Papers by Javier Esquivel
Crítica (México D. F. En línea), 1972
Planta Medica, 2005
Ocimum basilicum L. and Ocimum gratissimum L. (Lamiaceae) are widely distributed aromatic herbs u... more Ocimum basilicum L. and Ocimum gratissimum L. (Lamiaceae) are widely distributed aromatic herbs used in ethnomedicinal management of a range of inflammatory disorders. In the present work we evaluated the topical antiinflammatory effects of the volatile constituents extracted from the fresh leaves of these plant species. Fresh leaves of the plants were subjected to hydro distillation to obtain the volatile oils OBV and OGV from O. basilicum and O. gratissimum respectively. The fresh leaves were also extracted with n-hexane to obtain OBHE and OGHE respectively. OBV, OGV, OBHE and OGHE were screened for antiinflammatory effect using xylene-induced ear edema as a model of inflammation. Their chemical constituents were also analysed using GC/MS apparatus. At 50 µg/ear OBV, OGV, OBHE and OGHE exhibited significant (P<0.05) topical antiinflammatory effect with edema inhibitions of 50.0, 63.3, 62.7 and 80 % respectively. The effects were comparable (P<0.05) with that of 100 µg/ear hydrocortisone (% edema inhibition of 54.8). 11 of the compounds from OGV are monoterpenes while 4 are sesquiterpenes. 8 of the compounds identified in OGHE are oxygenated monoterpene derivatives, 5 are sesquiterpenes, and the others are long chain carboxylic acid, eugenol and phthalate derivatives. OGV and OGHE contain linalool, 1-terpinen-4-ol, alpha-caryophylene and trans longipinocarveol in common. Compounds identified in OBV include 2 monoterpenes, 7 oxygenated monoterpene derivatives, 2 sesquiterppenes, a long chain monocarboxylic acid and a triterpene, alpha-amyrin. OBV and OBHE contain eugenol acetate in common. Some of these identified volatile constituents may be contributing to the observed anti-inflammatory effects.
La LA84 Foundation es la organización que fue creada para administrar la porción del Sur de Calif... more La LA84 Foundation es la organización que fue creada para administrar la porción del Sur de California del excedente de los Juegos Olímpicos de 1984. Ubicada en la histórica Casa Britt desde 1985, la Fundación ha brindado más de $170 millones de dólares para crear, apoyar y expandir programas de deportes existentes y desarrollar el Centro de Recursos Deportivos Paul Ziffren (Paul Ziffren Sports Resource Center). Esta institución es un avanzado centro de aprendizaje y cultura del deporte que contiene libros, películas, fotografías y objetos deportivos históricos. Hasta la fecha, más de dos millones de niños y niñas, y más de 1000 organizaciones de deporte para jóvenes en todo el Sur de California se han beneficiado gracias a las donaciones de nuestra fundación.
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Papers by Javier Esquivel