Papers by Julian Martinez
Se realizó un estudio prospectivo de casos y controles con 315 pacientes, a los cuales se tomaron... more Se realizó un estudio prospectivo de casos y controles con 315 pacientes, a los cuales se tomaron biopsias endoscópicas del cuerpo gástrico. Según la metodología de Sydney se determinaron cambios histológicos de gastritis crónica, de su actividad, de la presencia de atrofia, de metaplasia intestinal y de infección por Helicobacter pylori. Mediante el análisis multivariado se encontró una asociación positiva entre la mayor edad de los pacientes y los cambios de atrofia gástrica corporal; para mayores de 65 años se determinó un OR de 3,33 (IC 95% 3,64), situación similar se observó para los cambios de metaplasia intestinal con un OR 2,97 (IC 95% 2,. Se observó que la infección por Helicobacter pylori disminuye con la edad; para menores de 40 años OR de 1,72 (IC 95% 1,60-1,84), entre los 40 y 64 años OR 0,84 (IC 95% 0,80-0,88) y para mayores de 65 años OR de 0,63 (IC95% 0,58-0,68) y se asocia fuertemente con la actividad de la inflamación gástrica 63 (IC 95% 24,63). Estos resultados son compatibles con la hipótesis que la gastritis crónica atrófica corporal es un cambio relacionado con el envejecimiento humano.
[Portal hypertension in pregnancy: report of a case]
Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
The coexistence of pregnancy and liver disease represents a complex clinical situation. Pregnancy... more The coexistence of pregnancy and liver disease represents a complex clinical situation. Pregnancy develops hypervolemic state due to increased splachnic blood flow, which contributes to increased portal pressure transmitted to collateral veins that increase the risk of variceal bleeding in these patients. We report the case of a 39 years old patient in the sixth pregnancy and without any previous medical history that presented pre-sinusoidal portal hypertension, and thanks to appropriate multidisciplinary management had an uncomplicated delivery. We review the literature relevant to the case.
[Gastric Kaposi sarcoma in a patient with HIV]
Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú, 2014
A 38 years old man with 48 hours of gastrointestinal bleeding was admitted to the hospital. The E... more A 38 years old man with 48 hours of gastrointestinal bleeding was admitted to the hospital. The EGD revealed red-purple nodules in the gastric antrum. Histopathologically, there were spindle cells and capillary size vascular proliferation. These findings were consistent with Kaposi sarcoma of the stomach. Immediately after, the patient had a positive test for HIV.
Determinación de los niveles de etanol, metanol y acetaldehído en el guarapo elaborado en los mun... more Determinación de los niveles de etanol, metanol y acetaldehído en el guarapo elaborado en los municipios de Cundinamarca Determination of the ethanol, methanol and acetaldehído levels in the guarapo prepared in Cundinamarca's municipalities SUMMARY Objective: To determine ethanol, acetaldehyde and methanol concentrations in guarapo consumed by patients with alcoholic hepatic cirrhosis in the Colombian State of Cundinamarca. Methods: Phase one: Retrospective survey of clinical records of patients with alcoholic hepatic cirrhosis due to chronic consumption of guarapo seen in La Samaritana University Hospital in Bogotá. Phase two: Collection of guarapo samples in the villages identified and chemical analysis by means of high performance gas chromatography. Results: All samples showed ethanol concentrations in the range of 0,50 % to 6,94%. In 41 of them acetaldehyde was present in variable concentrations. None of them were positive for methanol. The samples with the higher ethanol concentrations came from Gualivá, Rionegro and Tequendama, which are the provinces with the higher number of patients with alcoholic hepatic cirrhosis seen in La Samaritana University Hospital.
Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en …
Revista médica de …, 2002
... Diana M Cittelly P 1 , Mónica G Huertas 2 , Julián D Martínez, Ricardo Oliveros, Héctor Posso... more ... Diana M Cittelly P 1 , Mónica G Huertas 2 , Julián D Martínez, Ricardo Oliveros, Héctor Posso, María Mercedes Bravo 3 , Oscar Orozco D. ... [ Links ]. 6. Fujioka T, Honda S, Tokieda M. Helicobacter pylori infection and gastric carcinoma in animal models. ...
Treatment of Helicobacter pylori infections remains an unsolved problem in clinical practice beca... more Treatment of Helicobacter pylori infections remains an unsolved problem in clinical practice because of the high percentage of failures to eradicate the bacteria. The main cause is that antibiotic resistance varies with the geographical area under study. Several techniques have been developed to study the bacteria's sensitivity in vitro, but they are diffi cult to use in clinical practice, and they are costly. It is also important to recognize that sensitivity in vitro is not always directly related to sensitivity in vivo. Nevertheless, these techniques can help improve the results of eradication. This article reviews the mechanisms of resistance and reviews articles published in Latin America on in vitro resistance to the antibiotics most frequently used in eradication schemes. The review found 35 studies in Latin America with a total of 3,358 isolates. Forty-eight percent of the studies used the E-test for sensitivity, 37% used agar dilution, and 8% used agar diffusion. The studies show considerable heterogeneity with important differences among countries in the region and even among studies in the same country. In vitro resistance to metronidazole was 65.7%, in vitro resistance to amoxicillin was 6.5 in vitro resistance to clarithromycin was 14%, in vitro resistance to tetracycline was 8.3% to, in vitro resistance to levofl oxacin was 39% and in vitro resistance to furazolidone was 6.9%.
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Papers by Julian Martinez