Papers by Gabriela Trentin Scortegagna
Anestesicos locais, contendo ou nao vasoconstritores, sao utilizados para realizacao da grande ma... more Anestesicos locais, contendo ou nao vasoconstritores, sao utilizados para realizacao da grande maioria dos procedimentos em odontologia. Porem, o uso de forma inadequada pode levar a serios riscos para a saude do paciente, principalmente se este possuir alguma alteracao sistemica. O objetivo do presente estudo foi avaliar o nivel de conhecimento dos cirurgioes dentistas com relacao a utilizacao de anestesicos locais, frente a pacientes especiais com diabetes, hipertensao, cardiopatias, gestantes e com hipertireoidismo. O estudo teve um delineamento quantitativo do tipo transversal e os dados foram coletados atraves de um questionario adaptado pela equipe como unico instrumento para coleta de dados. Os dados foram submetidos a uma analise estatistica descritiva. Do total de 200 participantes, 53% nao possuiam especializacao e 47% eram especialistas, a maioria tinha de 1 a 5 anos de formados (34%), 6 a 10 anos de formados (16%) ou eram academicos do ultimo ano do curso de odontologia ...
Full Dentistry in Science
Clinical immunology (Orlando, Fla.), Aug 15, 2016
High dose immunosuppression followed by autologous hematopoietic stem cell transplantation (AHSCT... more High dose immunosuppression followed by autologous hematopoietic stem cell transplantation (AHSCT) induces prolonged clinical remission in multiple sclerosis (MS) patients. However, how patient immune profiles are associated with clinical outcomes has not yet been completely elucidated. In this study, 37 MS patients were assessed for neurological outcomes, thymic function and long-term immune reconstitution after AHSCT. Patients were followed for a mean (SD) of 68.5 (13.9) months post-transplantation and were retrospectively clustered into progression- and non-progression groups, based on Expanded Disease Status Scale (EDSS) outcomes at last visit. After AHSCT, both patient groups presented increased regulatory T-cell subset counts, early expansion of central- and effector-memory CD8(+)T-cells and late thymic reactivation. However, the non-progression group presented early expansion of PD-1-expressing CD8(+)T-cells. Here, we suggest that along with increased numbers of regulatory T-...
Frontiers in immunology, 2017
Autologous hematopoietic stem cell transplantation (AHSCT) increases C-peptide levels and induces... more Autologous hematopoietic stem cell transplantation (AHSCT) increases C-peptide levels and induces insulin independence in patients with type 1 diabetes. This study aimed to investigate how clinical outcomes may associate with the immunological status, especially concerning the balance between immunoregulation and autoreactivity. Twenty-one type 1 diabetes patients were monitored after AHSCT and assessed every 6 months for duration of insulin independence, C-peptide levels, frequencies of islet-specific autoreactive CD8(+) T cells (CTL), regulatory lymphocyte subsets, thymic function, and T-cell repertoire diversity. In median follow-up of 78 (range 15-106) months, all patients became insulin-independent, resuming insulin after median of 43 (range 6-100) months. Patients were retrospectively divided into short- or prolonged-remission groups, according to duration of insulin independence. For the entire follow-up, CD3(+)CD4(+) T-cell numbers remained lower than baseline in both groups...
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Papers by Gabriela Trentin Scortegagna