Domino liver transplantation (DLT) using grafts from patients with familial amyloidotic polyneuro... more Domino liver transplantation (DLT) using grafts from patients with familial amyloidotic polyneuropathy (FAP) is an established procedure at many transplantation centers. However, data evaluating the long-term outcome of DLT are limited. The aim of the present study was to analyze the risk of de novo polyneuropathy, possibly because of amyloidosis, and the patient survival after DLT. At our department, 28 DLT using FAP grafts were conducted between January 1997 and December 2005. One patient was twice subjected to DLT. Postoperative neurological monitoring of peripheral nerve function was performed with electroneurography (ENeG) in 20 cases. An ENeG index based on 12 parameters was calculated and correlated to age and/or height. Three patients developed ENeG signs of polyneuropathy 2-5 years after the DLT, but with no clinical symptoms. The 1-, 3-and 5-year actuarial patient survival in hepatocellular carcinoma (HCC) patients (n ¼ 12) and non-HCC patients (n ¼ 15) was 67%, 15%, 15% and 93%, 93%, 80%, respectively (P ¼ 0.001). Development of impaired nerve conduction in a proportion of patients may indicate that de novo amyloidosis occurs earlier than previously expected. Survival after DLT was excellent except in patients with advanced HCC.
Journal of Neurology, Neurosurgery & Psychiatry, 1998
Objective-This study was designed to establish whether a ratio of three units of Dysport ® is equ... more Objective-This study was designed to establish whether a ratio of three units of Dysport ® is equivalent to one unit of Botox ® for the treatment of cervical dystonia. Methods-Patients with predominantly rotational cervical dystonia, and a minimum of four previous Botox treatments, were randomised to receive either the clinically indicated dose of Botox or three times that dose in Dysport units. Study botulinum toxin was administered in a double blind fashion, to one or more clinically indicated muscles, at one or more sites per muscle. Patients returned for assessment two, four, eight, and 12 weeks after treatment.
Domino liver transplantation (DLT) using grafts from patients with familial amyloidotic polyneuro... more Domino liver transplantation (DLT) using grafts from patients with familial amyloidotic polyneuropathy (FAP) is an established procedure at many transplantation centers. However, data evaluating the long-term outcome of DLT are limited. The aim of the present study was to analyze the risk of de novo polyneuropathy, possibly because of amyloidosis, and the patient survival after DLT. At our department, 28 DLT using FAP grafts were conducted between January 1997 and December 2005. One patient was twice subjected to DLT. Postoperative neurological monitoring of peripheral nerve function was performed with electroneurography (ENeG) in 20 cases. An ENeG index based on 12 parameters was calculated and correlated to age and/or height. Three patients developed ENeG signs of polyneuropathy 2-5 years after the DLT, but with no clinical symptoms. The 1-, 3-and 5-year actuarial patient survival in hepatocellular carcinoma (HCC) patients (n ¼ 12) and non-HCC patients (n ¼ 15) was 67%, 15%, 15% and 93%, 93%, 80%, respectively (P ¼ 0.001). Development of impaired nerve conduction in a proportion of patients may indicate that de novo amyloidosis occurs earlier than previously expected. Survival after DLT was excellent except in patients with advanced HCC.
Journal of Neurology, Neurosurgery & Psychiatry, 1998
Objective-This study was designed to establish whether a ratio of three units of Dysport ® is equ... more Objective-This study was designed to establish whether a ratio of three units of Dysport ® is equivalent to one unit of Botox ® for the treatment of cervical dystonia. Methods-Patients with predominantly rotational cervical dystonia, and a minimum of four previous Botox treatments, were randomised to receive either the clinically indicated dose of Botox or three times that dose in Dysport units. Study botulinum toxin was administered in a double blind fashion, to one or more clinically indicated muscles, at one or more sites per muscle. Patients returned for assessment two, four, eight, and 12 weeks after treatment.
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