We measure the large-scale real-space power spectrum Pk using luminous red galaxies (LRGs) in the... more We measure the large-scale real-space power spectrum Pk using luminous red galaxies (LRGs) in the Sloan Digital Sky Survey (SDSS) and use this measurement to sharpen constraints on cosmological parameters from the Wilkinson Microwave Anisotropy Probe (WMAP). We employ a matrix-based power spectrum estimation method using Pseudo-Karhunen-Loe `ve eigenmodes, producing uncorrelated minimum-variance measurements in 20 k-bands of both the clustering power and its anisotropy due to
Proceedings of the 2020 4th International Conference on Vision, Image and Signal Processing, 2020
A complex web of supply chains is a common feature of construction projects. With the different t... more A complex web of supply chains is a common feature of construction projects. With the different types of parties involved in a project and the amount of paperwork generated, the supply chain process can be time-consuming, an easy target for fraud and is prone to human errors. Blockchain is an emerging technology that can transform, simplify and make a network of information more secure. In the context of the supply chain, digitalised documents and real-time information can lead to cost-savings in any operation. Its embedded feature of transparency and integrity proves itself to be reliable. In addition, there are two less widely considered advantages that are particularly suitable for applying in the administration and management of the complex web of supply chains in the construction industry. The two additional advantages are dispute avoidance and dispute resolution, which will be discussed in this paper. The use of blockchain in supply chains carries legal issues. This could be a contributing factor to its slower rate of adoption than widely anticipated after the rapid emergence of its first application in the financial system of cryptocurrency, commonly known as Bitcoin. This paper identifies and proposes solutions to three key legal issues arising from the use of blockchain technology in supply chains. They are (a) restricted use of smart contracts to prescribed outcomes only; (b) concerns relating to access and ownership of using a shared blockchain platform; and (c) multi-jurisdiction concerns over where governing laws apply.
Background. The appropriate use of adjuvant therapy in patients with gross totally resected atypi... more Background. The appropriate use of adjuvant therapy in patients with gross totally resected atypical meningioma requires an accurate assessment of recurrence risk. We sought to determine whether cytogenetic/genetic characterization may facilitate better estimation of the probability of recurrence. Methods. We first analyzed our clinical database, including high-resolution DNA copy number data, to identify 11 common copy number aberrations in a pilot cohort of meningiomas of all grades. We summed these aberrations to devise a cytogenetic abnormality score (CAS) and determined the CAS from archived tissue of a separate cohort of 32 patients with gross totally resected atypical meningioma managed with surgery alone. Propensity score adjusted Cox regression was used to determine whether the CAS was predictive of recurrence. Results. An association between higher CAS and higher grade was noted in our pilot cohort with heterogeneity among atypical tumors. Among the 32 patients who underwent gross total resection of an atypical meningioma, the CAS was not significantly associated with age, gender, performance status, or tumor size/location but was associated with the risk of recurrence on univariable analysis (hazard ratio per aberration ¼ 1.52; 95% CI ¼ 1.08 -2.14; P ¼ .02). After adjustment, the impact of the dichotomized number of copy aberrations remained significantly associated with recurrence risk (hazard ratio ¼ 4.47; 95% CI ¼ 1.01 -19.87; P ¼ .05). Conclusions. The number of copy number aberrations is strongly associated with recurrence risk in patients with atypical meningioma following gross total resection and may inform the appropriate use of adjuvant radiation therapy in these patients or be useful for stratification in clinical trials.
We measure the large-scale real-space power spectrum Pk using luminous red galaxies (LRGs) in the... more We measure the large-scale real-space power spectrum Pk using luminous red galaxies (LRGs) in the Sloan Digital Sky Survey (SDSS) and use this measurement to sharpen constraints on cosmological parameters from the Wilkinson Microwave Anisotropy Probe (WMAP). We employ a matrix-based power spectrum estimation method using Pseudo-Karhunen-Loe `ve eigenmodes, producing uncorrelated minimum-variance measurements in 20 k-bands of both the clustering power and its anisotropy due to
Proceedings of the 2020 4th International Conference on Vision, Image and Signal Processing, 2020
A complex web of supply chains is a common feature of construction projects. With the different t... more A complex web of supply chains is a common feature of construction projects. With the different types of parties involved in a project and the amount of paperwork generated, the supply chain process can be time-consuming, an easy target for fraud and is prone to human errors. Blockchain is an emerging technology that can transform, simplify and make a network of information more secure. In the context of the supply chain, digitalised documents and real-time information can lead to cost-savings in any operation. Its embedded feature of transparency and integrity proves itself to be reliable. In addition, there are two less widely considered advantages that are particularly suitable for applying in the administration and management of the complex web of supply chains in the construction industry. The two additional advantages are dispute avoidance and dispute resolution, which will be discussed in this paper. The use of blockchain in supply chains carries legal issues. This could be a contributing factor to its slower rate of adoption than widely anticipated after the rapid emergence of its first application in the financial system of cryptocurrency, commonly known as Bitcoin. This paper identifies and proposes solutions to three key legal issues arising from the use of blockchain technology in supply chains. They are (a) restricted use of smart contracts to prescribed outcomes only; (b) concerns relating to access and ownership of using a shared blockchain platform; and (c) multi-jurisdiction concerns over where governing laws apply.
Background. The appropriate use of adjuvant therapy in patients with gross totally resected atypi... more Background. The appropriate use of adjuvant therapy in patients with gross totally resected atypical meningioma requires an accurate assessment of recurrence risk. We sought to determine whether cytogenetic/genetic characterization may facilitate better estimation of the probability of recurrence. Methods. We first analyzed our clinical database, including high-resolution DNA copy number data, to identify 11 common copy number aberrations in a pilot cohort of meningiomas of all grades. We summed these aberrations to devise a cytogenetic abnormality score (CAS) and determined the CAS from archived tissue of a separate cohort of 32 patients with gross totally resected atypical meningioma managed with surgery alone. Propensity score adjusted Cox regression was used to determine whether the CAS was predictive of recurrence. Results. An association between higher CAS and higher grade was noted in our pilot cohort with heterogeneity among atypical tumors. Among the 32 patients who underwent gross total resection of an atypical meningioma, the CAS was not significantly associated with age, gender, performance status, or tumor size/location but was associated with the risk of recurrence on univariable analysis (hazard ratio per aberration ¼ 1.52; 95% CI ¼ 1.08 -2.14; P ¼ .02). After adjustment, the impact of the dichotomized number of copy aberrations remained significantly associated with recurrence risk (hazard ratio ¼ 4.47; 95% CI ¼ 1.01 -19.87; P ¼ .05). Conclusions. The number of copy number aberrations is strongly associated with recurrence risk in patients with atypical meningioma following gross total resection and may inform the appropriate use of adjuvant radiation therapy in these patients or be useful for stratification in clinical trials.
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Papers by Ian Dunn