La vertiente septentrional de la Sierra de los Filabres (Almería) ha sido objeto entre 1955 y 198... more La vertiente septentrional de la Sierra de los Filabres (Almería) ha sido objeto entre 1955 y 1983 de importantes acciones de repoblación forestal, con la finalidad de favorecer la conservación de los suelos, atenuar los fenómenos erosivos y reducir el ritmo de aterramiento de los embalses. Utilizando una adaptación del Método para la Evaluación de la Erosión desarrollado por la ITC se ha podido apreciar cómo antes del comienzo de las repoblaciones el nivel de susceptibilidad a la erosión era considerablemente alto y cómo tras la conclusión de éstas ha disminuido de forma significativa.
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects extremely preterm infants... more Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects extremely preterm infants and remains - despite improvements in neonatal intensive care - a major cause of neonatal mortality and morbidity. Cell-therapeutic strategies employing mesenchymal stem cells (MSC) have been shown to modulate lung development in BPD models. Herein, we evaluate the potential of human amniotic fluid (hAF)-SC and hAF-SC with upregulated expression of vascular endothelial growth factor (VEGF) as cell-therapeutic agents for BPD. Preterm rabbit pups were raised in normoxia (21% O2) or hyperoxia (≥95% O2). Hyperoxia-exposed pups randomly received an intraperitoneal injection of fibroblasts, naïve hAF-SC, or hAF-SC-VEGF on postnatal day (PN) 0. On PN7, surviving pups were tested for pulmonary (forced oscillation technique) and vascular (pulmonary artery Doppler ultrasound) function, and lungs were processed for morphometric measurements of parenchymal and vascular structure and inflammation. I...
The amniotic fluid is a clinically accessible source of mesenchymal stem cells (AF-MSC) during ge... more The amniotic fluid is a clinically accessible source of mesenchymal stem cells (AF-MSC) during gestation, which enables autologous cellular therapy for perinatal disorders. The origin of AF-MSC remains elusive: renal and neuronal progenitors have been isolated from the AF-MSC pool, yet no cells with pulmonary characteristics. We analyzed gene expression of pulmonary and renal markers of 212 clonal lines of AF-MSC isolated from amniocentesis samples. AF-MSC were cultured on dishes coated with extracellular matrix (ECM) proteins from decellularized fetal rabbit lungs. In vivo differentiation potential of AF-MSC that expressed markers suggestive of lung fate was tested by renal subcapsular injections in immunodeficient mice. Of all the isolated AF-MSC lines 26% were positive for lung endodermal markers FOXA2 and NKX2.1 and lacked expression of renal markers (KSP). This AF-MSC subpopulation expressed other lung-specific factors, including IRX1, P63, FOXP2, LGR6, SFTC and PDPN. Pulmonary...
International journal of molecular sciences, Jan 24, 2016
Bronchopulmonary dysplasia (BPD) is caused by preterm neonatal lung injury and results in oxygen ... more Bronchopulmonary dysplasia (BPD) is caused by preterm neonatal lung injury and results in oxygen dependency and pulmonary hypertension. Current clinical management fails to reduce the incidence of BPD, which calls for novel therapies. Fetal rabbits have a lung development that mimics humans and can be used as a translational model to test novel treatment options. In preterm rabbits, exposure to hyperoxia leads to parenchymal changes, yet vascular damage has not been studied in this model. In this study we document the early functional and structural changes of the lung vasculature in preterm rabbits that are induced by hyperoxia after birth. Pulmonary artery Doppler measurements, micro-CT barium angiograms and media thickness of peripheral pulmonary arteries were affected after seven days of hyperoxia when compared to controls. The parenchyma was also affected both at the functional and structural level. Lung function testing showed higher tissue resistance and elastance, with a dec...
Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficia... more Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth. To study the inflammatory, structural and functional effects of caffeine in an animal model of BPD. Preterm New Zealand-Dendermonde rabbits (gestational day 28; term 31) were randomized to three groups: normoxia-placebo (N-P), hyperoxia-placebo (H-P) and hyperoxia-caffeine (H-C). Lung function was assessed on postnatal day 5, along with airway morphometry, vascular morphometry and a score observing airway inflammation. Caffeine improved lung function by increasing lung volume [mean displaced volume N-P: 40.1 ± 6 ml/kg, H-P: 27.8 ± 8 ml/kg and H-C: 34.4 ± 7 ml/kg (p < 0.05); total lung capacity: N-P: 1.17 ± 0.1 ml, H-P: 0.67 ± 0.1 ml and H-C: 1.1 ± 0.1 ml (p < 0.05)], decreasing tissue damping [N-P: 2.7 ± 0.3 cm H2O/ml, H-P: 4.6 ± 0.6 cm H2O/ml and H-C: 3.2 ± 0.4 cm H2O/ml (...
The purpose of this study is to add more insight to the relationship between recent climate chang... more The purpose of this study is to add more insight to the relationship between recent climate change and modifications in plant cover in supratimberline areas of Spain's Central Mountain Range. A 118 hectare study site was chosen at Puerto de los Neveros pass (2100 m) located on the ridge Peñalara (Montes Carpetanos), and between the high basins of the Lozoya and Eresma rivers. Historically, the pass is associated with the most abundant and long lasting snow accumulations in the Guadarrama Mountains, and with frequent use of the snow by local populations. A collection of sequenced aerial photographs of the plant cover was used to interpret the vegetation's spatial dynamics in relation to the evolution of thermal and snow depth variables recorded for the period 1951-2006 at the weather station at Puerto de Navacerrada. The significant value of the resulting coefficients confirms that plant cover at Puerto de los Neveros has been greatly affected by climate change, particularly ...
the results showed a correlation among the 18 climate-related parameters for the period 1951-2000... more the results showed a correlation among the 18 climate-related parameters for the period 1951-2000. High index values and a basic similarity in tendencies confirmed that the extension of the plant facies had changed in accordance with variations in temperature and snow cover. As are result, it was determined that plant cover was sensitive to climate changes that had occurred during the study period and had responded by reducing the extent of the snowfields, hydrophytic meadows and open scrublands while expanding the pychroxerophytic meadows and dense scrublands.
This paper tries to ascertain the validity of Kalman Filtering in forecasting technological subst... more This paper tries to ascertain the validity of Kalman Filtering in forecasting technological substitution. It is also concerned with this process in the Spanish Telecommunications Sector. With that aim, the ability of this methodology and that of Ordinary Least Square in describing and forecasting the different substitution processes that have taken place in this sector are compared. Some conclusions are drawn from the different speeds of substitution observed between both processes, and it is also stated that Kalman Filtering is superior to Ordinary Least Square, both in estimating and in forecasting in the short term.
El Tratado de la reforma del entendimiento está comprendido en las Obras póstumas, publicadas, tr... more El Tratado de la reforma del entendimiento está comprendido en las Obras póstumas, publicadas, tras algunos meses de la muerte del autor, por sus amigos 1 . Le precede un Aviso al lector, que se hallará más adelante. También se menciona en el prefacio general, verosímilmente escrito por Jarig Jelles 2 . Sabemos así que este escrito es uno de los más viejos de Spinoza y que quedó inconcluso, a despecho del deseo del autor de completarlo, debido a «la dificultad de la obra, a las profundas investigaciones y al infinito saber que requería».
La vertiente septentrional de la Sierra de los Filabres (Almería) ha sido objeto entre 1955 y 198... more La vertiente septentrional de la Sierra de los Filabres (Almería) ha sido objeto entre 1955 y 1983 de importantes acciones de repoblación forestal, con la finalidad de favorecer la conservación de los suelos, atenuar los fenómenos erosivos y reducir el ritmo de aterramiento de los embalses. Utilizando una adaptación del Método para la Evaluación de la Erosión desarrollado por la ITC se ha podido apreciar cómo antes del comienzo de las repoblaciones el nivel de susceptibilidad a la erosión era considerablemente alto y cómo tras la conclusión de éstas ha disminuido de forma significativa.
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects extremely preterm infants... more Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects extremely preterm infants and remains - despite improvements in neonatal intensive care - a major cause of neonatal mortality and morbidity. Cell-therapeutic strategies employing mesenchymal stem cells (MSC) have been shown to modulate lung development in BPD models. Herein, we evaluate the potential of human amniotic fluid (hAF)-SC and hAF-SC with upregulated expression of vascular endothelial growth factor (VEGF) as cell-therapeutic agents for BPD. Preterm rabbit pups were raised in normoxia (21% O2) or hyperoxia (≥95% O2). Hyperoxia-exposed pups randomly received an intraperitoneal injection of fibroblasts, naïve hAF-SC, or hAF-SC-VEGF on postnatal day (PN) 0. On PN7, surviving pups were tested for pulmonary (forced oscillation technique) and vascular (pulmonary artery Doppler ultrasound) function, and lungs were processed for morphometric measurements of parenchymal and vascular structure and inflammation. I...
The amniotic fluid is a clinically accessible source of mesenchymal stem cells (AF-MSC) during ge... more The amniotic fluid is a clinically accessible source of mesenchymal stem cells (AF-MSC) during gestation, which enables autologous cellular therapy for perinatal disorders. The origin of AF-MSC remains elusive: renal and neuronal progenitors have been isolated from the AF-MSC pool, yet no cells with pulmonary characteristics. We analyzed gene expression of pulmonary and renal markers of 212 clonal lines of AF-MSC isolated from amniocentesis samples. AF-MSC were cultured on dishes coated with extracellular matrix (ECM) proteins from decellularized fetal rabbit lungs. In vivo differentiation potential of AF-MSC that expressed markers suggestive of lung fate was tested by renal subcapsular injections in immunodeficient mice. Of all the isolated AF-MSC lines 26% were positive for lung endodermal markers FOXA2 and NKX2.1 and lacked expression of renal markers (KSP). This AF-MSC subpopulation expressed other lung-specific factors, including IRX1, P63, FOXP2, LGR6, SFTC and PDPN. Pulmonary...
International journal of molecular sciences, Jan 24, 2016
Bronchopulmonary dysplasia (BPD) is caused by preterm neonatal lung injury and results in oxygen ... more Bronchopulmonary dysplasia (BPD) is caused by preterm neonatal lung injury and results in oxygen dependency and pulmonary hypertension. Current clinical management fails to reduce the incidence of BPD, which calls for novel therapies. Fetal rabbits have a lung development that mimics humans and can be used as a translational model to test novel treatment options. In preterm rabbits, exposure to hyperoxia leads to parenchymal changes, yet vascular damage has not been studied in this model. In this study we document the early functional and structural changes of the lung vasculature in preterm rabbits that are induced by hyperoxia after birth. Pulmonary artery Doppler measurements, micro-CT barium angiograms and media thickness of peripheral pulmonary arteries were affected after seven days of hyperoxia when compared to controls. The parenchyma was also affected both at the functional and structural level. Lung function testing showed higher tissue resistance and elastance, with a dec...
Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficia... more Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth. To study the inflammatory, structural and functional effects of caffeine in an animal model of BPD. Preterm New Zealand-Dendermonde rabbits (gestational day 28; term 31) were randomized to three groups: normoxia-placebo (N-P), hyperoxia-placebo (H-P) and hyperoxia-caffeine (H-C). Lung function was assessed on postnatal day 5, along with airway morphometry, vascular morphometry and a score observing airway inflammation. Caffeine improved lung function by increasing lung volume [mean displaced volume N-P: 40.1 ± 6 ml/kg, H-P: 27.8 ± 8 ml/kg and H-C: 34.4 ± 7 ml/kg (p < 0.05); total lung capacity: N-P: 1.17 ± 0.1 ml, H-P: 0.67 ± 0.1 ml and H-C: 1.1 ± 0.1 ml (p < 0.05)], decreasing tissue damping [N-P: 2.7 ± 0.3 cm H2O/ml, H-P: 4.6 ± 0.6 cm H2O/ml and H-C: 3.2 ± 0.4 cm H2O/ml (...
The purpose of this study is to add more insight to the relationship between recent climate chang... more The purpose of this study is to add more insight to the relationship between recent climate change and modifications in plant cover in supratimberline areas of Spain's Central Mountain Range. A 118 hectare study site was chosen at Puerto de los Neveros pass (2100 m) located on the ridge Peñalara (Montes Carpetanos), and between the high basins of the Lozoya and Eresma rivers. Historically, the pass is associated with the most abundant and long lasting snow accumulations in the Guadarrama Mountains, and with frequent use of the snow by local populations. A collection of sequenced aerial photographs of the plant cover was used to interpret the vegetation's spatial dynamics in relation to the evolution of thermal and snow depth variables recorded for the period 1951-2006 at the weather station at Puerto de Navacerrada. The significant value of the resulting coefficients confirms that plant cover at Puerto de los Neveros has been greatly affected by climate change, particularly ...
the results showed a correlation among the 18 climate-related parameters for the period 1951-2000... more the results showed a correlation among the 18 climate-related parameters for the period 1951-2000. High index values and a basic similarity in tendencies confirmed that the extension of the plant facies had changed in accordance with variations in temperature and snow cover. As are result, it was determined that plant cover was sensitive to climate changes that had occurred during the study period and had responded by reducing the extent of the snowfields, hydrophytic meadows and open scrublands while expanding the pychroxerophytic meadows and dense scrublands.
This paper tries to ascertain the validity of Kalman Filtering in forecasting technological subst... more This paper tries to ascertain the validity of Kalman Filtering in forecasting technological substitution. It is also concerned with this process in the Spanish Telecommunications Sector. With that aim, the ability of this methodology and that of Ordinary Least Square in describing and forecasting the different substitution processes that have taken place in this sector are compared. Some conclusions are drawn from the different speeds of substitution observed between both processes, and it is also stated that Kalman Filtering is superior to Ordinary Least Square, both in estimating and in forecasting in the short term.
El Tratado de la reforma del entendimiento está comprendido en las Obras póstumas, publicadas, tr... more El Tratado de la reforma del entendimiento está comprendido en las Obras póstumas, publicadas, tras algunos meses de la muerte del autor, por sus amigos 1 . Le precede un Aviso al lector, que se hallará más adelante. También se menciona en el prefacio general, verosímilmente escrito por Jarig Jelles 2 . Sabemos así que este escrito es uno de los más viejos de Spinoza y que quedó inconcluso, a despecho del deseo del autor de completarlo, debido a «la dificultad de la obra, a las profundas investigaciones y al infinito saber que requería».
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