The purpose of this research is to determine the authority of the Kerinci Regency Government in m... more The purpose of this research is to determine the authority of the Kerinci Regency Government in managing the tourism sector of Lake Kerinci and to find out whether the Kerinci Regency Government has prepared a master plan for tourism development. The formulation of the problem studied is about how the authority of the Kerinci Regency Government in managing the tourism sector of Lake Kerinci? and whether the development of the Master plan has been in accordance with tourism?. This research is empirical juridical, based on the results of the study it can be concluded that the tourism management carried out by the Kerinci Regency Government has not been running well. This is due to the lack of coordination between regional apparatus and the inconsistency from the government, as well as the lack of human resources according to the field of work, as well as the lack of coordination and cooperation as well as follow-up from the Jambi Provincial Government in tourism development and manage...
The proteasome is the main proteolytic system for targeted protein degradation in the cell. Its f... more The proteasome is the main proteolytic system for targeted protein degradation in the cell. Its function is fine-tuned according to cellular needs. Regulation of proteasome function by mitochondrial metabolism, however, is unknown. Here, we demonstrate that mitochondrial dysfunction reduces the assembly and activity of the 26S proteasome in the absence of oxidative stress. Impaired respiratory complex I function leads to metabolic reprogramming of the Krebs cycle and deficiency in aspartate. Aspartate supplementation activates assembly and activity of 26S proteasomes via transcriptional activation of the proteasome assembly factors p28 and Rpn6. This metabolic adaptation of 26S proteasome function involves sensing of aspartate via the mTORC1 pathway. Metformin treatment of primary human cells similarly reduced assembly and activity of 26S proteasome complexes, which was fully reversible and rescued by supplementation of aspartate or pyruvate. Of note, respiratory dysfunction conferred resistance towards the proteasome inhibitor Bortezomib. Our study uncovers a fundamental novel mechanism of how mitochondrial metabolism adaptively adjusts protein degradation by the proteasome. It thus unravels unexpected consequences of defective mitochondrial metabolism in disease or drug-targeted mitochondrial reprogramming for proteasomal protein degradation in the cell. As metabolic inhibition of proteasome function can be alleviated by treatment with aspartate or pyruvate, our results also have therapeutic implications.
This research aims to analyze protection policies for health workers amidst COVID-19. Through sta... more This research aims to analyze protection policies for health workers amidst COVID-19. Through statute approach and based on the rights theory, this study examines legal development, or legal framework is needed to formulate and to protect health worker. Since the COVID-19 outbreak spreads quickly and massively, Health worker is at the forefront of handling COVID-19, but they are also vulnerable to get infected by the virus. Some cases showed that many health workers tested positive after providing health services. The findings of the research showed that the right of medical workers to get personal protective equipment and safety guarantees were not enough to protect them. On the other hand, the community was still ignoring the risk of this disease and broke the health protocol in the public place. Health workers can perform their job effectively if people are in healthy condition and do not need to go to the hospital. To containment measures of the COVID-19 State has to choose one ...
The massive forest and land fires in Indonesia have been raging and caused haze disaster. The haz... more The massive forest and land fires in Indonesia have been raging and caused haze disaster. The haze disaster is not suffered only in Indonesian territory, but it has become a transnational disaster resulting in extensive economic and health quality losses. In addition, the disaster has led damage to agricultural land and disruption of diplomatic relations among affected states. The number of perpetrators of forest and land fires that increase annually shows that the enforcement of criminal law is relatively ineffective. This article covers the problem whether the principle of strict liability can be applied to the perpetrators of forest burning. In 2019, forest fires in the Jambi Province had took placed in estimated 165.86.58 hectares. The forest fire is the main source of transnational haze disaster. Law enforcement on forest fires in Jambi has not provided a deterrent effect yet. There are forty-six companies acquiring fires in their concession land areas. Unfortunately, only four...
ABSTRAKArtikel ini bertujuan untuk menganalisis konsep perlindungan korban melalui kompensasi dal... more ABSTRAKArtikel ini bertujuan untuk menganalisis konsep perlindungan korban melalui kompensasi dalam peradilan pidana anak sebagai wujud tanggungjawab negara. Peradilan Pidana Anak di Indonesia melalui Undang-Undang Nomor 11 Tahun 2012 mengedepankan penyelesaian perkara anak melalui keadilan restoratif yang memberikan perlindungan yang seimbang antara perlindungan pelaku anak melalui diversi dan perlindungan korban tindak pidana anak. Diversi yang memberikan perlindungan yang seimbang antara pelaku dan korban ini merupakan pembaharuan dalam hukum pidana anak yang berkeadilan untuk semua pihak (Victim-offender oriented). Keterlibatan korban/keluarganya dan pelaku/keluarganya sangat menentukan berhasil atau tidaknya diversi dalam penyelesaian perkara anak. Posisi pelaku/keluarganya dan korban/keluarganya adalah sejajar. Kepentingan kedua belah pihak harus sama dan seimbang. Perlindungan korban melalui kompensasi merupakan wujud tanggungjawab negara terhadap warga negara yang menjadi ko...
Penelitian ini bertujuan untuk mengetahui dan menganalisis Bentuk Implementasi kebijakan pengemb... more Penelitian ini bertujuan untuk mengetahui dan menganalisis Bentuk Implementasi kebijakan pengembangan taman dalam melestarikan Ruang Terbuka Hijau di Kota Jambi dan menganalisis Bentuk strategi kebijakan pengembangan taman dalam penataan ruang Terbuka Hijau (RTH) di Kota Jambi. Pendekatan yang digunakan bersifat yuridis empiris, secara yuridis melihat peraturan perundang-undangan yang mengatur tentang Bentuk Kebijakan yang dilakukan Dinas Lingkungan Hidup sebagai Oraganisasi Perangkat Daerah (OPD) yang mempunyai kewenangan dalam Penataan Ruang Terbuka Hijau terhadap Pengembangan Taman Di Kota Jambi. Penelitian ini diharapkan Sesuai Undang-Undang Republik Indonesia Nomor 26 Tahun 2007 tentang Penataan Ruang Pasal 11 ayat (2) bahwa: pemerintah kota mempunyai wewenang dalam pelaksanaan penataan ruang wilayah kota yang meliputi perencanaan tata ruang wilayah kota, pemanfaatan ruang wilayah kota dan pengendalian pemanfaatan ruang wilayah kota. kekurangan Ruang Terbuka Hijau salah sat...
Applicability of Law. 32 of 2009 on the Protection and Management of the Environment an integrat... more Applicability of Law. 32 of 2009 on the Protection and Management of the Environment an integrated licensing increasingly strict environmental field. Nevertheless, there are still many problems to the implementation of an integrated licensing is the inconsistency of the sectoral rules, ego-sectoral technical agencies, the strong economic interests than the interests of environmental protectionand social welfare. Implementation of an integrated licensing system requires integration of the environmental field of governance, institutions, power, mechanisms and requirements to achieve sustainable environmental management. That requires the synchronization settings, the integration of sustainable development and institutional models of integrated environmental permit system. Key words: environment, licensing system, integrated.
This article aims to examine the correlation between the concept of proper enforcement of the law... more This article aims to examine the correlation between the concept of proper enforcement of the law as stipulated in Article 5 (2) of the 1945 Constitution of Indonesia and the establishment and implementation of government regulation on environment and forestry. This article is a normative legal research with statute, historical, and conceptual approaches. The result shows that proper legal enforcement means two things, namely, establishment and enactment of government regulation by the President and the content of the regulation that does not contradict the law. Failure to comply with the law means the President does not establish or enforce a government regulation as mandated or the content of the regulation is not in line with the law. If the President does form or enforce the implementation of government regulation, this means that the President violates his oath and promise to uphold the Constitution and to serve the nation. If the content of the regulation contradicts with the...
The right to obtain a good and healthy environment is a constitutional right of citizens expressl... more The right to obtain a good and healthy environment is a constitutional right of citizens expressly regulated in the 1945 Constitution of the Republic of Indonesia. However, this right has not been fully felt due to forest and land burning activities that occur every year in Sumatra and Kalimantan. For this reason, a condition for law enforcement is needed to solve the problem. This study basically answered two questions on how important is progressive law enforcement in burning forests? What is the concept of progressive law enforcement as intended?. Therefore, the findings stated that first, progressive law enforcement on forestburning cases has a philosophical and sociological urgency. Second, in efforts to progressively enforce law-burning cases, judges need to get out of the confines of the text in the law by always paying attention to the concept of the strict liability and precautionary principle to bring justice to every citizen who is negatively affected by the burning of forests.
The purpose of this research is to determine the authority of the Kerinci Regency Government in m... more The purpose of this research is to determine the authority of the Kerinci Regency Government in managing the tourism sector of Lake Kerinci and to find out whether the Kerinci Regency Government has prepared a master plan for tourism development. The formulation of the problem studied is about how the authority of the Kerinci Regency Government in managing the tourism sector of Lake Kerinci? and whether the development of the Master plan has been in accordance with tourism?. This research is empirical juridical, based on the results of the study it can be concluded that the tourism management carried out by the Kerinci Regency Government has not been running well. This is due to the lack of coordination between regional apparatus and the inconsistency from the government, as well as the lack of human resources according to the field of work, as well as the lack of coordination and cooperation as well as follow-up from the Jambi Provincial Government in tourism development and manage...
The proteasome is the main proteolytic system for targeted protein degradation in the cell. Its f... more The proteasome is the main proteolytic system for targeted protein degradation in the cell. Its function is fine-tuned according to cellular needs. Regulation of proteasome function by mitochondrial metabolism, however, is unknown. Here, we demonstrate that mitochondrial dysfunction reduces the assembly and activity of the 26S proteasome in the absence of oxidative stress. Impaired respiratory complex I function leads to metabolic reprogramming of the Krebs cycle and deficiency in aspartate. Aspartate supplementation activates assembly and activity of 26S proteasomes via transcriptional activation of the proteasome assembly factors p28 and Rpn6. This metabolic adaptation of 26S proteasome function involves sensing of aspartate via the mTORC1 pathway. Metformin treatment of primary human cells similarly reduced assembly and activity of 26S proteasome complexes, which was fully reversible and rescued by supplementation of aspartate or pyruvate. Of note, respiratory dysfunction conferred resistance towards the proteasome inhibitor Bortezomib. Our study uncovers a fundamental novel mechanism of how mitochondrial metabolism adaptively adjusts protein degradation by the proteasome. It thus unravels unexpected consequences of defective mitochondrial metabolism in disease or drug-targeted mitochondrial reprogramming for proteasomal protein degradation in the cell. As metabolic inhibition of proteasome function can be alleviated by treatment with aspartate or pyruvate, our results also have therapeutic implications.
This research aims to analyze protection policies for health workers amidst COVID-19. Through sta... more This research aims to analyze protection policies for health workers amidst COVID-19. Through statute approach and based on the rights theory, this study examines legal development, or legal framework is needed to formulate and to protect health worker. Since the COVID-19 outbreak spreads quickly and massively, Health worker is at the forefront of handling COVID-19, but they are also vulnerable to get infected by the virus. Some cases showed that many health workers tested positive after providing health services. The findings of the research showed that the right of medical workers to get personal protective equipment and safety guarantees were not enough to protect them. On the other hand, the community was still ignoring the risk of this disease and broke the health protocol in the public place. Health workers can perform their job effectively if people are in healthy condition and do not need to go to the hospital. To containment measures of the COVID-19 State has to choose one ...
The massive forest and land fires in Indonesia have been raging and caused haze disaster. The haz... more The massive forest and land fires in Indonesia have been raging and caused haze disaster. The haze disaster is not suffered only in Indonesian territory, but it has become a transnational disaster resulting in extensive economic and health quality losses. In addition, the disaster has led damage to agricultural land and disruption of diplomatic relations among affected states. The number of perpetrators of forest and land fires that increase annually shows that the enforcement of criminal law is relatively ineffective. This article covers the problem whether the principle of strict liability can be applied to the perpetrators of forest burning. In 2019, forest fires in the Jambi Province had took placed in estimated 165.86.58 hectares. The forest fire is the main source of transnational haze disaster. Law enforcement on forest fires in Jambi has not provided a deterrent effect yet. There are forty-six companies acquiring fires in their concession land areas. Unfortunately, only four...
ABSTRAKArtikel ini bertujuan untuk menganalisis konsep perlindungan korban melalui kompensasi dal... more ABSTRAKArtikel ini bertujuan untuk menganalisis konsep perlindungan korban melalui kompensasi dalam peradilan pidana anak sebagai wujud tanggungjawab negara. Peradilan Pidana Anak di Indonesia melalui Undang-Undang Nomor 11 Tahun 2012 mengedepankan penyelesaian perkara anak melalui keadilan restoratif yang memberikan perlindungan yang seimbang antara perlindungan pelaku anak melalui diversi dan perlindungan korban tindak pidana anak. Diversi yang memberikan perlindungan yang seimbang antara pelaku dan korban ini merupakan pembaharuan dalam hukum pidana anak yang berkeadilan untuk semua pihak (Victim-offender oriented). Keterlibatan korban/keluarganya dan pelaku/keluarganya sangat menentukan berhasil atau tidaknya diversi dalam penyelesaian perkara anak. Posisi pelaku/keluarganya dan korban/keluarganya adalah sejajar. Kepentingan kedua belah pihak harus sama dan seimbang. Perlindungan korban melalui kompensasi merupakan wujud tanggungjawab negara terhadap warga negara yang menjadi ko...
Penelitian ini bertujuan untuk mengetahui dan menganalisis Bentuk Implementasi kebijakan pengemb... more Penelitian ini bertujuan untuk mengetahui dan menganalisis Bentuk Implementasi kebijakan pengembangan taman dalam melestarikan Ruang Terbuka Hijau di Kota Jambi dan menganalisis Bentuk strategi kebijakan pengembangan taman dalam penataan ruang Terbuka Hijau (RTH) di Kota Jambi. Pendekatan yang digunakan bersifat yuridis empiris, secara yuridis melihat peraturan perundang-undangan yang mengatur tentang Bentuk Kebijakan yang dilakukan Dinas Lingkungan Hidup sebagai Oraganisasi Perangkat Daerah (OPD) yang mempunyai kewenangan dalam Penataan Ruang Terbuka Hijau terhadap Pengembangan Taman Di Kota Jambi. Penelitian ini diharapkan Sesuai Undang-Undang Republik Indonesia Nomor 26 Tahun 2007 tentang Penataan Ruang Pasal 11 ayat (2) bahwa: pemerintah kota mempunyai wewenang dalam pelaksanaan penataan ruang wilayah kota yang meliputi perencanaan tata ruang wilayah kota, pemanfaatan ruang wilayah kota dan pengendalian pemanfaatan ruang wilayah kota. kekurangan Ruang Terbuka Hijau salah sat...
Applicability of Law. 32 of 2009 on the Protection and Management of the Environment an integrat... more Applicability of Law. 32 of 2009 on the Protection and Management of the Environment an integrated licensing increasingly strict environmental field. Nevertheless, there are still many problems to the implementation of an integrated licensing is the inconsistency of the sectoral rules, ego-sectoral technical agencies, the strong economic interests than the interests of environmental protectionand social welfare. Implementation of an integrated licensing system requires integration of the environmental field of governance, institutions, power, mechanisms and requirements to achieve sustainable environmental management. That requires the synchronization settings, the integration of sustainable development and institutional models of integrated environmental permit system. Key words: environment, licensing system, integrated.
This article aims to examine the correlation between the concept of proper enforcement of the law... more This article aims to examine the correlation between the concept of proper enforcement of the law as stipulated in Article 5 (2) of the 1945 Constitution of Indonesia and the establishment and implementation of government regulation on environment and forestry. This article is a normative legal research with statute, historical, and conceptual approaches. The result shows that proper legal enforcement means two things, namely, establishment and enactment of government regulation by the President and the content of the regulation that does not contradict the law. Failure to comply with the law means the President does not establish or enforce a government regulation as mandated or the content of the regulation is not in line with the law. If the President does form or enforce the implementation of government regulation, this means that the President violates his oath and promise to uphold the Constitution and to serve the nation. If the content of the regulation contradicts with the...
The right to obtain a good and healthy environment is a constitutional right of citizens expressl... more The right to obtain a good and healthy environment is a constitutional right of citizens expressly regulated in the 1945 Constitution of the Republic of Indonesia. However, this right has not been fully felt due to forest and land burning activities that occur every year in Sumatra and Kalimantan. For this reason, a condition for law enforcement is needed to solve the problem. This study basically answered two questions on how important is progressive law enforcement in burning forests? What is the concept of progressive law enforcement as intended?. Therefore, the findings stated that first, progressive law enforcement on forestburning cases has a philosophical and sociological urgency. Second, in efforts to progressively enforce law-burning cases, judges need to get out of the confines of the text in the law by always paying attention to the concept of the strict liability and precautionary principle to bring justice to every citizen who is negatively affected by the burning of forests.
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