit. Material and Methods: We enrolled 39 patients into the study. Patients intubated outside the intensive care unit (emergency service, prior to operation) were excluded. All intubation procedures were performed by residents in internal medicine. Data about the patient and complications were recorded by the same person. Results: At least one complication was seen in 41% of all patients. Life-threatening complications such as severe hypoxemia (12%) and severe cardiovascular collapse (7%) were found. Difficult intubation (23%), aspiration (10%), esophageal intubation (10%), dental injury (10%), and dangerous agitation (3%) were found as moderate complications. Acute respiratory failure was the most common reason for intensive care unit admission (59%) and intubation (74%). Within one hour before intubation, the highest and lowest mean heart rate was higher than those who developed complications. No complications were observed in patients who were intubed at the first attempt. All complications occurred in patients who had two or more trials. Conclusion: Complications of endotracheal intubation is an important problem in intensive care units. Intubation success on the first attempt prevents complications. As the number of endotracheal intubation with the assistance of laryngoscopy increased, it was seen that complications related to the procedure also increased.
Clinical Nutrition, Sep 1, 2018
were analysed by using spearman correlation test and univariate general linear model. Results: A ... more were analysed by using spearman correlation test and univariate general linear model. Results: A significant negative correlations were observed between serum magnesium level and body fat percentage (rho ¼ À0.288; p¼0.002) and body fat mass (rho¼À0.215; p¼0.019). Dietary magnesium intake was positively correlated with lean body mass in overall sample (rho¼0.268; p¼0.003) and this correlation was more strong for patients who have at least one chronic complication of diabetes (n¼62, rho¼0.378; p¼0.002). Body fat mass was significantly higher in patients with hypomagnesemia (<0.75 mmol/l) as compared to patients with normomagnesemia (!0.75 mmol/l) after adjusting for a large range of dietary and nondietary confounders (respectively 35.4±9.4 kg, 34.6±10.2 kg; p¼0.034). Conclusions: Our results suggest that clinical care should therefore focus on screening serum magnesium levels and providing adequate intake of dietary magnesium to control adiposity in type 2 diabetes.
Journal of critical and intensive care, 2021
Uploads
Papers by Kürşat Gündoğan