Papers by Gülbin Gökçay Gökçay
Tuberculin Skin Test in Children, 2013
Çocukların sağlıklı büyümesinde en önemli unsurlardan biri, bebeklerin emzirilmesidir. Emzirme da... more Çocukların sağlıklı büyümesinde en önemli unsurlardan biri, bebeklerin emzirilmesidir. Emzirme danışmanlığı başarılı emzirmenin sağlanmasında önemli rol oynar. Bu araştırmada ailelerin bir emzirme danışmanlığı birimine başvurma nedenleri ve sonuçları irdelenmiştir. Gereç ve Yöntemler: Bir emzirme danışmanlığı birimine başvuran 90 anne ve bebeğe ait dosya retrospektif olarak değerlendirildi. Doğum kliniğinde doğum yapan annelere haftada 2 gün hizmet veren bu birim hakkında bilgi verilmekte, gerektiğinde başvurabilecekleri belirtilmekteydi. Her başvuru sırasında doldurulan emzirme danışmanlığı formları incelenerek anne ve bebeklerin bazı özellikleri, emzirme danışmanlığı alma nedenleri, emzirme danışmanlığında saptanan sorunlar ve öneriler değerlendirildi.
Journal of Clinical Research in Pediatric Endocrinology, 2022
What is already known on this topic? Incorporation of WHO standards into pediatric practice has b... more What is already known on this topic? Incorporation of WHO standards into pediatric practice has been the subject of debate in many countries, particularly those using national reference data for child growth assessment. What this study adds? WHO growth standards do not reflect the growth of Turkish children and may substantially alter the prevalence of short stature and underweight in 0-5 years of age.
Türk çocuklarında vücut ağırlığı, boy uzunluğu, baş çevresi ve vücut kitle indeksi referans değerleri
Çocuk Sağlığı ve …, 2008
Page 1. Çocuk Sağlığı ve Hastalıkları Dergisi 2008; 51: 1-14 Orijinal Makale Türk çocuklarında vü... more Page 1. Çocuk Sağlığı ve Hastalıkları Dergisi 2008; 51: 1-14 Orijinal Makale Türk çocuklarında vücut ağırlığı, boy uzunluğu, baş çevresi ve vücut kitle indeksi referans değerleri Olcay Neyzi1, Hülya Günöz2, Andrzej Furman3 ...
Pediatric Research, 2017
BACKGROUND: In this study, we examined the hypothesis that weight gain and linear growth during t... more BACKGROUND: In this study, we examined the hypothesis that weight gain and linear growth during the first years of life influence the onset of puberty both in girls and in boys. METHODS: A cohort of 157 healthy children, aged 6-9 years, was evaluated and their growth patterns were analyzed retrospectively. Repeated measures mixed model was used to examine the longitudinal anthropometric data. RESULTS: Girls with pubertal signs were heavier than their peers starting at 9 months of age (P = 0.02), and the difference became more evident over time (Po0.001). Accelerated weight gain between 6 and 15 months of age was found to increase the odds of having a pubertal sign at the study visit (odds ratio (OR) = 34.5) after adjusting for birth weight, gestational age and current age, height, weight, and BMI (P = 0.004). Anthropometric indices of boys with or without pubertal signs were not significantly different at the study visit, but boys with accelerated height gain between 9 and 15 months of age were more likely to have pubertal signs (OR = 15.8) after adjusting for birth weight, gestational age and current age, height, weight, and BMI (P = 0.016). CONCLUSION: Early growth acceleration might be important for the timing of puberty in both genders.
European Journal of Endocrinology, 2008
BackgroundGhrelin, the natural ligand of the GH secretagogue receptor, has potent orexigenic effe... more BackgroundGhrelin, the natural ligand of the GH secretagogue receptor, has potent orexigenic effect. Ghrelin levels are negatively associated with insulin secretion, increased in anorexia, and reduced in obesity. Increased ghrelin levels may be associated with early postnatal growth in preterm born children.ObjectiveAim of this study was to evaluate ghrelin and insulin levels at prepubertal ages in preterm born children born appropriate for gestational age (AGA) or small for gestational age (SGA) and relationships with catch-up growth (CUG) in a prospective cross-sectional study.MethodsEighty-four preterm born children grouped as preterm SGA (n=28) and preterm AGA (n=56) were evaluated at age 4.7±0.2 and 4.7±0.1 years with respect to their ghrelin and insulin levels. Their data were compared with that of body mass index matched term SGA (n=35) and term AGA (n=44) children of age 4.6±0.2 and 3.8±0.1 years. All children had height appropriate for their target height. CUG was defined a...
European Journal of Endocrinology, 2009
BackgroundGhrelin is the natural ligand of GH secretagogue receptor. It has several metabolic fun... more BackgroundGhrelin is the natural ligand of GH secretagogue receptor. It has several metabolic functions including regulation of food intake, energy homeostasis, and body weight. An inverse relationship between fasting plasma ghrelin and insulin concentrations has been shown. Being born large for gestational age (LGA) has an increased risk of developing insulin resistance.ObjectiveThe aim of this study was to evaluate ghrelin levels in LGA born children who have no obesity at prepubertal ages and the effect of intrauterine and postnatal growth on ghrelin levels.Patients and methodsThirty-two (17F, 15M) LGA born non-obese children (mean (±s.e.m.) age 4.4±0.3 years) were evaluated with respect to glucose, insulin, and ghrelin levels. Their data were compared with that of non-obese 45 (19F, 26M) appropriate for gestational age (AGA) children (mean (±s.e.m.) age 4.0±0.1 years).ResultsLGA children, who had similar age and body mass index (BMI) standard deviation score (SDS) as AGA childre...
Clinical Endocrinology, 2009
Background and objective Being born as large for gestational age (LGA) has an increased risk of d... more Background and objective Being born as large for gestational age (LGA) has an increased risk of developing insulin resistance. Hypoadiponectinaemia is associated with insulin resistance. The aim of this study was to evaluate adiponectin levels and insulin resistance in association with body composition in LGA born non-obese children at prepubertal ages. Patients and methods Thirty-five (17 female and 18 male) LGA born non-obese children (mean age 4•8 ± 0•3 years) were evaluated with respect to glucose, insulin, IGFBP-1, leptin, adiponectin levels and body composition by DEXA. Their data were compared to that of non-obese 49 (20 female, 29 male) appropriate for gestational age (AGA) children (mean age 3•8 ± 0•1 year). Results LGA children, who had similar body mass index standard deviation scores (BMI SDS) as AGA children, had significantly higher insulin (P = 0•043) and statistically borderline significant homeostasis model assessment-insulin resistance (HOMA-IR) levels (P = 0•054) than those of AGA children. Adiponectin levels were significantly lower in LGA than AGA children (P = 0•004) even after controlling for age, sex and BMI (P = 0•016). IGFBP-1, leptin levels and body composition did not show a difference. When the LGA group was divided into subgroups according to birth weight, the analysis revealed that after controlling for BMI, being an LGA and having a higher birth weight in the upper half were associated with lower adiponectin levels (estimated marginal means of logarithmic adiponectin levels 2•6 ± 0•2 vs. 2•1 ± 0•2 μ g/ml, P = 0•042). Conclusion LGA children have higher insulin and lower adiponectin levels than AGA children in spite of similar BMI. Adiponectin is a better indicator of insulin resistance in LGA children at prepubertal ages and is affected by birth weight.
Clinical Endocrinology, 2008
SummaryBackground Premature born children may show insulin resistance in childhood which may be ... more SummaryBackground Premature born children may show insulin resistance in childhood which may be due to intrauterine or postnatal adverse environmental factors.Objective Aim of this study was to evaluate insulin resistance and body composition in preterm born children born appropriate for gestational age (AGA) or small for gestational age (SGA) and relations with IGF‐I, IGFBP‐3 axis.Methods Ninety‐three preterm born children grouped as premature SGA (n = 30) and premature AGA (n = 63) were evaluated at age 4·6 ± 0·2 years and 4·7 ± 0·1 years with respect to their glucose, insulin, IGF‐I, IGFBP‐3, IGFBP‐1, leptin levels and body composition by dual‐energy X‐ray absorptiometry. Their data were compared to that of body mass index (BMI) matched term SGA (n = 42) and term AGA (n = 44) children of age 4·5 ± 0·2 and 3·8 ± 0·1 years. All children had height appropriate for their target height. Insulin resistance was evaluated by basal insulin and homeostasis model assessment for insulin r...
Clinical Endocrinology, 2008
SummaryBackground Being small for gestational age (SGA) at birth and postnatal growth pattern ma... more SummaryBackground Being small for gestational age (SGA) at birth and postnatal growth pattern may have an impact on insulin resistance and body composition in later life. Adiponectin is a strong determinant of insulin sensitivity.Objective The aim of this study was to evaluate insulin resistance and adiponectin levels in SGA born children with catch‐up growth (CUG) in the absence of obesity in prepubertal ages and relations with body composition and insulin‐like growth factor binding protein (IGFBP)‐1.Methods Twenty‐four (15F, 9M) SGA born children with CUG but without obesity were evaluated at age 6·3 ± 0·5 years with respect to glucose, insulin, IGFBP‐1, leptin and adiponectin levels, and body composition by dual‐energy X‐ray absorptiometry (DEXA). Their data were compared to that of 62 (27F, 35M) appropriate for gestational age (AGA) children.Results SGA and AGA children had similar height standard deviation score (SDS) corrected for parental height and body mass index (BMI) ...
Haemophilus influenzae type b carriage among 3- to 24-month-old Turkish children
Epidemiology and Infection, 2005
OSMANGAZİ JOURNAL OF MEDICINE, 2020
Özet: Bu çalışmada çocuk onkoloji servisinde solid organ malignitesi tanısı ile takip edilmiş ola... more Özet: Bu çalışmada çocuk onkoloji servisinde solid organ malignitesi tanısı ile takip edilmiş olan hastaların kemoterapi öncesi ve sonrası hepatit b virusu (HBV) ve varisella zoster virusu (VZV) serolojilerinin değerlendirilme oranları, antikor yanıtlarının tedavi sonrası değişip değişmediğinin saptanması ve buna neden olabilecek faktörlerin araştırılması amaçlanmıştır. Çalışmamızda Mart 2016-Nisan 2019 tarihleri arasında çocuk onkoloji servisinde solid organ malignitesi tanısı ile takip edilen ve kemoterapi almış olan hastaların dosyaları geriye dönük olarak değerlendirilmiştir. Çocukluk çağı kanseri (lösemi dışı) nedeni ile takip edilmiş olan 75 hastanın 24'ü (%32) kız idi. Anti Hbs antikoru bakılan 70 hastanın 44'ünde (%58.6) anti Hbs pozitif, anti VZV antikoru bakılan 62 hastadan, 48'inde (%64) anti VZV pozitif idi. Kemoterapi öncesi anti Hbs pozitif olan 44 hastanın 8'inde (%18.1) kemoterapi sonrası anti Hbs negatifleşmiştir. Kemoterapi öncesi anti VZV pozitif saptanan 48 hastanın 4'ünde (%8.3) kemoterapi sonrası anti VZV negatifleşmiştir. Tek doz suçiçeği aşı yanıtının kemoterapi sonrası kaybolma oranı, doğal yol ile gelişmiş antikor yanıtının negatifleşme oranından daha yüksek saptanmıştır. Daha önce bu iki durumu karşılaştıran çalışma olmadığı için verilerimiz yol gösterici olabilir. Pürin analoğu, siklofosfamid, steroid kullanımı ve hastalık evresi ile anti HBs ve anti VZV serolojilerinin negatifleşmesi arasında ilişki saptanmamıştır. Onkoloji hastalarının tedavi öncesi ve sonrası bağışıklık durumlarının değerlendirilmesi konusunda daha geniş çaplı çalışmalara ihtiyaç vardır ve bu hastalar için rehberler oluşturulması uygun olacaktır.
Tuberculin skin test in children, 2015
Hareket bozuklukları çocukluk çağında birçok neden ile gelişebilen bir durum olup, ayırıcı tanıda... more Hareket bozuklukları çocukluk çağında birçok neden ile gelişebilen bir durum olup, ayırıcı tanıda yön gösterici bir fizik muayene bulgusu olabilmektedir. Özellikle stereotipik hareketleri fark edilip erken dönemde tedavi şansı yakalanan bireylerde tedavi süreçleri daha olumlu seyredebilmektedir. Bu makalede stereotipik hareketleri fark edilen ve ailevi davranışsal düzenlemeler ile düzelen gelişimsel koordinasyon bozukluğu ön tanılı bir sütçocuğu ele alınmıştır.
Beslenme bozuklukları ve çocuk
Perspective of Family, School System and Health Services in Enuresis
Indian pediatrics, 1994
A group of 245 well nourished infants with acute diarrhea were screened for carbohydrate malabsor... more A group of 245 well nourished infants with acute diarrhea were screened for carbohydrate malabsorption by evaluating stool pH and reducing substances in the stools. Carbohydrate malabsorption was diagnosed in 28 cases (11%). Clinical features of carbohydrate intolerance were present in only one case. The duration of diarrhea after admission ranged from 1 to 13 days (mean 3.9 days). An oral lactose tolerance test was consistent with lactase deficiency in 32% of all cases. Thin layer chromatography showed many carbohydrates including monosaccharides in the stools, indicating that the defect in intestinal absorption was not specific for lactose.
The Pediatric Infectious Disease Journal, 2003
Background. Despite high vaccination coverage, single dose measles immunization programs have bee... more Background. Despite high vaccination coverage, single dose measles immunization programs have been unsuccessful in eliminating the disease. Because seroconversion rates are lower in infants vaccinated before 12 months of age, a second dose of measles vaccine is recommended at 15 months. The aim of this study was to determine the seroconversion rates in children after the first and second doses of measles vaccinations at 9 and 15 months of age. Methods. Study population comprised 116 infants attending the Well Baby Clinic of Istanbul University, Faculty of Medicine. Serum speci
School Based Health Services Project In Turkey
ABSTRACT Abstract Book: 52.
Noro Psikiyatri Arsivi, 2016
Measuring head circumference is an easy, non-invasive, and inexpensive method to screen for norma... more Measuring head circumference is an easy, non-invasive, and inexpensive method to screen for normal growth and development (1). Head growth is more rapid in the first years of life; therefore, most head circumference growth charts have been produced for this time period. Head circumference reaches approximately 90% of the adult size at 3 years and 95% at 5 years of age (2). Head size may be an important predictor of the severity of neurological insults or degeneration and a significant predictor of brain volume in children aged more than 3 years (3,4). Thus, measuring head circumference and monitoring head growth after the age of 3 years is helpful for diagnosing neurologic disorders and various genetic syndromes (5). In Turkey, the current head circumference growth charts commonly used by Turkish clinicians are for children aged less than 36 months (6). Clinicians in Turkey who want to assess head circumference after the age of 36 months have to use growth charts produced in other countries, such as data from Nellhaus (7) or the United States head circumference reference data (5,8). Although some local studies have provided head circumference reference values, the maximum age of the children in these studies is 12 years (9,10,11). There is a need to assess the head circumference of Turkish children aged more than 12 years; this data would be especially useful to child neurologists. In this study, we aimed to develop head circumference growth references charts for age, height, and waist circumference in Turkish children aged 5-18 years. METHODS We aimed to develop percentiles of head circumference for age, height, and waist circumference for children aged between 5 and 18 years. A cross-sectional study was performed between 2010 and 2013 in İzmit, the administrative center of Kocaeli Province, Turkey. Kocaeli, which is situated east of İstanbul, is the most industrialized district in Turkey. Because of the job opportunities related to industrialization, the residents of Kocaeli are mostly migrants from other regions in Turkey. Therefore, the population pattern in Kocaeli is considered to be representative of that in Turkey (12).
Informed Parents- Safe Environment for Children
Çocuk Dergisi / Journal of Child
The Turkish Journal of Pediatrics
Background. The prevalence of obesity in childhood is increasing all over the world and the World... more Background. The prevalence of obesity in childhood is increasing all over the world and the World Health Organization (WHO) regards obesity as one of the most important public health problems. The aim of our study was to investigate the changes in body mass index (BMI) in children between 6 and 11 years of age and to evaluate the factors affecting this change in two different schools. Methods. We conducted a cross-sectional epidemiological study between January and March 2016 in two different schools. School age children from two different ages (6 and 11 years) participated in the study. Children's sociodemographic characteristics and daily habits were evaluated by a questionnaire. Weight, height, body fat ratio were measured. Results. Of all 495 students, 270 were in the 6-year old group. According to BMI classification 21.2% of students were overweight and 14.5% obese. From 6 to 11 years of age percentages of overweight and obese students increased slightly (1%). The mean daily screen time was high among overweight and obese students (p<0.05). The obesity rate (15.9%) was higher in public school, than in private school (6%). There was an obesogenic environment in the public school; sport facilities were limited, there was a canteen selling junk food and fizzy drink, but there was no free drinking water. Screen times of 11 year-old students were longer, and regular breakfast rates were lower than those of 6 year-old group (p<0.05). Conclusions. In our study prevalence of obesity was 14.5%, and overweight was 21.2%. According to our findings obesogenic environment seemed to be a contributing factor of obesity. Screen time should also be considered in attempts to prevent obesity.
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Papers by Gülbin Gökçay Gökçay