Juan Escudero

Followers

Following

Co-authors

Public Views

Michael Spivey

University of California, Merced

Don Ross

University College Cork

Julian Kiverstein

Academic Medical Centre/ Universiteit van Amsterdam

David Seamon

Kansas State University

Antonio Cabral

UERJ - Universidade do Estado do Rio de Janeiro / Rio de Janeiro State University

Meera Mary Sunny

Indian Institute of Technology Gandhinagar

Samuel LÉZÉ

École Normale Supérieure de Lyon

Jaume Rossello-Mir

Universitat de les Illes Balears

Paolo Carta

University of Trento

Roberto Colombo

Università Cattolica del Sacro Cuore (Catholic University of the Sacred Heart)

Interests

Uploads

Papers by Juan Escudero

Circles Are Detected Faster Than Downward-Pointing Triangles in a Speeded Response Task

Perception, 2020

Simple geometric shapes are associated with facial emotional expressions. According to previous r... more Simple geometric shapes are associated with facial emotional expressions. According to previous research, a downward-pointing triangle conveys the threatening perception of an angry facial expression, and a circle conveys the pleasant perception of a happy facial expression. Some studies showed that downward-pointing triangles have the advantage to capture attention faster than circles. Other studies proposed that curvature enhances visual detection and guides attention. We tested a downward-pointing triangle and a circle as target stimuli for a speeded response task. The distractors were two stimuli that resulted from the mixture of both targets to control for low-level features’ balanced presentation. We used 3 × 3, 4 × 4, and 5 × 5 matrices to test whether these shapes led attention to an efficient response. In Experiment 1, participants responded faster to the circle than to the downward-pointing triangle. They also responded slower to both targets as the number of distractors i...

Download

Dimensiones factoriales de la experiencia estética

Download

DIMENSIONES FACTORIALES DE LA EXPERIENCIA ESTÉTICA Psicothema, año/vol. 15, número 003 Universidad de Oviedo

by Jaume Rossello-Mir and Juan Escudero

redalyc.uaemex.mx

El objetivo de este artículo consiste en justificar experimentalmente la existencia de un factor ... more El objetivo de este artículo consiste en justificar experimentalmente la existencia de un factor general que relaciona belleza, estética y arte analizando, mediante la técnica del diferencial semántico, las respuestas de los participantes a estímulos de diversa condición artística en las categorías de «bello», «agradable», «interesante» y «original».

Download

[Green light laser efficacy in patients with prostatic hyperplasia treatment with 5-alpha reductase inhibitors]

Actas urologicas españolas, 2009

High prevalence of BPH and gradual ageing of the population, combined with the existence of effec... more High prevalence of BPH and gradual ageing of the population, combined with the existence of effective medical treatments for this condition, has led to an increasing use of surgery in patients on long-term treatment with 5-alpha reductase inhibitors (5-ARIs). Initially, patients treated with 5-ARIs were not considered good candidates for photoselective vaporization of the prostate with green laser. To assess, using a retrospective study based on our experience, wheter long-term treatment (longer than 6 months) with 5-alpha reductase inhibitors decreases effectiveness of photoselective vaporization of the prostate with green light laser in BPH. From September 2005 to January 2008, 102 patients underwent photoselective vaporization of the prostate with green light laser. Of these, 25 patients (24.5%) had been treated with 5-ARIs for at least 6 months, and the remaining 77 patients (75.5%) were used as controls. A retrospective study was conducted to compare the pre- and postoperative ...

Association of a mineralocorticoid receptor gene polymorphism with hypertension in a Spanish population

To assess the association of polymorphisms and haplotypes of the mineralocorticoid receptor (MR) ... more To assess the association of polymorphisms and haplotypes of the mineralocorticoid receptor (MR) (NR3C2) gene to the risk of essential hypertension (HTN) in a Spanish population. This is a population-based study which included 1,502 subjects (748 women) &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;18 years old. Twenty-four polymorphisms of NR3C2 gene were analyzed by using SNPlex (Genotyping System based on OLA/PCR technology). Alleles of the single-nucleotide polymorphism (SNP) rs5522 were significantly associated with the risk of HTN, both in the recessive and codominant models adjusted by age, gender, and body mass index (BMI). Genotype GG of the rs5522 showed to be protective against HTN odds ratio (OR) 0.10 (0.02-0.56), P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01. One haplotype, which included the G allele of the rs5522, was also associated with reduced risk of HTN and four haplotypes which included the A allele were associated with increased risk of HTN. When the 24-h urinary sodium excretion and the estimated glomerular filtration rate (eGFR) were added, they did not reduce the significance level. Interaction between genotypes of the rs5522 and quartiles of 24-h sodium excretion has been observed. In subjects with the AA genotype, those with higher urinary sodium excretion had the lowest risk to be hypertensive. A functional polymorphism of the NR3C2 gene was associated with risk of HTN. The data provided in this study seems to give credit to the hypothesis of the participation of MR gene in the development of HTN, although further studies are necessary to better assess its real impact.

$Research paper thumbnail of Angina refractaria por fenómeno de robo en arteria mamaria interna resuelta mediante embolización$

Angina refractaria por fenómeno de robo en arteria mamaria interna resuelta mediante embolización

Revista Española de Cardiología, 1998

Nt‐proBNP in haemodialysis patients: A preliminary study

Scandinavian Journal of Clinical & Laboratory Investigation, 2008

N-terminal pro-brain natriuretic peptide (Nt-proBNP) is a marker of left ventricular function. Al... more N-terminal pro-brain natriuretic peptide (Nt-proBNP) is a marker of left ventricular function. Although many factors can increase left ventricular dysfunction in haemodialysis patients, the role of Nt-proBNP is uncertain. Serum concentrations of Nt-proBNP and troponin T were measured by electrochemiluminescence and C-reactive protein by immunoturbidimetry in 52 dialysis patients followed-up for 36 months. Nt-proBNP correlated (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05) with time on haemodialysis (rho=0.345), left ventricular mass index (r=0.596), troponin T level (r=0.605) and age (r=0.296). Patients with a history of heart disease showed higher levels of Nt-proBNP (median; minimum-maximum ngl/L) (15,571; 1,553-209,451) than those without (4,535; 751-115,078) (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.01). Sensitivity and specificity of Nt-proBNP in the detection of left ventricular dysfunction (ventricular ejection fraction &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 45%) were 1.0 and 0.782, respectively. In the univariate analysis, patients with Nt-proBNP levels &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; or = 33,314 ng/L, CRP &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; or = 5 mg/L or troponin T &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; or = 0.1 microg/L had poorer probabilities of 1-year, 2-year and 3-year survival than patients with lower levels. Unfavourable prognostic factors in the multivariate analysis were CRP &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 5 mg/L and Tn T &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.1 microg/L. Nt-proBNP showed good diagnostic performance for detecting left ventricular dysfunction and was an important predictor of mortality in haemodialysis patients in the univariate analysis. In the multivariate analysis, Nt-proBNP lost its prognostic value, whereas for CRP and Tn T it was maintained.

Nitric oxide promotes strong cytotoxicity of phenolic compounds against Escherichia coli: the influence of antioxidant defenses

Free Radical Biology and Medicine, 2003

The induction of mutagenic and cytotoxic effects by simple phenolics, including catechol (CAT), 3... more The induction of mutagenic and cytotoxic effects by simple phenolics, including catechol (CAT), 3,4dihydroxyphenylacetic acid (DOPAC), hydroquinone (HQ), and 2,5-dihydroxyphenylacetic (homogentisic) acid (HGA), appears to occur through an oxidative mechanism based on the ability of these compounds to undergo autoxidation, leading to quinone formation with the production of reactive oxygen species. This is supported by the detection of such adverse effects in plate assays using Escherichia coli tester strains deficient in the OxyR function, but not in OxyR ϩ strains. The OxyR protein is a redox-sensitive regulator of genes encoding antioxidant enzymes including catalase and alkyl hydroperoxide reductase, which would eliminate hydrogen peroxide. Methyl-substituted phenolics such as 4-methylcatechol (MCAT) and methylhydroquinone (MHQ) produced, in addition to oxidative toxicity, marked cytotoxic effects against OxyR ϩ cells, thus revealing a mechanism of toxicity not mediated by hydrogen peroxide that could involve quinones and quinone methides arising from MCAT and MHQ oxidation. Quinone compounds could also be responsible for the enhanced cytotoxicity of certain phenolics when combined with a nitric oxide (NO • ) donor such as diethylamine/NO (DEA/NO). Phenolics scavenge NO • and, in turn, NO • oxidizes phenolics to form their quinone derivatives. In OxyR ϩ cells, where the oxidative toxicity is inhibited, DEA/NO promoted exceptional increases in the cytotoxicity of CAT and 3,4-dihydroxycinnamic (caffeic) acid (CAF), which both exhibited very low oxidative cytotoxicity, as well as in that of MCAT, HQ, and MHQ. In contrast, DEA/NO failed to promote toxicity by DOPAC and HGA, probably due to their ability to undergo oxidative polymerization, leading to the formation of melanins. Spectroscopic studies demonstrated quinone generation from the oxidation of CAF, HQ, and MHQ by DEA/NO. The o-quinone derived from CAF was rather unstable and decomposed during its isolation. For the generation of toxic quinones, e.g., to be used as therapeutic agents producing antitumor or antibacterial effects, the isolation step could be avoided with the method proposed. It combines quinone precursors, i.e. phenolic compounds, with an oxidant such as NO • .

Download

Utilidad de la endoscopia virtual y el Uro-TC en el diagnóstico de tumores del tracto urinario superior

Archivos Españoles de Urología (Ed. impresa), 2006

Joaquín Ulises Juan Escudero Avenida Juan Carlos I, 7 03370 Redován. Alicante. (España) chimojuan... more