Papers by Javier Manrique Hinojosa
Reportaje fotográfico: Lunas del desierto
Revista De La Universidad De Mexico, Jun 1, 2004
Revista Peruana de Ginecología y Obstetricia, Nov 12, 2015
El cáncer de mama constituye la segunda neoplasia maligna más frecuente en el mundo y es la quint... more El cáncer de mama constituye la segunda neoplasia maligna más frecuente en el mundo y es la quinta causa de muerte por cáncer en las mujeres. En el Perú, ocupa el segundo lugar en incidencia y es la tercera causa de muerte por cáncer en la mujer. La mamografía como tamizaje se empieza a utilizar en la década de 1960 con el objeto de detectar lesiones sospechosas de cáncer antes de que sean clínicamente evidentes, lo más pequeñas, para mejorar el pronóstico y la sobrevida de las pacientes portadoras de este tumor. Se han realizado múltiples estudios para evaluar la importancia de la mamografía como tamizaje, así como también para definir a qué edad comenzar con el tamizaje, cuál es la frecuencia con la que se debe recomendar y hasta qué edad mantener su indicación. En este artículo de revisión se expone el rol de la mamografía como despistaje, las controversias sobre su uso, incluído los efectos colaterales y el estado de la mamografía como tamizaje en el Perú con las recomendaciones existentes. Palabras clave: Mama; Neoplasias de la mama; Cáncer de mama; Mamografía.
Reportaje Gráfico: Leonora Carrington
Revista De La Universidad De Mexico, Jul 1, 2011
European Archives of Oto-Rhino-Laryngology, 2020
Purpose The treatment strategy of parotid gland tumours depends mainly on the histopathological t... more Purpose The treatment strategy of parotid gland tumours depends mainly on the histopathological type of the lesion. Fineneedle aspiration biopsy (FNAB) is recommended in preoperative diagnostics. The aim of the study was to evaluate the FNAB standing in the diagnostic algorithm of parotid gland lesions and to correlate FNAB results in relation to the definitive histopathological diagnosis. Material and methods The retrospective analyses of 651 examined and consequently surgically treated parotid gland lesions at the
IEEE Access, 2020
The prototype filter design problem is investigated for the filter bank multicarrier (FBMC) syste... more The prototype filter design problem is investigated for the filter bank multicarrier (FBMC) system of the fifth generation (5G) physical-layer wireless communications. In order to further suppress the side lobe energy within a certain frequency range, different constraint factors need to be introduced to meet the various side lobe energy suppression demands. In this paper, we formulate a dual-objective optimization problem which minimizes the stopband energy with constrained factors and subjects to the ISI/ICI constraints. Considering the uncertain constrained factors, a suboptimization problem is proposed by constraining the total stopband energy and the side lobe energy of the first segment to minimize the side lobe energy of the second or the third segments. Then, the nested sequential quadratic program-genetic algorithm (NSGA), one of the artificial intelligence (AI) aided algorithms, is introduced to obtain the optimal solution of the dual-objective problem, in which the genetic algorithm (GA) is applied to acquire the optimal constrained factors and the sequential quadratic program (SQP) is applied to acquire the optimal filter coefficients. Numerical results validate that the proposed method can achieve orientated side lobe energy suppression at specified segments for satisfying different side lobe energy suppression requirements with the confirmed algorithm convergence. INDEX TERMS Artificial intelligence (AI), filter bank multicarrier (FBMC), genetic algorithm (GA), oriented side lobe energy suppression, prototype filter design.
Detección del virus de papiloma humano por medio del método de cobas® 4800 en mujeres de Lima, Perú
s providing particular insights into the topic area were presented orally by the authors in each ... more s providing particular insights into the topic area were presented orally by the authors in each of the workshops. Workshop leaders were encouraged to conclude their workshops with a brief set of prioritized recommendations to identify the key directions for further development of interventional activities beyond this Congress. The objective of this session was to explore the individual and societal factors that influence cancer and NCD risk. The following four issues were selected for in-depth discussion in the workshops: ‰ Individual and provider-level interventions for reducing cancer risk. ‰ Community-based interventions for reducing cancer risk. ‰ Policy-based interventions for reducing cancer risk. ‰ Regional interventions for reducing cancer risk. Plenary presentations 1. Cancer and NCD prevention from a global perspective Graham A Colditz, Washington University in St Louis, USA The burden of cancer is predominantly experienced in lowand middle-income countries (9). Changing ...
Mamografía como instrumento de tamizaje en cáncer de mama
Revista Peruana de Ginecología y Obstetricia, 2015
Breast cancer is the second most frequent malignant neoplasm in the world and the fifth cause of ... more Breast cancer is the second most frequent malignant neoplasm in the world and the fifth cause of death from cancer in women. In Peru, breast cancer is second in incidence and the third cause of death from cancer in women. Mammography screening began in 1960 with the goal of detecting cancer at its smallest size before clinically evident in order to have better prognosis and survival. Several trials have been done since to determine mammography importance as a screening method and to establish age to begin, frequency and when to stop screening. In this article the role of mammography as screening tool is reviewed, as well as controversies on use, side effects, and recommendations on its use in Peru.
Human Papilloma Virus detection through the cobas® 4800 system in women from Lima, Peru
Gaceta Mexicana de Oncolog�a
Horizonte Médico (Lima)
Rol de la biopsia por aspiración con aguja fina (BAAF) en el abordaje diagnóstico de tumoraciones... more Rol de la biopsia por aspiración con aguja fina (BAAF) en el abordaje diagnóstico de tumoraciones mamarias palpables en el Instituto Nacional de Enfermedades Neoplásicas, Lima-Perú
Revista Peruana de Medicina Experimental y Salud Pública
Médico especialista en Cirugía General y Oncológica; b obstetra especialista en Atención Primaria... more Médico especialista en Cirugía General y Oncológica; b obstetra especialista en Atención Primaria con mención en Cáncer Ginecológico; c médico genetista; biólogo molecular; d doctora en Educación; e obstetra.
Revista Peruana de Medicina Experimental y Salud Pública, 2013
El cáncer es una enfermedad genética producto de alteraciones en la secuencia o expresión del ADN... more El cáncer es una enfermedad genética producto de alteraciones en la secuencia o expresión del ADN. Estas alteraciones, según su origen, nos permiten clasificar el cáncer como esporádico y hereditario o familiar. En base a los registros de cáncer, en el Perú se espera que del 5 al 30% de todos los pacientes con cáncer, que equivale aproximadamente entre 2000 a 12 000 personas, presentarían cáncer del tipo familiar o hereditario, lo que representaría un similar número de familias con un riesgo mayor de desarrollar cáncer que el de la población en general. El propósito de la asesoría genética es identificar cánceres hereditarios en una familia con el fin de prevenir la enfermedad y la muerte por este mal. Es una estrategia que nos puede permitir detectar y diagnosticar con antelación estos cánceres. Es por este motivo que en el Instituto Nacional de Enfermedades Neoplásicas del Perú se realizan consultas de diagnóstico y asesoría genética desde hace cinco años, constituyéndose en un elemento importante para la lucha contra el cáncer, sin embargo, para lograr un mayor impacto en la salud requiere ampliar y fortalecer el proceso de capacitación en genética y asesoría genética a profesionales de la salud, sobre todo a médicos y enfermeras.
Soil transmitted helminth infections are associated with an increase in human papillomavirus prevalence and a Th2 cytokine signature in cervical fluids
The Journal of infectious diseases, Jan 20, 2015
An ecological correlation between ICC incidence and burden of soil transmitted helminths (STHs) ... more An ecological correlation between ICC incidence and burden of soil transmitted helminths (STHs) is hypothesized to explain the excess in detectable HPV infection in Latin America via a global T helper type 2 (Th2)-biased mucosal immune response secondary to STH infection. The association between current STH infection and HPV prevalence was compared in STH endemic and non-endemic regions of Peru. Adjusted prevalence ratios with robust variance were estimated as an effect measure of STH infection on HPV prevalence in each study site. Soluble immune marker profiles in STH-infected and STH-uninfected women were compared using Spearman's rank correlation with Sidak correction. STH infection in the helminth-endemic region of the Peruvian Amazon was associated with a 60% higher prevalence of HPV, compared to STH-uninfected women [PR=1.6, 95% CI 1.0-2.7]. Non-STH parasitic/protozoal infections in the non-helminth endemic population of Peru was not associated with HPV prevalence. A Th...
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Papers by Javier Manrique Hinojosa