Papers by Hamzeh Hosseinzadeh
Zenodo (CERN European Organization for Nuclear Research), Aug 3, 2023
To evaluate the effect of thoracic epidural anesthesia (TEA) on tissue oxygen delivery and utiliz... more To evaluate the effect of thoracic epidural anesthesia (TEA) on tissue oxygen delivery and utilization in patients undergoing cardiac surgery. This prospective observational study was conducted in a tertiary referral heart hospital. A total of 25 patients undergoing elective off-pump coronary artery bypass surgery were enrolled in this study. All patients received thoracic epidural catheter in the most prominent inter-vertebral space between C7 and T3 on the day before operation. On the day of surgery, an arterial catheter and Swan Ganz catheter (capable of measuring cardiac index) was inserted. After administering full dose of local anesthetic in the epidural space, serial hemodynamic and oxygen transport parameters were measured for 30 minute prior to administration of general anesthesia, with which the study was culminated. A significant decrease in oxygen delivery index with insignificant changes in oxygen extraction and consumption indices was observed. We conclude that TEA does not affect tissue oxygenation despite a decrease in arterial pressures and cardiac output.
shiraz e medical journal, May 31, 2011
Objectives: Perianesthesia aspiration is a threatening side effect, whose severity depends on pH ... more Objectives: Perianesthesia aspiration is a threatening side effect, whose severity depends on pH and volume of aspirated gastric juice. Because of the loss of consciousness while anesthesia, the protective reflexes disappear and expose the person in the risk of aspiration. Pharmacological attempts have been made to eliminate the risk of pulmonary aspiration. The aim of this study was to compare oral pantoprazole and famotidine on gastric volume and pH in elective surgeries. Methods: In a double-blind randomized clinical trial, 120 candidates of elective surgery were randomized into 3 groups (control or C, pantoprazole or P and famotidine or F groups). The patients in group C ،P and F were given placebo ،pantoprazole 40mg and famotidine 40mg orally at 11 pm a night before surgery respectively. After induction of anesthesia, gastric contents were aspirated and analyzed for the pH and volume. Results: PH values were 2.87±0.92 in group C, 4.53±1.29 in group P and 3.79±1.97 in group F. There was statistical difference between groups C, P and F (p<0.05). The results showed a considerable decrease in the gastric volume in groups P and F comparing to group C. (p<0.05). Conclusion: We concluded that oral pantoprazole is effective in reducing gastric pH comparing to famotidine and placebo،and famotidine is effective in reducing gastric volume comparing to pantoprazole.
DOAJ (DOAJ: Directory of Open Access Journals), Sep 1, 2012
Background: Nausea and vomiting are common complications of anesthesia and surgery. Patients unde... more Background: Nausea and vomiting are common complications of anesthesia and surgery. Patients undergoing tympanoplasty are exposed to a higher risk of postoperative nausea vomiting (PONV). These complications may alter the results of reconstruction and anatomical alignments. Numerous antiemetics have been studied to prevent and treat PONV in patients undergoing tympanoplasty. The aim of this study was to compare the effect of intravenous ondansetron and dexamethasone on post-tympanoplasty PONV. Methods: In a double-blind randomized controlled clinical trial, 219 patients were divided into three groups including one receiving ondansetron, one receiving dexamethazone, and one receiving distilled water. All patients were subjected to tympanoplasty type I. The patients in the first group received ondansetron (4 mg IV), second group received oexamethasone (8 mg IV), and third group received distilled water prior to induction of anesthesia. Using Bellivelle ' s scoring system, the incidence of PONV and its severity during the 24-hour period after surgery were measured and compared. Results: There was no significant difference among PONV in the three groups in the first two hours after the surgery. However, in 2-8, 8-16 and 16-24 hours after the surgery the PONV in ondansetron and dexamethasone groups were significantly lower than that in the control group. Conclusion: Ondansetron and dexamethasone were more effective than placebo in controlling PONV after tympanoplasty surgeries. Moreover, dexamethasone was more effective than ondansetron in preventing PONV.
Armaghane danesh, Jul 10, 2007
journal of north khorasan university of medical sciences, Sep 1, 2011
journal of north khorasan university of medical sciences, Mar 1, 2017
Background and Objective: Sore throat is a common and unpleasant complication of anesthesia which... more Background and Objective: Sore throat is a common and unpleasant complication of anesthesia which often occurs after the extubation. This study was conducted to compare the effects of two pharyngeal packing methods (wet pack with saline and wet pack with 1% of Lidocaine) on postoperative sore throat after the nasal surgery. Materials and Methods: Sixty patients aged between 18-70 years with ASA I-II-III who were candidates for elective nasal surgery and categorized in two groups were enrolled in this double-blind randomized clinical trial. In the first group dampened gauze with 10 cc/kg was used for pharyngeal packing. Patients underwent general anesthesia with a similar method and after intubation, pharyngeal pack was placed with Magill forceps and in the end of operation before extubation was removed. Amount of sore throat, coughing, odynophagia, hoarseness, laryngeal spasm, nausea, and vomiting were assessed and compared after the extubation. Results: There weren't any significant differences between groups in term of weight, height, sex, age, duration of surgery, and type of surgery (p=0.194). Also there wasn't significant difference in sore throat between the lidocaine and placebo group. Conclusions: There wasn't any significant difference in sore throat between two groups of Lidocaine and placebo.
Medical journal of Tabriz University of Medical Sciences and Health Services, Mar 11, 2012
Background and Objectives: The use of laryngeal mask airway (LMA) is an alternative route in vari... more Background and Objectives: The use of laryngeal mask airway (LMA) is an alternative route in various surgeries such as gynecologic laparoscopy. However, air leak around LMA cuff may lead to gastric distension and inadequate ventilation during positive pressure ventilation in comparison with endotracheal tube (ETT). The aim of the present study was to compare laryngeal mask airway with endotracheal tube during gynecologic laparoscopy. Materials and Methods: One hundred women were randomly divided into LMA or ETT groups for airway management. During the laparoscopy, a surgeon, blinded to the type of airway, scored stomach size on an ordinal scale of 0-10 at initial insertion of the laparoscope and immediately before the conclusion of the surgical procedure. Oxygen saturation, EtCO2, and hemodynamic parameters (HR, BP) were compared between the two groups. Results: Demographic data, peritoneal insufflations time and total anesthetic time were similar for both groups (P>0.05). Alterations in gastric distension before or after peritoneal insufflations were similar in both groups (P>0.05). There were no significant differences in SpO2, ETCO2 or hemodynamic parameters during surgery or in recovery between two groups (P>0.05). With regard to the postoperative respiratory complications, cough was more common in ETT group. Conclusion: In this study we concluded that a correctly seated LMA or ETT provided equally effective pulmonary ventilation without clinically significant gastric distension in all patients.
Medical journal of Tabriz University of Medical Sciences and Health Services, Dec 6, 2015
Purpose Propofol is commonly used with remifentanil for induction of general anesthesia (GA); how... more Purpose Propofol is commonly used with remifentanil for induction of general anesthesia (GA); however, it often leads to hypotension. Intraoperative hypotension is associated with postoperative adverse events. By contrast, thiopental has less negative inotropic effects on hemodynamics compared to propofol, which could be suitable to prevent hypotension during GA induction. In the present age-stratified, randomized, assessor-blinded study, using the ClearSight ® system, we compared the hemodynamic effects of propofol and thiopental during GA induction under remifentanil infusion in non-cardiac surgery. Methods Patients were divided into young (20-40 year), middle (41-70 year), and elderly (> 70 year) groups (n = 20, each group). General anesthesia was induced with remifentanil 0.3 μg/kg/min, followed by propofol (2.0, 1.5, and 1.2 mg/kg) or thiopental (5.0, 4.0, and 3.0 mg/kg) in the young, middle, and elderly groups, respectively. The primary outcome was the difference in the decrease in mean arterial blood pressure between patients receiving propofol and thiopental in each age group. The secondary outcomes included other hemodynamic parameters and minimal bispectral index values measured up to 10 min after tracheal intubation. Results The decrease in mean arterial blood pressure was greater in patients receiving propofol than those receiving thiopental (− 45.4 vs − 26.6 mmHg and − 45.7 vs − 28.9 mmHg, P = 0.003 and 0.007, respectively), whereas no significant difference was observed in the young age group (P = 0.96). Conclusions Thiopental is a more suitable agent than propofol for avoiding hypotension during GA induction under remifentanil infusion in the middle and elderly patients.
Nausea and vomiting following breast surgery are the most common complications of this surgery; T... more Nausea and vomiting following breast surgery are the most common complications of this surgery; The incidence of these complications varies in different ethnicities and geographical areas. The aim of this study was to evaluate the changes in the severity of nausea and vomiting following breast surgery at different times. This cross-sectional descriptive study was performed during 2019 and 2020 in Imam Reza Hospital (Tabriz Medical Sciences) with the participation of 174 women candidates for breast surgery. The severity of nausea and vomiting at different times until after discharge was measured and recorded for each patient and its severity changes over time were measured by Chi-square test. The results of nausea showed that the highest rate of nausea was on the day of surgery and the lowest rate of nausea was on the second day after surgery. The highest number of vomiting was in the day after surgery and the lowest amount of vomiting was in two days after surgery. Pain intensity wa...
Medical journal of Tabriz University of Medical Sciences and Health Services, 2012
Journal of Anesthesia, 2019
Purpose Propofol is commonly used with remifentanil for induction of general anesthesia (GA); how... more Purpose Propofol is commonly used with remifentanil for induction of general anesthesia (GA); however, it often leads to hypotension. Intraoperative hypotension is associated with postoperative adverse events. By contrast, thiopental has less negative inotropic effects on hemodynamics compared to propofol, which could be suitable to prevent hypotension during GA induction. In the present age-stratified, randomized, assessor-blinded study, using the ClearSight ® system, we compared the hemodynamic effects of propofol and thiopental during GA induction under remifentanil infusion in non-cardiac surgery. Methods Patients were divided into young (20-40 year), middle (41-70 year), and elderly (> 70 year) groups (n = 20, each group). General anesthesia was induced with remifentanil 0.3 μg/kg/min, followed by propofol (2.0, 1.5, and 1.2 mg/kg) or thiopental (5.0, 4.0, and 3.0 mg/kg) in the young, middle, and elderly groups, respectively. The primary outcome was the difference in the decrease in mean arterial blood pressure between patients receiving propofol and thiopental in each age group. The secondary outcomes included other hemodynamic parameters and minimal bispectral index values measured up to 10 min after tracheal intubation. Results The decrease in mean arterial blood pressure was greater in patients receiving propofol than those receiving thiopental (− 45.4 vs − 26.6 mmHg and − 45.7 vs − 28.9 mmHg, P = 0.003 and 0.007, respectively), whereas no significant difference was observed in the young age group (P = 0.96). Conclusions Thiopental is a more suitable agent than propofol for avoiding hypotension during GA induction under remifentanil infusion in the middle and elderly patients.
International Journal of Heat and Mass Transfer, 2019
In order to obtain the most uniform temperature of the load, heat transfer in heat treatment furn... more In order to obtain the most uniform temperature of the load, heat transfer in heat treatment furnaces used in the steel industry was studied. Different two-equation turbulence models were compared with experimental results. The Realizable k-e model, predicts the load center line temperature better than the other two models, and it agrees closer to the experimental data. Also, by considering the radiation effect in the numerical simulation, the results were improved by 33% compared with experimental data. Finally, from different configurations of the burners studied and the results showed that the best temperature uniformity would be achieved for the configuration when the burners were located in a three down-three up arrangement.
Pak J Med Sci October- …, 2010
Objective: After neuraxial anesthesia, back pain is the most common complaint. The back pain may ... more Objective: After neuraxial anesthesia, back pain is the most common complaint. The back pain may be related to needle trauma or surgical positioning or transient neurotoxicity of concentrated local anesthetics. The goal of this study was to compare the incidence of back pain following spinal anesthesia with hyperbaric lidocaine 5% and bupivacaine 0.5% and spinal needle insertion spaces. Methodology: In this clinical trial after approving ethics committee and obtaining patients consent, we included 176 adult patients with physical status of I-II ASA from May 2006 to May 2008 undergoing various elective urologic surgeries under spinal anesthesia in Imam Hospital in Tabriz, Iran. Patients were allocated randomly in two equal groups. Group lidocaine, a nesthetized with hyperbaric 5% lidocaine and group bupivacaine. All patients were interviewed 6, 24, 48 hours after surgery for back pain. Results: This study indicated no statistically significance difference in the incidence of back pain following spinal anesthesia considering age and frequency of needle puncture during spinal anesthesia. Incidence of back pain was higher in lidocaine group than bupivacaine group (31.82% vs. 18.18%; respectively; P<0.001).Incidence of back pain was higher in L 3-4 interspace of needle insertion than L4-5 (23.7% vs. 12.8%, respectively; P<0.001). The intensity of back pain was slight and tolerable in 77% of the cases, and the back pain in all the patients lasted not more than 48 hours. Conclusion: This study implies that the area of needle insertion and type of anesthetics have effects on the back pain following spinal anesthesia.
Objective: To compare intubating laryngeal mask airway (ILMA) with direct laryngoscopy in patient... more Objective: To compare intubating laryngeal mask airway (ILMA) with direct laryngoscopy in patients with cervical spine injury.
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Papers by Hamzeh Hosseinzadeh