Indian Journal of Natural Products and Resources, Nov 11, 2021
Syzyzium cumini (Myrtaceae) is an evergreen tropical tree mostly found in South East Asia. Extrac... more Syzyzium cumini (Myrtaceae) is an evergreen tropical tree mostly found in South East Asia. Extracts of fruits and seeds are extensively used in the treatment of diabetes. Other folkloric uses include treatment of cold, cough, fever, skin problem and genitourinary tract ulcer. The present study evaluated the anti-ulcer activity of the seeds of S. cumini against different ulcer models in rats. The anti-ulcer activity of the methanol extract and ethyl acetate fraction of methanol extract of S. cumini seed was evaluated in ethanol, pylorus ligation, Aspirin + pylorus ligation and stress-induced gastric ulcer model. The study biomarkers used were gastric volume, pH, ulcer index and free acidity. The extract and fraction at the dose level of 200 mg/kg caused a significant (P <0.05) reduction in the ulcer index, free acidity while there was an increase in the pH value of the test in comparison to the solvent control group. Experimentally, it was observed that animals who received ethyl acetate fraction had relatively improved protection of gastric ulcer as demonstrated by different biomarkers. The present study showed that the ethyl acetate fraction of methanol extract of S. cumini seed possesses potential anti-ulcer activity. This may be due to a linear relationship between the antioxidant value of the seeds as reported earlier by several authors due to rich in phenolic compounds, which in turn is responsible for mucosal cytoprotection of the stomach and hence, participate in the enhancement of mucosal defence mechanism.
Objective: Current study is based on the pattern analysis of various antimicrobial prescriptions ... more Objective: Current study is based on the pattern analysis of various antimicrobial prescriptions for the treatment of female lower genital tract infection and its validation of rational use in a tertiary care hospital of Odisha. Methods: The current prospective investigation was carried out in outpatient department of Obstetrics and Gynaecology department at a tertiary care hospital over a period of six months. A suitable data collection was carried out from female lower genital tract infection patients who were of 11-55 years of age group. Results: The study result found that most commonly prescribed antimicrobials were antifungal (azoles derivatives) and its combination with other antimicrobials. The other antimicrobials include, topical (8.4%)/single antimicrobial oral (2.8%)/ combination (intravaginal as well as oral- 50%) followed by other antimicrobials like linozolid (4.8%). Our study reveals that, antifungal agents are the most common antimicrobial drugs prescribed on the ...
Introduction: Mussaenda philippica (Rubiaceae) is a shrub distributed in all the planes of India,... more Introduction: Mussaenda philippica (Rubiaceae) is a shrub distributed in all the planes of India, Philippines and SouthEast Asia. Its synonyms are M. grandiflora, M. acutifolia, M. frondosa etc. The plant is preferred as medication for the treatment of jaundice, dysentery, stomachache and influenza. The current study was based on the evaluation of antiulcer property of M. philippica leaves extract. Methods: The methods used were pylorus ligated, ethanol induced and 0.2(M) NaOH induced ulcer in rats. Results: In pylorus ligation model, aqueous extract (200 mg/kg) produced a substantial reduction in ulcer index followed by decrease in gastric volume, total acidity associated with a raise in pH, which, confirmed that tested extract of the plant act by altering the mucosal barrier Thus, the gastro protective effect of this extract may be due to the presence of flavonoid in the plant. In the same way, aqueous extract of the plant showed significant effect against ethanol induced gastric ulcer in rat as compared to methanol-treated group, which, may be due to leukotriene antagonistic effect or the inhibition of 5-lipooxygenase pathway. In NaOH induced ulcer model, aqueous extract of M. philippica revealed significant antiulcer effects on the basis of pH effect and ulcer index in rats. The anti-ulcerogenic and anti-secretory effect of the tested M. philippica leaves extracts point out its possible cyto-protective effect. Conclusion: In conclusion the aqueous extract of M. philippica leaves possess potential antiulcer activity in experimental rat models.
The genus Millettia belongs to Fabaceae includes 200 species which are distributed in tropical an... more The genus Millettia belongs to Fabaceae includes 200 species which are distributed in tropical and subtropical regions of the world. Plants belong to this genus are used as folkloric medicine, for the treatment of different ailments like in wound healing, boil, sores, skin diseases, snake bite, muscle aches, pains, rheumatic arthritis, and gynaecological diseases. The aim of the review is to provide updated, comprehensive and categorized information on the aspects of ethnobotanical, phytochemical, pharmacological uses and toxicity of genus Millettia in order to identify their therapeutic potential and generate space for future research opportunities. The present study comprises of isolated flavonoids, phenolic compounds, phytosterols, saponins, alkaloids, polysaccharides, terpenoids and resins and pharmacological activities of various Millettia species. The relevant data were searched by using the keyword ''Millettia" in different scientific databases like, ''Google Scholar"; ''NISCAIR repository"; ''Pub Med"; ''Science Direct"; ''Scopus" and the taxonomy is validated by ''The Plant List". This review discusses the existing information of the traditional evaluation as well as phytochemical and pharmacological evaluation of the extract and active constituents of the genus ''Millettia". This review confirms that several Millettia species have emerged as a high-quality medicine in a traditional system for arthritis, wound healing, inflammation, skin diseases. Numerous conventional uses of Millettia species have been validated by modern pharmacology research. Intensive investigations of the genus Millettia relating to phytochemistry and pharmacology, especially their mechanism of action, safety, and efficacy could be the future research interests by the researcher in the area of phytomedicine.
Indian Journal of Natural Products and Resources, Nov 11, 2021
Syzyzium cumini (Myrtaceae) is an evergreen tropical tree mostly found in South East Asia. Extrac... more Syzyzium cumini (Myrtaceae) is an evergreen tropical tree mostly found in South East Asia. Extracts of fruits and seeds are extensively used in the treatment of diabetes. Other folkloric uses include treatment of cold, cough, fever, skin problem and genitourinary tract ulcer. The present study evaluated the anti-ulcer activity of the seeds of S. cumini against different ulcer models in rats. The anti-ulcer activity of the methanol extract and ethyl acetate fraction of methanol extract of S. cumini seed was evaluated in ethanol, pylorus ligation, Aspirin + pylorus ligation and stress-induced gastric ulcer model. The study biomarkers used were gastric volume, pH, ulcer index and free acidity. The extract and fraction at the dose level of 200 mg/kg caused a significant (P <0.05) reduction in the ulcer index, free acidity while there was an increase in the pH value of the test in comparison to the solvent control group. Experimentally, it was observed that animals who received ethyl acetate fraction had relatively improved protection of gastric ulcer as demonstrated by different biomarkers. The present study showed that the ethyl acetate fraction of methanol extract of S. cumini seed possesses potential anti-ulcer activity. This may be due to a linear relationship between the antioxidant value of the seeds as reported earlier by several authors due to rich in phenolic compounds, which in turn is responsible for mucosal cytoprotection of the stomach and hence, participate in the enhancement of mucosal defence mechanism.
Objective: Current study is based on the pattern analysis of various antimicrobial prescriptions ... more Objective: Current study is based on the pattern analysis of various antimicrobial prescriptions for the treatment of female lower genital tract infection and its validation of rational use in a tertiary care hospital of Odisha. Methods: The current prospective investigation was carried out in outpatient department of Obstetrics and Gynaecology department at a tertiary care hospital over a period of six months. A suitable data collection was carried out from female lower genital tract infection patients who were of 11-55 years of age group. Results: The study result found that most commonly prescribed antimicrobials were antifungal (azoles derivatives) and its combination with other antimicrobials. The other antimicrobials include, topical (8.4%)/single antimicrobial oral (2.8%)/ combination (intravaginal as well as oral- 50%) followed by other antimicrobials like linozolid (4.8%). Our study reveals that, antifungal agents are the most common antimicrobial drugs prescribed on the ...
Introduction: Mussaenda philippica (Rubiaceae) is a shrub distributed in all the planes of India,... more Introduction: Mussaenda philippica (Rubiaceae) is a shrub distributed in all the planes of India, Philippines and SouthEast Asia. Its synonyms are M. grandiflora, M. acutifolia, M. frondosa etc. The plant is preferred as medication for the treatment of jaundice, dysentery, stomachache and influenza. The current study was based on the evaluation of antiulcer property of M. philippica leaves extract. Methods: The methods used were pylorus ligated, ethanol induced and 0.2(M) NaOH induced ulcer in rats. Results: In pylorus ligation model, aqueous extract (200 mg/kg) produced a substantial reduction in ulcer index followed by decrease in gastric volume, total acidity associated with a raise in pH, which, confirmed that tested extract of the plant act by altering the mucosal barrier Thus, the gastro protective effect of this extract may be due to the presence of flavonoid in the plant. In the same way, aqueous extract of the plant showed significant effect against ethanol induced gastric ulcer in rat as compared to methanol-treated group, which, may be due to leukotriene antagonistic effect or the inhibition of 5-lipooxygenase pathway. In NaOH induced ulcer model, aqueous extract of M. philippica revealed significant antiulcer effects on the basis of pH effect and ulcer index in rats. The anti-ulcerogenic and anti-secretory effect of the tested M. philippica leaves extracts point out its possible cyto-protective effect. Conclusion: In conclusion the aqueous extract of M. philippica leaves possess potential antiulcer activity in experimental rat models.
The genus Millettia belongs to Fabaceae includes 200 species which are distributed in tropical an... more The genus Millettia belongs to Fabaceae includes 200 species which are distributed in tropical and subtropical regions of the world. Plants belong to this genus are used as folkloric medicine, for the treatment of different ailments like in wound healing, boil, sores, skin diseases, snake bite, muscle aches, pains, rheumatic arthritis, and gynaecological diseases. The aim of the review is to provide updated, comprehensive and categorized information on the aspects of ethnobotanical, phytochemical, pharmacological uses and toxicity of genus Millettia in order to identify their therapeutic potential and generate space for future research opportunities. The present study comprises of isolated flavonoids, phenolic compounds, phytosterols, saponins, alkaloids, polysaccharides, terpenoids and resins and pharmacological activities of various Millettia species. The relevant data were searched by using the keyword ''Millettia" in different scientific databases like, ''Google Scholar"; ''NISCAIR repository"; ''Pub Med"; ''Science Direct"; ''Scopus" and the taxonomy is validated by ''The Plant List". This review discusses the existing information of the traditional evaluation as well as phytochemical and pharmacological evaluation of the extract and active constituents of the genus ''Millettia". This review confirms that several Millettia species have emerged as a high-quality medicine in a traditional system for arthritis, wound healing, inflammation, skin diseases. Numerous conventional uses of Millettia species have been validated by modern pharmacology research. Intensive investigations of the genus Millettia relating to phytochemistry and pharmacology, especially their mechanism of action, safety, and efficacy could be the future research interests by the researcher in the area of phytomedicine.
Uploads
Papers by Rasmita Jena