Esther Granell

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Tracy Beck Fenwick

The Australian National University

Everita Silina

The New School University

Bruce Chapman

University of Toronto

David Seamon

Kansas State University

Fabio Cuzzolin

Oxford Brookes University

Joseph Raz

Columbia University

Nelson Mauro Maldonato

Università degli Studi di Napoli "Federico II"

Rory Smead

Northeastern University

Pedro Ponte e Sousa

Universidade Portucalense (UPT)

Rifat Latifi

The University of Arizona

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Papers by Esther Granell

Resolved heart tamponade and controlled exophthalmos, facial pain and diabetes insipidus due to Erdheim-Chester disease

BMJ Case Reports, 2018

A 69-year-old woman suffering from exophthalmos and facial pain came to us referred for aetiologi... more A 69-year-old woman suffering from exophthalmos and facial pain came to us referred for aetiological diagnosis of exophthalmos. Orbital MRI showed thinned extrinsic ocular musculature, intraconal fat infiltration, retro-ocular compression and thickening of maxillary and sphenoid sinus walls. She had been suffering from diabetes insipidus for the last 7 years. During our diagnosis process, she presented signs of cardiac tamponade. Transthoracic heart ultrasound revealed large pericardial effusion and a heterogeneous mass that compressed the right ventricle. No osteosclerotic lesions on appendicular bones were present. Pericardiocentesis temporarily controlled tamponade and corticoid therapy temporarily abated exophthalmos. Pericardiectomy definitively resolved tamponade. Histological examination of pericardial tissue was conclusive of Erdheim-Chester disease. Exophthalmos responded to pegylated interferon-alpha-2a. Facial bone pain disappeared after zoledronic acid and interferon tre...

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Automated scoring of collaterals, blood pressure, and clinical outcome after endovascular treatment in patients with acute ischemic stroke and large-vessel occlusion

Frontiers in Neurology

IntroductionWe aimed to determine whether the degree of collateral circulation is associated with... more IntroductionWe aimed to determine whether the degree of collateral circulation is associated with blood pressure at admission in acute ischemic stroke patients treated with endovascular treatment and to determine its prognostic value.MethodsWe evaluated patients with anterior large vessel occlusion treated with endovascular treatment in a single-center prospective registry. We collected clinical and radiological data. Automated and validated software (Brainomix Ltd., Oxford, UK) was used to generate the collateral score (CS) from the baseline single-phase CT angiography: 0, filling of ≤10% of the occluded MCA territory; 1, 11–50%; 2, 51–90%; 3, >90%. When dichotomized, we considered that CS was good (CS = 2–3), or poor (CS = 0–1). We performed bivariate and multivariable ordinal logistic regression analysis to predict CS categories in our population. The secondary outcome was to determine the influence of automated CS on functional outcome at 3 months. We defined favorable functi...

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Brain changes on 3T MR imaging and spectroscopy in fragile X premutation

Accuracy of bilateral inferior petrosal sinus sampling in Cushing's syndrome

Transcranial Duplex Sonography Predicts Outcome following an Intracerebral Hemorrhage

American Journal of Neuroradiology, 2017

Several radiologic features such as hematoma volume are related to poor outcome following an intr... more Several radiologic features such as hematoma volume are related to poor outcome following an intracerebral hemorrhage and can be measured with transcranial duplex sonography. We sought to determine the prognostic value of transcranial duplex sonography in patients with intracerebral hemorrhage. We conducted a prospective study of patients diagnosed with spontaneous intracerebral hemorrhage. Transcranial duplex sonography examinations were performed within 2 hours of baseline CT, and we recorded the following variables: hematoma volume, midline shift, third ventricle and lateral ventricle diameters, and the pulsatility index in both MCAs. We correlated these data with the CT scans and assessed the prognostic value of the transcranial duplex sonography measurements. We assessed early neurologic deterioration during hospitalization and mortality at 1-month follow-up. We included 35 patients with a mean age of 72.2 Ϯ 12.8 years. Median baseline hematoma volume was 9.85 mL (interquartile range, 2.74 -68.29 mL). We found good agreement and excellent correlation between transcranial duplex sonography and CT when measuring hematoma volume (r ϭ 0.791; P Ͻ .001) and midline shift (r ϭ 0.827; P Ͻ .001). The logistic regression analysis with transcranial duplex sonography measurements showed that hematoma volume was an independent predictor of early neurologic deterioration (OR, 1.078; 95% CI, 1.023-1.135) and mortality (OR, 1.089; 95% CI, 1.020 -1.160). A second regression analysis with CT variables also demonstrated that hematoma volume was associated with early neurologic deterioration and mortality. When we compared the rating operation curves of both models, their predictive power was similar. Transcranial duplex sonography showed an excellent correlation with CT in assessing hematoma volume and midline shift in patients with intracerebral hemorrhage. Hematoma volume measured with transcranial duplex sonography was an independent predictor of poor outcome. END ϭ early neurologic deterioration; HV ϭ hematoma volume; ICH ϭ intracerebral hemorrhage; IQR ϭ interquartile range; LV ϭ lateral ventricle; MLS ϭ midline shift; IIIV ϭ third ventricle; TDS ϭ transcranial duplex sonography S pontaneous intracerebral hemorrhage (ICH) is a major cause of morbidity and mortality, 1 with half of the events related to case fatality occurring within the first 48 hours. 2 Thus, identifying variables that contribute to early neurologic deterioration (END) and mortality is of enormous importance. An early estimation of the prognosis is crucial for deciding on a treatment plan. Several neuroimaging prognostic factors include hematoma volume (HV), hematoma enlargement, midline shift (MLS), and intraventricular hemorrhage, and CT is the technique most frequently used to assess them. However, in the early stages, it can be difficult to monitor these radiologic features with repeat CT due to the clinical and/or hemodynamic state of the patient and the risk of radiation overexposure. Transcranial duplex sonography (TDS) is a noninvasive technique that provides simultaneous 2D imaging of brain parenchyma and hemodynamic information from the main cerebral arteries. The role of TDS is well-established in the assessment of ischemic stroke, but its usefulness in acute ICH has been reported in only a few studies. Visualization of acute ICH with TDS is feasible: The ICH can be identified as a hyperechoic mass. Additionally, TDS allows

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Depression and Anxiety Scores Are Associated with Amygdala Volume in Cushing's Syndrome: Preliminary Study

Introduction. Cushing's syndrome (CS) has repeatedly been associated with hippocampal volume... more Introduction. Cushing's syndrome (CS) has repeatedly been associated with hippocampal volume reductions, while little information is available on the amygdala, another structure rich in glucocorticoid receptors. The aim of the study was to analyze amygdala volume in patients with CS and its relationship with anxiety, depression, and hormone levels. Material and Methods. 39 CS patients (16 active and 23 patients in remission) and 39 healthy controls matched for age, sex, and education level completed anxiety (STAI) and depression tests (BDI-II) and underwent a 3 Tesla brain MRI and endocrine testing. Amygdala volumes were analysed with FreeSurfer software. Results. Active CS patients had smaller right (but not left) amygdala volumes when compared to controls ( = 0.045). Left amygdala volumes negatively correlated with depression scores ( = −0.692, = 0.003) and current anxiety state scores ( = −0.617, = 0.011) in active CS patients and with anxiety trait scores ( = −0.440, = 0.03...

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Trigeminal neuralgia: causes and MR findings

Poster: "ECR 2013 / C-2035 / Trigeminal neuralgia: causes and MR findings " by: " ... more

Decreased cortical thickness on MRI in patients with Cushing's syndrome: preliminary experience

Traumatismo cráneo-espinal infantil

Poster: "SERAM 2012 / S-0892 / Traumatismo craneo-espinal infantil" by: "N. Soria,... more

Utilidad de la susceptibilidad magnética en el diagnóstico de la patología cortical cerebral

Poster: "SERAM 2012 / S-1111 / Utilidad de la susceptibilidad magnetica en el diagnostico de... more

Pacientes con primeros episodios psicóticos: estudio de volumetría cerebral mediante RM 3T

Poster: "SERAM 2014 / S-1120 / Pacientes con primeros episodios psicoticos: estudio de volum... more Poster: "SERAM 2014 / S-1120 / Pacientes con primeros episodios psicoticos: estudio de volumetria cerebral mediante RM 3T. " by: "F. Nunez Marin1, E. Granell 1, Y. Vives Gilabert2, A. Alonso Solis2, I. Corripio Collado1, B. Gomez-Anson1; 1Barcelona/ES, 2Cerdanyola del Valles/ES"

Imagen radiológica del oído medio e interno operado y sus complicaciones. Que debemos saber

Poster: "SERAM 2012 / S-1564 / “Imagen radiologica del oido medio e interno operado y sus co... more

Alteraciones en la sustancia blanca cerebral (RM-Difusion tensorial) en pacientes con dolor agudo y crónico

Poster: "SERAM 2012 / S-0755 / Alteraciones en la sustancia blanca cerebral (RM-Difusion ten... more

Imaging of lymphomas of the head and neck

Poster: "ECR 2013 / C-2051 / Imaging of lymphomas of the head and neck " by: " G. ... more

La disrupción tálamo-cortical en pacientes con dolor crónico neuropático: Estudio RM estructural, espectroscópico, difusión tensorial y funcional en reposo

Poster: "SERAM 2014 / S-0425 / La disrupcion talamo-cortical en pacientes con dolor cronico ... more Poster: "SERAM 2014 / S-0425 / La disrupcion talamo-cortical en pacientes con dolor cronico neuropatico: Estudio RM estructural, espectroscopico, difusion tensorial y funcional en reposo." by: "E. Granell1, F. Nunez Marin1, M. Genove Cortada1, Y. Vives Gilabert2, E. Catala Puigbo1, B. Gomez-Anson1; 1Barcelona/ES, 2Cerdanyola del Valles/ES"

Abstract 2276: Microhemorrhage Burden Increases the Risk of Hematoma Growth in Patients with Intracerebral Hemorrhage

Stroke, 2012

Introduction Microhemorrhages (MH) are lesions detected on radiological studies resulting from an... more

Characteristics of gliobastomas (GBM) not resected (only biopsied) homogeneosuly treated with Stupp regimen. Results from the GLIOCAT study

Annals of Oncology

P16.04 Practical application of intraoperative tractography on awake brain surgery

Neuro-Oncology

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Isolated Propriospinal Myoclonus as a Presentation of Cervical Myelopathy

Tremor and Other Hyperkinetic Movements

Validation of the pathological classification of lymph node metastasis for head and neck tumors (HNSCC) according to the 8th edition of the TNM Classification of Malignant Tumors (8th TNM)

Journal of Clinical Oncology

6014 Background: Changes in 8th TNM edition are a specific staging for p16+oropharyngeal carcinom... more 6014 Background: Changes in 8th TNM edition are a specific staging for p16+oropharyngeal carcinoma and the inclusion of extracapsular spread (ECS) in N extension. We evaluate the improvement in prognostic capacity from the inclusion of the ECS in HNSCC patients treated with a neck dissection (ND). Methods: Retrospective study based on prospectively collected information of 1188 HNSCC patients (oral cavity, HPV-oropharynx, hypopharynx, or larynx) diagnosed from 1990 to 2013, treated with unilateral or bilateral ND and a minimum fw-up of 2 years. We performed 1820 ND: 410 radical, 1410 selective ND; 683 patients (60.1%) had bilateral ND. Mean lymph nodes/patient: 32.6 (SD 19.9, 7-118). In 157 cases (13.8%) ND was performed after radiotherapy (RT, n =71) or chemoradiotherapy (CHRT, n = 86) with a median interval of 8.5 weeks (6-10). 596 patients (52.4%) had postoperative RT (n=525) or CHRT (n=71). Mean fw-up: 5.6 years (SD 4.9): 213 patients (18.7%) had local failure, 158 (13.9%) regio...