Papers by Gérardin Patrick
The American journal of tropical medicine and hygiene, 2002
Thrombocytopenia is a common finding in malaria, but its prognostic value has not been addressed ... more Thrombocytopenia is a common finding in malaria, but its prognostic value has not been addressed in children. The relationship between thrombocytopenia (platelet count < 100,000/mm3 on admission) and severity and outcome was investigated prospectively in children hospitalized with falciparum malaria in Dakar, Senegal, an area that is hypoendemic for malaria. Of 288 falciparum cases, 215 matched the 2000 World Health Organization definition of severe malaria. Median platelet counts were lower (98,000/mm3 versus 139,000/mm3; P < 0.02) among severe cases than in mild cases, and in children who died than among those who recovered (68,500/mm3 versus 109,000/mm3; P < 0.002). In severe cases, children presenting with a platelet count < 100,000/mm3 were more likely to die (odds ratio [OR] = 6.31, 95% confidence interval [CI] = 2.0-26.0). Moreover, multivariate analysis identified thrombocytopenia as an independent predictor of death (OR = 13.3, 95% CI = 3.2-55.1). Our data show ...
Revue d'Épidémiologie et de Santé Publique, 2008
Evaluation Au Senegal Du Devenir Des Enfants Transferes Pour Chirurgie Cardiaque
STUDY OF LONG-TERM OUTCOME IN SENEGALESE CHILDREN SENT ABROAD FOR CARDIAC SURGERY A B S T R ACTTh... more STUDY OF LONG-TERM OUTCOME IN SENEGALESE CHILDREN SENT ABROAD FOR CARDIAC SURGERY A B S T R ACTThe incidence of childhood heart disease in developing countries is high,but access to cardiac surge ry is limited. This mismat ch has given rise to nu m e rous humanitarian programs aimed at sending ch i l d ren ab road for surgical tre at m e n t . H owever little is ava i l able about the long-term outcome of these interventions. In 1999 we conducted a re t ro s p e c t ive study of 168 S e n egalese ch i l d ren undergoing fo l l ow-up at the Prinicipal Hospital in Dakar after being tra n s fe rred to Europe or the Ivo ry Coast for surgical tre atment thanks to the Te rre des Hommes A s s o c i ation. A total of 85 ch i l d ren presented congenital heart disease (CHD) and 83 presented acquired heart disease (AHD). Fifteen patients did not undergo surge ry due to either contra i n d i c ations or pre o- p e rat ive death. At the end of study,23 ch i l d ren had been lost to fo l l ow-up...
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2002
PLoS Medicine, 2008
An outbreak of chikungunya virus affected over one-third of the population of La Réunion Island b... more An outbreak of chikungunya virus affected over one-third of the population of La Réunion Island between March 2005 and December 2006. In June 2005, we identified the first case of mother-to-child chikungunya virus transmission at the Groupe Hospitalier Sud-Réunion level-3 maternity department. The goal of this prospective study was to characterize the epidemiological, clinical, biological, and radiological features and outcomes of all the cases of vertically transmitted chikungunya infections recorded at our institution during this outbreak.
Pediatric Critical Care Medicine, 2006
Journal of Antimicrobial Chemotherapy, 2014
Objectives: In British Columbia (BC), Canada, neuraminidase inhibitors (NIs) were publicly funded... more Objectives: In British Columbia (BC), Canada, neuraminidase inhibitors (NIs) were publicly funded during the 2009 A(H1N1)pdm09 pandemic for treatment of high-risk patients and/or anyone with moderate-to-severe illness. We assessed antiviral effectiveness (AVE) against hospitalization in that context.
Emerging Infectious Diseases, 2010
Mother-to-child transmission of chikungunya virus was reported during the 2005-2006 outbreak on R... more Mother-to-child transmission of chikungunya virus was reported during the 2005-2006 outbreak on Réunion Island, France. To determine the effects of this virus on pregnancy outcomes, we conducted a study of pregnant women in Réunion in 2006. The study population was composed of 1,400 pregnant women (628 uninfected, 658 infected during pregnancy, 27 infected before pregnancy, and 87 infected on unknown dates). We compared pregnancy outcomes for 655 (628 + 27) women not infected during pregnancy with 658 who were infected during pregnancy. Infection occurred during the fi rst trimester for 15% of the infected women, the second for 59%, and the third for 26%. Only hospital admission during pregnancy differed between infected and uninfected women (40% vs. 29%). Other outcomes (cesarean deliveries, obstetric hemorrhaging, preterm births, stillbirths after 22 weeks, birthweight, congenital malformations, and newborn admissions) were similar. This virus had no observable effect on pregnancy outcomes.
Revue d'Épidémiologie et de Santé Publique, 2010
Revue d'Épidémiologie et de Santé Publique, 2008
Chikungunya = alphavirus, famille des Togaviridae, proche des flavivirus de la dengue et du Wes... more Chikungunya = alphavirus, famille des Togaviridae, proche des flavivirus de la dengue et du West Nile, isolé pour la première fois en 1952 Avant l'épidémie de Chikungunya dans l'Océan Indien Circulation à l'état endémo-épidémique en Afrique, Inde, Asie du Sud -Est Taux d'attaque rapportés jusqu'à 80 -90% Ré -émergences possibles 7 à 20 après première apparition Une arbovirose tropicale « bénigne » un peu négligée Après l'épidémie de Chikungunya dans l'Océan Indien Une catastrophe sanitaire sans précédent dans un pays développé Meilleure connaissance sur le virus, ses vecteurs, et sur la maladie Un regard différent sur les arbovirus Une risque sanitaire émergent global très surveillé
Gynécologie Obstétrique & Fertilité, 2011
PLoS Neglected Tropical Diseases, 2014
Little is known about the neurocognitive outcome in children exposed to perinatal mother-to-child... more Little is known about the neurocognitive outcome in children exposed to perinatal mother-to-child Chikungunya virus (p-CHIKV) infection.
Gynécologie Obstétrique & Fertilité, 2011
This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.
Médecine et Maladies Infectieuses, 2008
Reçu le 13 juillet 2007 ; accepté le 21 janvier 2008 Disponible sur Internet le 18 avril 2008 Rés... more Reçu le 13 juillet 2007 ; accepté le 21 janvier 2008 Disponible sur Internet le 18 avril 2008 Résumé Objectifs. -Décrire l'incidence de l'infection bactérienne néonatale précoce (IBNP) dans le Sud-Réunion ; étudier l'application des critères de l'Anaes 2002. Patients et méthodes. -Analyse des données consécutives, recueillies du 1 er janvier 2001 au 31 décembre 2004 pour toutes les naissances vivantes du groupe hospitalier Sud-Réunion.
Revue d'Épidémiologie et de Santé Publique, 2008
PLoS ONE, 2011
Background: To date, there is little information that reflects the true extent of spread of the p... more Background: To date, there is little information that reflects the true extent of spread of the pH1N1/2009v influenza pandemic at the community level as infection often results in mild or no clinical symptoms. This study aimed at assessing through a prospective study, the attack rate of pH1N1/2009 virus in Reunion Island and risk factors of infection, during the 2009 season.
PLoS ONE, 2010
Background: Pregnant women have been identified as a group at risk, both for respiratory complica... more Background: Pregnant women have been identified as a group at risk, both for respiratory complications than for the admissions to the Intensive Care Unit (ICU) during the 2009 H1N1 influenza pandemic (pdm). The purpose of this prospective register-based cohort-study was to characterize the clinical virulence of the pdm (H1N1/09)v during pregnancy in La Réunion.
PLoS ONE, 2009
Background: Persistent symptoms, mainly joint and muscular pain and depression, have been reporte... more Background: Persistent symptoms, mainly joint and muscular pain and depression, have been reported several months after Chikungunya virus (CHIKV) infection. Their frequency and their impact on quality of life have not been compared with those of an unexposed population. In the present study, we aimed to describe the frequency of prolonged clinical manifestations of CHIKV infection and to measure the impact on quality of life and health care consumption in comparison with that of an unexposed population, more than one year after infection.
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Papers by Gérardin Patrick