Open Access Macedonian Journal of Medical Sciences
BACKGROUND: Perilipin is very important for the regulation of the deposition and mobilization of ... more BACKGROUND: Perilipin is very important for the regulation of the deposition and mobilization of fats. The human perilipin gene (PLIN) is near the locus for risk of obesity and hypertriglyceridemia. The PLIN gene is thought to be involved in the occurrence of metabolic syndrome. AIM: The aim of this research is to determine the role of variations of the PLIN gene (PLN4 11482 G>A) as a risk factor for component of metabolic syndrome. METHODS: This study involved a total of 160 subjects consisting of 80 with metabolic syndrome and 80 controls. Genotype analysis was done with the polymerase chain reaction-restriction fragment length polymorphism method. The data were analyzed with t-tests to compare the subjects’ characteristics between metabolic syndrome groups and controls. Risk factors of PLIN genotypes were calculated with odds ratio and multivariate regression analysis was used to determine the role of the PLIN gene with each biochemical characteristic. RESULTS: The result was ...
Dioscorea alata L. tubers (DA) are suspected to prevent diabetes mellitus (DM) because they have ... more Dioscorea alata L. tubers (DA) are suspected to prevent diabetes mellitus (DM) because they have a low glycemic index. However, only a few reports about the anti-diabetic effect of DA were reported up to date. This study aims to analyze the effect of DA consumption on several diabetic biomarkers through in vitro, in vivo, and in silico analysis. METHODS: In vitro experiments were conducted by observing the anti-inflammatory activity of DA extract, steroidal saponins (SDA) isolated from DA, and diosgenin in lymphocyte cell cultures. The tumor necrosis factor (TNF)-α and interferon (IFN)-γ percentages were analyzed by flow cytometry. In vivo study involved 24 healthy adolescents that were given a boiled DA 10 hours post-prandial. The blood sugar levels were measured at 0, 30, 60, and 120 min after treatment. Furthermore, the in silico study was carried out by analyzing the active compounds and predicting the biological activity, the target proteins, and interactions of target proteins with compounds contained in DA. RESULTS: DA extract, SDA isolated from DA, and diosgenin at 50 µg/mL significantly reduced proinflammatory cytokines TNF-α and IFN-γ in lymphocyte cell culture. The blood glucose levels in the DA group were lower at 30 and 60 min after treatment. Based on the in silico study, the anti-diabetic activity of DA was speculated to be attributed to the mechanisms of anti-hyperglycemia, prevention of mitochondrial dysfunction, anti-inflammation, and treated insulin resistance. Several proteins included in the DM pathway became the protein target of compounds contained in DA. CONCLUSION: DA potentially have an anti-diabetic activity through several mechanisms.
Prosiding Seminar Nasional Program Pengabdian Masyarakat
Kegiatan olahraga semakin meningkat akhir-akhir ini terutama masa pandemi COVID-19. Selain untuk ... more Kegiatan olahraga semakin meningkat akhir-akhir ini terutama masa pandemi COVID-19. Selain untuk meningkatkan daya tahan tubuh, olahraga juga bermanfaat untuk mengisi waktu luang selama masa pandemi. Olahraga dapat mengakibatkan cedera antara lain cedera di mata. Beberapa kelainan mata akibat cedera olahraga dapat mengakibatkan kelainan di mata baik ringan maupun berat. Bentuk cedera mata akibat olahraga antara lain hematom palpebra, perdarahan subkonjungtiva, ruptur kornea, hifema, katarak traumatika, subluksasi lensa, ablatio retina dan lain sebagainya. Jenis trauma mata yang tidak dikenali dan tidak ditangani dengan baik secara cepat dan tepat dapat menimbulkan komplikasi lebih lanjut dan dapat berakibat fatal bahkan kebutaan. WHO tahun 2007 melaporkan terdapat lebih dari 7 juta orang menderita buta setiap tahun. Sampai saat ini terdapat 180 juta orang di seluruh dunia mengalami gangguan penglihatan dan 40-45 juta menderita kebutaan. Indonesia memegang posisi tertinggi di South E...
Prosiding Seminar Nasional Program Pengabdian Masyarakat
Proses pembuatan batik tentu tidak dapat terhindarkan dari penggunaan pewarna untuk menghasilkan ... more Proses pembuatan batik tentu tidak dapat terhindarkan dari penggunaan pewarna untuk menghasilkan batik yang cantik. Secara umum, pewarnaan batik ada dua acara yaitu dengan bahan alami dan bahan sintetis. Saat ini, pewarnaan batik di Indonesia mulai banyak beralih dari pemakaian bahan alami menjadi bahan pewarna sintetis. Pewarna sintetis yang digunakan dapat mengandung logam berat diantaranya timbal (Pb) dan kromium (Cr). Pemakaian logam berat dalam waktu lama akan mengganggu kesehatan. Para pembatik juga sering tidak memakai sarung tangan saat melakukan pewarnaan sehingga hal ini akan dapat meningkatkan risiko terjadinya masalah anemia tersebut jika berlangsung dalam waktu lama. Tujuan: meningkatkan pengetahuan penyakit anemia akibat penggunaan cat sintetis pada pembuatan batik dan bagaimana cara pencegahannya. Metode: Kegiatan Pendidikan kesehatan dilaksanakan secara tatap muka dengan dimulai dengan pretes kemudian sesi pemaparan materi dan diakhiri sesi postes untuk mengukur kebe...
Mutiara Medika: Jurnal Kedokteran dan Kesehatan, 2006
The role of family in the management of diabetic patients is needed to minimize the complication ... more The role of family in the management of diabetic patients is needed to minimize the complication and improve the blood glucose level. The objective ofthe research was to identify the role offamily in self-care of diabetic patients at home. It was a retrospective descriptive study using a cross-sectional design. The research subjects were family members of diabetic patients who accompanied patients coming to Internal Medicine Polyclinic, General Hospital ofPKU Muhammadiyah Yogyakarta from 22 September to 28 October 2005. The research sample was 50 respondents who were selected with a purposive sampling technique. Data was collected using a questionnaire. Data analysis used a formula ofP = “ X100% and the results were categorized into good, fair, unfavorable, and poor. The research revealed that the role offamily in self-care of diabetic patients at home which was considered as good was 58%. The role of the family included aspects of patient education (100%), food planning (66%), exercises (56%), pharmacological therapy (68%), and diabetic foot care (42%). Similarly, the self-management of diabetic patients at home which was considered as good was 58%. The findings showed that the role of the family is important in self-care ofdiabetic patients at home. This is importantfor health care providers to advocate the patient’s family to actively participate in care giving and motivating the diabetic patients in self-care at home. Peran keluarga dalam perawatan penderita diabetes melitus diperlukan untuk meminimalkan terjadinya komplikasi dan memperbaiki kadar glukosa darah. Tujuan penelitian adalah untuk mengetahui peran keluarga dalam perawatan penderita diabetes melitus secara mandiri di rumah. Jenis penelitian adalah deskriptif retrospektif dengan pendekatan cross-sectional. Subyek penelitian adalah anggota keluarga klien yang mendampingi ke poliklinik penyakit dalam RSU PKU Muhammadiyah Yogyakarta pada tanggal 22 September sampai dengan 28 Oktober2005. Jumlah sampel adalah 50 responden dengan teknik purposive sampling. Pengumpulan data dengan kuesioner. Analisis data dengan menggunakan rumus P = — x 100% hasilnya dikategorikan menjadi baik, cukup baik, kurang baik, dan tidak baik. Hasil penelitian menunjukkan peran keluarga dalam perawatan penderita DM secara mandiri di rumah yang dikategorikan baik adalah 58%. Peran keluarga tersebut dibagi dalam aspek penyuluhan 100%, perencanaan makan 66%, latihan jasmani 56%, terapi farmakologi 68%, dan perawatan kaki diabetes 42%, sedangkan pengelolaan penderita diabetes melitus secara mandiri di rumah yang dikategorikan baik adalah 58%. Hasil penelitian menunjukkan peran keluarga penting dalam merawat penderita DM secara mandiri di rumah karena keluargapenderita DM perlu berperan aktif dalam merawat dan memotivasi penderita DM dalam perawatan mandiri di rumah.
Bioscientia Medicina : Journal of Biomedicine and Translational Research, 2022
Background. The mortality rate due to cardiovascular disease increases; one of the effects of hyp... more Background. The mortality rate due to cardiovascular disease increases; one of the effects of hypercholesterolemia conditions, dyslipidemia, hypertriglyceridemia, and metabolic syndrome, not handled properly and thoroughly. This phenomenon becomes the factor that the researchers took this research topic. This study aims to determine okra (Abelmoschus esculentus L.) immersion water on an increase in high density lipoprotein (HDL) levels and decrease in LDL (low density lipoprotein) levels in high fat diet model Wistar rats. Methods. This experimental study used 30 Wistar male rats (Rattus norvegicus) divided into six groups, namely normal rats (P1), positive control (P2), standard (P3), dose 1 treatment groups (P4), dose 2 treatment groups (P5), and dose 2 treatment groups (P6). The data were collected by measuring HDL and LDL levels before and after receiving okra (Abelmoschus esculentus L.) immersion water. The data were analyzed by paired sample t-test, Wilcoxon test, ANOVA test a...
JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat), 2022
Kasus penyakit degeneratif/kronis cukup banyak terutama Diabetes Mellitus (DM). Penyakit DM ini d... more Kasus penyakit degeneratif/kronis cukup banyak terutama Diabetes Mellitus (DM). Penyakit DM ini dapat mengakibatkan berbagai komplikasi termasuk komplikasi di mata. Keterlambatan deteksi dini komplikasi di mata akibat penyakit DM tentunya dapat menyebabkan keadaan yang semakin parah dan akan menambah beban biaya bagi penderita serta dapat menimbulkan disabilitas. Peran kader sangat penting dalam pencegahan prevalensi DM tersebut. Kegiatan ini bertujuan untuk diseminasi informasi dan peningkatan pengetahuan masyarakat dan kader dusun Watu tentang penyakit DM serta melatih para kader agar dapat melakukan pengukuran kadar gula darah. Pelaksanaan kegiatan dengan memberikan pendidikan kesehatan secara online dalam bentuk webinar dengan aplikasi Zoom Meeting. Kegiatan pendidikan kesehatan dimulai dengan pretes kemudian sesi pemaparan materi dan diakhiri sesi postes untuk mengukur keberhasilan kegiatan dan tingkat pengetahuan peserta. Kegiatan sesi praktik pengukuran gula darah dilaksanak...
Prosiding Seminar Nasional Program Pengabdian Masyarakat, 2021
Kondisi wabah pandemi Coronaviruses Disease 2019 (Covid-19) tak kunjung berakhir. Hal ini memberi... more Kondisi wabah pandemi Coronaviruses Disease 2019 (Covid-19) tak kunjung berakhir. Hal ini memberi dampak buruk terhadap berbagai aspek kehidupan baik kesehatan, pendidikan, sosial, ekonomi, budaya, psikis, mental, dan lainnya. Salah satu dampak buruk dari aspek sosial, psikis, dan mental adalah adanya kasus penyalahgunaan narkoba yang masih kita jumpai pada masa pandemi ini, bahkan kasusnya mengalami peningkatan. Kegiatan penyuluhan ini bertujuan memberikan pengetahuan dan kewaspadaan masyarakat terhadap penyalahgunaan NAPZA sehingga bisa dilakukan tindakan pencegahan. Pelaksanaan kegiatan secara virtual melalui aplikasi Google Meet kepada pemuda dusun Brajan, Pleret, Bantul, Yogyakarta. Sebelas peserta kegiatan mendapatkan pendidikan kesehatan berupa pemaparan materi dan diakhiri dengan sesi tanya jawab. Peningkatan pengetahuan diukur dengan cara membandingkan perbedaan antara nilai pretest dan nilai posttest sehingga diketahui peningkatan nilai posttest dibandingkan nilai pretest....
The genetic variation of nicotinamide phosphoribosyl transferase (NAMPT) gene rs4730153 is report... more The genetic variation of nicotinamide phosphoribosyl transferase (NAMPT) gene rs4730153 is reported to be associated with cardiometabolic risk, but the results are inconsistent between populations. Ethnicity, metabolic risk and lifestyle play a role in the association of the genetic variant and the metabolic syndrome (MetS). To the best of our knowledge, no research has yet been published concerning the Javanese population, so this study aimed to investigate the association of rs4730153 with MetS and its interaction with metabolic risk and lifestyle. The GG genotype (p = 0.031; OR 95% CI 3.88 [1.13–13.33]), GA+GG genotype (p = 0.048; OR 95% CI 10.52 [1.02–108.01]) and G allele carrier (p = 0.006; OR 95% CI 4.19 [1.51–11.64]) of rs4730153 had a higher risk of the MetS after adjusting for obesity, hypercholesterolemia, smoking and food intake. The risk was statistically significant for the younger age group ≤ 45 years old. The GG, GA+GG genotype and G allele carrier of rs4730153 have ...
Hipertensi merupakan penyakit yang ditandai dengan adanya peningkatan tekanan darah dan dapat dis... more Hipertensi merupakan penyakit yang ditandai dengan adanya peningkatan tekanan darah dan dapat disebabkan oleh berbagai faktor baik genetik ataupun non-genetik. Faktor risiko hipertensi diantaranya gaya hidup tidak sehat, usia, jenis kelamin, obesitas dan riwayat keluarga menderita hipertensi. Salah satu gaya hidup yang berhubungan dengan kejadian hipertensi adalah peningkatan konsumsi garam. Mengetahui hubungan kadar natrium serum dengan tekanan darah pada individu dengan riwayat keluarga hipertensi.jenis penelitian adalahcase-control study. Pengambilan data sampel dengan purposive sampling. Subjek penelitian sebanyak 83 orang (42 orang kelompok kasus dan 41 orang kelompok kontrol). Uji satatistik terhadap hasil penelitain dengan uji spearman untuk mengetahui hubungan kadar natrium serum dan tekanan darah. P value antara kadar natrium dengan tekanan darah sistolik (p= 0,649) dan nilai r=0,051, P value antara kadar natrium dengan tekanan darah diastolik (p= 0,395) dan nilai r=0,095. Tidak terdapat hubungan bermakna antara kadar natrium serum dengan tekanan darah sistolik dan diastolik pada individu dengan riwayat keluarga hipertensi dan tanpa hipertensi.
Proceedings of the Third International Conference on Sustainable Innovation 2019 – Health Science and Nursing (IcoSIHSN 2019), 2019
Background: A corneal foreign body is one of the main causes of blindness. The effects can range ... more Background: A corneal foreign body is one of the main causes of blindness. The effects can range from mild infections (corneal abration, keratitis) to severe damage (endophthalmitis) depending on the type of material. Late-stage complications can cause permanent blindness. Objective: This study aimed to determine the effect of types of corneal foreign body material on the severity of eye infection. Methods: This study was a non-experimental research with analytic observational and crosssectional methods. Subjects were 30 patients. The samples were male and female patients (10-70 years old) who came to the eye clinic with a history of exposure to corneal foreign bodies of less than 8 days. The study was conducted by interviews and visual examination on the anterior segments of the eyes. The analysis used Statistical Package for the Social Sciences (Simple Linear Regression and Spearman tests). Results: There were several types of foreign body material that affected the cornea; gram i...
Cigarette smoke contains numerous substances containing free radicals and can prompt oxidative pr... more Cigarette smoke contains numerous substances containing free radicals and can prompt oxidative pressure. The buildup of free radicals cannot be neutralized by antioxidants for essential cancer prevention agent supplements from outside. In relation to that, the peel of citrus sinensis is expected to contain cell reinforcements that may eliminate free radicals. This study aims to determine the potential effect of Citrus sinensis peel extract on MDA levels in rats induced by cigarette smoke. This investigation is an experimental study with pre and post-test control groups. The 25 subjects of Rattus Norvergicus were divided into five groups: normal group, positive group, Treatment 1 (37.5 mg/kg BW Citrus sinensis peel extract), Treatment 2 (75 mg/kg BW Citrus sinensis peel extract) and Treatment 3 (112.5 mg/kg BW Citrus sinensis peel extract). Analysis of statistics resulted in a huge distinction between pre-test and post-test with p-value <0.05 (Wilcoxon test). Consequently, the Kru...
Diabetes mellitus (DM) is a chronic disease and it is called as a silent killer because this dise... more Diabetes mellitus (DM) is a chronic disease and it is called as a silent killer because this disease is unrecognized by the diabetics. However, when it is already known the complication is occurred. It is recognized by the increase of blood glucose level (hyperglycemia) as the main character of Diabetes Mellitus (DM). This condition causes the increase of the Reactive Oxygen Species (ROS) in a chronic condition. Then, insulin resistance is caused by the oxidative stress in fat, muscle and liver tissue. Moreover, insulin resistance produces several oxidative stress mediators including (TNF- α). This research aims to determine the effect of suweg flour (Amorphophallus campanulatus) on TNF-α level in rats diabetic model. The method used in the research was an experimental laboratory of pre-post control group test conducted in 28 days. The subjects of this research were 25 Rattus Novergicus wistar strains, (P1) positif control (P2), standart (P3) and two treatment groups (P4 and P5). ...
Background Standard insulin resistance (IR) marker now available was HOMA-IR which is expensive a... more Background Standard insulin resistance (IR) marker now available was HOMA-IR which is expensive and not available widely as routine test so surrogated marker was needed. Adiposity excess, glucose and lipid metabolism marker were the three metabolic risk strongly correlated with IR. Epidemiology study found triglyceride glucose index (TyG), visceral adiposity index (VAI) dan lipid accumulation product (LAP) could predict HOMA-IR. Adding the 3rd metabolic risk such adiposity excess to TyG index gained discrimination value to predict IR. To the best of our knowledge this study never been held before in Javanese, Indonesia. Aims of this study was to investigated ability of the three index as single or combination to predict IR in Indonesia. Methods study design was cross sectional with 184 participants. IR describe as HOMA-IR more than 75 percentiles for each gender. Spearman correlation and receiver operating characteristic (ROC) was construct to recognized ability of the metabolic ind...
Promosi kesehatan pada hakikatnya adalah suatu kegiatan atau usaha menyampaikan pesan kesehatan k... more Promosi kesehatan pada hakikatnya adalah suatu kegiatan atau usaha menyampaikan pesan kesehatan kepada masyarakat, kelompok, atau individu. Dengan adanya pesan tersebut maka diharapkan masyarakat, kelompok, atau individu dapat memperoleh pengetahuan tentang kesehatan yang lebih baik. Pengetahuan tersebut akhirnya diharapkan dapat berpengaruh terhadap perilaku. Dengan kata lain, adanya promosi tersebut diharapkan dapat membawa akibat terhadap perubahan perilaku sasaran. Promosi kesehatan dapat meningkatkan pengetahuan dan kewaspadaan terhadap masalah tertentu, mempengaruhi persepsi, kepercayaan dan sikap yang dapat mengubah norma-norma sosial, meningkatkan keinginan untuk memanfaatkan pelayanan kesehatan yang ada, mengubah mitos yang tidak benar tentang penyakit dan sakit. Prinsip pokok promosi kesehatan identik dengan pendidikan kesehatan, yaitu proses belajar yang menyangkut 3 persoalan yakni masukan (input), proses, dan keluaran (output). Media promosi kesehatan merupakan saluran ...
Journal of thee Medical Sciences (Berkala Ilmu Kedokteran), 2021
The prevalence of metabolic syndrome (MetS) is high worldwide which it can increase the risk of s... more The prevalence of metabolic syndrome (MetS) is high worldwide which it can increase the risk of some diseases such as cardiovascular disease, type 2 diabetes mellitus even mortality. The prevalence pattern and determinants of MetS risk factors might differ among ethnics in Indonesia. This study aimed to determine the anthropometry and metabolic measurements determinants to predict the MetS prevalence of the Javanese population in Yogyakarta. It was a case control study conducted from December 2018 to March 2019 involving 214 Javanese subjects aged 20-74 years resided in Yogyakarta Special Region, Indonesia. NCEP ATP III criteria were used to identify MetS as case and not diagnosed with MetS as control. The results showed that BMI, WC, BP, total cholesterol and HDL-C were significantly different between MetS and non MetS patients (p<0.005). In MetS subjects, prevalence of obesity was 75.3%, visceral fat was 75.3%, WC 92.95%, WHtR 97.64% and total cholesterol/HDL-C ratio 553%, which independently increased the risk of MetS 7. 30, 5.32, 13.37, 20.75, and 7.16 times, respectively. Result of logistic regression analysis showed central obesity based on WC increased the risk of Met-S by 17.62 time and the ratio of total cholesterol/HDL-C>5 by 9.54 time. In conclusion, WHtR is a better marker for MetS prediction independently. However, the WHtR in combination with WC and total cholesterol/HDL-C ratio are better for MetS prediction in the Javanese population. Prevalensi sindrom metabolic (SM) tinggi di seluruh dunia yang dapat meningkatkan risiko berbagai penyakit seperti kardiovaskular, diabetes melitus tipe 2 bahkan kematian. Pola prevalensi dan determinan faktor risiko SM mungkin berbeda antar etnik di Indonesia. Penelitian ini bertujuan untuk menetapkan determinan pengukuran antopometri danmetabolik untuk memprediksi SM pada etnis Jawa di Yogyakarta. Penelitian ini adalah penelitian kasus control yang dilakukan antra Desember 2018 sampai Maret 2019 dengan melibatkan 214 orang Jawa berumur 20-74 tahun tinggal di Daerah Istimewa Yogyakarta, Indonesia. Kriteria NCEP ATP III digunakan untuk mengidentifikasi SM sebagai kelompok kasus dan tidak mengalami SM sebagai kelompok kontrol. Hasil penelitian menunjukkan bahwa BMI, WC, BP, kolesterol total dan HDL-C antara kelompok SM dan non SM (p<0,005). Pada kelompok SM, prevalensi obesitas adalah 75,3%, lemak visceral adalah 75,3%, WC 92,95%, WHtR 97,64% dan rasio kolesterol total/HDL-C 55,3%, yang secara independen meningkatkan risiko SM masing-masing sebesar 7. 30, 5.32, 13.37, 20.75, dan 7.16 kali. Hasil analisis regresi logistik menunjukkan obesitas sentral berdasarkan WC meningkatkan risiko SM sebesar 17,62 kali dan rasio kolesterol total/HDL-C >5 sebesar 9,54 kali. Hasil penelitian menunjukkan bahwa WHtR adalah penanda yang lebih baik untuk memprediksi SM secara independent.Namun, WHtR bersama WC dan rasiokolesterol total/ HDL-C lebih baik untuk mengidentifikasi SM pada populasi Jawa.
Open Access Macedonian Journal of Medical Sciences
BACKGROUND: Perilipin is very important for the regulation of the deposition and mobilization of ... more BACKGROUND: Perilipin is very important for the regulation of the deposition and mobilization of fats. The human perilipin gene (PLIN) is near the locus for risk of obesity and hypertriglyceridemia. The PLIN gene is thought to be involved in the occurrence of metabolic syndrome. AIM: The aim of this research is to determine the role of variations of the PLIN gene (PLN4 11482 G>A) as a risk factor for component of metabolic syndrome. METHODS: This study involved a total of 160 subjects consisting of 80 with metabolic syndrome and 80 controls. Genotype analysis was done with the polymerase chain reaction-restriction fragment length polymorphism method. The data were analyzed with t-tests to compare the subjects’ characteristics between metabolic syndrome groups and controls. Risk factors of PLIN genotypes were calculated with odds ratio and multivariate regression analysis was used to determine the role of the PLIN gene with each biochemical characteristic. RESULTS: The result was ...
Dioscorea alata L. tubers (DA) are suspected to prevent diabetes mellitus (DM) because they have ... more Dioscorea alata L. tubers (DA) are suspected to prevent diabetes mellitus (DM) because they have a low glycemic index. However, only a few reports about the anti-diabetic effect of DA were reported up to date. This study aims to analyze the effect of DA consumption on several diabetic biomarkers through in vitro, in vivo, and in silico analysis. METHODS: In vitro experiments were conducted by observing the anti-inflammatory activity of DA extract, steroidal saponins (SDA) isolated from DA, and diosgenin in lymphocyte cell cultures. The tumor necrosis factor (TNF)-α and interferon (IFN)-γ percentages were analyzed by flow cytometry. In vivo study involved 24 healthy adolescents that were given a boiled DA 10 hours post-prandial. The blood sugar levels were measured at 0, 30, 60, and 120 min after treatment. Furthermore, the in silico study was carried out by analyzing the active compounds and predicting the biological activity, the target proteins, and interactions of target proteins with compounds contained in DA. RESULTS: DA extract, SDA isolated from DA, and diosgenin at 50 µg/mL significantly reduced proinflammatory cytokines TNF-α and IFN-γ in lymphocyte cell culture. The blood glucose levels in the DA group were lower at 30 and 60 min after treatment. Based on the in silico study, the anti-diabetic activity of DA was speculated to be attributed to the mechanisms of anti-hyperglycemia, prevention of mitochondrial dysfunction, anti-inflammation, and treated insulin resistance. Several proteins included in the DM pathway became the protein target of compounds contained in DA. CONCLUSION: DA potentially have an anti-diabetic activity through several mechanisms.
Prosiding Seminar Nasional Program Pengabdian Masyarakat
Kegiatan olahraga semakin meningkat akhir-akhir ini terutama masa pandemi COVID-19. Selain untuk ... more Kegiatan olahraga semakin meningkat akhir-akhir ini terutama masa pandemi COVID-19. Selain untuk meningkatkan daya tahan tubuh, olahraga juga bermanfaat untuk mengisi waktu luang selama masa pandemi. Olahraga dapat mengakibatkan cedera antara lain cedera di mata. Beberapa kelainan mata akibat cedera olahraga dapat mengakibatkan kelainan di mata baik ringan maupun berat. Bentuk cedera mata akibat olahraga antara lain hematom palpebra, perdarahan subkonjungtiva, ruptur kornea, hifema, katarak traumatika, subluksasi lensa, ablatio retina dan lain sebagainya. Jenis trauma mata yang tidak dikenali dan tidak ditangani dengan baik secara cepat dan tepat dapat menimbulkan komplikasi lebih lanjut dan dapat berakibat fatal bahkan kebutaan. WHO tahun 2007 melaporkan terdapat lebih dari 7 juta orang menderita buta setiap tahun. Sampai saat ini terdapat 180 juta orang di seluruh dunia mengalami gangguan penglihatan dan 40-45 juta menderita kebutaan. Indonesia memegang posisi tertinggi di South E...
Prosiding Seminar Nasional Program Pengabdian Masyarakat
Proses pembuatan batik tentu tidak dapat terhindarkan dari penggunaan pewarna untuk menghasilkan ... more Proses pembuatan batik tentu tidak dapat terhindarkan dari penggunaan pewarna untuk menghasilkan batik yang cantik. Secara umum, pewarnaan batik ada dua acara yaitu dengan bahan alami dan bahan sintetis. Saat ini, pewarnaan batik di Indonesia mulai banyak beralih dari pemakaian bahan alami menjadi bahan pewarna sintetis. Pewarna sintetis yang digunakan dapat mengandung logam berat diantaranya timbal (Pb) dan kromium (Cr). Pemakaian logam berat dalam waktu lama akan mengganggu kesehatan. Para pembatik juga sering tidak memakai sarung tangan saat melakukan pewarnaan sehingga hal ini akan dapat meningkatkan risiko terjadinya masalah anemia tersebut jika berlangsung dalam waktu lama. Tujuan: meningkatkan pengetahuan penyakit anemia akibat penggunaan cat sintetis pada pembuatan batik dan bagaimana cara pencegahannya. Metode: Kegiatan Pendidikan kesehatan dilaksanakan secara tatap muka dengan dimulai dengan pretes kemudian sesi pemaparan materi dan diakhiri sesi postes untuk mengukur kebe...
Mutiara Medika: Jurnal Kedokteran dan Kesehatan, 2006
The role of family in the management of diabetic patients is needed to minimize the complication ... more The role of family in the management of diabetic patients is needed to minimize the complication and improve the blood glucose level. The objective ofthe research was to identify the role offamily in self-care of diabetic patients at home. It was a retrospective descriptive study using a cross-sectional design. The research subjects were family members of diabetic patients who accompanied patients coming to Internal Medicine Polyclinic, General Hospital ofPKU Muhammadiyah Yogyakarta from 22 September to 28 October 2005. The research sample was 50 respondents who were selected with a purposive sampling technique. Data was collected using a questionnaire. Data analysis used a formula ofP = “ X100% and the results were categorized into good, fair, unfavorable, and poor. The research revealed that the role offamily in self-care of diabetic patients at home which was considered as good was 58%. The role of the family included aspects of patient education (100%), food planning (66%), exercises (56%), pharmacological therapy (68%), and diabetic foot care (42%). Similarly, the self-management of diabetic patients at home which was considered as good was 58%. The findings showed that the role of the family is important in self-care ofdiabetic patients at home. This is importantfor health care providers to advocate the patient’s family to actively participate in care giving and motivating the diabetic patients in self-care at home. Peran keluarga dalam perawatan penderita diabetes melitus diperlukan untuk meminimalkan terjadinya komplikasi dan memperbaiki kadar glukosa darah. Tujuan penelitian adalah untuk mengetahui peran keluarga dalam perawatan penderita diabetes melitus secara mandiri di rumah. Jenis penelitian adalah deskriptif retrospektif dengan pendekatan cross-sectional. Subyek penelitian adalah anggota keluarga klien yang mendampingi ke poliklinik penyakit dalam RSU PKU Muhammadiyah Yogyakarta pada tanggal 22 September sampai dengan 28 Oktober2005. Jumlah sampel adalah 50 responden dengan teknik purposive sampling. Pengumpulan data dengan kuesioner. Analisis data dengan menggunakan rumus P = — x 100% hasilnya dikategorikan menjadi baik, cukup baik, kurang baik, dan tidak baik. Hasil penelitian menunjukkan peran keluarga dalam perawatan penderita DM secara mandiri di rumah yang dikategorikan baik adalah 58%. Peran keluarga tersebut dibagi dalam aspek penyuluhan 100%, perencanaan makan 66%, latihan jasmani 56%, terapi farmakologi 68%, dan perawatan kaki diabetes 42%, sedangkan pengelolaan penderita diabetes melitus secara mandiri di rumah yang dikategorikan baik adalah 58%. Hasil penelitian menunjukkan peran keluarga penting dalam merawat penderita DM secara mandiri di rumah karena keluargapenderita DM perlu berperan aktif dalam merawat dan memotivasi penderita DM dalam perawatan mandiri di rumah.
Bioscientia Medicina : Journal of Biomedicine and Translational Research, 2022
Background. The mortality rate due to cardiovascular disease increases; one of the effects of hyp... more Background. The mortality rate due to cardiovascular disease increases; one of the effects of hypercholesterolemia conditions, dyslipidemia, hypertriglyceridemia, and metabolic syndrome, not handled properly and thoroughly. This phenomenon becomes the factor that the researchers took this research topic. This study aims to determine okra (Abelmoschus esculentus L.) immersion water on an increase in high density lipoprotein (HDL) levels and decrease in LDL (low density lipoprotein) levels in high fat diet model Wistar rats. Methods. This experimental study used 30 Wistar male rats (Rattus norvegicus) divided into six groups, namely normal rats (P1), positive control (P2), standard (P3), dose 1 treatment groups (P4), dose 2 treatment groups (P5), and dose 2 treatment groups (P6). The data were collected by measuring HDL and LDL levels before and after receiving okra (Abelmoschus esculentus L.) immersion water. The data were analyzed by paired sample t-test, Wilcoxon test, ANOVA test a...
JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat), 2022
Kasus penyakit degeneratif/kronis cukup banyak terutama Diabetes Mellitus (DM). Penyakit DM ini d... more Kasus penyakit degeneratif/kronis cukup banyak terutama Diabetes Mellitus (DM). Penyakit DM ini dapat mengakibatkan berbagai komplikasi termasuk komplikasi di mata. Keterlambatan deteksi dini komplikasi di mata akibat penyakit DM tentunya dapat menyebabkan keadaan yang semakin parah dan akan menambah beban biaya bagi penderita serta dapat menimbulkan disabilitas. Peran kader sangat penting dalam pencegahan prevalensi DM tersebut. Kegiatan ini bertujuan untuk diseminasi informasi dan peningkatan pengetahuan masyarakat dan kader dusun Watu tentang penyakit DM serta melatih para kader agar dapat melakukan pengukuran kadar gula darah. Pelaksanaan kegiatan dengan memberikan pendidikan kesehatan secara online dalam bentuk webinar dengan aplikasi Zoom Meeting. Kegiatan pendidikan kesehatan dimulai dengan pretes kemudian sesi pemaparan materi dan diakhiri sesi postes untuk mengukur keberhasilan kegiatan dan tingkat pengetahuan peserta. Kegiatan sesi praktik pengukuran gula darah dilaksanak...
Prosiding Seminar Nasional Program Pengabdian Masyarakat, 2021
Kondisi wabah pandemi Coronaviruses Disease 2019 (Covid-19) tak kunjung berakhir. Hal ini memberi... more Kondisi wabah pandemi Coronaviruses Disease 2019 (Covid-19) tak kunjung berakhir. Hal ini memberi dampak buruk terhadap berbagai aspek kehidupan baik kesehatan, pendidikan, sosial, ekonomi, budaya, psikis, mental, dan lainnya. Salah satu dampak buruk dari aspek sosial, psikis, dan mental adalah adanya kasus penyalahgunaan narkoba yang masih kita jumpai pada masa pandemi ini, bahkan kasusnya mengalami peningkatan. Kegiatan penyuluhan ini bertujuan memberikan pengetahuan dan kewaspadaan masyarakat terhadap penyalahgunaan NAPZA sehingga bisa dilakukan tindakan pencegahan. Pelaksanaan kegiatan secara virtual melalui aplikasi Google Meet kepada pemuda dusun Brajan, Pleret, Bantul, Yogyakarta. Sebelas peserta kegiatan mendapatkan pendidikan kesehatan berupa pemaparan materi dan diakhiri dengan sesi tanya jawab. Peningkatan pengetahuan diukur dengan cara membandingkan perbedaan antara nilai pretest dan nilai posttest sehingga diketahui peningkatan nilai posttest dibandingkan nilai pretest....
The genetic variation of nicotinamide phosphoribosyl transferase (NAMPT) gene rs4730153 is report... more The genetic variation of nicotinamide phosphoribosyl transferase (NAMPT) gene rs4730153 is reported to be associated with cardiometabolic risk, but the results are inconsistent between populations. Ethnicity, metabolic risk and lifestyle play a role in the association of the genetic variant and the metabolic syndrome (MetS). To the best of our knowledge, no research has yet been published concerning the Javanese population, so this study aimed to investigate the association of rs4730153 with MetS and its interaction with metabolic risk and lifestyle. The GG genotype (p = 0.031; OR 95% CI 3.88 [1.13–13.33]), GA+GG genotype (p = 0.048; OR 95% CI 10.52 [1.02–108.01]) and G allele carrier (p = 0.006; OR 95% CI 4.19 [1.51–11.64]) of rs4730153 had a higher risk of the MetS after adjusting for obesity, hypercholesterolemia, smoking and food intake. The risk was statistically significant for the younger age group ≤ 45 years old. The GG, GA+GG genotype and G allele carrier of rs4730153 have ...
Hipertensi merupakan penyakit yang ditandai dengan adanya peningkatan tekanan darah dan dapat dis... more Hipertensi merupakan penyakit yang ditandai dengan adanya peningkatan tekanan darah dan dapat disebabkan oleh berbagai faktor baik genetik ataupun non-genetik. Faktor risiko hipertensi diantaranya gaya hidup tidak sehat, usia, jenis kelamin, obesitas dan riwayat keluarga menderita hipertensi. Salah satu gaya hidup yang berhubungan dengan kejadian hipertensi adalah peningkatan konsumsi garam. Mengetahui hubungan kadar natrium serum dengan tekanan darah pada individu dengan riwayat keluarga hipertensi.jenis penelitian adalahcase-control study. Pengambilan data sampel dengan purposive sampling. Subjek penelitian sebanyak 83 orang (42 orang kelompok kasus dan 41 orang kelompok kontrol). Uji satatistik terhadap hasil penelitain dengan uji spearman untuk mengetahui hubungan kadar natrium serum dan tekanan darah. P value antara kadar natrium dengan tekanan darah sistolik (p= 0,649) dan nilai r=0,051, P value antara kadar natrium dengan tekanan darah diastolik (p= 0,395) dan nilai r=0,095. Tidak terdapat hubungan bermakna antara kadar natrium serum dengan tekanan darah sistolik dan diastolik pada individu dengan riwayat keluarga hipertensi dan tanpa hipertensi.
Proceedings of the Third International Conference on Sustainable Innovation 2019 – Health Science and Nursing (IcoSIHSN 2019), 2019
Background: A corneal foreign body is one of the main causes of blindness. The effects can range ... more Background: A corneal foreign body is one of the main causes of blindness. The effects can range from mild infections (corneal abration, keratitis) to severe damage (endophthalmitis) depending on the type of material. Late-stage complications can cause permanent blindness. Objective: This study aimed to determine the effect of types of corneal foreign body material on the severity of eye infection. Methods: This study was a non-experimental research with analytic observational and crosssectional methods. Subjects were 30 patients. The samples were male and female patients (10-70 years old) who came to the eye clinic with a history of exposure to corneal foreign bodies of less than 8 days. The study was conducted by interviews and visual examination on the anterior segments of the eyes. The analysis used Statistical Package for the Social Sciences (Simple Linear Regression and Spearman tests). Results: There were several types of foreign body material that affected the cornea; gram i...
Cigarette smoke contains numerous substances containing free radicals and can prompt oxidative pr... more Cigarette smoke contains numerous substances containing free radicals and can prompt oxidative pressure. The buildup of free radicals cannot be neutralized by antioxidants for essential cancer prevention agent supplements from outside. In relation to that, the peel of citrus sinensis is expected to contain cell reinforcements that may eliminate free radicals. This study aims to determine the potential effect of Citrus sinensis peel extract on MDA levels in rats induced by cigarette smoke. This investigation is an experimental study with pre and post-test control groups. The 25 subjects of Rattus Norvergicus were divided into five groups: normal group, positive group, Treatment 1 (37.5 mg/kg BW Citrus sinensis peel extract), Treatment 2 (75 mg/kg BW Citrus sinensis peel extract) and Treatment 3 (112.5 mg/kg BW Citrus sinensis peel extract). Analysis of statistics resulted in a huge distinction between pre-test and post-test with p-value <0.05 (Wilcoxon test). Consequently, the Kru...
Diabetes mellitus (DM) is a chronic disease and it is called as a silent killer because this dise... more Diabetes mellitus (DM) is a chronic disease and it is called as a silent killer because this disease is unrecognized by the diabetics. However, when it is already known the complication is occurred. It is recognized by the increase of blood glucose level (hyperglycemia) as the main character of Diabetes Mellitus (DM). This condition causes the increase of the Reactive Oxygen Species (ROS) in a chronic condition. Then, insulin resistance is caused by the oxidative stress in fat, muscle and liver tissue. Moreover, insulin resistance produces several oxidative stress mediators including (TNF- α). This research aims to determine the effect of suweg flour (Amorphophallus campanulatus) on TNF-α level in rats diabetic model. The method used in the research was an experimental laboratory of pre-post control group test conducted in 28 days. The subjects of this research were 25 Rattus Novergicus wistar strains, (P1) positif control (P2), standart (P3) and two treatment groups (P4 and P5). ...
Background Standard insulin resistance (IR) marker now available was HOMA-IR which is expensive a... more Background Standard insulin resistance (IR) marker now available was HOMA-IR which is expensive and not available widely as routine test so surrogated marker was needed. Adiposity excess, glucose and lipid metabolism marker were the three metabolic risk strongly correlated with IR. Epidemiology study found triglyceride glucose index (TyG), visceral adiposity index (VAI) dan lipid accumulation product (LAP) could predict HOMA-IR. Adding the 3rd metabolic risk such adiposity excess to TyG index gained discrimination value to predict IR. To the best of our knowledge this study never been held before in Javanese, Indonesia. Aims of this study was to investigated ability of the three index as single or combination to predict IR in Indonesia. Methods study design was cross sectional with 184 participants. IR describe as HOMA-IR more than 75 percentiles for each gender. Spearman correlation and receiver operating characteristic (ROC) was construct to recognized ability of the metabolic ind...
Promosi kesehatan pada hakikatnya adalah suatu kegiatan atau usaha menyampaikan pesan kesehatan k... more Promosi kesehatan pada hakikatnya adalah suatu kegiatan atau usaha menyampaikan pesan kesehatan kepada masyarakat, kelompok, atau individu. Dengan adanya pesan tersebut maka diharapkan masyarakat, kelompok, atau individu dapat memperoleh pengetahuan tentang kesehatan yang lebih baik. Pengetahuan tersebut akhirnya diharapkan dapat berpengaruh terhadap perilaku. Dengan kata lain, adanya promosi tersebut diharapkan dapat membawa akibat terhadap perubahan perilaku sasaran. Promosi kesehatan dapat meningkatkan pengetahuan dan kewaspadaan terhadap masalah tertentu, mempengaruhi persepsi, kepercayaan dan sikap yang dapat mengubah norma-norma sosial, meningkatkan keinginan untuk memanfaatkan pelayanan kesehatan yang ada, mengubah mitos yang tidak benar tentang penyakit dan sakit. Prinsip pokok promosi kesehatan identik dengan pendidikan kesehatan, yaitu proses belajar yang menyangkut 3 persoalan yakni masukan (input), proses, dan keluaran (output). Media promosi kesehatan merupakan saluran ...
Journal of thee Medical Sciences (Berkala Ilmu Kedokteran), 2021
The prevalence of metabolic syndrome (MetS) is high worldwide which it can increase the risk of s... more The prevalence of metabolic syndrome (MetS) is high worldwide which it can increase the risk of some diseases such as cardiovascular disease, type 2 diabetes mellitus even mortality. The prevalence pattern and determinants of MetS risk factors might differ among ethnics in Indonesia. This study aimed to determine the anthropometry and metabolic measurements determinants to predict the MetS prevalence of the Javanese population in Yogyakarta. It was a case control study conducted from December 2018 to March 2019 involving 214 Javanese subjects aged 20-74 years resided in Yogyakarta Special Region, Indonesia. NCEP ATP III criteria were used to identify MetS as case and not diagnosed with MetS as control. The results showed that BMI, WC, BP, total cholesterol and HDL-C were significantly different between MetS and non MetS patients (p<0.005). In MetS subjects, prevalence of obesity was 75.3%, visceral fat was 75.3%, WC 92.95%, WHtR 97.64% and total cholesterol/HDL-C ratio 553%, which independently increased the risk of MetS 7. 30, 5.32, 13.37, 20.75, and 7.16 times, respectively. Result of logistic regression analysis showed central obesity based on WC increased the risk of Met-S by 17.62 time and the ratio of total cholesterol/HDL-C>5 by 9.54 time. In conclusion, WHtR is a better marker for MetS prediction independently. However, the WHtR in combination with WC and total cholesterol/HDL-C ratio are better for MetS prediction in the Javanese population. Prevalensi sindrom metabolic (SM) tinggi di seluruh dunia yang dapat meningkatkan risiko berbagai penyakit seperti kardiovaskular, diabetes melitus tipe 2 bahkan kematian. Pola prevalensi dan determinan faktor risiko SM mungkin berbeda antar etnik di Indonesia. Penelitian ini bertujuan untuk menetapkan determinan pengukuran antopometri danmetabolik untuk memprediksi SM pada etnis Jawa di Yogyakarta. Penelitian ini adalah penelitian kasus control yang dilakukan antra Desember 2018 sampai Maret 2019 dengan melibatkan 214 orang Jawa berumur 20-74 tahun tinggal di Daerah Istimewa Yogyakarta, Indonesia. Kriteria NCEP ATP III digunakan untuk mengidentifikasi SM sebagai kelompok kasus dan tidak mengalami SM sebagai kelompok kontrol. Hasil penelitian menunjukkan bahwa BMI, WC, BP, kolesterol total dan HDL-C antara kelompok SM dan non SM (p<0,005). Pada kelompok SM, prevalensi obesitas adalah 75,3%, lemak visceral adalah 75,3%, WC 92,95%, WHtR 97,64% dan rasio kolesterol total/HDL-C 55,3%, yang secara independen meningkatkan risiko SM masing-masing sebesar 7. 30, 5.32, 13.37, 20.75, dan 7.16 kali. Hasil analisis regresi logistik menunjukkan obesitas sentral berdasarkan WC meningkatkan risiko SM sebesar 17,62 kali dan rasio kolesterol total/HDL-C >5 sebesar 9,54 kali. Hasil penelitian menunjukkan bahwa WHtR adalah penanda yang lebih baik untuk memprediksi SM secara independent.Namun, WHtR bersama WC dan rasiokolesterol total/ HDL-C lebih baik untuk mengidentifikasi SM pada populasi Jawa.
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