Psychoanalysis is based on the principle that many factors guiding a person's feelings, think... more Psychoanalysis is based on the principle that many factors guiding a person's feelings, thinking, and action remain outside his or her conscious awareness. These unconscious emotional processes influence one's current relationships, work life, sense of self, and ability to feel pleasure. Recent reviews of neuroscientific work confirm that many of Freud's original observations, not least the pervasive influence of non‐ conscious processes and the organizing function of emotions for thinking, have found confirmation in laboratory studies The integration of psychoanalytic ideas with modern science is unlikely to interest investigators from other disciplines unless psychoanalysis can actually contribute to directing or to informing data collection in these disciplines. The isolation of psychoanalysis should be replaced by active collaboration with other mental health disciplines. The proposed reflection would like to stress the virtuous relationship between psychiatry and ps...
424 RIASSUNTO. Viene descritta la storia di una coppia di coniugi che hanno subito in età infanti... more 424 RIASSUNTO. Viene descritta la storia di una coppia di coniugi che hanno subito in età infantile ripetuti traumi fisici e psi-chici nel loro contesto familiare. La situazione della coppia si sostiene per alcuni anni su un equilibrio precario con frequen-ti litigi e aggressioni fisiche e si conclude drammaticamente con un tentato omicidio. Viene ricostruito in un setting di ascol-to psicoterapico a indirizzo psicoanalitico il quadro psicopatologico della donna, autrice dell'atto violento, e valorizzata l'im-portanza e l'impellenza pulsionale dei fantasmi transgenerazionali che l'hanno condotta a scegliere un partner complemen-tare e collusivo, a sua volta vittima di violenze familiari, e trovarsi, compulsivamente, ad agire l'atto omicidale mancato tra i suoi genitori. Viene discusso il caso alla luce dell'ipotesi della trasmissione dei fantasmi transgenerazionali e della psicopato-logia dell'impulso violento. PAROLE CHIAVE: violenze genitoriali, psicopa...
Cephalalgia : an international journal of headache, 1985
Platelet function in vitro and in vivo (ADP-induced platelet aggregation, circulating platelet ag... more Platelet function in vitro and in vivo (ADP-induced platelet aggregation, circulating platelet aggregates, beta-thromboglobulin plasma levels) has been studied in children with common migraine, in headache-free intervals. Migraine patients demonstrated increased circulating platelet aggregates when compared with controls. Moreover, two of ten patients had pathological beta-thromboglobulin levels. These data indicate that in some children with migraine there is an abnormality of platelet function during headache-free periods.
Cephalalgia : an international journal of headache, 1985
Successful migraine prophylaxis with flunarizine has been reported in adults by several authors. ... more Successful migraine prophylaxis with flunarizine has been reported in adults by several authors. We used flunarizine in a double-blind, placebo controlled, randomized trial in childhood migraine. Twenty-four children with classical or common migraine were followed by a 12-week flunarizine treatment period. Each patient took 5 mg/day of the drug before going to sleep. Twenty-four children with similar clinical characteristics were assigned to placebo treatment. Efficacy of flunarizine versus placebo was assessed on the basis of the reduction of headache frequency and duration. A statistical comparison was performed between values reported in the treatment period and those in the three months before. Children treated with flunarizine experienced a statistically significant reduction in headache (66%) and duration (51%). These results were statistically superior to those observed in the placebo group. Sixteen patients on flunarizine therapy experienced an improvement of more than 50% o...
Vertigo symptomatology associated with migraine is quite frequent. Its manifestations may precede... more Vertigo symptomatology associated with migraine is quite frequent. Its manifestations may precede, accompany or replace the algetic crises. Although several studies have been carried out in adults, lit- erature concerning migraine and vertigo in childhood is lacking. The aim of this paper was to assess hearing and balance functions in 25 children, suffering from common or classic migraine, during periods
Flunarizine was found to be effective in the acute treatment of isosorbide dinitrate induced migr... more Flunarizine was found to be effective in the acute treatment of isosorbide dinitrate induced migraine attacks, when given in a dosage of 10 mg sublingually. The present study consists of two parts: in the first preliminary investigation, 7 out of 8 migraine patients who developed a typical migraine attack after isosorbide dinitrate were relieved of pain within about 10 minutes. On the basis of this result a second, randomized controlled open trial was performed, in which the acute efficacy of flunarizine was compared with ergotamine tartrate, 0.25 mg i.m., on 40 migraine patients. Flunarizine was found as effective as ergotamine (75% positive responses in the flunarizine group, 70% in the ergotamine group). The mean latency of the flunarizine effect was significantly lower than that of the ergotamine (r< 0.001, Student's t test). Moreover sublingual flunarizine was found to be virtually devoid of side effects.
We have compared the migraine-inducing effect of nitroglycerin ointment applied to the frontotemp... more We have compared the migraine-inducing effect of nitroglycerin ointment applied to the frontotemporal region of the head, which is innervated by the ophthalmic and maxillary divisions of the trigeminal nerve, with that of nitroglycerin applied to the chin (innervated by the mandibular division), the posterolateral region of the neck (innervated by the second and third cervical roots), the lateral surface of the proximal third of the forearm (innervated by the sixth cervical root), and the medial surface of the upper-arm region (second dorsal root). One hundred patients suffering from migraine without aura were randomly divided into five equal groups. Each group received an application of 5 mg nitroglycerin in 2% ointment on a preselected body area for 2 hours. Frontotemporal nitroglycerin induced a significantly greater number of early onset migraine attacks with respect to the arm and forearm regions. In all cases, nitroglycerin applied to the frontotemporal region resulted in subsequent migraine, whereas there was a significant number of negative trials with nitroglycerin applied to the neck, arm, and forearm vs the frontotemporal area. It, therefore, appears that the trigeminal nerve endings in the affected frontotemporal region are particularly sensitive to the migraine-inducing effect of the nitrate. This suggests a peripheral neurogenic hypothesis of migraine genesis.
An 8-month, double-blind, placebo-controlled, crossover trial of flunarizine in the prophylaxis o... more An 8-month, double-blind, placebo-controlled, crossover trial of flunarizine in the prophylaxis of migraine has been performed in 70 children. After 4 weeks of medication-free base-line observation, 35 children (group A) received flunarizine (5 mg/day) and 35 (group B) received placebo over a 12-week period. After a 4-week washout they crossed treatments for another 12 weeks. Sixty-three patients completed the trial. In both groups flunarizine significantly reduced the frequency and average duration of headache attacks. In group A efficacy was maintained after placebo crossover for the last 4 months of the study. Five subjects in group B stopped placebo because of ineffectiveness; two children in group A discontinued flunarizine treatment, one because of excessive daytime sedation and the other because therapy was ineffective. The main side effects were daytime sedation and weight gain. It is concluded that flunarizine is an effective drug for the treatment of childhood migraine. In...
Vertigo symptomatology associated with migraine is quite frequent. Its manifestations may precede... more Vertigo symptomatology associated with migraine is quite frequent. Its manifestations may precede, accompany or replace the algetic crises. Although several studies have been carried out in adults, literature concerning migraine and vertigo in childhood is lacking. The aim of this paper was to assess hearing and balance functions in 25 children, suffering from common or classic migraine, during periods free from attacks. The sample was normal from the audiological point of view, except one with conductive hearing loss. On the other hand, only 4 subjects (16% of the sample) had both a negative past history and negative vestibular testing. The remaining 21 patients reported balance disorders and/or a positive vestibular testing. Our study outlines the involvement of vestibular pathways in pediatric migraine without any coincidental involvement of auditory pathways.
Psychoanalysis is based on the principle that many factors guiding a person's feelings, think... more Psychoanalysis is based on the principle that many factors guiding a person's feelings, thinking, and action remain outside his or her conscious awareness. These unconscious emotional processes influence one's current relationships, work life, sense of self, and ability to feel pleasure. Recent reviews of neuroscientific work confirm that many of Freud's original observations, not least the pervasive influence of non‐ conscious processes and the organizing function of emotions for thinking, have found confirmation in laboratory studies The integration of psychoanalytic ideas with modern science is unlikely to interest investigators from other disciplines unless psychoanalysis can actually contribute to directing or to informing data collection in these disciplines. The isolation of psychoanalysis should be replaced by active collaboration with other mental health disciplines. The proposed reflection would like to stress the virtuous relationship between psychiatry and ps...
424 RIASSUNTO. Viene descritta la storia di una coppia di coniugi che hanno subito in età infanti... more 424 RIASSUNTO. Viene descritta la storia di una coppia di coniugi che hanno subito in età infantile ripetuti traumi fisici e psi-chici nel loro contesto familiare. La situazione della coppia si sostiene per alcuni anni su un equilibrio precario con frequen-ti litigi e aggressioni fisiche e si conclude drammaticamente con un tentato omicidio. Viene ricostruito in un setting di ascol-to psicoterapico a indirizzo psicoanalitico il quadro psicopatologico della donna, autrice dell'atto violento, e valorizzata l'im-portanza e l'impellenza pulsionale dei fantasmi transgenerazionali che l'hanno condotta a scegliere un partner complemen-tare e collusivo, a sua volta vittima di violenze familiari, e trovarsi, compulsivamente, ad agire l'atto omicidale mancato tra i suoi genitori. Viene discusso il caso alla luce dell'ipotesi della trasmissione dei fantasmi transgenerazionali e della psicopato-logia dell'impulso violento. PAROLE CHIAVE: violenze genitoriali, psicopa...
Cephalalgia : an international journal of headache, 1985
Platelet function in vitro and in vivo (ADP-induced platelet aggregation, circulating platelet ag... more Platelet function in vitro and in vivo (ADP-induced platelet aggregation, circulating platelet aggregates, beta-thromboglobulin plasma levels) has been studied in children with common migraine, in headache-free intervals. Migraine patients demonstrated increased circulating platelet aggregates when compared with controls. Moreover, two of ten patients had pathological beta-thromboglobulin levels. These data indicate that in some children with migraine there is an abnormality of platelet function during headache-free periods.
Cephalalgia : an international journal of headache, 1985
Successful migraine prophylaxis with flunarizine has been reported in adults by several authors. ... more Successful migraine prophylaxis with flunarizine has been reported in adults by several authors. We used flunarizine in a double-blind, placebo controlled, randomized trial in childhood migraine. Twenty-four children with classical or common migraine were followed by a 12-week flunarizine treatment period. Each patient took 5 mg/day of the drug before going to sleep. Twenty-four children with similar clinical characteristics were assigned to placebo treatment. Efficacy of flunarizine versus placebo was assessed on the basis of the reduction of headache frequency and duration. A statistical comparison was performed between values reported in the treatment period and those in the three months before. Children treated with flunarizine experienced a statistically significant reduction in headache (66%) and duration (51%). These results were statistically superior to those observed in the placebo group. Sixteen patients on flunarizine therapy experienced an improvement of more than 50% o...
Vertigo symptomatology associated with migraine is quite frequent. Its manifestations may precede... more Vertigo symptomatology associated with migraine is quite frequent. Its manifestations may precede, accompany or replace the algetic crises. Although several studies have been carried out in adults, lit- erature concerning migraine and vertigo in childhood is lacking. The aim of this paper was to assess hearing and balance functions in 25 children, suffering from common or classic migraine, during periods
Flunarizine was found to be effective in the acute treatment of isosorbide dinitrate induced migr... more Flunarizine was found to be effective in the acute treatment of isosorbide dinitrate induced migraine attacks, when given in a dosage of 10 mg sublingually. The present study consists of two parts: in the first preliminary investigation, 7 out of 8 migraine patients who developed a typical migraine attack after isosorbide dinitrate were relieved of pain within about 10 minutes. On the basis of this result a second, randomized controlled open trial was performed, in which the acute efficacy of flunarizine was compared with ergotamine tartrate, 0.25 mg i.m., on 40 migraine patients. Flunarizine was found as effective as ergotamine (75% positive responses in the flunarizine group, 70% in the ergotamine group). The mean latency of the flunarizine effect was significantly lower than that of the ergotamine (r< 0.001, Student's t test). Moreover sublingual flunarizine was found to be virtually devoid of side effects.
We have compared the migraine-inducing effect of nitroglycerin ointment applied to the frontotemp... more We have compared the migraine-inducing effect of nitroglycerin ointment applied to the frontotemporal region of the head, which is innervated by the ophthalmic and maxillary divisions of the trigeminal nerve, with that of nitroglycerin applied to the chin (innervated by the mandibular division), the posterolateral region of the neck (innervated by the second and third cervical roots), the lateral surface of the proximal third of the forearm (innervated by the sixth cervical root), and the medial surface of the upper-arm region (second dorsal root). One hundred patients suffering from migraine without aura were randomly divided into five equal groups. Each group received an application of 5 mg nitroglycerin in 2% ointment on a preselected body area for 2 hours. Frontotemporal nitroglycerin induced a significantly greater number of early onset migraine attacks with respect to the arm and forearm regions. In all cases, nitroglycerin applied to the frontotemporal region resulted in subsequent migraine, whereas there was a significant number of negative trials with nitroglycerin applied to the neck, arm, and forearm vs the frontotemporal area. It, therefore, appears that the trigeminal nerve endings in the affected frontotemporal region are particularly sensitive to the migraine-inducing effect of the nitrate. This suggests a peripheral neurogenic hypothesis of migraine genesis.
An 8-month, double-blind, placebo-controlled, crossover trial of flunarizine in the prophylaxis o... more An 8-month, double-blind, placebo-controlled, crossover trial of flunarizine in the prophylaxis of migraine has been performed in 70 children. After 4 weeks of medication-free base-line observation, 35 children (group A) received flunarizine (5 mg/day) and 35 (group B) received placebo over a 12-week period. After a 4-week washout they crossed treatments for another 12 weeks. Sixty-three patients completed the trial. In both groups flunarizine significantly reduced the frequency and average duration of headache attacks. In group A efficacy was maintained after placebo crossover for the last 4 months of the study. Five subjects in group B stopped placebo because of ineffectiveness; two children in group A discontinued flunarizine treatment, one because of excessive daytime sedation and the other because therapy was ineffective. The main side effects were daytime sedation and weight gain. It is concluded that flunarizine is an effective drug for the treatment of childhood migraine. In...
Vertigo symptomatology associated with migraine is quite frequent. Its manifestations may precede... more Vertigo symptomatology associated with migraine is quite frequent. Its manifestations may precede, accompany or replace the algetic crises. Although several studies have been carried out in adults, literature concerning migraine and vertigo in childhood is lacking. The aim of this paper was to assess hearing and balance functions in 25 children, suffering from common or classic migraine, during periods free from attacks. The sample was normal from the audiological point of view, except one with conductive hearing loss. On the other hand, only 4 subjects (16% of the sample) had both a negative past history and negative vestibular testing. The remaining 21 patients reported balance disorders and/or a positive vestibular testing. Our study outlines the involvement of vestibular pathways in pediatric migraine without any coincidental involvement of auditory pathways.
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Papers by Fulvio Sorge