Papers by Igor Rzhepakovsky
Modern Applied Science, 2014
As a result of research it was succeeded to receive the model of non-alcoholic steatohepatitis wh... more As a result of research it was succeeded to receive the model of non-alcoholic steatohepatitis which is characterized by obesity, violation of the structural organization, a fabric necrosis, formation of fibrosis of a liver. The developed model of non-alcoholic steatohepatitis allows to study also staging of development of a fatty desease of the liver which is characterized by formation of a steatogepatitis and fibrosis. In quality the inducing factors the high-fat diet and antibiotics were used. The offered NASH model can be used in the field of chronic experiments for an assessment of extent of violation of a functional condition of hepatobiliary system and for search of the effective pharmacotheurapeutichepatoprotective agents.
Conducted research shows that the resistance of organ to various influences depends on level of
... more Conducted research shows that the resistance of organ to various influences depends on level of
its organization. The tissue systems consisting of actively dividing cells on various stages of differentiation
are more subject for various influences, than the organs consisting of highly specialized cells with low degree
of proliferative activity. The conducted research shows that the studied organs can conditionally be divided
into two groups depending on the value of an existing structural variety. The liver, kidneys, pancreas, stomach,
mammary gland, skin, ovaries and endometriya entered the first group. These organs are characterized by H
value bigger than 2 bits. All types of muscles and the lungs, which have made the second group, are
characterized by the H value less than 2 bits. Level of the greatest possible information capacity and the
information morphological organization in tissues of dogs is defined by extent of differentiation of tissue and
level of its mitotic activity. Thus, quite essential level of information morphological organization and rather high
levels of relative morphological entropy, information morphological redundancy are noted in the tissues
consisting of highly specialized, low-active or inactive in proliferative aspect cells. Such biosystems are rather
steady against influences as in them sufficient level of reserves which can be involved in adaptation process
remains.
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Papers by Igor Rzhepakovsky
its organization. The tissue systems consisting of actively dividing cells on various stages of differentiation
are more subject for various influences, than the organs consisting of highly specialized cells with low degree
of proliferative activity. The conducted research shows that the studied organs can conditionally be divided
into two groups depending on the value of an existing structural variety. The liver, kidneys, pancreas, stomach,
mammary gland, skin, ovaries and endometriya entered the first group. These organs are characterized by H
value bigger than 2 bits. All types of muscles and the lungs, which have made the second group, are
characterized by the H value less than 2 bits. Level of the greatest possible information capacity and the
information morphological organization in tissues of dogs is defined by extent of differentiation of tissue and
level of its mitotic activity. Thus, quite essential level of information morphological organization and rather high
levels of relative morphological entropy, information morphological redundancy are noted in the tissues
consisting of highly specialized, low-active or inactive in proliferative aspect cells. Such biosystems are rather
steady against influences as in them sufficient level of reserves which can be involved in adaptation process
remains.
its organization. The tissue systems consisting of actively dividing cells on various stages of differentiation
are more subject for various influences, than the organs consisting of highly specialized cells with low degree
of proliferative activity. The conducted research shows that the studied organs can conditionally be divided
into two groups depending on the value of an existing structural variety. The liver, kidneys, pancreas, stomach,
mammary gland, skin, ovaries and endometriya entered the first group. These organs are characterized by H
value bigger than 2 bits. All types of muscles and the lungs, which have made the second group, are
characterized by the H value less than 2 bits. Level of the greatest possible information capacity and the
information morphological organization in tissues of dogs is defined by extent of differentiation of tissue and
level of its mitotic activity. Thus, quite essential level of information morphological organization and rather high
levels of relative morphological entropy, information morphological redundancy are noted in the tissues
consisting of highly specialized, low-active or inactive in proliferative aspect cells. Such biosystems are rather
steady against influences as in them sufficient level of reserves which can be involved in adaptation process
remains.