International Journal of Gastrointestinal Cancer, Aug 1, 1994
Luminal proteolytic activity (PA) of different colonic segments was ascertained in animals subjec... more Luminal proteolytic activity (PA) of different colonic segments was ascertained in animals subjected to pancreatic duct ligation (PDL) and in control rats. The PDL rats revealed a significant PA reduction in the cecum, proximal colon (P < 0.01), and distal colon (P < 0.005). Proteolytic activity, trypsin, and chymotrypsin activity in control rats diminished progressively from the cecum to the distal colon. Conversely in PDL rats, we found maximal PA in distal colon. The conclusion is drawn that a significant proportion of colonic proteolytic activity can be attributed to pancreatic proteases with a maximal contribution at cecum level.
Poster presentations kg/m 2 before TED administration and 18.9 (14.6-25.4) kg/m 2 after TED admin... more Poster presentations kg/m 2 before TED administration and 18.9 (14.6-25.4) kg/m 2 after TED administration (p = 0.014). Although there were no significant differences in albumin (p = 0.53), eGFR (p = 0.66), and Ht (p = 0.089), the PS calorie /week was significantly decreased from 6581 (244-14000) kcal to 3747(0-8820) kcal after TED administration (p = 0.0001). Ten patients (50.0%) experienced gastrointestinal stoma complications, including stoma swelling and/or prolapse during the observation period. Abdominal pain occurred in 7 cases (35.0%), catheter-related infection in five patients (25.0%), oedema in 4 patients (20.0%), nausea in 2 patients (10.0%), abdominal distension in 3 patients (15.0%), and upper respiratory tract infection in 1 patient (5.0%). All the symptoms were transient and tolerable. Although 3 patients discontinued TED due to nausea and abdominal pain and were excluded from this analysis, these symptoms improved after the discontinuation. Conclusion: TED reduced PS volume at week 4 in CD patients with SBS-IF, and the BMI and the PS calorie requirement were improved during the observational period without serious adverse events.
« PreviousNext »Gastroenterology Volume 114, Supplement 1 , Page A386, 15 April 1998. Celiac dise... more « PreviousNext »Gastroenterology Volume 114, Supplement 1 , Page A386, 15 April 1998. Celiac disease and epilepsy with cerebral calcifications. P. Kenny ,; R. Benavente ,; J. De Paula. PDF. No abstract is available. To read the body of this article, please view the PDF online. ...
This study was performed in 15 healthy control subjects (8 males- age 23-70 and 7 females age 20-... more This study was performed in 15 healthy control subjects (8 males- age 23-70 and 7 females age 20-74) as a way to compare the total and segmental colonic transit time with two different type of radiopaque markers. One type of markers was 3 mm cut sections of a radiopaque polietilene 14 French Levine tube, with a medium weight of 64.3 mg and a specific gravity (SG) of 1.28. The other type were 7 mm lenticular insoluble barium (lentils) with medium weight of 231 mg and a SG of 1.87. Each subject ingested 20 markers of each type with the breakfast and front and profile plain films of the abdomen were taken 24 and 48 hs after. The total colonic transit time for the polietilene markers was 17.7 hs and 27.3 hs for the barium type (BM) (p < 0.001). The segmental transit time for right colon was 2.4 hs (PM) and 9.7 hs (PM) and 9.7 hs (BM) (p < 0.001) in the left colon 9.5 hs (PM) and 11.3 hs (BM) and in rectoanun 5.9 hs (BM) with no statistical significance. the physical characteristic...
Fifteen patients suffering from different types of constipation were studied by means of radiopaq... more Fifteen patients suffering from different types of constipation were studied by means of radiopaque markers in order to know: a) If there is a correlation between the clinical state and the physiopathological motor variables of idiopatic constipation. b) The efficacy of a compound that combines its bulk action to its stimulation of the intestinal wall. Based on the results it is concluded that: The methodology is not useful in order to differentiate the colon motor behaviours in idiopatic constipation if these differences really exist. The evacuative effect of the compound was easily and objectively demonstrated by the acceleration of the radiopaque markers along the right colon. There was a good correlation between the subjective assessment done by the physician, and the patient and the objective results.
The human gut harbors dense and diverse microbial communities which have an impact on host&#3... more The human gut harbors dense and diverse microbial communities which have an impact on host&#39;s health. The symbiotic relationship between gut microbial communities and host can be optimized by pharmacological or nutritional intervention on the intestinal ecosystem using probiotics or prebiotics. Worldwide research on the use of prebiotics and probiotics in human and animal health has accelerated in recent years. However, there is lack of information about the practical use of probiotics and prebiotics in Medicine. A major area for medical applications has been the prevention or treatment of gastrointestinal diseases. Recently, a group of international experts appointed by the World Gastroenterology Organization prepared a practical guideline on the current indications of probiotics and prebiotics in Gastroenterology. The full text of the guideline is published in the current issue of our Journal. The document underscores strain-specificity of the clinical effects, and provides precise information on which specific probiotic strains or prebiotic compounds are useful for what particular clinical indications (see Table 3).
The American Journal of Clinical Nutrition, Apr 1, 1991
To determine whether short-chain triglycerides (SCTs, 1:1 triacetin:tributyrin, wt:wt) enhance in... more To determine whether short-chain triglycerides (SCTs, 1:1 triacetin:tributyrin, wt:wt) enhance intestinal adaptation in short-bowel syndrome (SBS), male Sprague-Dawley rats underwent 60% distal small-bowel resection with cecectomy and received either a chemically defined diet (CD) or a CD containing 40% of nonprotein energy as either medium-chain triglycerides (MCTs) or SCTs. After 12 d the SCT group had significantly increased jejunal mucosal weight compared with the MCT and CD groups and had significantly increased segment weight and mucosal protein compared with the CD group. In the colon the SCT group had significantly increased segment and mucosal weights and mucosal protein and DNA compared with both the MCT and CD groups. Body-weight change and measurements of serum ketones, albumin, glucose, and triglycerides revealed no significant differences among groups. SCTs improved jejunal and colonic adaptive growth and maintained comparable nutritional status in SBS when compared with CD alone or CD with MCTs.
Journal of Parenteral and Enteral Nutrition, Jul 1, 1988
Administration of an elemental diet to rats given methotrexate (MTX), 20 mg/kg intraperitoneally ... more Administration of an elemental diet to rats given methotrexate (MTX), 20 mg/kg intraperitoneally (ip), results in 100% mortality from severe enterocolitis. Previous studies indicate that glutamine (GLN), which is not present in elemental diets, is the preferred oxidative substrate for the gut' and may facilitate intestinal recovery after injury. 2 This study investigated the effects of a glutamine-supplemented elemental diet (GLN-ED) on nutritional status, intestinal morphometry, bacterial translocation and survival in this lethal model of intestinal injury. Three experiments were performed. In the first experiment, rats received an intragastric elemental diet supplemented with either 2% GLN or an equivalent amount of glycine (Control). After 4 days animals received either MTX, 20 mg/kg ip, or saline ip and were killed 3 days later. The GLN-ED resulted in significantly decreased weight loss, improved nitrogen retention, and increased mucosal weight, protein, and DNA content of the jejunum and colon. In the second experiment rats were assigned to diet as in the first experiment, but all animals received MTX. Control diet animals died within 120 hrs of MTX administration. The GLN-ED group had significantly longer survival time and decreased mortality. In the third experiment animals were assigned to diet and MTX as in the first experiment. Ninety-six hrs later aortic blood cultures revealed enteric bacteremia in animals administered MTX. GLN-ED resulted in a significant reduction in the incidence of bacteremia. These experiments showed that a GLN-ED significantly improved nutritional status, decreased intestinal injury, decreased bacterial translocation, and resulted in improved survival in a lethal model of enterocolitis.
HAL (Le Centre pour la Communication Scientifique Directe), Mar 1, 2008
Background/aims: functional constipation is a prevalent problem within the western population. Th... more Background/aims: functional constipation is a prevalent problem within the western population. There is evidence supporting the fact that the inclusion of pre and probiotics in the diet can favorably modify the intestinal function. The present study evaluates the effect of the consumption of Activia ® , a yogurt containing 10 8 UFC/g of Bifidobacterium animalis (DN-173 010) and fructoligosaccharide, in women between the ages of 18 and 55 with and without functional constipation (Rome II criteria). Methods: after a stabilization and a basal period, women were randomized to receive 2 units/day of Activia or a lacteous dessert without probiotics (control) for a period of 14 days. Afterwards the groups were intercrossed for another 14 days. Results: of the 399 women who started the study, 378 were eligible for study participation. In the group of women with functional constipation (n= 266), the consumption of the symbiotic was associated with a higher bowel evacuation rate (6.1±2.7 depositions/week with Activia vs. 5.0±2.6 dep./week in the control group; P<0.01), an improvement in the quality of the stools according to the Bristol scale (3.6±1.0 vs. 3.4±1.0; P<0.01), a reduced perception of straining effort (1.9±0.8 vs. 2.2±0.9; P<0.01) and a reduced perception of pain associated with defecation (0.1±0.2 vs. 0.2±0.3; P<0.01). In the group of women without constipation (n=112) there were statistically significant variations in equal sense but of smaller magnitude, with the exception of pain which, having a very low value in the basal period, did not experience changes. Conclusion: the consumption of a symbiotic yogurt by women with functional constipation showed a significant improvement in the parameters related with bowel evacuation. The use of this symbiotic food can result in a useful and safe tool for managing constipation.
Objectives: To describe the most characteristic imaging findings for sclerosing encapsulating per... more Objectives: To describe the most characteristic imaging findings for sclerosing encapsulating peritonitis, with an emphasis on the computed tomography findings. Conclusion: The incidence of sclerosing encapsulating peritonitis is low. The pathophysiology of this condition is unclear. Two types are recognised: idiopathic and secondary; the secondary type is generally a complication of peritoneal dialysis. Its nonspecific clinical presentation and the absence of blood markers mean that sclerosing encapsulating peritonitis is usually diagnosed late. Thus, it is important to know the imaging signs; these include thickening and calcification of the peritoneum and dilation of bowel loops with thickening and calcification of bowel walls, whether in isolation or in association with loculated ascites. Although ultrasonography allows the complexity of the collections to be evaluated, computed tomography is the most useful technique for the general assessment of the signs mentioned above.
BACKGROUND: Previous studies have demonstrated that patients post cholecystectomy have had no def... more BACKGROUND: Previous studies have demonstrated that patients post cholecystectomy have had no definitive association with colorectal adenomatous polyps. It is thought that chronic inflammation from bile acids may lead to increase development of colorectal polyps. Post cholecystectomy chronic diarrhea is likely from bile acid exposure. Additionally chronic constipation is thought to be an risk factor for colorectal cancer. The purpose of this study is to investigate for an increased risk for colorectal adenomas in post cholecystectomy patients and to look for the association of polyps with chronic diarrhea in these patients. METHODS: We performed a retrospective chart review of the patients who underwent cholecystectomy between 01/2001-12/2012 who also had a colonoscopy following surgery. Patients without a personal history of IBD, colorectal polyps and/or family history of colorectal cancer were included in the study. Patients were further divided into two groups, those with and without chronic diarrhea. Polyps were further classified based on histology and location. RESULTS: A total of 395 patients were included in the study (63% female, with a mean age of 50 y). The average number of years between the cholecystectomy and a colonoscopy was 2.6 years. An increased risk for colorectal polyps 151(38%) (95% confidence interval (CI)-0.33-0.43) was found among these patients when compared to an average risk in general population aged 50 y (20%). A total of 28% patients in the study were found to have proximal colon polyps (0.28, 95% CI 0.21 to 0.36) and no significant difference was found when compared to the average risk population (13-37%). In contrast an increased risk of polyps in distal colon 48% (0.48, 95% CI: 0.40 to 0.56) was found when compared to the average risk population (25-40%). Twenty five percent of patients had polyps in both proximal and distal colon 37/151 (0.25; 95% CI 0.18 to 0.32), statistics were not compared to the general population. Hyper plastic polyps were found in 37% (0.37, 95%CI: 0.29 to 0.45) patients, which were not found to be at increased risk when compared to average risk (20-40%). Adenomas, 55% (0.55, 95% CI: 0.46 to 0.63), were found to be at increased risk when compared to average risk (25-30%). Additionally an increased risk was found for serrated polyps, 9% (0.09, 95% CI 0.05 to 0.15), when compared to average risk (1-7%). In patients with chronic diarrhea the proportion of polyps was 0.26 compared to 0.43 in those without chronic diarrhea. (Odds ratio=0.47, 95% CI 0.29-0.75, P=0.002), revealing a negative association of polyps with chronic diarrhea in this set of patients. CONCLUSIONS: Cholecystectomy was found to increase the risk for distal colorectal adenomas/polyps. Chronic diarrhea was found to be negatively associated with colorectal polyps in this set of patients.
Objectives: To describe the most characteristic imaging findings for sclerosing encapsulating per... more Objectives: To describe the most characteristic imaging findings for sclerosing encapsulating peritonitis, with an emphasis on the computed tomography findings. Conclusion: The incidence of sclerosing encapsulating peritonitis is low. The pathophysiology of this condition is unclear. Two types are recognised: idiopathic and secondary; the secondary type is generally a complication of peritoneal dialysis. Its nonspecific clinical presentation and the absence of blood markers mean that sclerosing encapsulating peritonitis is usually diagnosed late. Thus, it is important to know the imaging signs; these include thickening and calcification of the peritoneum and dilation of bowel loops with thickening and calcification of bowel walls, whether in isolation or in association with loculated ascites. Although ultrasonography allows the complexity of the collections to be evaluated, computed tomography is the most useful technique for the general assessment of the signs mentioned above.
OBJECTIVES To describe the most characteristic imaging findings for sclerosing encapsulating peri... more OBJECTIVES To describe the most characteristic imaging findings for sclerosing encapsulating peritonitis, with an emphasis on the computed tomography findings. CONCLUSION The incidence of sclerosing encapsulating peritonitis is low. The pathophysiology of this condition is unclear. Two types are recognized: idiopathic and secondary; the secondary type is generally a complication of peritoneal dialysis. Its nonspecific clinical presentation and the absence of blood markers mean that sclerosing encapsulating peritonitis is usually diagnosed late. Thus, it is important to know the imaging signs; these include thickening and calcification of the peritoneum and dilation of bowel loops with thickening and calcification of bowel walls, whether in isolation or in association with loculated ascites. Although ultrasonography allows the complexity of the collections to be evaluated, computed tomography is the most useful technique for the general assessment of the signs mentioned above.
International Journal of Gastrointestinal Cancer, Aug 1, 1994
Luminal proteolytic activity (PA) of different colonic segments was ascertained in animals subjec... more Luminal proteolytic activity (PA) of different colonic segments was ascertained in animals subjected to pancreatic duct ligation (PDL) and in control rats. The PDL rats revealed a significant PA reduction in the cecum, proximal colon (P &lt; 0.01), and distal colon (P &lt; 0.005). Proteolytic activity, trypsin, and chymotrypsin activity in control rats diminished progressively from the cecum to the distal colon. Conversely in PDL rats, we found maximal PA in distal colon. The conclusion is drawn that a significant proportion of colonic proteolytic activity can be attributed to pancreatic proteases with a maximal contribution at cecum level.
Poster presentations kg/m 2 before TED administration and 18.9 (14.6-25.4) kg/m 2 after TED admin... more Poster presentations kg/m 2 before TED administration and 18.9 (14.6-25.4) kg/m 2 after TED administration (p = 0.014). Although there were no significant differences in albumin (p = 0.53), eGFR (p = 0.66), and Ht (p = 0.089), the PS calorie /week was significantly decreased from 6581 (244-14000) kcal to 3747(0-8820) kcal after TED administration (p = 0.0001). Ten patients (50.0%) experienced gastrointestinal stoma complications, including stoma swelling and/or prolapse during the observation period. Abdominal pain occurred in 7 cases (35.0%), catheter-related infection in five patients (25.0%), oedema in 4 patients (20.0%), nausea in 2 patients (10.0%), abdominal distension in 3 patients (15.0%), and upper respiratory tract infection in 1 patient (5.0%). All the symptoms were transient and tolerable. Although 3 patients discontinued TED due to nausea and abdominal pain and were excluded from this analysis, these symptoms improved after the discontinuation. Conclusion: TED reduced PS volume at week 4 in CD patients with SBS-IF, and the BMI and the PS calorie requirement were improved during the observational period without serious adverse events.
« PreviousNext »Gastroenterology Volume 114, Supplement 1 , Page A386, 15 April 1998. Celiac dise... more « PreviousNext »Gastroenterology Volume 114, Supplement 1 , Page A386, 15 April 1998. Celiac disease and epilepsy with cerebral calcifications. P. Kenny ,; R. Benavente ,; J. De Paula. PDF. No abstract is available. To read the body of this article, please view the PDF online. ...
This study was performed in 15 healthy control subjects (8 males- age 23-70 and 7 females age 20-... more This study was performed in 15 healthy control subjects (8 males- age 23-70 and 7 females age 20-74) as a way to compare the total and segmental colonic transit time with two different type of radiopaque markers. One type of markers was 3 mm cut sections of a radiopaque polietilene 14 French Levine tube, with a medium weight of 64.3 mg and a specific gravity (SG) of 1.28. The other type were 7 mm lenticular insoluble barium (lentils) with medium weight of 231 mg and a SG of 1.87. Each subject ingested 20 markers of each type with the breakfast and front and profile plain films of the abdomen were taken 24 and 48 hs after. The total colonic transit time for the polietilene markers was 17.7 hs and 27.3 hs for the barium type (BM) (p < 0.001). The segmental transit time for right colon was 2.4 hs (PM) and 9.7 hs (PM) and 9.7 hs (BM) (p < 0.001) in the left colon 9.5 hs (PM) and 11.3 hs (BM) and in rectoanun 5.9 hs (BM) with no statistical significance. the physical characteristic...
Fifteen patients suffering from different types of constipation were studied by means of radiopaq... more Fifteen patients suffering from different types of constipation were studied by means of radiopaque markers in order to know: a) If there is a correlation between the clinical state and the physiopathological motor variables of idiopatic constipation. b) The efficacy of a compound that combines its bulk action to its stimulation of the intestinal wall. Based on the results it is concluded that: The methodology is not useful in order to differentiate the colon motor behaviours in idiopatic constipation if these differences really exist. The evacuative effect of the compound was easily and objectively demonstrated by the acceleration of the radiopaque markers along the right colon. There was a good correlation between the subjective assessment done by the physician, and the patient and the objective results.
The human gut harbors dense and diverse microbial communities which have an impact on host&#3... more The human gut harbors dense and diverse microbial communities which have an impact on host&#39;s health. The symbiotic relationship between gut microbial communities and host can be optimized by pharmacological or nutritional intervention on the intestinal ecosystem using probiotics or prebiotics. Worldwide research on the use of prebiotics and probiotics in human and animal health has accelerated in recent years. However, there is lack of information about the practical use of probiotics and prebiotics in Medicine. A major area for medical applications has been the prevention or treatment of gastrointestinal diseases. Recently, a group of international experts appointed by the World Gastroenterology Organization prepared a practical guideline on the current indications of probiotics and prebiotics in Gastroenterology. The full text of the guideline is published in the current issue of our Journal. The document underscores strain-specificity of the clinical effects, and provides precise information on which specific probiotic strains or prebiotic compounds are useful for what particular clinical indications (see Table 3).
The American Journal of Clinical Nutrition, Apr 1, 1991
To determine whether short-chain triglycerides (SCTs, 1:1 triacetin:tributyrin, wt:wt) enhance in... more To determine whether short-chain triglycerides (SCTs, 1:1 triacetin:tributyrin, wt:wt) enhance intestinal adaptation in short-bowel syndrome (SBS), male Sprague-Dawley rats underwent 60% distal small-bowel resection with cecectomy and received either a chemically defined diet (CD) or a CD containing 40% of nonprotein energy as either medium-chain triglycerides (MCTs) or SCTs. After 12 d the SCT group had significantly increased jejunal mucosal weight compared with the MCT and CD groups and had significantly increased segment weight and mucosal protein compared with the CD group. In the colon the SCT group had significantly increased segment and mucosal weights and mucosal protein and DNA compared with both the MCT and CD groups. Body-weight change and measurements of serum ketones, albumin, glucose, and triglycerides revealed no significant differences among groups. SCTs improved jejunal and colonic adaptive growth and maintained comparable nutritional status in SBS when compared with CD alone or CD with MCTs.
Journal of Parenteral and Enteral Nutrition, Jul 1, 1988
Administration of an elemental diet to rats given methotrexate (MTX), 20 mg/kg intraperitoneally ... more Administration of an elemental diet to rats given methotrexate (MTX), 20 mg/kg intraperitoneally (ip), results in 100% mortality from severe enterocolitis. Previous studies indicate that glutamine (GLN), which is not present in elemental diets, is the preferred oxidative substrate for the gut' and may facilitate intestinal recovery after injury. 2 This study investigated the effects of a glutamine-supplemented elemental diet (GLN-ED) on nutritional status, intestinal morphometry, bacterial translocation and survival in this lethal model of intestinal injury. Three experiments were performed. In the first experiment, rats received an intragastric elemental diet supplemented with either 2% GLN or an equivalent amount of glycine (Control). After 4 days animals received either MTX, 20 mg/kg ip, or saline ip and were killed 3 days later. The GLN-ED resulted in significantly decreased weight loss, improved nitrogen retention, and increased mucosal weight, protein, and DNA content of the jejunum and colon. In the second experiment rats were assigned to diet as in the first experiment, but all animals received MTX. Control diet animals died within 120 hrs of MTX administration. The GLN-ED group had significantly longer survival time and decreased mortality. In the third experiment animals were assigned to diet and MTX as in the first experiment. Ninety-six hrs later aortic blood cultures revealed enteric bacteremia in animals administered MTX. GLN-ED resulted in a significant reduction in the incidence of bacteremia. These experiments showed that a GLN-ED significantly improved nutritional status, decreased intestinal injury, decreased bacterial translocation, and resulted in improved survival in a lethal model of enterocolitis.
HAL (Le Centre pour la Communication Scientifique Directe), Mar 1, 2008
Background/aims: functional constipation is a prevalent problem within the western population. Th... more Background/aims: functional constipation is a prevalent problem within the western population. There is evidence supporting the fact that the inclusion of pre and probiotics in the diet can favorably modify the intestinal function. The present study evaluates the effect of the consumption of Activia ® , a yogurt containing 10 8 UFC/g of Bifidobacterium animalis (DN-173 010) and fructoligosaccharide, in women between the ages of 18 and 55 with and without functional constipation (Rome II criteria). Methods: after a stabilization and a basal period, women were randomized to receive 2 units/day of Activia or a lacteous dessert without probiotics (control) for a period of 14 days. Afterwards the groups were intercrossed for another 14 days. Results: of the 399 women who started the study, 378 were eligible for study participation. In the group of women with functional constipation (n= 266), the consumption of the symbiotic was associated with a higher bowel evacuation rate (6.1±2.7 depositions/week with Activia vs. 5.0±2.6 dep./week in the control group; P<0.01), an improvement in the quality of the stools according to the Bristol scale (3.6±1.0 vs. 3.4±1.0; P<0.01), a reduced perception of straining effort (1.9±0.8 vs. 2.2±0.9; P<0.01) and a reduced perception of pain associated with defecation (0.1±0.2 vs. 0.2±0.3; P<0.01). In the group of women without constipation (n=112) there were statistically significant variations in equal sense but of smaller magnitude, with the exception of pain which, having a very low value in the basal period, did not experience changes. Conclusion: the consumption of a symbiotic yogurt by women with functional constipation showed a significant improvement in the parameters related with bowel evacuation. The use of this symbiotic food can result in a useful and safe tool for managing constipation.
Objectives: To describe the most characteristic imaging findings for sclerosing encapsulating per... more Objectives: To describe the most characteristic imaging findings for sclerosing encapsulating peritonitis, with an emphasis on the computed tomography findings. Conclusion: The incidence of sclerosing encapsulating peritonitis is low. The pathophysiology of this condition is unclear. Two types are recognised: idiopathic and secondary; the secondary type is generally a complication of peritoneal dialysis. Its nonspecific clinical presentation and the absence of blood markers mean that sclerosing encapsulating peritonitis is usually diagnosed late. Thus, it is important to know the imaging signs; these include thickening and calcification of the peritoneum and dilation of bowel loops with thickening and calcification of bowel walls, whether in isolation or in association with loculated ascites. Although ultrasonography allows the complexity of the collections to be evaluated, computed tomography is the most useful technique for the general assessment of the signs mentioned above.
BACKGROUND: Previous studies have demonstrated that patients post cholecystectomy have had no def... more BACKGROUND: Previous studies have demonstrated that patients post cholecystectomy have had no definitive association with colorectal adenomatous polyps. It is thought that chronic inflammation from bile acids may lead to increase development of colorectal polyps. Post cholecystectomy chronic diarrhea is likely from bile acid exposure. Additionally chronic constipation is thought to be an risk factor for colorectal cancer. The purpose of this study is to investigate for an increased risk for colorectal adenomas in post cholecystectomy patients and to look for the association of polyps with chronic diarrhea in these patients. METHODS: We performed a retrospective chart review of the patients who underwent cholecystectomy between 01/2001-12/2012 who also had a colonoscopy following surgery. Patients without a personal history of IBD, colorectal polyps and/or family history of colorectal cancer were included in the study. Patients were further divided into two groups, those with and without chronic diarrhea. Polyps were further classified based on histology and location. RESULTS: A total of 395 patients were included in the study (63% female, with a mean age of 50 y). The average number of years between the cholecystectomy and a colonoscopy was 2.6 years. An increased risk for colorectal polyps 151(38%) (95% confidence interval (CI)-0.33-0.43) was found among these patients when compared to an average risk in general population aged 50 y (20%). A total of 28% patients in the study were found to have proximal colon polyps (0.28, 95% CI 0.21 to 0.36) and no significant difference was found when compared to the average risk population (13-37%). In contrast an increased risk of polyps in distal colon 48% (0.48, 95% CI: 0.40 to 0.56) was found when compared to the average risk population (25-40%). Twenty five percent of patients had polyps in both proximal and distal colon 37/151 (0.25; 95% CI 0.18 to 0.32), statistics were not compared to the general population. Hyper plastic polyps were found in 37% (0.37, 95%CI: 0.29 to 0.45) patients, which were not found to be at increased risk when compared to average risk (20-40%). Adenomas, 55% (0.55, 95% CI: 0.46 to 0.63), were found to be at increased risk when compared to average risk (25-30%). Additionally an increased risk was found for serrated polyps, 9% (0.09, 95% CI 0.05 to 0.15), when compared to average risk (1-7%). In patients with chronic diarrhea the proportion of polyps was 0.26 compared to 0.43 in those without chronic diarrhea. (Odds ratio=0.47, 95% CI 0.29-0.75, P=0.002), revealing a negative association of polyps with chronic diarrhea in this set of patients. CONCLUSIONS: Cholecystectomy was found to increase the risk for distal colorectal adenomas/polyps. Chronic diarrhea was found to be negatively associated with colorectal polyps in this set of patients.
Objectives: To describe the most characteristic imaging findings for sclerosing encapsulating per... more Objectives: To describe the most characteristic imaging findings for sclerosing encapsulating peritonitis, with an emphasis on the computed tomography findings. Conclusion: The incidence of sclerosing encapsulating peritonitis is low. The pathophysiology of this condition is unclear. Two types are recognised: idiopathic and secondary; the secondary type is generally a complication of peritoneal dialysis. Its nonspecific clinical presentation and the absence of blood markers mean that sclerosing encapsulating peritonitis is usually diagnosed late. Thus, it is important to know the imaging signs; these include thickening and calcification of the peritoneum and dilation of bowel loops with thickening and calcification of bowel walls, whether in isolation or in association with loculated ascites. Although ultrasonography allows the complexity of the collections to be evaluated, computed tomography is the most useful technique for the general assessment of the signs mentioned above.
OBJECTIVES To describe the most characteristic imaging findings for sclerosing encapsulating peri... more OBJECTIVES To describe the most characteristic imaging findings for sclerosing encapsulating peritonitis, with an emphasis on the computed tomography findings. CONCLUSION The incidence of sclerosing encapsulating peritonitis is low. The pathophysiology of this condition is unclear. Two types are recognized: idiopathic and secondary; the secondary type is generally a complication of peritoneal dialysis. Its nonspecific clinical presentation and the absence of blood markers mean that sclerosing encapsulating peritonitis is usually diagnosed late. Thus, it is important to know the imaging signs; these include thickening and calcification of the peritoneum and dilation of bowel loops with thickening and calcification of bowel walls, whether in isolation or in association with loculated ascites. Although ultrasonography allows the complexity of the collections to be evaluated, computed tomography is the most useful technique for the general assessment of the signs mentioned above.
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