PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 2020
Angka kejadian kanker kulit yang dijumpai di Indonesia cukup tinggi sekitar 5,9-7,8%. Salah satu ... more Angka kejadian kanker kulit yang dijumpai di Indonesia cukup tinggi sekitar 5,9-7,8%. Salah satu penyebabnya adalah paparan sinar UV berlebihan pada kulit. Dengan demikian diperlukan adanya suatu produk yang dapat melindungi kulit dari bahaya sinar UV. Pada penelitian terdahulu buah jamblang dilaporkan memiliki nilai faktor perlindungan terhadap matahari (sun protection factor/SPF) yaitu 2,278±0,25% yang berpotensi untuk dibuat sediaan tabir surya. Penelitian ini bertujuan untuk membuat formula losion ekstrak buah jamblang (Syzygium cumini (L.) Skeels) yang kemudian diuji karakteristik fisik dan efektivitas tabir surya dari produk tersebut. Buah jamblang kering dihaluskan dan diayak pada 40/60 mesh sehingga didapatkan serbuk simplisia dan dihitung rendemennya. Sebanyak 100 g serbuk diekstraksi dengan metode remaserasi dalam pelarut etanol 70% selama 3x24 jam dan ditambahkan secukupnya HCl 37% hingga pH 1. Maserat kemudian disaring dan dipekatkan dengan rotary evaporator sampai diper...
Background : Oxidants or free radicals caused all abnormalities in this human body and to make li... more Background : Oxidants or free radicals caused all abnormalities in this human body and to make liver cells damaged. Various natural products have been observing for drugs or compounds as antioxidants as Roselle ( Hibiscus sabdariffa L ). Objective: The aim of this study was to determine ethanolic extract of roselle protect Method: Roselle was extracted by maceration 60 %ethanol with a ratio of dry calyx and solvents are (1:3) stirer for 24 hours , then is filtered and concentrated by Rotary evaporator at 60°C . Maserate was transferred into a porcelain cup and evaporated on water bath at 60°C . Condensed extract is then stored in a sealed container and be identified .Forty-five Male Sprague Dawley rats age of 4 weeks divided into 9 groups: group I are baseline, group II and III was DMBA control group at day 7 and 35 (Single dose 75 mg/kgbw) . Group IV , V and VI are roselle extract treatment groups with variations each dose group of 10 mg / kg , 50 mg/kg and 100 mg/kgbw on day 7 ind...
Purpose: To determine the effect of rosella (Hibiscus sabdariffa L) extract on glutathione-S-tras... more Purpose: To determine the effect of rosella (Hibiscus sabdariffa L) extract on glutathione-S-trasferase (GST) activity and its hepatoprotective effect. Methods: A total of 25 rats were divided randomly into 5 groups (5 rats per group). Group I served as the baseline, group II was the negative control group, while groups III, IV and V were treated with rosella extract at doses of 10, 50 and 100 mg /kg /day, respectively for 35 days. On day 36, the animals were given a single dose of dimethyl benz(a)anthracene (DMBA) orally. After one week, blood was taken from the sinus orbitalis for measurement of serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT) activities by a kinetic method with DIasys® kit. The activity of GST was measured in liver homogenate using 1-choloro-2,4-dinitrobenzene (CDNB) method, while the expression of GST gene was determined by reverse transcriptase polymerase chain reaction (RT-PCR). Results: Treatment with rosella e...
The ethanolic extract of soursop leaves (Annona muricata L.) is reported as an antioxidant agent ... more The ethanolic extract of soursop leaves (Annona muricata L.) is reported as an antioxidant agent with an IC50 value of 14.48 μg/mL. This research aimed to examine physical characteristics and investigate the antioxidant activity of the ethanolic extract of soursop leaves in a scrub cream. Soursop leaves powder was extracted with 70% ethanol and formulated as scrub cream at the concentration of 1.4%, 2.8%, and 4.2%, then evaluated for physical characteristics. The antioxidant activity was evaluated using DPPH (1.1-diphenyl-2 picrylhydrazyl) method. The result showed that the scrub cream at all concentrations tested fulfilled all physical characteristics required for good topical preparations. These included organoleptic, homogeneity, viscosity, pH, spreadability, and adhesion. The IC50 value of the scrub cream at the concentration of 1.4%, 2.8 %, and 4.2% were 30.72, 26.82, and 24.03 μg/mL, respectively. The IC50 values indicated that the scrub creams exhibit radical scavenging activ...
Pengetahuan masyarakat akan penggunaan jamu sebagai alternatif dan pendamping pengobatan sangat r... more Pengetahuan masyarakat akan penggunaan jamu sebagai alternatif dan pendamping pengobatan sangat rendah dan belum terlalu populer di masyarakat. Kementerian Kesehatan melalui Badan Penelitian dan Pengembangan Kesehatan menjalankan program saintifikasi jamu (SJ) berdasarkan Peraturan Kementerian Kesehatan RI No.003/PerMenKes/I/2010 telah membuktikan khasiat jamu dengan metode penelitian berbasis pelayanan. Sehingga potensi pengobatan dengan jamu ini bisa disosialisasikan kepada masyarakat untuk menekan potensi peningkatan penderita penyakit asam urat pada warga muhammadiyah dan sekitar wilayah desa Pliken, Kembaran, Banyumas. Metode yang digunakan yaitu penyuluhan terkait dengan potensi penyakit, patofisiologi penyakit, pengobatan konvnsional terkini, deteksi dini, dan cara pencegahannya baik dengan perbaikan pola makan dan hidup sehat serta mengkonsumsi jamu sebagai alternatif pengobatan asam urat. Praktek pembuatan jamu saintifik dengan memperkenalkan bahan baku herbal dan cara peng...
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 2020
Angka kejadian kanker kulit yang dijumpai di Indonesia cukup tinggi sekitar 5,9-7,8%. Salah satu ... more Angka kejadian kanker kulit yang dijumpai di Indonesia cukup tinggi sekitar 5,9-7,8%. Salah satu penyebabnya adalah paparan sinar UV berlebihan pada kulit. Dengan demikian diperlukan adanya suatu produk yang dapat melindungi kulit dari bahaya sinar UV. Pada penelitian terdahulu buah jamblang dilaporkan memiliki nilai faktor perlindungan terhadap matahari (sun protection factor/SPF) yaitu 2,278±0,25% yang berpotensi untuk dibuat sediaan tabir surya. Penelitian ini bertujuan untuk membuat formula losion ekstrak buah jamblang (Syzygium cumini (L.) Skeels) yang kemudian diuji karakteristik fisik dan efektivitas tabir surya dari produk tersebut. Buah jamblang kering dihaluskan dan diayak pada 40/60 mesh sehingga didapatkan serbuk simplisia dan dihitung rendemennya. Sebanyak 100 g serbuk diekstraksi dengan metode remaserasi dalam pelarut etanol 70% selama 3x24 jam dan ditambahkan secukupnya HCl 37% hingga pH 1. Maserat kemudian disaring dan dipekatkan dengan rotary evaporator sampai diper...
Background : Oxidants or free radicals caused all abnormalities in this human body and to make li... more Background : Oxidants or free radicals caused all abnormalities in this human body and to make liver cells damaged. Various natural products have been observing for drugs or compounds as antioxidants as Roselle ( Hibiscus sabdariffa L ). Objective: The aim of this study was to determine ethanolic extract of roselle protect Method: Roselle was extracted by maceration 60 %ethanol with a ratio of dry calyx and solvents are (1:3) stirer for 24 hours , then is filtered and concentrated by Rotary evaporator at 60°C . Maserate was transferred into a porcelain cup and evaporated on water bath at 60°C . Condensed extract is then stored in a sealed container and be identified .Forty-five Male Sprague Dawley rats age of 4 weeks divided into 9 groups: group I are baseline, group II and III was DMBA control group at day 7 and 35 (Single dose 75 mg/kgbw) . Group IV , V and VI are roselle extract treatment groups with variations each dose group of 10 mg / kg , 50 mg/kg and 100 mg/kgbw on day 7 ind...
Purpose: To determine the effect of rosella (Hibiscus sabdariffa L) extract on glutathione-S-tras... more Purpose: To determine the effect of rosella (Hibiscus sabdariffa L) extract on glutathione-S-trasferase (GST) activity and its hepatoprotective effect. Methods: A total of 25 rats were divided randomly into 5 groups (5 rats per group). Group I served as the baseline, group II was the negative control group, while groups III, IV and V were treated with rosella extract at doses of 10, 50 and 100 mg /kg /day, respectively for 35 days. On day 36, the animals were given a single dose of dimethyl benz(a)anthracene (DMBA) orally. After one week, blood was taken from the sinus orbitalis for measurement of serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT) activities by a kinetic method with DIasys® kit. The activity of GST was measured in liver homogenate using 1-choloro-2,4-dinitrobenzene (CDNB) method, while the expression of GST gene was determined by reverse transcriptase polymerase chain reaction (RT-PCR). Results: Treatment with rosella e...
The ethanolic extract of soursop leaves (Annona muricata L.) is reported as an antioxidant agent ... more The ethanolic extract of soursop leaves (Annona muricata L.) is reported as an antioxidant agent with an IC50 value of 14.48 μg/mL. This research aimed to examine physical characteristics and investigate the antioxidant activity of the ethanolic extract of soursop leaves in a scrub cream. Soursop leaves powder was extracted with 70% ethanol and formulated as scrub cream at the concentration of 1.4%, 2.8%, and 4.2%, then evaluated for physical characteristics. The antioxidant activity was evaluated using DPPH (1.1-diphenyl-2 picrylhydrazyl) method. The result showed that the scrub cream at all concentrations tested fulfilled all physical characteristics required for good topical preparations. These included organoleptic, homogeneity, viscosity, pH, spreadability, and adhesion. The IC50 value of the scrub cream at the concentration of 1.4%, 2.8 %, and 4.2% were 30.72, 26.82, and 24.03 μg/mL, respectively. The IC50 values indicated that the scrub creams exhibit radical scavenging activ...
Pengetahuan masyarakat akan penggunaan jamu sebagai alternatif dan pendamping pengobatan sangat r... more Pengetahuan masyarakat akan penggunaan jamu sebagai alternatif dan pendamping pengobatan sangat rendah dan belum terlalu populer di masyarakat. Kementerian Kesehatan melalui Badan Penelitian dan Pengembangan Kesehatan menjalankan program saintifikasi jamu (SJ) berdasarkan Peraturan Kementerian Kesehatan RI No.003/PerMenKes/I/2010 telah membuktikan khasiat jamu dengan metode penelitian berbasis pelayanan. Sehingga potensi pengobatan dengan jamu ini bisa disosialisasikan kepada masyarakat untuk menekan potensi peningkatan penderita penyakit asam urat pada warga muhammadiyah dan sekitar wilayah desa Pliken, Kembaran, Banyumas. Metode yang digunakan yaitu penyuluhan terkait dengan potensi penyakit, patofisiologi penyakit, pengobatan konvnsional terkini, deteksi dini, dan cara pencegahannya baik dengan perbaikan pola makan dan hidup sehat serta mengkonsumsi jamu sebagai alternatif pengobatan asam urat. Praktek pembuatan jamu saintifik dengan memperkenalkan bahan baku herbal dan cara peng...
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