Iman Beheshti

Followers

Following

Public Views

Phone: 8048792710
Address: Integrative Brain Imaging Center (IBIC) National Center of Neuro
National Center of Neurology and Psychiatry (NCNP), Japan

less

Steven Pinker

Harvard University

James Elkins

School of the Art Institute of Chicago

Maurizio Forte

Duke University

Armando Marques-Guedes

UNL - New University of Lisbon

Prof.Amjad Al-Nasser

Yarmouk University

Fabio Cuzzolin

Oxford Brookes University

Saiful Mahdi

Universitas Syiah Kuala Banda Aceh

José Francisco Pessanha

UERJ - Universidade do Estado do Rio de Janeiro / Rio de Janeiro State University

Bogdan Gabrys

University of Technology Sydney

PALIMOTE JUSTICE

RIVERS STATE POLYTECHNIC

Interests

Uploads

Papers by Iman Beheshti

Cerebrovascular lesion loads and accelerated brain aging: insights into the cognitive spectrum

Frontiers in dementia, Jun 21, 2024

Sex-based Disparities in Brain Aging: A Focus on Parkinson's Disease

arXiv (Cornell University), Sep 17, 2023

Parkinson's disease (PD) is linked to faster brain aging. Sex is recognized as an important facto... more Parkinson's disease (PD) is linked to faster brain aging. Sex is recognized as an important factor in PD, such that males are twice as likely as females to have the disease and have more severe symptoms and a faster progression rate. Despite previous research, there remains a significant gap in understanding the function of sex in the process of brain aging in PD patients. METHODS: The T1-weighted MRI-driven brain-predicted age difference (i.e., brain-PAD: the actual age subtracted from the brain-predicted age) was computed in a group of 373 PD patients (mean age ± SD: 61.37 ± 9.81, age range: 33-85, 34% female) from the Parkinson's Progression Marker Initiative database using a robust brain-age estimation framework that was trained on 949 healthy subjects. Linear regression models were used to investigate the association between brain-PAD and clinical variables in PD, stratified by sex. All female PD patients were used in the correlational analysis while the same number of males were selected based on propensity score matching method considering age, education level, age of symptom onset, and clinical symptom severity. RESULTS: Despite both patient groups being matched for demographics, motor and non-motor symptoms, it was observed that males with Parkinson's disease (PD-M) exhibited a significantly higher mean brain age-delta than their female counterparts (PD-F) (t(256)= 2.50, p = 0.012). In the propensity score-matched PD-M group (PD-M*), brain-PAD was found to be associated with a decline in general cognition, a worse degree of sleep behavior disorder, reduced visuospatial acuity, and caudate atrophy. Conversely, no significant links were observed between these factors and brain-PAD in the PD-F group. DISCUSSION: Having 'older' looking brains in PD-M than PD-F supports the idea that sex plays a vital function in PD, such that the PD mechanism may be different in males and females. This study has the potential to broaden our understanding of dissimilarities in brain aging between sexes in the context of PD.

Iman Beheshti

Related Authors

Uploads

Papers by Iman Beheshti

Log In