Clinical cancer research : an official journal of the American Association for Cancer Research, Jan 23, 2015
Cancer vaccines aim to generate and maintain anti-tumor immune responses. We designed a phase I/I... more Cancer vaccines aim to generate and maintain anti-tumor immune responses. We designed a phase I/IIa clinical trial to test a vaccine formulation composed of Montanide ISA-51 (Incomplete Freund's Adjuvant), LAG-3Ig (IMP321, a non-Toll like Receptor agonist with adjuvant properties) and five synthetic peptides derived from tumor-associated antigens (four short 9/10-mers targeting CD8 T-cells, and one longer 15-mer targeting CD4 T-cells). Primary endpoints were safety and T-cell responses. Sixteen metastatic melanoma patients received serial vaccinations. Up to 9 injections were subcutaneously administered in 3 cycles, each with 3 vaccinations every 3 weeks, with 6-14 weeks interval between cycles. Blood samples were collected at baseline, one week after the 3rd, 6th and 9th vaccination, and 6 months after the last vaccination. Circulating T-cells were monitored by tetramer staining directly ex vivo, and by combinatorial tetramer and cytokine staining on in vitro stimulated cells. ...
The present paper aims at examining the extent to which Moroccan cinema could establish a diaspor... more The present paper aims at examining the extent to which Moroccan cinema could establish a diasporic visual discourse that cements national identity and contests the impact of westernization on migrants. Moreover, through the analysis the way in which independent identities are constructed in the host land, the article tries to incorporate a feminist discourse to highlight the role of the female subject in retrieving its own agency by challenging patriarchal oppression. Therefore, we argue that Mohammed Ismail’s feature-length film Ici et là (Here and There) has partially succeeded in creating a space for its diasporic subjects to build up their own independent identities beyond the scope of westernization and patriarchy.
1 [email protected] 2 [email protected] 3 [email protected] Abstract COTS-based d... more 1 [email protected] 2 [email protected] 3 [email protected] Abstract COTS-based development (CBD) process consists in five main steps including identifying COTS products candidates, selecting the most appropriate one and assembling it with the other components. In practice, this process is not yet obvious to follow. Many methods are proposed to support one or several steps of the process. But, which method to use and how to apply it still remains problematic. The MAP is a process meta-model proposed to support methods specification and their enactment. We have already used the MAP to express the CBD process, and the MAP was also used to express PORE, a COTS selection method. In this paper, we propose to generalize the use of the MAP to express both the CBD process and COTS related methods, especially selection ones. As a result, the developer is guided in the process of choosing the appropriate method and its application.
Clinical cancer research : an official journal of the American Association for Cancer Research, Jan 23, 2015
Cancer vaccines aim to generate and maintain anti-tumor immune responses. We designed a phase I/I... more Cancer vaccines aim to generate and maintain anti-tumor immune responses. We designed a phase I/IIa clinical trial to test a vaccine formulation composed of Montanide ISA-51 (Incomplete Freund's Adjuvant), LAG-3Ig (IMP321, a non-Toll like Receptor agonist with adjuvant properties) and five synthetic peptides derived from tumor-associated antigens (four short 9/10-mers targeting CD8 T-cells, and one longer 15-mer targeting CD4 T-cells). Primary endpoints were safety and T-cell responses. Sixteen metastatic melanoma patients received serial vaccinations. Up to 9 injections were subcutaneously administered in 3 cycles, each with 3 vaccinations every 3 weeks, with 6-14 weeks interval between cycles. Blood samples were collected at baseline, one week after the 3rd, 6th and 9th vaccination, and 6 months after the last vaccination. Circulating T-cells were monitored by tetramer staining directly ex vivo, and by combinatorial tetramer and cytokine staining on in vitro stimulated cells. ...
The present paper aims at examining the extent to which Moroccan cinema could establish a diaspor... more The present paper aims at examining the extent to which Moroccan cinema could establish a diasporic visual discourse that cements national identity and contests the impact of westernization on migrants. Moreover, through the analysis the way in which independent identities are constructed in the host land, the article tries to incorporate a feminist discourse to highlight the role of the female subject in retrieving its own agency by challenging patriarchal oppression. Therefore, we argue that Mohammed Ismail’s feature-length film Ici et là (Here and There) has partially succeeded in creating a space for its diasporic subjects to build up their own independent identities beyond the scope of westernization and patriarchy.
1 [email protected] 2 [email protected] 3 [email protected] Abstract COTS-based d... more 1 [email protected] 2 [email protected] 3 [email protected] Abstract COTS-based development (CBD) process consists in five main steps including identifying COTS products candidates, selecting the most appropriate one and assembling it with the other components. In practice, this process is not yet obvious to follow. Many methods are proposed to support one or several steps of the process. But, which method to use and how to apply it still remains problematic. The MAP is a process meta-model proposed to support methods specification and their enactment. We have already used the MAP to express the CBD process, and the MAP was also used to express PORE, a COTS selection method. In this paper, we propose to generalize the use of the MAP to express both the CBD process and COTS related methods, especially selection ones. As a result, the developer is guided in the process of choosing the appropriate method and its application.
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Papers by H. Hajjami