Papers by Ilknur K I V A N Ç Altunay
Anais Brasileiros De Dermatologia, Aug 1, 2018
Anais Brasileiros de Dermatologia METHODS Patients and controls This cross-sectional study includ... more Anais Brasileiros de Dermatologia METHODS Patients and controls This cross-sectional study included 31 patients with AK and 29 healthy controls, all with a normal body mass index (BMI; 18-25kg/m 2), as it has been shown that vitamin D deficiency is asso
Turkderm, Feb 8, 2016
The relationship between uraemic pruritus and quality of life scores in hemodialysis patients
Journal of The European Academy of Dermatology and Venereology, Mar 1, 2000
PubMed, 2015
Background: Basal cell carcinoma (BCC) has been stratified into low- and high-risk according to t... more Background: Basal cell carcinoma (BCC) has been stratified into low- and high-risk according to their propensity for local recurrence. Risk factors for recurrence include histologic subtype, anatomic location (i.e. H-zone of the face), horizontal diameter, and patient health status. Objective: To assess if favorable (superficial, nodular, adenoid and trabecular) and unfavorable (infiltrative, morpheaform, micronodular, metatypical, basosquamous) histopathological subtypes of BCC do correlate with anatomic location on the face (facial high risk versus non-high risk zones). Methods: Histopathological specimens of all facial BCCs, which were histopathologically diagnosed in the Pathology Department of Şişli Etfal Training Hospital, between the years 2008 and 2014 were retrospectively studied. Histopathological aggressive and non-aggressive subtypes as well as the presence of ulceration were correlated with facial high-risk (i.e. H-zone) and low risk anatomical locations. Results: Of 184 BCC of unfavorable subtypes, 101 cases were identified in facial high-risk anatomical region (H-zone) compared to 83 cases at non H-zone (P = 0.553). On the other hand the ulceration rate was significantly higher for unfavorable histological subtypes than in the favorable histopathological subtype group (P = 0.042). Regarding anatomic site, ulceration frequency was not significantly different for the H-versus non-high risk zones (P = 0.335). Conclusions: A correlation of unfavorable histopathological subtype of BCC and high-risk anatomical location (i.e. H-zone) was not observed in our study. Our results however confirmed a significantly higher rate of ulceration in the subgroup of aggressive histopathological BCC forms. Thus, factors other than histopathological subtype (such as narrow excision margin related to difficult surgical technique in H-zone, microcirculation, vasculature and host inflammatory response) may be responsible for the high recurrence rate in facial H-zone-located BCCs.
Turkiye Klinikleri Journal of Dermatology, 2020
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2017
Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia, 2016
BACKGROUND Although chronic pruritus (CP) is one of the most frequent symptoms seen in dermatolog... more BACKGROUND Although chronic pruritus (CP) is one of the most frequent symptoms seen in dermatology outpatients, the characteristics of CP have not been thoroughly examined. Our aim was to determine the point prevalence of CP in patients attending a dermatology outpatient clinic and to examine its sociodemographic and clinical characteristics. METHODS Patients attending our dermatology outpatient clinic were prospectively enrolled in the study. Sociodemographic data and dermatological diagnoses were recorded. A questionnaire providing information about pruritus was answered by patients with CP. Data were evaluated statistically. RESULTS The data of 1428 patients (46% male, 54% female, age range 18-94, mean age 40.52±17.4) were evaluated, and the point prevalence of CP was found to be 30.9%. When patients with and without CP were compared, statistically significant results were obtained regarding age, education level, and occupational status (P<0.05). The mean severity measured by ...
Advances in Skin & Wound Care, 2020
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of follicular pilosebaceous ... more Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of follicular pilosebaceous units. Chronic, active, and poorly controlled disease may lead to squamous cell carcinoma (SCC). The diagnosis and treatment of SCC in HS is particularly challenging because SCC lesions may be easily mistaken for HS lesions. Current medical literature recommends aggressive surgical excision with at least 2-cm margins. In this article, the authors describe a giant perianal SCC arising in a patient with HS who was treated with surgical resection and radiotherapy.
Turkish Journal of Psychiatry, 2021
Anais Brasileiros de Dermatologia, 2021
Background Lichen simplex chronicus is a dermatological condition due to excessive scratching, wi... more Background Lichen simplex chronicus is a dermatological condition due to excessive scratching, with few studies on psychoneuroimmunology. Objective We aimed to estimate the levels of stress, depression, and anxiety, and to measure serum levels of neurotrophins in patients with lichen simplex chronicus, and to correlate these parameters with the severity of the disease and pruritus. Methods Thirty-six patients with lichen simplex chronicus and 36 age- and sex-matched healthy controls were included. Each participant was administered the Hospital Anxiety and Depression Scale and Perceived Stress Scale questionnaires, along with a visual analog scale for pruritus. Levels of neurotrophins (brain-derived neurotrophic factor, neurotrophin-3, nerve growth factor, glial cell line-derived neurotrophic factor) were determined by ELISA assays. Results The scores of Perceived Stress Scale-10, Hospital Anxiety and Depression Scale were statistically higher in patients (p < 0.05 for all). The serum levels of all neurotrophins were significantly lower in patients compared to healthy controls (p < 0.05 for all). Disease severity showed no correlation with all four neurotrophins. In linear regression models applied for increased visual analog scale-pruritus scores and disease severity these two variables were statistically significant predictors (p = 0.043). Study limitations A direct causal relationship was not addressed. Conclusion Lichen simplex chronicus patients are at risk of increased levels of stress, anxiety, depression, and present decreased levels of neurotrophins, that may suggest a role in the pathophysiology of this disorder.
Contact Dermatitis, 2021
BackgroundHand eczema (HE) has increased among healthcare workers (HCWs) working in coronavirus d... more BackgroundHand eczema (HE) has increased among healthcare workers (HCWs) working in coronavirus disease‐2019 (COVID‐19) units, and was associated with increased hand hygiene practices.ObjectivesTo compare the prevalence and clinical characteristics of HE, and hand hygiene practices in HCWs working in COVID‐19 and non‐COVID‐19 units.MethodsA total of 244 HCWs working in COVID‐19 (n = 118) and non‐COVID‐19 patient care units (n = 126) were examined by dermatologists with regard to demographic parameters and hand hygiene practices. The COVID‐19 and non‐COVID‐19 groups were matched at a 1:1 ratio according to age, atopy, and generalized dry skin.ResultsHE was more frequent in the COVID‐19 group (48.3% vs 12.7%, P < .001), whereas working years (P < .05) and additional housework at home (P < .001) were longer in the non‐COVID‐19 group. After the development of HE, moisturizing creams were reported to be more frequently used in the COVID group (P < .001). Topical corticosteroi...
Pediatric Dermatology, 2020
Background/ObjectivesOncology patients present with various skin manifestations related to primar... more Background/ObjectivesOncology patients present with various skin manifestations related to primary disease and treatments. Although these skin toxicities are well described in adults, studies of pediatric oncology patients are limited. The objective of this study was to evaluate the cutaneous findings in pediatric oncology patients receiving chemotherapy.MethodsIn this prospective cohort study conducted from December 2018 to March 2020, all pediatric oncology patients were examined and patients who had a dermatologic finding at any point during their treatments were recorded. Dermatologic examinations were performed by the same dermatologists, and biopsy and microbiologic tests were performed according to clinical need. Patients were grouped according to their oncologic diagnoses and types of chemotherapies.ResultsA total of 80 patients with a mean age of 9.1 ± 5.0 years were included in the study. Seventy‐five (93.7%) of them developed a dermatologic manifestation during the study ...
Journal of Cosmetic Dermatology, 2021
BackgroundRecent data suggest that rosacea is related to cardiovascular diseases (CVD) due to its... more BackgroundRecent data suggest that rosacea is related to cardiovascular diseases (CVD) due to its inflammatory nature and immune dysregulation.AimThe aim of this study was to evaluate the values of epicardial fat thickness (EFT) and the ankle‐brachial index (ABI) in patients with rosacea, as indicators of subclinical atherosclerosis and CVD risk.MethodsThis prospective case‐control study was carried out on 62 participants, including 31 rosacea patients and 31 controls. The values of EFT and ABI were measured in all subjects.ResultsThe mean thickness of EFT was statistically higher in rosacea patients (0.54 ± 0.12 mm) than in the controls (0.39 ± 0.05 mm) (P < 0.01). ABI was not significantly different between the subjects with rosacea and the comparison group (1.02 ± 0.1 vs 0.98 ± 0.07; P = 0.131). A total of 29% of the rosacea patients had mitral valve insufficiency (MVI), while 3.2% of the control group had MVI (P = 0.006). A mild degree of tricuspid valve insufficiency (TVI) w...
Dermatologic Therapy, 2021
A higher incidence of gastrointestinal diseases has been well established in patients with rosace... more A higher incidence of gastrointestinal diseases has been well established in patients with rosacea. However, no screening tool has been introduced for gastrointestinal disease development in rosacea. Fecal calprotectin (FC) is a calcium‐binding protein, mainly derived from polymorpho‐nuclear cells, such as neutrophils. It has been established as a marker of gastrointestinal inflammation. The aim of the present study was to evaluate FC levels in patients with rosacea without any gastrointestinal diseases. A prospective, case‐control study was planned to investigate the relationship between rosacea and gastrointestinal involvement by evaluating FC levels and the Gastrointestinal Symptom Rating Scale (GSRS). A total of 47 patients with rosacea and 39 healthy control subjects were included in the study. The FC levels were statistically significantly higher in rosacea group than in the control group (65.96 ± 58.86 ng/mL vs 31.99 ± 20.12 ng/mL, P = .026, respectively). A statistically significant difference was also observed in GSRS values between the patient and the control groups (30.26 ± 12.48 vs 22.62 ± 7.64, P = .001, respectively). A positive correlation was noted between FC levels and the values of GSRS in the study group (r: 0.354; P = .001) and in the rosacea group (r = 0.392, P = .006). The measurement of FC may be useful in the early detection of gastrointestinal system diseases that may accompany rosacea and may provide a pathway to develop treatment strategies targeting both skin and intestinal mucosa.
SiSli Etfal Hastanesi Tip Bulteni / The Medical Bulletin of Sisli Hospital, 2020
H ealthy lifestyle is the capability of the individual to control his/her behaviors that can infl... more H ealthy lifestyle is the capability of the individual to control his/her behaviors that can influence general health and to prefer the behaviors that are beneficial for the health status while arranging daily activities. Health behavior is defined as overt behavioral patterns, actions, and habits related to health protection and health promotion. [1] Psoriasis is a chronic, inflammatory skin disease which can also display multisystem involvement with accompanying comorbidities. [2] It is known that altering lifestyle behaviors is advantageous in preventing psoriasis and/or reducing disease severity. [3-8] In our study, we purposed to determine lifestyle behaviors in psoriasis patients comparing with healthy controls. Methods Eighty psoriasis patients without psoriatic arthritis, who admitted to the dermatology outpatient clinics of two centers Objectives: The purpose of our study was to compare healthy lifestyle behaviors between psoriasis patients and healthy controls. Methods: This case-control study included 80 psoriasis patients and 80 sex-and age-matched healthy controls aged over 18. Participants completed the socio-demographic data form and the Health-Promoting Lifestyle Profile II (HPLP-II). The HPLP-II consists of 52 items and measures six components of health-promoting behavior outcomes: Nutrition, physical activity, health responsibility, spiritual growth, interpersonal relations, and stress management. Higher scores show that the individual applies the specified health behaviors at a high level. Results: HPLP-II total scores were 128.3±21.1 in patient group and 132.5±22.3 in control group. Based on the scores, psoriasis patients showed a moderate level of health-promoting lifestyle, while controls showed a good level of health-promoting lifestyle. Spiritual growth score of patients (mean±SD = 25.6±4.9) was statistically lower than the controls (mean±SD = 27.3±4.5) (p=0.040). In addition, spiritual growth score and disease duration were negatively correlated in the patient group (r=-0.287, p=0.01). Furthermore, nutrition score of those with additional comorbidity was significantly higher than those with psoriasis alone in patient group (p=0.002). Conclusion: This is the first study to compare healthy lifestyle behaviors of psoriasis patients and healthy volunteers in Turkish population. The task of dermatologists is not only the medical treatment of psoriasis lesions but also questioning patients' lifestyle behaviors and supporting the development of healthy behaviors in patients.
Dermatologic Therapy, 2020
Anais Brasileiros de Dermatologia, 2019
Primary male genital melanomas are very rare; they are associated with high mortality and late de... more Primary male genital melanomas are very rare; they are associated with high mortality and late detection. Scrotal melanoma is the least common presentation and only 23 cases have been reported. Herein, the authors present a 30-year-old patient with stage IIIC (T4b, N2a, M0) scrotal melanoma in order to report the characteristics, treatment, and outcome, as well as to emphasize the importance of examination of the genitals, education of patients about self-examination and destigmatizing genital lesions to increase the likelihood of earlier detection.
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Papers by Ilknur K I V A N Ç Altunay