Pharmacists now need a higher level of competence in other to meet drug information needs of thei... more Pharmacists now need a higher level of competence in other to meet drug information needs of their clients. The objective of this article was to map out the Standard Operating Procedure in the establishment of a drug information and resource center (DIRC) in a State University in Nigeria. The main functions will be provision of drug information services, medication counseling, professional training and other related activities. Those to operate the DIRC will require specific training in communication skills, knowledge of literature resources and dissemination skills. The requirements for the center include infrastructure, staff structure and funds. Drug information sources will comprise tertiary, secondary and primary literatures. Drug information is a fine-tuning channel to getting to a zero defect in medication error. Therefore, competence and cooperation among all health care professionals in the facility are needed to make a success of the project. Introduction The new trends in...
Malaria is a major health concern in children aged less than five years old, globally. In Nigeria... more Malaria is a major health concern in children aged less than five years old, globally. In Nigeria, it was estimated that 300,000 children die annually from malaria. Thus, this study aims to evaluate the clinical response of a brand of arthemether-lumefantrine (AL) for clearing parasitaemia in children aged less than five years old. This was a prospective study of the clinical and parasitological responses to the treatment of uncomplicated Plasmodium falciparum (P. falciparum) malaria using a popular dispersible brand of AL 20/120 mg. A hundred participants within 6–59 months with P. falciparum malaria were enrolled in the study and participants who could not complete the follow-ups were excluded. The drug was administered to participants following same dosage regimen on days 0, 1, 2 and followed-up on days 3, 7, 14, 21 and 28 in which the participants were assessed clinically and parasitologically. Data was analysed using MS-Excel 2010 and SPSS version 18. Kaplan-Meier survival anal...
Indian Journal of Pharmaceutical Education and Research, Dec 26, 2023
Background: To assess the self-reported quality of education received by undergraduate pharmacy s... more Background: To assess the self-reported quality of education received by undergraduate pharmacy students and to explore factors influencing career choice. Materials and Methods: A pretested questionnaire was administered to a convenient sample of 2090 pharmacy students in their professional years from selected universities in Nigeria. Respondent's characteristics and responses were reported as simple proportions and percentages. Results: The response rate was 71%. Only 1028 (69.3%) originally intended to study pharmacy. The desire to provide health care services, 531 (51.7%) and parental pressure 178 (39.0%) were the major motivation for studying pharmacy. More than half, 827 (55.7%) strongly agreed or agreed that the pharmacy training adequately prepared them to practice effectively. However nearly half 740 (49.9%) felt that the pharmacy curriculum was overloaded. Community pharmacy was the most preferred practice area 372 (26.5%) followed by hospital pharmacy practice. Conclusion: Majority of the students considered the quality of undergraduate pharmacy education to be adequate although unnecessarily overloaded. The desire to provide health care services and parental influence were the greatest motivational factors for studying pharmacy. The most preferred area of practice was community pharmacy.
International Journal of Preclinical & Pharmaceutical Research PRESCRIPTION PATTERN AND ADHERENCE TO ANTIHYPERTENSIVES AMONG PREGNANT WOMEN IN CENTRAL HOSPITAL WARRI, DELTA STATE, NIGERIA
Pregnancy induced hypertension poses a threat to both mother and the foetus as it is a reason for... more Pregnancy induced hypertension poses a threat to both mother and the foetus as it is a reason for increased risk of perinatal complications including the death of a mother or the child. Aim to evaluate the pattern of prescription of antihypertensives and the rate of adherence to these medications in pregnancy. Using both retrospective and prospective approaches, the study carried out in Central Hospital Warri, Delta State covered the assessment of 198 case folders of patients from October, 2009 to December, 2012 and interview of 100 patients within a six month period. Data were collected from the case files into a data collection form while the interview was conducted with the administration of a validated, closed ended 16-item questionnaire. Data were entered into a statistical table and analysed using the SPSS version 17.0 statistical package. Hypertension in pregnancy was prevalent among women carrying their first pregnancy (32.8%) and child bearing age of between 28-32years (34....
Antidiabetic Fallacy of Vernonia Amygdalina (Bitter Leaves) in Human Diabetes
Asian Pacific Journal of Tropical Medicine, 2009
Objective: Aim of present study is to scientifically, verify the antidiabetic activity/potency of... more Objective: Aim of present study is to scientifically, verify the antidiabetic activity/potency of Vernonia amygdalina in human diabetes. Methods: A search was made at Nnewi, South-East Nigeria for known diabetes who use Vernonia amygdalina either as their sole or supplementary antidiabetic. A total of ten volunteers comprising, eight females and two males were recruited. They were all of age range of 36-50 and average weight of 78 kg and suffering from non-insulin form of diabetes. The purpose of the study was explained to them and their consent obtained. They were asked not to take any other antidiabetic outside Vernonia amygdalina throughout the four weeks study period. There was however, no form of restrictions to their choice of diet or life style. They were requested to abstain from any drugs a week prior to commencement of study. Their prescriber's dosage range was followed and minimum daily dose of 210 mL (approximately 220 mg of dry extract) was administered in Week-I, f...
Assessment of Medication Knowledge Among Adults with Diabetes mellitus in a Nigerian Teaching Hospital
Background: Previous research had suggested a relationship between patients’ knowledge of their m... more Background: Previous research had suggested a relationship between patients’ knowledge of their medications and their adherence to treatment instructions.Objective: To assess medication knowledge among adults with diabetes mellitus at the Olabisi Onabanjo University Teaching Hospital (OOUTH), Sagamu, Ogun State.Methods: This was a cross sectional study of 152 adults with either Type-1 or Type-2 diabetes mellitus attending the Diabetes Clinic of the OOUTH. A two-part questionnaire was used to collect data on demography and knowledge of their medications.Results: Out of the one hundred and fifty two respondents, 60.5% were females and majority, (50.7%) fell within the 60-79 years age group. Majority (76.3%) of the patients reported very good medication knowledge, 32% and 46.1% knew the names and number of all the drugs they were taking respectively. Majority (96.1%) were aware they were receiving treatment for diabetes mellitus. The pharmacist was rated as the main information provide...
A685 Objectives: Succinic acid as endogenous metabolite, has a wide range of applications in medi... more A685 Objectives: Succinic acid as endogenous metabolite, has a wide range of applications in medical care. We conduct research on the development of new medicines based on succinic acid, ascorbic acid and rutin for the prevention and treatment of influenza. A systematic review was carried out to perform a qualitative assessment of succinic acid adding in the various medicines and to determine of their pharmacological action. MethOds: MEDLINE®, EMBASE®, Scopus, Cochrane Library databases and clinical trials registers between 1966 and Jun 2015 were performed. To analyze the RCT were selected and Review on the Study of the pharmacological action of drugs, which include succinic acid. Quality of evidence was assessed and each article was rated of quality. Results: Our study included 29 articles (23 RCT and 6 Review). The evidence varied in terms of: scope and years of research, type of treatment, study duration, sample size (< 100 to> 500 patients). Generally, the mean age of included patients was middle. For pharmacological properties and by relevance RCT are grouped as follows: antigypoxic action were 7 RCT (2003-2013 years), improve iron absorption in the gastrointestinal tract-6 RCT (1966-1974), hepatoprotective-4 RCT (2013-2014 years). One RCT proves the efficiency of succinic acid used in gastroenterology (a combination with omeprazole, 2012), depression (2013), in transplantation (1993) at menopause (2008), renal failure (2013), to improve body temperature during surgery (2007). Analysis of Review opens the new prospects for the use of succinic acid in cancer, diabetes and hepatitis C treatment. cOnclusiOns: A comprehencive overview of these studies estimated the evidence of succinic acid addition of the drugs. Succinic acid as endogenous metabolite, is a part of drugs of different pharmacological actions. These clinical trial results have been retrieved and give the possibility to develop of new drugs with succinic acid also in Ukraine.
World Journal of Pharmaceutical Sciences Adherence among psychiatric outpatients in psychiatric hospital Uselu, Benin City, Nigeria
Patients adherence studies are essential for evaluating the quality of care delivery of a health ... more Patients adherence studies are essential for evaluating the quality of care delivery of a health facility and patients' role in improving their conditions. To determine the adherence level of psychiatric outpatients to prescribed medications and impacting factors. A cross-sectional study was done from April to September, 2013. Consecutive sampling method was used for data collection. A total of 250 adult patients (18years and above) attending the psychiatric clinic with various psychiatric illnesses participated in the study. A well-structured self-report 10-item Medication Adherence Rating Scale (MARS) was used. Information gathered were socio demographics and clinical variables affecting patient's adherence to medications. Data was analyzed with respect to gender, adherence level and factors affecting patient's adherence. Patients' adherence to psychotropic medication was 63.6% and affecting factors were amount spent per clinic visit, perception of social support, ...
in terms of longer length of stay, more readmissions and higher consumption of drugs. The average... more in terms of longer length of stay, more readmissions and higher consumption of drugs. The average quality of the studies was moderate. Further research is needed to establish the degree of burden of agitation and containment borne by hospitals and the health care system.
Patients adherence studies are essential for evaluating the quality of care delivery of a health ... more Patients adherence studies are essential for evaluating the quality of care delivery of a health facility and patients’ role in improving their conditions. To determine the adherence level of psychiatric out-patients to prescribed medications and impacting factors. A cross-sectional study was done from April to September, 2013. Consecutive sampling method was used for data collection. A total of 250 adult patients (18years and above) attending the psychiatric clinic with various psychiatric illnesses participated in the study. A well-structured self-report 10-item Medication Adherence Rating Scale (MARS) was used. Information gathered were socio demographics and clinical variables affecting patient’s adherence to medications. Data was analyzed with respect to gender, adherence level and factors affecting patient’s adherence. Patients’ adherence to psychotropic medication was 63.6% and affecting factors were amount spent per clinic visit, perception of social support, alcohol intake,...
Physicians’ Antimalarial Utilization Practices in Children below 5 years in a Secondary and Primary Health Facilities in Delta State
Research Journal of Pharmacy and Technology
Malaria is an epidemic with 1.3% reduction in annual per capital economic growth rate. This study... more Malaria is an epidemic with 1.3% reduction in annual per capital economic growth rate. This study was to assess physicians’ antimalarial utilization in children below five years and conformity to guidelines. This is a retrospective and cross-sectional random sampling of prescriptions of antimalarials in under five between January 2012 and December 2014 in the secondary facility and January 2012 to December 2017 in two health facilities. Data was recorded using WHO indicator forms and analyzed using SPSS. Exactly, 800 prescriptions giving a total of 1,243 and 1313 drugs were prescribed in the Secondary Facility (CH), Warri and Primary Health Care (PHC), Oria respectively with an average of drugs prescribed per encounter (DPPE), CH (3.1 ± 0.01) and PHC, (3.3 ± 0.1). Antimalarials, were the most prescribed. Generic prescription was more in PHC (59%) than in CH (58%). Syrups were most prescribed 70.96% in CH, Warri and 53% in PHC, Oria. However, 27(50.9%) of physicians based prescriptio...
Prevalence of Neonatal Jaundice on Central Hospital, Warri, Delta State, Nigeria
Purpose: To determine the prevalence and predisposing factors of Neonatal Jaundice in a health-ca... more Purpose: To determine the prevalence and predisposing factors of Neonatal Jaundice in a health-care facility in Delta State.Methods: 272 babies (aged 1 – 30 days) the Neonatal Clinic of the Department of Child Health, Central Hospital, Warri, Delta State between June 2009 and June 2010 were examined daily for evidence of jaundice. Those with serum bilirubin ³15mg/100ml were subjected to additional clinical and laboratory investigations to determine the  predisposing/etiologic factors for jaundice. The socio-demographic data of their mothers were assessed using a semi-structured questionnaire. The data generated were analyzed.Results: Of the 160 male and 112 female babies sampled, 56 males (21%) and 33 females (12%) were found to be jaundiced. Majority of the cases (72.4% males, 70.8% females) had known predisposing/etiologic factors. The mothers who were single and divorced had relatively higher cases of jaundiced babies (50% and 35.5%, respectively). The prevalence ...
Malaysian Journal of Pharmaceutical Sciences, 2021
Malaria is a major health concern in children aged less than five years old, globally. In Nigeria... more Malaria is a major health concern in children aged less than five years old, globally. In Nigeria, it was estimated that 300,000 children die annually from malaria. Thus, this study aims to evaluate the clinical response of a brand of arthemether-lumefantrine (AL) for clearing parasitaemia in children aged less than five years old. This was a prospective study of the clinical and parasitological responses to the treatment of uncomplicated Plasmodium falciparum (P. falciparum) malaria using a popular dispersible brand of AL 20/120 mg. A hundred participants within 6–59 months with P. falciparum malaria were enrolled in the study and participants who could not complete the follow-ups were excluded. The drug was administered to participants following same dosage regimen on days 0, 1, 2 and followed-up on days 3, 7, 14, 21 and 28 in which the participants were assessed clinically and parasitologically. Data was analysed using MS-Excel 2010 and SPSS version 18. Kaplan-Meier survival anal...
Malaysian Journal of Pharmaceutical Sciences, 2021
World Health Organization (WHO) classified Nigeria as a hyper-endemic hepatitis B surface antigen... more World Health Organization (WHO) classified Nigeria as a hyper-endemic hepatitis B surface antigen (HBsAg) positive nation with prevalence ≥ 8%. This study intends to add information that could strengthen established database to improve awareness and prevention of hepatitis B virus (HBV) infection. We aimed to evaluate seroprevalence and trend of HBsAg among blood donors in Olabisi Onabanjo University Teaching Hospital (OOUTH), Sagamu, Ogun State, Nigeria over a five-year period. Data from records of 7,102 individuals aged ≥ 20 years old who donated blood to blood bank in this hospital from January 2012 to December 2016 were analysed for gender, age, number of donors per year and HBsAg status. Data analysis was done with Statistical Package for Social Sciences software. P ≤ 0.05 was considered statistically significant. Males were in the majority (6,547 [92.2%]). Age 30–39 years old was the major group (3,052 [43.0%]). Pooled HBsAg seroprevalence was 486 (6.8%). Females had the highe...
The aim of this study was to determine the magnitude of HIV/AIDS related stigmatization, discrimi... more The aim of this study was to determine the magnitude of HIV/AIDS related stigmatization, discrimination and coping strategies among people living with HIV/AIDS (PLHIV) at University College Hospital Ibadan. The study adopted a descriptive cross-sectional study design carried out among 700 PLHIV selected using a systematic random sampling technique from May to June 2010. A validated pretested questionnaire was used to collect the data which was analysed using SPSS version 16. The mean age of the respondents was 40.0 ± 9.40 years and more were females (474, 67.70%). About 212 (30.30%) have experienced stigmatization with verbal insult (138, 65.10%), subjection to ridicule (134, 63.20%) and avoidance by friends (89, 42.0%) being the most reported forms of induced stigmatization/discrimination. In addition, there was no significant relationship of experiencing stigmatization/discrimination by gender (P=0.097). However, more females experienced physical assault than male. Strategies ado...
Dhaka University Journal of Pharmaceutical Sciences, 2020
The rate of psychoactive substance (PAS) use in the adolescent group is increasing around the wor... more The rate of psychoactive substance (PAS) use in the adolescent group is increasing around the world. Drug abuse has a negative impact on students’ education especially that of secondary school students. This study aimed to assess the prevalence of psychoactive substance use and knowledge of the health consequences among secondary school students in Ogun State, Nigeria. A cross-sectional study was carried out among 528 consenting students selected using random sampling method. Data obtained using a validated modified World Health Organization’s guidelines questionnaire were analyzed with SPSS 20, p-Value ≤ 0.05 was considered significant. Majority (78.8%) were within the age group 15-18 years, males were 61.4%. Alcohol (95.0%) ranked first of all the substances been consumed among the current PAS users. Age was highly significantly associated with PAS use. Average knowledge of health consequences of PAS use was 11.5%. There is need for continuous health educational intervention to bo...
Background: The world health organization (WHO) estimates that every 45 seconds an African child ... more Background: The world health organization (WHO) estimates that every 45 seconds an African child dies of malaria while several others lay ill. Also, studies have shown that home-based management of malaria could improve prompt access to antimalarial medications for African children. Objective: This study aimed at assessing the home based management practices among care givers of children below five years in Delta State. Methods: This study was a descriptive cross-sectional survey used to assess the home based management practices of malaria in children under age five. 459 consenting Caregivers of children under five (6 to 59 months) were purposively selected from different churches during Sundays and Wednesdays midweek services through balloting from two communities in Central and North Senatorial Districts of Delta State (Oghara and Obiaruku). Prior to the commencement of the study, the caregivers were thoroughly counselled on the objectives of the study, and a pretested structured...
A483 (75 patients each). The 75 patients on our intervention group were educated by the Pharmacis... more A483 (75 patients each). The 75 patients on our intervention group were educated by the Pharmacist on diabetes and hypertension, their complications, risks, preventive measures and management. This was done at least six times during the study period unlike the control group who received no such education. In particular, they were counseled on the need for medication and treatment adherence such as clinic visits, and life style modifications including diet and exercise. Outcome measure included changes in fasting blood sugar (FBS), blood pressure (BP), body mass index (BMI) and adherence to instructions. Results: There were no statistical differences between the baseline and 6 months data of the control group as mean fasting blood sugar were 162.2 ± 69.1 and 159.9 ±57.2 (P= 0.825) and mean systolic blood pressure of 144.7 ± 23.8 and 145.5±18.6 (P= 0.819) respectively. The intervention group had mean fasting blood sugar of 156.7 ± 30.5 and 131.8± 40.4 (P< 0.001) and mean systolic blood pressure of 146.4 ± 13.9 and 133.8 ± 18.5 (P< 0.001) respectively. Adherence levels to medication taking in the groups were 42.7% : 94.7% respectively (P= 0.001). ConClusions: In diabetes management, patient education and counseling have become key tools in achieving both glycaemic and blood pressure control.
Pharmacists now need a higher level of competence in other to meet drug information needs of thei... more Pharmacists now need a higher level of competence in other to meet drug information needs of their clients. The objective of this article was to map out the Standard Operating Procedure in the establishment of a drug information and resource center (DIRC) in a State University in Nigeria. The main functions will be provision of drug information services, medication counseling, professional training and other related activities. Those to operate the DIRC will require specific training in communication skills, knowledge of literature resources and dissemination skills. The requirements for the center include infrastructure, staff structure and funds. Drug information sources will comprise tertiary, secondary and primary literatures. Drug information is a fine-tuning channel to getting to a zero defect in medication error. Therefore, competence and cooperation among all health care professionals in the facility are needed to make a success of the project. Introduction The new trends in...
Malaria is a major health concern in children aged less than five years old, globally. In Nigeria... more Malaria is a major health concern in children aged less than five years old, globally. In Nigeria, it was estimated that 300,000 children die annually from malaria. Thus, this study aims to evaluate the clinical response of a brand of arthemether-lumefantrine (AL) for clearing parasitaemia in children aged less than five years old. This was a prospective study of the clinical and parasitological responses to the treatment of uncomplicated Plasmodium falciparum (P. falciparum) malaria using a popular dispersible brand of AL 20/120 mg. A hundred participants within 6–59 months with P. falciparum malaria were enrolled in the study and participants who could not complete the follow-ups were excluded. The drug was administered to participants following same dosage regimen on days 0, 1, 2 and followed-up on days 3, 7, 14, 21 and 28 in which the participants were assessed clinically and parasitologically. Data was analysed using MS-Excel 2010 and SPSS version 18. Kaplan-Meier survival anal...
Indian Journal of Pharmaceutical Education and Research, Dec 26, 2023
Background: To assess the self-reported quality of education received by undergraduate pharmacy s... more Background: To assess the self-reported quality of education received by undergraduate pharmacy students and to explore factors influencing career choice. Materials and Methods: A pretested questionnaire was administered to a convenient sample of 2090 pharmacy students in their professional years from selected universities in Nigeria. Respondent's characteristics and responses were reported as simple proportions and percentages. Results: The response rate was 71%. Only 1028 (69.3%) originally intended to study pharmacy. The desire to provide health care services, 531 (51.7%) and parental pressure 178 (39.0%) were the major motivation for studying pharmacy. More than half, 827 (55.7%) strongly agreed or agreed that the pharmacy training adequately prepared them to practice effectively. However nearly half 740 (49.9%) felt that the pharmacy curriculum was overloaded. Community pharmacy was the most preferred practice area 372 (26.5%) followed by hospital pharmacy practice. Conclusion: Majority of the students considered the quality of undergraduate pharmacy education to be adequate although unnecessarily overloaded. The desire to provide health care services and parental influence were the greatest motivational factors for studying pharmacy. The most preferred area of practice was community pharmacy.
International Journal of Preclinical & Pharmaceutical Research PRESCRIPTION PATTERN AND ADHERENCE TO ANTIHYPERTENSIVES AMONG PREGNANT WOMEN IN CENTRAL HOSPITAL WARRI, DELTA STATE, NIGERIA
Pregnancy induced hypertension poses a threat to both mother and the foetus as it is a reason for... more Pregnancy induced hypertension poses a threat to both mother and the foetus as it is a reason for increased risk of perinatal complications including the death of a mother or the child. Aim to evaluate the pattern of prescription of antihypertensives and the rate of adherence to these medications in pregnancy. Using both retrospective and prospective approaches, the study carried out in Central Hospital Warri, Delta State covered the assessment of 198 case folders of patients from October, 2009 to December, 2012 and interview of 100 patients within a six month period. Data were collected from the case files into a data collection form while the interview was conducted with the administration of a validated, closed ended 16-item questionnaire. Data were entered into a statistical table and analysed using the SPSS version 17.0 statistical package. Hypertension in pregnancy was prevalent among women carrying their first pregnancy (32.8%) and child bearing age of between 28-32years (34....
Antidiabetic Fallacy of Vernonia Amygdalina (Bitter Leaves) in Human Diabetes
Asian Pacific Journal of Tropical Medicine, 2009
Objective: Aim of present study is to scientifically, verify the antidiabetic activity/potency of... more Objective: Aim of present study is to scientifically, verify the antidiabetic activity/potency of Vernonia amygdalina in human diabetes. Methods: A search was made at Nnewi, South-East Nigeria for known diabetes who use Vernonia amygdalina either as their sole or supplementary antidiabetic. A total of ten volunteers comprising, eight females and two males were recruited. They were all of age range of 36-50 and average weight of 78 kg and suffering from non-insulin form of diabetes. The purpose of the study was explained to them and their consent obtained. They were asked not to take any other antidiabetic outside Vernonia amygdalina throughout the four weeks study period. There was however, no form of restrictions to their choice of diet or life style. They were requested to abstain from any drugs a week prior to commencement of study. Their prescriber's dosage range was followed and minimum daily dose of 210 mL (approximately 220 mg of dry extract) was administered in Week-I, f...
Assessment of Medication Knowledge Among Adults with Diabetes mellitus in a Nigerian Teaching Hospital
Background: Previous research had suggested a relationship between patients’ knowledge of their m... more Background: Previous research had suggested a relationship between patients’ knowledge of their medications and their adherence to treatment instructions.Objective: To assess medication knowledge among adults with diabetes mellitus at the Olabisi Onabanjo University Teaching Hospital (OOUTH), Sagamu, Ogun State.Methods: This was a cross sectional study of 152 adults with either Type-1 or Type-2 diabetes mellitus attending the Diabetes Clinic of the OOUTH. A two-part questionnaire was used to collect data on demography and knowledge of their medications.Results: Out of the one hundred and fifty two respondents, 60.5% were females and majority, (50.7%) fell within the 60-79 years age group. Majority (76.3%) of the patients reported very good medication knowledge, 32% and 46.1% knew the names and number of all the drugs they were taking respectively. Majority (96.1%) were aware they were receiving treatment for diabetes mellitus. The pharmacist was rated as the main information provide...
A685 Objectives: Succinic acid as endogenous metabolite, has a wide range of applications in medi... more A685 Objectives: Succinic acid as endogenous metabolite, has a wide range of applications in medical care. We conduct research on the development of new medicines based on succinic acid, ascorbic acid and rutin for the prevention and treatment of influenza. A systematic review was carried out to perform a qualitative assessment of succinic acid adding in the various medicines and to determine of their pharmacological action. MethOds: MEDLINE®, EMBASE®, Scopus, Cochrane Library databases and clinical trials registers between 1966 and Jun 2015 were performed. To analyze the RCT were selected and Review on the Study of the pharmacological action of drugs, which include succinic acid. Quality of evidence was assessed and each article was rated of quality. Results: Our study included 29 articles (23 RCT and 6 Review). The evidence varied in terms of: scope and years of research, type of treatment, study duration, sample size (< 100 to> 500 patients). Generally, the mean age of included patients was middle. For pharmacological properties and by relevance RCT are grouped as follows: antigypoxic action were 7 RCT (2003-2013 years), improve iron absorption in the gastrointestinal tract-6 RCT (1966-1974), hepatoprotective-4 RCT (2013-2014 years). One RCT proves the efficiency of succinic acid used in gastroenterology (a combination with omeprazole, 2012), depression (2013), in transplantation (1993) at menopause (2008), renal failure (2013), to improve body temperature during surgery (2007). Analysis of Review opens the new prospects for the use of succinic acid in cancer, diabetes and hepatitis C treatment. cOnclusiOns: A comprehencive overview of these studies estimated the evidence of succinic acid addition of the drugs. Succinic acid as endogenous metabolite, is a part of drugs of different pharmacological actions. These clinical trial results have been retrieved and give the possibility to develop of new drugs with succinic acid also in Ukraine.
World Journal of Pharmaceutical Sciences Adherence among psychiatric outpatients in psychiatric hospital Uselu, Benin City, Nigeria
Patients adherence studies are essential for evaluating the quality of care delivery of a health ... more Patients adherence studies are essential for evaluating the quality of care delivery of a health facility and patients' role in improving their conditions. To determine the adherence level of psychiatric outpatients to prescribed medications and impacting factors. A cross-sectional study was done from April to September, 2013. Consecutive sampling method was used for data collection. A total of 250 adult patients (18years and above) attending the psychiatric clinic with various psychiatric illnesses participated in the study. A well-structured self-report 10-item Medication Adherence Rating Scale (MARS) was used. Information gathered were socio demographics and clinical variables affecting patient's adherence to medications. Data was analyzed with respect to gender, adherence level and factors affecting patient's adherence. Patients' adherence to psychotropic medication was 63.6% and affecting factors were amount spent per clinic visit, perception of social support, ...
in terms of longer length of stay, more readmissions and higher consumption of drugs. The average... more in terms of longer length of stay, more readmissions and higher consumption of drugs. The average quality of the studies was moderate. Further research is needed to establish the degree of burden of agitation and containment borne by hospitals and the health care system.
Patients adherence studies are essential for evaluating the quality of care delivery of a health ... more Patients adherence studies are essential for evaluating the quality of care delivery of a health facility and patients’ role in improving their conditions. To determine the adherence level of psychiatric out-patients to prescribed medications and impacting factors. A cross-sectional study was done from April to September, 2013. Consecutive sampling method was used for data collection. A total of 250 adult patients (18years and above) attending the psychiatric clinic with various psychiatric illnesses participated in the study. A well-structured self-report 10-item Medication Adherence Rating Scale (MARS) was used. Information gathered were socio demographics and clinical variables affecting patient’s adherence to medications. Data was analyzed with respect to gender, adherence level and factors affecting patient’s adherence. Patients’ adherence to psychotropic medication was 63.6% and affecting factors were amount spent per clinic visit, perception of social support, alcohol intake,...
Physicians’ Antimalarial Utilization Practices in Children below 5 years in a Secondary and Primary Health Facilities in Delta State
Research Journal of Pharmacy and Technology
Malaria is an epidemic with 1.3% reduction in annual per capital economic growth rate. This study... more Malaria is an epidemic with 1.3% reduction in annual per capital economic growth rate. This study was to assess physicians’ antimalarial utilization in children below five years and conformity to guidelines. This is a retrospective and cross-sectional random sampling of prescriptions of antimalarials in under five between January 2012 and December 2014 in the secondary facility and January 2012 to December 2017 in two health facilities. Data was recorded using WHO indicator forms and analyzed using SPSS. Exactly, 800 prescriptions giving a total of 1,243 and 1313 drugs were prescribed in the Secondary Facility (CH), Warri and Primary Health Care (PHC), Oria respectively with an average of drugs prescribed per encounter (DPPE), CH (3.1 ± 0.01) and PHC, (3.3 ± 0.1). Antimalarials, were the most prescribed. Generic prescription was more in PHC (59%) than in CH (58%). Syrups were most prescribed 70.96% in CH, Warri and 53% in PHC, Oria. However, 27(50.9%) of physicians based prescriptio...
Prevalence of Neonatal Jaundice on Central Hospital, Warri, Delta State, Nigeria
Purpose: To determine the prevalence and predisposing factors of Neonatal Jaundice in a health-ca... more Purpose: To determine the prevalence and predisposing factors of Neonatal Jaundice in a health-care facility in Delta State.Methods: 272 babies (aged 1 – 30 days) the Neonatal Clinic of the Department of Child Health, Central Hospital, Warri, Delta State between June 2009 and June 2010 were examined daily for evidence of jaundice. Those with serum bilirubin ³15mg/100ml were subjected to additional clinical and laboratory investigations to determine the  predisposing/etiologic factors for jaundice. The socio-demographic data of their mothers were assessed using a semi-structured questionnaire. The data generated were analyzed.Results: Of the 160 male and 112 female babies sampled, 56 males (21%) and 33 females (12%) were found to be jaundiced. Majority of the cases (72.4% males, 70.8% females) had known predisposing/etiologic factors. The mothers who were single and divorced had relatively higher cases of jaundiced babies (50% and 35.5%, respectively). The prevalence ...
Malaysian Journal of Pharmaceutical Sciences, 2021
Malaria is a major health concern in children aged less than five years old, globally. In Nigeria... more Malaria is a major health concern in children aged less than five years old, globally. In Nigeria, it was estimated that 300,000 children die annually from malaria. Thus, this study aims to evaluate the clinical response of a brand of arthemether-lumefantrine (AL) for clearing parasitaemia in children aged less than five years old. This was a prospective study of the clinical and parasitological responses to the treatment of uncomplicated Plasmodium falciparum (P. falciparum) malaria using a popular dispersible brand of AL 20/120 mg. A hundred participants within 6–59 months with P. falciparum malaria were enrolled in the study and participants who could not complete the follow-ups were excluded. The drug was administered to participants following same dosage regimen on days 0, 1, 2 and followed-up on days 3, 7, 14, 21 and 28 in which the participants were assessed clinically and parasitologically. Data was analysed using MS-Excel 2010 and SPSS version 18. Kaplan-Meier survival anal...
Malaysian Journal of Pharmaceutical Sciences, 2021
World Health Organization (WHO) classified Nigeria as a hyper-endemic hepatitis B surface antigen... more World Health Organization (WHO) classified Nigeria as a hyper-endemic hepatitis B surface antigen (HBsAg) positive nation with prevalence ≥ 8%. This study intends to add information that could strengthen established database to improve awareness and prevention of hepatitis B virus (HBV) infection. We aimed to evaluate seroprevalence and trend of HBsAg among blood donors in Olabisi Onabanjo University Teaching Hospital (OOUTH), Sagamu, Ogun State, Nigeria over a five-year period. Data from records of 7,102 individuals aged ≥ 20 years old who donated blood to blood bank in this hospital from January 2012 to December 2016 were analysed for gender, age, number of donors per year and HBsAg status. Data analysis was done with Statistical Package for Social Sciences software. P ≤ 0.05 was considered statistically significant. Males were in the majority (6,547 [92.2%]). Age 30–39 years old was the major group (3,052 [43.0%]). Pooled HBsAg seroprevalence was 486 (6.8%). Females had the highe...
The aim of this study was to determine the magnitude of HIV/AIDS related stigmatization, discrimi... more The aim of this study was to determine the magnitude of HIV/AIDS related stigmatization, discrimination and coping strategies among people living with HIV/AIDS (PLHIV) at University College Hospital Ibadan. The study adopted a descriptive cross-sectional study design carried out among 700 PLHIV selected using a systematic random sampling technique from May to June 2010. A validated pretested questionnaire was used to collect the data which was analysed using SPSS version 16. The mean age of the respondents was 40.0 ± 9.40 years and more were females (474, 67.70%). About 212 (30.30%) have experienced stigmatization with verbal insult (138, 65.10%), subjection to ridicule (134, 63.20%) and avoidance by friends (89, 42.0%) being the most reported forms of induced stigmatization/discrimination. In addition, there was no significant relationship of experiencing stigmatization/discrimination by gender (P=0.097). However, more females experienced physical assault than male. Strategies ado...
Dhaka University Journal of Pharmaceutical Sciences, 2020
The rate of psychoactive substance (PAS) use in the adolescent group is increasing around the wor... more The rate of psychoactive substance (PAS) use in the adolescent group is increasing around the world. Drug abuse has a negative impact on students’ education especially that of secondary school students. This study aimed to assess the prevalence of psychoactive substance use and knowledge of the health consequences among secondary school students in Ogun State, Nigeria. A cross-sectional study was carried out among 528 consenting students selected using random sampling method. Data obtained using a validated modified World Health Organization’s guidelines questionnaire were analyzed with SPSS 20, p-Value ≤ 0.05 was considered significant. Majority (78.8%) were within the age group 15-18 years, males were 61.4%. Alcohol (95.0%) ranked first of all the substances been consumed among the current PAS users. Age was highly significantly associated with PAS use. Average knowledge of health consequences of PAS use was 11.5%. There is need for continuous health educational intervention to bo...
Background: The world health organization (WHO) estimates that every 45 seconds an African child ... more Background: The world health organization (WHO) estimates that every 45 seconds an African child dies of malaria while several others lay ill. Also, studies have shown that home-based management of malaria could improve prompt access to antimalarial medications for African children. Objective: This study aimed at assessing the home based management practices among care givers of children below five years in Delta State. Methods: This study was a descriptive cross-sectional survey used to assess the home based management practices of malaria in children under age five. 459 consenting Caregivers of children under five (6 to 59 months) were purposively selected from different churches during Sundays and Wednesdays midweek services through balloting from two communities in Central and North Senatorial Districts of Delta State (Oghara and Obiaruku). Prior to the commencement of the study, the caregivers were thoroughly counselled on the objectives of the study, and a pretested structured...
A483 (75 patients each). The 75 patients on our intervention group were educated by the Pharmacis... more A483 (75 patients each). The 75 patients on our intervention group were educated by the Pharmacist on diabetes and hypertension, their complications, risks, preventive measures and management. This was done at least six times during the study period unlike the control group who received no such education. In particular, they were counseled on the need for medication and treatment adherence such as clinic visits, and life style modifications including diet and exercise. Outcome measure included changes in fasting blood sugar (FBS), blood pressure (BP), body mass index (BMI) and adherence to instructions. Results: There were no statistical differences between the baseline and 6 months data of the control group as mean fasting blood sugar were 162.2 ± 69.1 and 159.9 ±57.2 (P= 0.825) and mean systolic blood pressure of 144.7 ± 23.8 and 145.5±18.6 (P= 0.819) respectively. The intervention group had mean fasting blood sugar of 156.7 ± 30.5 and 131.8± 40.4 (P< 0.001) and mean systolic blood pressure of 146.4 ± 13.9 and 133.8 ± 18.5 (P< 0.001) respectively. Adherence levels to medication taking in the groups were 42.7% : 94.7% respectively (P= 0.001). ConClusions: In diabetes management, patient education and counseling have become key tools in achieving both glycaemic and blood pressure control.
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Papers by John Arute