... 2001, Moraleda et al. 2006]. ... Transmission of HBV is not only possible through help to acc... more ... 2001, Moraleda et al. 2006]. ... Transmission of HBV is not only possible through help to accident victims but also through the joint use of hygiene articles, eg nail scissors, nail files, razors of all kinds and even callosity planes. ...
... 2001, Moraleda et al. 2006]. ... Transmission of HBV is not only possible through help to acc... more ... 2001, Moraleda et al. 2006]. ... Transmission of HBV is not only possible through help to accident victims but also through the joint use of hygiene articles, eg nail scissors, nail files, razors of all kinds and even callosity planes. ...
Beiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine, 1994
After following up approximately 200,000 blood donors with 1st- and 2nd-generation anti-HCV tests... more After following up approximately 200,000 blood donors with 1st- and 2nd-generation anti-HCV tests the authors suggest: 1) to neglect earlier 1st-generation-positive anti-HCV results when the donor is negative in 2nd-generation ELISAs; 2) after a donation positive in a 2nd-generation test the following donation must not be used even if it is negative; a third, negative donation can be used; 3) a donor with two different donations positive in 2nd-generation ELISAs should be excluded from the donor pool.
Beiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine, 1994
The authors discuss the quality control criteria for autologous blood donations. They recommend t... more The authors discuss the quality control criteria for autologous blood donations. They recommend that all autologous donations be tested for serological markers of blood-transmissible diseases. Marker-positive donors should not donate autologous blood. If autologous donation seems indispensable, infectious donations should be clearly marked as infectious.
Deutsche medizinische Wochenschrift (1946), Jan 16, 1987
Since 1985 all donor blood in the Federal Republic of Germany (FRG) and West Berlin (WB) have bee... more Since 1985 all donor blood in the Federal Republic of Germany (FRG) and West Berlin (WB) have been routinely tested for HIV antibodies. The blood donor services of the German and Bavarian Red Cross have pooled their anti-HIV test data for the first year of operation (July 1985-June 1986) to obtain information on the prevalence of HIV antibodies in blood donors and in donated blood. Of 2.27 million units of blood, donated by 1.33 million donors, 218 were anti-HIV positive in the Western Blot Test, i.e. a prevalence rate of 10 per 100,000 donors. The prevalence was, as expected, higher in males than females. During the test period the anti-HIV prevalence fell, both as a total and in all subpopulations. In the second quarter of 1986 it had decreased to 6 per 100,000 donated units.
Deutsche medizinische Wochenschrift (1946), Jan 9, 1988
Of a total of 5.6 million blood donations by 1.6 million German Red Cross donors between July, 19... more Of a total of 5.6 million blood donations by 1.6 million German Red Cross donors between July, 1985 and December, 1987 tested for HIV antibodies 210 were found to be positive in at least one Western blot. Calculated per quarter, the prevalence (for first-time donors) of 10 per 100,000 in 1985 decreased to 4 per 100,000 in 1986, while the incidence (for multiple donors) was a constant 2 per 100,000 for each quarter in 1987. This indicates that new HIV infections were rare in blood donors and there was no exponential increase. Further analysis revealed that over 90% of those with confirmed Western blot positive results were members of risk groups or their direct contacts. The age and sex distribution conformed to the known pattern for AIDS cases in the Federal Republic of Germany. The data demonstrate that there is at present no indication of a rapid spread of HIV infections transmitted heterosexually among blood donors.
To examine the consistency and comparability of anti-hepatitis B core antigen (anti-HBcAg) assays... more To examine the consistency and comparability of anti-hepatitis B core antigen (anti-HBcAg) assays, four blood donation centers of the Red Cross in the Federal Republic of Germany tested 4,080 unselected blood donors with six different tests in parallel. Confirmation testing of reactive samples was done in the National Reference Center for Viral Hepatitis. Depending on the test kit used, 4.1 to 9.9% of serum samples were initially positive and 2.9 to 7.5% were repeatedly positive. Sixteen percent of serum samples were positive in at least one test but only three percent were positive in all six tests. Statistical analysis of frequency distribution of optical densities for each test suggested that there should be a correction of the cutoff values. This reduced the number of false-positive results by half, but a significant proportion of discrepant results could not be resolved. The lack of specificity and consistency requires cautious interpretation of isolated anti-HBcAg results in c...
... 2001, Moraleda et al. 2006]. ... Transmission of HBV is not only possible through help to acc... more ... 2001, Moraleda et al. 2006]. ... Transmission of HBV is not only possible through help to accident victims but also through the joint use of hygiene articles, eg nail scissors, nail files, razors of all kinds and even callosity planes. ...
... 2001, Moraleda et al. 2006]. ... Transmission of HBV is not only possible through help to acc... more ... 2001, Moraleda et al. 2006]. ... Transmission of HBV is not only possible through help to accident victims but also through the joint use of hygiene articles, eg nail scissors, nail files, razors of all kinds and even callosity planes. ...
Beiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine, 1994
After following up approximately 200,000 blood donors with 1st- and 2nd-generation anti-HCV tests... more After following up approximately 200,000 blood donors with 1st- and 2nd-generation anti-HCV tests the authors suggest: 1) to neglect earlier 1st-generation-positive anti-HCV results when the donor is negative in 2nd-generation ELISAs; 2) after a donation positive in a 2nd-generation test the following donation must not be used even if it is negative; a third, negative donation can be used; 3) a donor with two different donations positive in 2nd-generation ELISAs should be excluded from the donor pool.
Beiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine, 1994
The authors discuss the quality control criteria for autologous blood donations. They recommend t... more The authors discuss the quality control criteria for autologous blood donations. They recommend that all autologous donations be tested for serological markers of blood-transmissible diseases. Marker-positive donors should not donate autologous blood. If autologous donation seems indispensable, infectious donations should be clearly marked as infectious.
Deutsche medizinische Wochenschrift (1946), Jan 16, 1987
Since 1985 all donor blood in the Federal Republic of Germany (FRG) and West Berlin (WB) have bee... more Since 1985 all donor blood in the Federal Republic of Germany (FRG) and West Berlin (WB) have been routinely tested for HIV antibodies. The blood donor services of the German and Bavarian Red Cross have pooled their anti-HIV test data for the first year of operation (July 1985-June 1986) to obtain information on the prevalence of HIV antibodies in blood donors and in donated blood. Of 2.27 million units of blood, donated by 1.33 million donors, 218 were anti-HIV positive in the Western Blot Test, i.e. a prevalence rate of 10 per 100,000 donors. The prevalence was, as expected, higher in males than females. During the test period the anti-HIV prevalence fell, both as a total and in all subpopulations. In the second quarter of 1986 it had decreased to 6 per 100,000 donated units.
Deutsche medizinische Wochenschrift (1946), Jan 9, 1988
Of a total of 5.6 million blood donations by 1.6 million German Red Cross donors between July, 19... more Of a total of 5.6 million blood donations by 1.6 million German Red Cross donors between July, 1985 and December, 1987 tested for HIV antibodies 210 were found to be positive in at least one Western blot. Calculated per quarter, the prevalence (for first-time donors) of 10 per 100,000 in 1985 decreased to 4 per 100,000 in 1986, while the incidence (for multiple donors) was a constant 2 per 100,000 for each quarter in 1987. This indicates that new HIV infections were rare in blood donors and there was no exponential increase. Further analysis revealed that over 90% of those with confirmed Western blot positive results were members of risk groups or their direct contacts. The age and sex distribution conformed to the known pattern for AIDS cases in the Federal Republic of Germany. The data demonstrate that there is at present no indication of a rapid spread of HIV infections transmitted heterosexually among blood donors.
To examine the consistency and comparability of anti-hepatitis B core antigen (anti-HBcAg) assays... more To examine the consistency and comparability of anti-hepatitis B core antigen (anti-HBcAg) assays, four blood donation centers of the Red Cross in the Federal Republic of Germany tested 4,080 unselected blood donors with six different tests in parallel. Confirmation testing of reactive samples was done in the National Reference Center for Viral Hepatitis. Depending on the test kit used, 4.1 to 9.9% of serum samples were initially positive and 2.9 to 7.5% were repeatedly positive. Sixteen percent of serum samples were positive in at least one test but only three percent were positive in all six tests. Statistical analysis of frequency distribution of optical densities for each test suggested that there should be a correction of the cutoff values. This reduced the number of false-positive results by half, but a significant proportion of discrepant results could not be resolved. The lack of specificity and consistency requires cautious interpretation of isolated anti-HBcAg results in c...
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Papers by Gregor Caspari