Papers by Jorge Cahuich varela
Inflammation Research, 2010
Objective and design Monocyte locomotion inhibitory factor (MLIF), an amebic peptide with antiinf... more Objective and design Monocyte locomotion inhibitory factor (MLIF), an amebic peptide with antiinflammatory properties, was evaluated in collagen-induced arthritis (CIA) to test its effects on the onset and acute inflammatory response of arthritis. Material DBA1/J mice at 8-10 weeks of age were divided into four groups (eight mice per group). Treatment The adjuvant group received Freund adjuvant, the CIA group was immunized with collagen II, the MLIF/ CIA group received collagen II and MLIF, and the MLIF group received MLIF and Freund adjuvant. Methods All groups were evaluated clinically. Seven weeks after the collagen injection, at the peak of the clinical arthritis score, limb specimens were collected and histological studies and gene expression analysis using microarrays were performed. Results MLIF administered weekly as a preventive scheme delayed and reduced the severity of acute arthritis. MLIF induced gene changes in functional categories including adhesion molecules, matrix metalloproteinases, and inflammatory cytokines. Conclusions MLIF could be an interesting new molecule to investigate in the field of rheumatoid arthritis pathogenesis research for its potential to prevent inflammation.
Clinical Immunology, 2006
that activation of innate immune receptors may be important in the induction of IFN-I and the pat... more that activation of innate immune receptors may be important in the induction of IFN-I and the pathogenesis of SLE, we examined the activation of splenocytes from knockout mice by various innate immune receptor ligands. Data will be presented that demonstrate specific defects in proliferation and cytokine production in response to these ligands in knockout animals. Importantly, mice deficient for IFN-I signaling components failed to develop proteinuria, indicating that this pathway may play a pathogenic role in end-organ kidney damage. Therefore, this study further indicates a role for the IFN system in the pathogenesis of SLE.
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Papers by Jorge Cahuich varela