Sixty-two adults with acute lymphoblastic leukaemia (ALL) were treated with a modified BFM regime... more Sixty-two adults with acute lymphoblastic leukaemia (ALL) were treated with a modified BFM regimen. Forty-two (70%) achieved complete remission (CR). Twenty-one percent of all evaluable patients and 32.4 percent of complete responders are in continuous complete remission (CCR) at a median follow-up of 41 months (range 24-81 months). Long-term survival was better in T- ALL (47.1%) when compared to precursor-B ALL (4.8%) (P < 0.04).
Sixty-two adults with acute lymphoblastic leukaemia (ALL) were treated with a modified BFM regime... more Sixty-two adults with acute lymphoblastic leukaemia (ALL) were treated with a modified BFM regimen. Forty-two (70%) achieved complete remission (CR). Twenty-one percent of all evaluable patients and 32.4 percent of complete responders are in continuous complete remission (CCR) at a median follow-up of 41 months (range 24-81 months). Long-term survival was better in T- ALL (47.1%) when compared to precursor-B ALL (4.8%) (P < 0.04).
The Journal of the Association of Physicians of India, 1993
A short course of ciprofloxacin, 750 mgm b.i.d. for 7 days was found to be effective in the treat... more A short course of ciprofloxacin, 750 mgm b.i.d. for 7 days was found to be effective in the treatment of enteric fever in 21 hospitalized patients with S.typhi (18) and S.paratyphi A(3). Median time for fever response was 3 days. All isolates were susceptible to ciprofloxacin (MIC 0.0078-0.062 mcgm/ml). The mean serum peak and trough levels were 5.4 and 1.6 mcgm/ml respectively. Stool cultures were free of Salmonellae on follow up (11-24 weeks). Two developed recurrence of paratyphoid fever, 17 days and 4 months after therapy.
Our objective was to evaluate the incidence of aneurysm and the frequency of thrombus within an a... more Our objective was to evaluate the incidence of aneurysm and the frequency of thrombus within an aneurysm on unenhanced (18)F-FDG PET/CT studies. We reviewed 1,540 PET/CT scans from 926 patients. A log recorded whether each case of aneurysm had a suspected thrombus. The maximal standardized uptake value of the patent vessel was compared with the thrombus. Findings were confirmed using all available follow-up data. Aneurysm was found incidentally in 16 (1.7%) of the 926 patients, with 15 occurring in the abdominal aorta and 1 in the internal jugular vein. Seven of these 16 patients had shown suggestions of thrombus on unenhanced PET/CT, and in all 7, thrombi were confirmed on contrast-enhanced CT. In 1.7% of patients, aneurysm was found incidentally on PET/CT, and thrombus was present in 44% of these cases.
Dissection of a renal artery is rare and is usually associated with underlying arterial disease. ... more Dissection of a renal artery is rare and is usually associated with underlying arterial disease. Bilateral renal artery dissection following extreme exertion is exceptionally uncommon, and thus presents a diagnostic challenge. We report a case of a middle-aged, otherwise healthy man who presented to the hospital with left flank pain after a long bicycling trip. Initial laboratory tests and urinalysis were normal. Careful review of a contrast-enhanced computed tomography angiogram (CTA) with 3D reconstruction revealed bilateral segmental renal artery dissection and thrombosis with corresponding renal infarcts. He was treated medically and rapidly recovered.
We present the case of a 42-year-old woman with myotonic dystrophy and thymoma. She was treated w... more We present the case of a 42-year-old woman with myotonic dystrophy and thymoma. She was treated with combination chemotherapy followed by external beam radiation, and remains in remission 19 months after thymoma was diagnosed. The myotonic dystrophy is unchanged. Only six cases of this nature have been reported in the literature, and this patient is the first to be successfully treated with combined modality therapy.
The American Journal of the Medical Sciences, Jan 6, 2012
Portopulmonary hypertension (POPH) is a not infrequent but serious complication of liver cirrhosi... more Portopulmonary hypertension (POPH) is a not infrequent but serious complication of liver cirrhosis. Continuous intravenous epoprostenol infusion is a treatment option for this condition. Progressive splenomegaly with pancytopenia (hypersplenism) is associated with epoprostenol use in POPH. After recognizing a case of epoprostenol-induced hypersplenism that resolved upon stopping the drug, the authors retrospectively reviewed all patients treated with epoprostenol at the center for both POPH and pulmonary hypertension due to other causes. Five of 11 patients with POPH developed hypersplenism secondary to epoprostenol. In 1 patient, and possibly in a second, the hypersplenism resolved upon discontinuation of epoprostenol. None of 9 patients with pulmonary hypertension due to other causes developed splenomegaly. This report confirms hypersplenism as a complication of epoprostenol therapy for POPH. Furthermore, the authors demonstrate for the first time that hypersplenism may be reversed by stopping the medication and propose a mechanism for this phenomenon.
Sixty-two adults with acute lymphoblastic leukaemia (ALL) were treated with a modified BFM regime... more Sixty-two adults with acute lymphoblastic leukaemia (ALL) were treated with a modified BFM regimen. Forty-two (70%) achieved complete remission (CR). Twenty-one percent of all evaluable patients and 32.4 percent of complete responders are in continuous complete remission (CCR) at a median follow-up of 41 months (range 24-81 months). Long-term survival was better in T- ALL (47.1%) when compared to precursor-B ALL (4.8%) (P &lt; 0.04).
Sixty-two adults with acute lymphoblastic leukaemia (ALL) were treated with a modified BFM regime... more Sixty-two adults with acute lymphoblastic leukaemia (ALL) were treated with a modified BFM regimen. Forty-two (70%) achieved complete remission (CR). Twenty-one percent of all evaluable patients and 32.4 percent of complete responders are in continuous complete remission (CCR) at a median follow-up of 41 months (range 24-81 months). Long-term survival was better in T- ALL (47.1%) when compared to precursor-B ALL (4.8%) (P < 0.04).
The Journal of the Association of Physicians of India, 1993
A short course of ciprofloxacin, 750 mgm b.i.d. for 7 days was found to be effective in the treat... more A short course of ciprofloxacin, 750 mgm b.i.d. for 7 days was found to be effective in the treatment of enteric fever in 21 hospitalized patients with S.typhi (18) and S.paratyphi A(3). Median time for fever response was 3 days. All isolates were susceptible to ciprofloxacin (MIC 0.0078-0.062 mcgm/ml). The mean serum peak and trough levels were 5.4 and 1.6 mcgm/ml respectively. Stool cultures were free of Salmonellae on follow up (11-24 weeks). Two developed recurrence of paratyphoid fever, 17 days and 4 months after therapy.
Our objective was to evaluate the incidence of aneurysm and the frequency of thrombus within an a... more Our objective was to evaluate the incidence of aneurysm and the frequency of thrombus within an aneurysm on unenhanced (18)F-FDG PET/CT studies. We reviewed 1,540 PET/CT scans from 926 patients. A log recorded whether each case of aneurysm had a suspected thrombus. The maximal standardized uptake value of the patent vessel was compared with the thrombus. Findings were confirmed using all available follow-up data. Aneurysm was found incidentally in 16 (1.7%) of the 926 patients, with 15 occurring in the abdominal aorta and 1 in the internal jugular vein. Seven of these 16 patients had shown suggestions of thrombus on unenhanced PET/CT, and in all 7, thrombi were confirmed on contrast-enhanced CT. In 1.7% of patients, aneurysm was found incidentally on PET/CT, and thrombus was present in 44% of these cases.
Dissection of a renal artery is rare and is usually associated with underlying arterial disease. ... more Dissection of a renal artery is rare and is usually associated with underlying arterial disease. Bilateral renal artery dissection following extreme exertion is exceptionally uncommon, and thus presents a diagnostic challenge. We report a case of a middle-aged, otherwise healthy man who presented to the hospital with left flank pain after a long bicycling trip. Initial laboratory tests and urinalysis were normal. Careful review of a contrast-enhanced computed tomography angiogram (CTA) with 3D reconstruction revealed bilateral segmental renal artery dissection and thrombosis with corresponding renal infarcts. He was treated medically and rapidly recovered.
We present the case of a 42-year-old woman with myotonic dystrophy and thymoma. She was treated w... more We present the case of a 42-year-old woman with myotonic dystrophy and thymoma. She was treated with combination chemotherapy followed by external beam radiation, and remains in remission 19 months after thymoma was diagnosed. The myotonic dystrophy is unchanged. Only six cases of this nature have been reported in the literature, and this patient is the first to be successfully treated with combined modality therapy.
The American Journal of the Medical Sciences, Jan 6, 2012
Portopulmonary hypertension (POPH) is a not infrequent but serious complication of liver cirrhosi... more Portopulmonary hypertension (POPH) is a not infrequent but serious complication of liver cirrhosis. Continuous intravenous epoprostenol infusion is a treatment option for this condition. Progressive splenomegaly with pancytopenia (hypersplenism) is associated with epoprostenol use in POPH. After recognizing a case of epoprostenol-induced hypersplenism that resolved upon stopping the drug, the authors retrospectively reviewed all patients treated with epoprostenol at the center for both POPH and pulmonary hypertension due to other causes. Five of 11 patients with POPH developed hypersplenism secondary to epoprostenol. In 1 patient, and possibly in a second, the hypersplenism resolved upon discontinuation of epoprostenol. None of 9 patients with pulmonary hypertension due to other causes developed splenomegaly. This report confirms hypersplenism as a complication of epoprostenol therapy for POPH. Furthermore, the authors demonstrate for the first time that hypersplenism may be reversed by stopping the medication and propose a mechanism for this phenomenon.
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Papers by G. Kudva