Papers by Aleksandra Jankovic
Free Radical Biology and Medicine, Dec 1, 2021
Free Radical Biology and Medicine, Dec 1, 2021
Free Radical Biology and Medicine, May 1, 2023
Free Radical Biology and Medicine, May 1, 2023
Free Radical Biology and Medicine, Dec 1, 2021
Free Radical Biology and Medicine, Dec 1, 2021
Free Radical Biology and Medicine, Dec 1, 2021
Free Radical Biology and Medicine, Aug 1, 2022
Hrana i ishrana, 2020
Although its importance in human biology has been known ever since the emersion of scurvy, it was... more Although its importance in human biology has been known ever since the emersion of scurvy, it was not until the 20th century that vitamin C was discovered. Scurvy is a disease caused by severe vitamin C deficiency, which was very common among sailors on long sea journeys during the early modern period [1-3]. In 1753 Scottish naval surgeon James Lind identified citrus fruits as an effective cure for scurvy in the first-ever controlled clinical study [1,3,4]. Still, the reason why the citrus fruits had a therapeutic effect was yet to be discovered. The reducing agent responsible for preventing and curing the disease was first found in 1928 by Hungarian scientist Albert Szent-Györgyi. The offwhite crystalline substance that he isolated from plant juices and animal tissues (adrenal glands) and that he named hexuronic acid was thought to be a new hormone similar to simple sugars [5]. Still, a few years later, Svirbely and Szent-Györgyi confirmed that hexuronic acid was, in fact, vitamin C [6]. At the same time, W. A. Waugh and C. G. King isolated a crystalline vitamin C from lemon juice and reported that it had similar physical and chemical properties as hexuronic acid, including the antiscorbutic quality, and that it was identical with the hexuronic acid, which was indeed later confirmed [7]. In 1933 a team led by British chemist Walter N. Haworth defined the molecular structure of vitamin C (i.e., hexuronic acid), renaming it to the ascorbic acid [8]. Albert Szent-Györgyi and Walter N. Haworth were awarded the Nobel Prize in Physiology or Medicine and Chemistry, respectively, for their work on vitamin C.
Free Radical Biology and Medicine, Aug 1, 2022
Free Radical Biology and Medicine, May 1, 2018
Metabolic reactions that favor the production of free radicals generate oxidative stress and chai... more Metabolic reactions that favor the production of free radicals generate oxidative stress and chain reactions, which result in illnesses such as gastritis, cancer, arthritis, etc.* Gastric ulcer is deemed as an inflammatory pathology related to an infection by H. pylori, whose treatment includes tetracycline and omeprazole. Furthermore, the hypochlorous acid (HOCl) is released in the lymphocytes as immune response to inflammatory processes through in situ oxidation reactions. HOCl has been proven to degrade these medicines* and the treatment does not consider external factors that cause health problems (harmful lifestyles, stress, and environmental factors). In this context, we propose an alternative treatment to gastric ulcer based on spectroscopic and chromatographic results including the species Psidium Guajava L as gastric protector for combined treatment. This species has antioxidant properties, associated to ascorbic acid, carotenoids, and phenolic compounds*; anti-inflammatory properties thanks to flavonoids; analgesic properties due to triterpenes; and antibacterial properties because of tannins. **
Free Radical Biology and Medicine, 2021
Free Radical Biology and Medicine, May 1, 2023
Springer eBooks, Aug 30, 2008
ABSTRACT The uncontrolled expansion of white adipose tissue (WAT) seen in obesity predisposes aff... more ABSTRACT The uncontrolled expansion of white adipose tissue (WAT) seen in obesity predisposes affected individuals to health complications. Another type of fat, brown adipose tissue (BAT) has an opposing physiological function because it allows dissipation instead of storage of energy. Recent studies on the transcriptional control of adipocyte differentiation offer a new perspective on conversion between brown and white adipocytes. The ability of the adipose organ to interconvert its main cytotypes in order to meet changing metabolic needs is highly pertinent to the physiopathology of obesity and related to therapeutic strategies [1]. Thyroid hormones (TH) have an important role in modulation of brown adipose tissue (BAT) thermogenic function. The main objective of this work was to investigate capability of triiodothyronine to induce structural and functional changes of rat white adipocytes in retroperitoneal white adipose tissue (RWAT).
Royal Society Open Science, May 1, 2023
We previously demonstrated that hypothyroidism increases peroxisomal biogenesis in rat brown adip... more We previously demonstrated that hypothyroidism increases peroxisomal biogenesis in rat brown adipose tissue (BAT). We also showed heterogeneity in peroxisomal origin and their unique structural association with mitochondria and/or lipid bodies to carry out β-oxidation, contributing thus to BAT thermogenesis. Distinctive heterogeneity creates structural compartmentalization within peroxisomal population, raising the question of whether it is followed by their functional compartmentalization regarding localization/colocalization of two main acyl-CoA oxidase (ACOX) isoforms, ACOX1 and ACOX3. ACOX is the first and rate-limiting enzyme of peroxisomal β-oxidation, and, to date, their protein expression patterns in BAT have not been fully defined. Therefore, we used methimazole-induced hypothyroidism to study ACOX1 and ACOX3 protein expression and their tissue immunolocalization. Additionally, we analysed their specific peroxisomal localization and colocalization in parallel with peroxisomal structural compartmentalization in brown adipocytes. Hypothyroidism caused a linear increase in ACOX1 expression, while a temporary decrease in ACOX3 levels is only recovered to the control level at day 21. Peroxisomal ACOX1 and ACOX3 localization and colocalization patterns entirely mirrored heterogeneous peroxisomal biogenesis pathways and structural compartmentalization, e.g. associations with mitochondria and/or lipid bodies. Hence, different ACOX isoforms localization/colocalization creates distinct functional heterogeneity of peroxisomes and drives their functional compartmentalization in rat brown adipocytes.
Hrana i ishrana, 2014
This study investigated the effect of Mn chelate supplementation on the activity of antioxidant e... more This study investigated the effect of Mn chelate supplementation on the activity of antioxidant enzymes: copper zincand manganese-superoxide dismutase (CuZnSOD and MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and the amount of glutathione (GSH) in the blood, liver, brain, heart and small intestine of the rat. Increased Mn intake of 34% above daily intake (0.851 ± 0.045 mg Mn / kg b.wt.) induced changes in the antioxidant defense in the tissues of the rat. Decreased activity of peroxides-converting enzymes CAT and GSH-Px was found in all examined tissues (except GSH-Px activity in the liver). The amount of GSH was increased in plasma and liver, while it was decreased in heart and brain of supplemented animals. Treatment with Mn increases MnSOD activity in the liver, and CuZnSOD activity in the heart. The observed changes in antioxidant defense are closely connected with the newly established redox profile in the examined tissues after Mn supplementation.
Comparative Biochemistry and Physiology B, May 1, 2018
apoptosis, through restoring the pro-apoptotic proteins level (e.g. p53 and cytochrome c) that is... more apoptosis, through restoring the pro-apoptotic proteins level (e.g. p53 and cytochrome c) that is enhanced after the irradiation. In conclusion, our results show that rutin effectively prevents UV-induced damages associated with proinflammatory/prooxidative and proapoptotic activity.
Hrana i ishrana, 2018
Infertility is one of the most serious medical issues that is dramatically rising worldwide. Exte... more Infertility is one of the most serious medical issues that is dramatically rising worldwide. Extensive research dedicated to this problem clearly shows that infertility is a disease of modern society and that a nutrition has a great infl uence on the development of sterility. Thus, the impact of specifi c nutritional factors, i.e. diet pattern on both male and female fertility is included in this review. It is encouraging that modifi cation of nutritional habits can help couples to conceive spontaneously, or increase their chances of conception with in vitro fertilization (IVF) treatment.
Antioxidants & Redox Signaling, Mar 16, 2023
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Papers by Aleksandra Jankovic