An 81-year-old male with a recently diagnosed gastric neuroendocrine tumour was admitted to the N... more An 81-year-old male with a recently diagnosed gastric neuroendocrine tumour was admitted to the Nuclear Medicine Department. A fluorodeoxyglucose (FDG) positron emission tomography -computed tomography (PET/CT) study was requested for initial staging purposes. Oral contrast-enhanced axial PET/CT slices ) at the level of the stomach demonstrated diffuse mild gastric hypermetabolism. There was no other pathological finding in the rest of the body.
To compare response assessment according to the WHO, RECIST 1.1, EORTC, and PERCIST criteria in p... more To compare response assessment according to the WHO, RECIST 1.1, EORTC, and PERCIST criteria in patients diagnosed with malignant solid tumors and who had received cytotoxic chemotherapy to establish the strength of agreement between each criterion. Sixty patients with malignant solid tumors were included in this retrospective study. The baseline and the sequential follow-up fluorine-18-fluorodeoxyglucose PET/computed tomography (CT) of each patient were evaluated according to the WHO, RECIST 1.1, EORTC, and PERCIST criteria. PET/CT images were used for both metabolic and anatomic evaluation. The concurrent diagnostic CT and MRI images (performed within 1 week of PET/CT) were also utilized when needed. The results were compared using the κ-statistics. The response and progression rates according to the WHO criteria were 37 and 38%, respectively. The same ratios were also found for RECIST 1.1 (κ=1). The response and progression rates according to the EORTC criteria were 47 and 40%, respectively. When PERCIST criteria were used, one patient with progressive disease was upgraded to stable disease (κ=0.976). As we found the same results with WHO and RECIST 1.1 criteria, we used WHO criteria to compare the anatomic and metabolic criteria. When we compared the WHO and EORTC criteria, there was an agreement in 80% of the patients (κ=0.711). With WHO and PERCIST criteria, there was an agreement in 81.6% of the patients (κ=0.736). Significant agreement was detected when the WHO, RECIST 1.1, EORTC, and PERCIST criteria were compared both within as well as between each other.
The objective of this study was to assess the urine levels of interleukin-6 (IL-6) and interleuki... more The objective of this study was to assess the urine levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) as noninvasive markers of vesicoureteral reflux (VUR) and renal parenchymal scarring (RPS) in children in the absence of a recent urinary tract infection (UTI) episode. Urine concentrations of IL-6 and IL-8 in 114 children aged 1 month to 16 years were evaluated. The children were divided into four groups: group 1, 26 children with VUR and RPS; group 2, 27 children with VUR without RPS; group 3, 34 children with RPS without VUR, group 4, 27 children without VUR and RPS, as the control group. After the first assessment, the children were divided into four larger groups for comparison purposes: group A (groups 1+2), 53 children with VUR; group B (groups 3+4), 61 children without VUR; group C (groups 1+3), 60 children with RPS; group D (groups 2+4), 54 children without RPS. Urinary IL-6 and IL-8 concentrations were determined. To avoid dilution effects and to the standardize samples, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg). The median urine IL-6/creatinine was significantly higher in patients with VUR than in those without VUR (5.72 vs. 3.73). In patients with VUR, there was a significant but rather weak correlation between IL-6/creatinine concentrations and there flux grade (p<0.05, R=0.305). The median urine IL-8/creatinine was significantly higher in patients with RPS than in those without RPS (43.12 vs. 16.36). In patients with RPS, there was a significant but rather weak correlation between IL-8/creatinine concentrations and the renal scar grade (p<0.05, R=0.251). The results of this study provide preliminary evidence that children with VUR have a high urine IL-6 concentration, whereas children with RPS have a high urine IL-8 concentration.
European Journal of Nuclear Medicine and Molecular Imaging, May 17, 2002
Prolonged and persistent myocardial stunning has recently been demonstrated using technetium-99m ... more Prolonged and persistent myocardial stunning has recently been demonstrated using technetium-99m sestamibi gated single-photon emission tomography (SPET) myocardial perfusion imaging post exercise or pharmacological stress test. In this study, we investigated the early postischemic transient myocardial stunning on early and delayed poststress thallium-201 gated SPET myocardial perfusion imaging using segmental wall motion (WM) and wall thickening (WT) analysis. A total of 1,680 segments from 84 patients' studies (53 men and 31 women, mean age 60 years) were evaluated on both early and delayed thallium-201 gated SPET treadmill exercise (59) or dobutamine stress (25) myocardial perfusion imaging. Semiquantitative analysis of perfusion, WM and WT in all segments was performed by two observers. Segments were classified according to changes in WM and WT between early and delayed images into normal, fixed abnormality, or improved abnormality (transient stunning), and were further classified according to changes in perfusion into normal, fixed defects, or ischemic. There were significant correlations between perfusion and WM, perfusion and WT, and WM and WT segmental scores on both early and delayed images. Transient stunning was seen significantly (P<0.001) more often in ischemic segments than were normal or fixed perfusion defects using WM (58%) and WT (50%) assessments. There was also a significant correlation between the severity of ischemia and transient stunning with either WM (P<0.05) or WT (P<0.005) evaluation. Segmental myocardial contractility assessment from gated SPET 201 Tl myocardial perfusion imaging using WM and WT was comparable, and results correlated well with the myocardial perfusion assessment. Early transient myocardial stunning was frequently observed in ischemic segments and was related to the severity of myocardial ischemia.
[18F] Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a useful imaging tool in the... more [18F] Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a useful imaging tool in the management of patients with colorectal carcinoma. This technique has an essential role in the staging of patients prior to surgical resection of recurrence and metastases, in the localization of recurrence in patients with an unexplained rise in serum carcinoembryonic antigen, in the assessment of residual masses after treatment, in determining tumor response to therapy in neo-adjuvant settings, and in evaluating colorectal cancer prognosis. It is possible to measure and visualize metabolic changes in cancer cells via FDG-PET. Combined PET/CT scans permit exact localization with anatomical criteria of the hypermetabolic FDG avid malignant lesions. This review aims to outline the current and future role of FDG-PET in the field of colorectal cancer.
Thyroid cancer can appear as metastatic disease of an unknown primary origin, and fluorine-18 flu... more Thyroid cancer can appear as metastatic disease of an unknown primary origin, and fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomographic (PET) studies are helpful in the workup evaluation of these patients. The authors describe two patients who had metastatic disease from an unknown primary lesion. F-18 FDG PET studies played an important role in localizing the primary malignant site in the thyroid gland. The utility of F-18 FDG imaging in decreasing the number of procedures, cost, and inconvenience to patients is shown clearly in both cases.
The diagnostic value of Carbon-14 urea breath test (C-14 UBT) in the detection of Helicobacter py... more The diagnostic value of Carbon-14 urea breath test (C-14 UBT) in the detection of Helicobacter pylori (H. pylori) infection in non-operated patients has been proved. However, the efficacy of C-14 UBT in patients with partial gastric resection (PGR) has not been evaluated yet. Herein, the results of the C-14 UBT and H. pylori stool antigen test (HpSAT) in this patient group were compared with the endoscopic findings. Multi-breath samples C-14 UBT and HpSAT were performed in all patients on the same day. Histology was used as a gold standard for testing C-14 UBT and HpSAT diagnostic efficacies. 30 patients (mean age: 54.6 ± 11 year) with PGR were included. The sensitivity and specificity of standard C-14 UBT were 29 and 100 %, respectively. When breath samples were collected at 20th min, and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;35 CPM was selected as radioactivity threshold, the sensitivity raised to 86 % without any loss of specificity. The specificity and sensitivity of the HpSAT were 71 and 96 %, respectively. The sensitivity of the standard C-14 UBT was very poor for patients with PGR, and results of HpSAT were superior in this population. Certain modifications are needed if C-14 UBT is to be used in PGR patients.
Objectives: Fixed dose Iodine-131 (RAI) treatment is a simple method which does not obviate sophi... more Objectives: Fixed dose Iodine-131 (RAI) treatment is a simple method which does not obviate sophisticated calculations. In this study, we compared the results of fixed 10mCi and 15 mCi RAI treatment.Patients and Methods: In this study we included 55 patients who received fixed 10 mCi and 15 mCi RAI treatment between 1997-2008 years and were followed for at least 2 years. Then we analyzed the results as successful (euthyroid, hypothyroid) and unsuccessful (persistant hyperthyroid) treatment rates and other parameters that could have affected the results. Results: The success rate in patients who received 10 mCi RAI was 87% (euthyroid 9.1%, hypothyroid 78.2%). The success rate in patients who received 15 mCi RAI was 100% (hypothyroid). There is no statistically significant difference between these groups except mean propythiouracil doses (10 mCi: 190 mg, 15 mCi: 350 mg, p <0.05). Conclusion: Fixed 10 mCi and 15 mCi RAI dose applications were both successful in the treatment of Grav...
Amaç: Sabit doz Iyot-131 (RAI) tedavisi, karmaşık hesaplamalara ihtiyaç duymayan basit ancak etki... more Amaç: Sabit doz Iyot-131 (RAI) tedavisi, karmaşık hesaplamalara ihtiyaç duymayan basit ancak etkin bir seçenektir. Bu çalışmada, Graves hastalığında sabit 10 ve 15 mCi ile RAI tedavisi sonuçları karşılaştırıldı. Hastalar ve Yöntem: 1997-2008 tarihleri arasında sabit 10 mCi (n:48) ve sabit 15 mCi (n:9) RAI tedavisi almış ve en az 2 yıl takip edilmiş 55 hastanın takip dosyaları incelenerek başarılı (ötiroidi, hipotiroidi) ve başarısız (persiste hipertiroidi) tedavi oranları ile sonuçlara etkili olabilecek parametreler analiz edildi. Bulgular: 10 mCi alan grupta tedavi başarı oranı %87 (ötiroidi %9.1, hipotiroidi %78.2) olarak bulunurken, 15 mCi alan grupta bu değer %100 (hipotiroidi) olarak bulundu. Her iki grup arasında, kullanılan ortalama propylthiouracil dozu dışında (10 mCi: 190 mg, 15 mCi: 350 mg, p<0.05) anlamlı fark izlenmedi. Sonuç: Sabit 10 ve 15 mCi RAI doz uygulamalarının her ikisi de Graves hastalığının tedavisinde başarılı sonuç vermiştir. Sabit 10 mCi verilen hastala...
We investigated the effect of acarbose, an alpha-glucosidase and pancreatic alpha-amylase inhibit... more We investigated the effect of acarbose, an alpha-glucosidase and pancreatic alpha-amylase inhibitor, on gastric emptying of solid meals of varying nutrient composition and plasma responses of gut hormones. Gastric emptying was determined with scintigraphy in healthy subjects, and all studies were performed with and without 100 mg of acarbose, in random order, at least 1 wk apart. Acarbose did not alter the emptying of a carbohydrate-free meal, but it delayed emptying of a mixed meal and a carbohydrate-free meal given 2 h after sucrose ingestion. In meal groups with carbohydrates, acarbose attenuated responses of plasma insulin and glucose-dependent insulinotropic polypeptide (GIP) while augmenting responses of CCK, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY). With mixed meal + acarbose, area under the curve (AUC) of gastric emptying was positively correlated with integrated plasma response of GLP-1 (r = 0.68, P < 0.02). With the carbohydrate-free meal after sucrose and ...
A 31-year-old male patient with a biopsy-proven cutaneous malignant melanoma located in the inter... more A 31-year-old male patient with a biopsy-proven cutaneous malignant melanoma located in the interscapular area was referred to lymphoscintigraphy for preoperative sentinel lymph node mapping. Anterior and posterior planar images showed 3 hot spots suggesting left axillary sentinel nodes. Herein, we reported the contribution of preoperative SPECT/CT-guided sentinel lymph node excision on accurate staging, management, prognostic evaluation, and determination of the proper surgical positioning preoperatively.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India, 2014
A 60-year-old male who underwent left upper lobectomy because of recently diagnosed lung cancer w... more A 60-year-old male who underwent left upper lobectomy because of recently diagnosed lung cancer was admitted to the nuclear medicine department. A whole body fluorodeoxyglucose positron emission tomography/computed tomography (CT) that was performed for staging purposes, revealed an intense hypermetabolism in left vocal cord region corresponding with hyperdense mass-like material on CT scan.
Contrast-enhanced CT or MRI are used as a gold standard imaging modalities in the detection and c... more Contrast-enhanced CT or MRI are used as a gold standard imaging modalities in the detection and characterization of renal masses. On the other hand, the role of FDG PET/CT in evaluating primary or metastatic cancers of the kidney is limited due to the excretion of FDG through urinary tract. We reported the FDG PET/CT of a lung cancer patient with multiple metastases in both kidneys which were missed in previous PET/CT, and underestimated on sequential diagnostic abdominal CT study. None declared.
Vascular endothelial growth factor (VEGF) is a prognostic factor in breast cancer. One of the mec... more Vascular endothelial growth factor (VEGF) is a prognostic factor in breast cancer. One of the mechanisms of extra-skeletal uptake of Tc-99m-methylenediphosphonate (MDP) is suggested to be tumor vascularity. We studied the correlation between MDP uptake and VEGF and compared the diagnostic accuracy of mammography versus MDP-scintimammography (MDP-S). Fifty-four patients with suspicion of breast cancer were evaluated. Breast images were collected 5-10 minutes after injection of Tc-99m-MDP prior to biopsy. Tissue slides were stained using a rabbit-polyclonal anti-VEGF. MDP-S showed a diagnostic accuracy of 83.3% in BIRADS category 4 lesions. Four out of 23 benign lesions were false-positive. The tumor to background (TM/BG) ratio of early images of MDP-S was correlated with VEGF staining (p: 0.014) and with tumor size (p: 0.006). Early images of Tc-99m-MDP-S may satisfactorily identify cancers with increased neovascularization. MDP-S seems to be an accurate imaging modality, especially ...
Mastoid region recurrence is a rare entity either or at the time of recurrence. This paper presen... more Mastoid region recurrence is a rare entity either or at the time of recurrence. This paper presents a patient with an isolated mastoid recurrence following definitive treatment and discusses the therapeutic approach which may help in the treatment of such cases.
Revista Española de Medicina Nuclear e Imagen Molecular, 2014
Breast cancer lung metastases incidentally detected on bone SPECT/CT: A rare finding that might b... more Breast cancer lung metastases incidentally detected on bone SPECT/CT: A rare finding that might be missed on whole body scan Metástasis pulmonares de un cáncer de mama detectadas incidentalmente en SPECT/TC óseo: hallazgo infrecuente que puede pasar desapercibido en un rastreo corporal
An 81-year-old male with a recently diagnosed gastric neuroendocrine tumour was admitted to the N... more An 81-year-old male with a recently diagnosed gastric neuroendocrine tumour was admitted to the Nuclear Medicine Department. A fluorodeoxyglucose (FDG) positron emission tomography -computed tomography (PET/CT) study was requested for initial staging purposes. Oral contrast-enhanced axial PET/CT slices ) at the level of the stomach demonstrated diffuse mild gastric hypermetabolism. There was no other pathological finding in the rest of the body.
To compare response assessment according to the WHO, RECIST 1.1, EORTC, and PERCIST criteria in p... more To compare response assessment according to the WHO, RECIST 1.1, EORTC, and PERCIST criteria in patients diagnosed with malignant solid tumors and who had received cytotoxic chemotherapy to establish the strength of agreement between each criterion. Sixty patients with malignant solid tumors were included in this retrospective study. The baseline and the sequential follow-up fluorine-18-fluorodeoxyglucose PET/computed tomography (CT) of each patient were evaluated according to the WHO, RECIST 1.1, EORTC, and PERCIST criteria. PET/CT images were used for both metabolic and anatomic evaluation. The concurrent diagnostic CT and MRI images (performed within 1 week of PET/CT) were also utilized when needed. The results were compared using the κ-statistics. The response and progression rates according to the WHO criteria were 37 and 38%, respectively. The same ratios were also found for RECIST 1.1 (κ=1). The response and progression rates according to the EORTC criteria were 47 and 40%, respectively. When PERCIST criteria were used, one patient with progressive disease was upgraded to stable disease (κ=0.976). As we found the same results with WHO and RECIST 1.1 criteria, we used WHO criteria to compare the anatomic and metabolic criteria. When we compared the WHO and EORTC criteria, there was an agreement in 80% of the patients (κ=0.711). With WHO and PERCIST criteria, there was an agreement in 81.6% of the patients (κ=0.736). Significant agreement was detected when the WHO, RECIST 1.1, EORTC, and PERCIST criteria were compared both within as well as between each other.
The objective of this study was to assess the urine levels of interleukin-6 (IL-6) and interleuki... more The objective of this study was to assess the urine levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) as noninvasive markers of vesicoureteral reflux (VUR) and renal parenchymal scarring (RPS) in children in the absence of a recent urinary tract infection (UTI) episode. Urine concentrations of IL-6 and IL-8 in 114 children aged 1 month to 16 years were evaluated. The children were divided into four groups: group 1, 26 children with VUR and RPS; group 2, 27 children with VUR without RPS; group 3, 34 children with RPS without VUR, group 4, 27 children without VUR and RPS, as the control group. After the first assessment, the children were divided into four larger groups for comparison purposes: group A (groups 1+2), 53 children with VUR; group B (groups 3+4), 61 children without VUR; group C (groups 1+3), 60 children with RPS; group D (groups 2+4), 54 children without RPS. Urinary IL-6 and IL-8 concentrations were determined. To avoid dilution effects and to the standardize samples, urinary levels of IL-6 and IL-8 were expressed as the ratio of cytokine to urinary creatinine (pg/mg). The median urine IL-6/creatinine was significantly higher in patients with VUR than in those without VUR (5.72 vs. 3.73). In patients with VUR, there was a significant but rather weak correlation between IL-6/creatinine concentrations and there flux grade (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05, R=0.305). The median urine IL-8/creatinine was significantly higher in patients with RPS than in those without RPS (43.12 vs. 16.36). In patients with RPS, there was a significant but rather weak correlation between IL-8/creatinine concentrations and the renal scar grade (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05, R=0.251). The results of this study provide preliminary evidence that children with VUR have a high urine IL-6 concentration, whereas children with RPS have a high urine IL-8 concentration.
European Journal of Nuclear Medicine and Molecular Imaging, May 17, 2002
Prolonged and persistent myocardial stunning has recently been demonstrated using technetium-99m ... more Prolonged and persistent myocardial stunning has recently been demonstrated using technetium-99m sestamibi gated single-photon emission tomography (SPET) myocardial perfusion imaging post exercise or pharmacological stress test. In this study, we investigated the early postischemic transient myocardial stunning on early and delayed poststress thallium-201 gated SPET myocardial perfusion imaging using segmental wall motion (WM) and wall thickening (WT) analysis. A total of 1,680 segments from 84 patients' studies (53 men and 31 women, mean age 60 years) were evaluated on both early and delayed thallium-201 gated SPET treadmill exercise (59) or dobutamine stress (25) myocardial perfusion imaging. Semiquantitative analysis of perfusion, WM and WT in all segments was performed by two observers. Segments were classified according to changes in WM and WT between early and delayed images into normal, fixed abnormality, or improved abnormality (transient stunning), and were further classified according to changes in perfusion into normal, fixed defects, or ischemic. There were significant correlations between perfusion and WM, perfusion and WT, and WM and WT segmental scores on both early and delayed images. Transient stunning was seen significantly (P<0.001) more often in ischemic segments than were normal or fixed perfusion defects using WM (58%) and WT (50%) assessments. There was also a significant correlation between the severity of ischemia and transient stunning with either WM (P<0.05) or WT (P<0.005) evaluation. Segmental myocardial contractility assessment from gated SPET 201 Tl myocardial perfusion imaging using WM and WT was comparable, and results correlated well with the myocardial perfusion assessment. Early transient myocardial stunning was frequently observed in ischemic segments and was related to the severity of myocardial ischemia.
[18F] Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a useful imaging tool in the... more [18F] Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a useful imaging tool in the management of patients with colorectal carcinoma. This technique has an essential role in the staging of patients prior to surgical resection of recurrence and metastases, in the localization of recurrence in patients with an unexplained rise in serum carcinoembryonic antigen, in the assessment of residual masses after treatment, in determining tumor response to therapy in neo-adjuvant settings, and in evaluating colorectal cancer prognosis. It is possible to measure and visualize metabolic changes in cancer cells via FDG-PET. Combined PET/CT scans permit exact localization with anatomical criteria of the hypermetabolic FDG avid malignant lesions. This review aims to outline the current and future role of FDG-PET in the field of colorectal cancer.
Thyroid cancer can appear as metastatic disease of an unknown primary origin, and fluorine-18 flu... more Thyroid cancer can appear as metastatic disease of an unknown primary origin, and fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomographic (PET) studies are helpful in the workup evaluation of these patients. The authors describe two patients who had metastatic disease from an unknown primary lesion. F-18 FDG PET studies played an important role in localizing the primary malignant site in the thyroid gland. The utility of F-18 FDG imaging in decreasing the number of procedures, cost, and inconvenience to patients is shown clearly in both cases.
The diagnostic value of Carbon-14 urea breath test (C-14 UBT) in the detection of Helicobacter py... more The diagnostic value of Carbon-14 urea breath test (C-14 UBT) in the detection of Helicobacter pylori (H. pylori) infection in non-operated patients has been proved. However, the efficacy of C-14 UBT in patients with partial gastric resection (PGR) has not been evaluated yet. Herein, the results of the C-14 UBT and H. pylori stool antigen test (HpSAT) in this patient group were compared with the endoscopic findings. Multi-breath samples C-14 UBT and HpSAT were performed in all patients on the same day. Histology was used as a gold standard for testing C-14 UBT and HpSAT diagnostic efficacies. 30 patients (mean age: 54.6 ± 11 year) with PGR were included. The sensitivity and specificity of standard C-14 UBT were 29 and 100 %, respectively. When breath samples were collected at 20th min, and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;35 CPM was selected as radioactivity threshold, the sensitivity raised to 86 % without any loss of specificity. The specificity and sensitivity of the HpSAT were 71 and 96 %, respectively. The sensitivity of the standard C-14 UBT was very poor for patients with PGR, and results of HpSAT were superior in this population. Certain modifications are needed if C-14 UBT is to be used in PGR patients.
Objectives: Fixed dose Iodine-131 (RAI) treatment is a simple method which does not obviate sophi... more Objectives: Fixed dose Iodine-131 (RAI) treatment is a simple method which does not obviate sophisticated calculations. In this study, we compared the results of fixed 10mCi and 15 mCi RAI treatment.Patients and Methods: In this study we included 55 patients who received fixed 10 mCi and 15 mCi RAI treatment between 1997-2008 years and were followed for at least 2 years. Then we analyzed the results as successful (euthyroid, hypothyroid) and unsuccessful (persistant hyperthyroid) treatment rates and other parameters that could have affected the results. Results: The success rate in patients who received 10 mCi RAI was 87% (euthyroid 9.1%, hypothyroid 78.2%). The success rate in patients who received 15 mCi RAI was 100% (hypothyroid). There is no statistically significant difference between these groups except mean propythiouracil doses (10 mCi: 190 mg, 15 mCi: 350 mg, p <0.05). Conclusion: Fixed 10 mCi and 15 mCi RAI dose applications were both successful in the treatment of Grav...
Amaç: Sabit doz Iyot-131 (RAI) tedavisi, karmaşık hesaplamalara ihtiyaç duymayan basit ancak etki... more Amaç: Sabit doz Iyot-131 (RAI) tedavisi, karmaşık hesaplamalara ihtiyaç duymayan basit ancak etkin bir seçenektir. Bu çalışmada, Graves hastalığında sabit 10 ve 15 mCi ile RAI tedavisi sonuçları karşılaştırıldı. Hastalar ve Yöntem: 1997-2008 tarihleri arasında sabit 10 mCi (n:48) ve sabit 15 mCi (n:9) RAI tedavisi almış ve en az 2 yıl takip edilmiş 55 hastanın takip dosyaları incelenerek başarılı (ötiroidi, hipotiroidi) ve başarısız (persiste hipertiroidi) tedavi oranları ile sonuçlara etkili olabilecek parametreler analiz edildi. Bulgular: 10 mCi alan grupta tedavi başarı oranı %87 (ötiroidi %9.1, hipotiroidi %78.2) olarak bulunurken, 15 mCi alan grupta bu değer %100 (hipotiroidi) olarak bulundu. Her iki grup arasında, kullanılan ortalama propylthiouracil dozu dışında (10 mCi: 190 mg, 15 mCi: 350 mg, p<0.05) anlamlı fark izlenmedi. Sonuç: Sabit 10 ve 15 mCi RAI doz uygulamalarının her ikisi de Graves hastalığının tedavisinde başarılı sonuç vermiştir. Sabit 10 mCi verilen hastala...
We investigated the effect of acarbose, an alpha-glucosidase and pancreatic alpha-amylase inhibit... more We investigated the effect of acarbose, an alpha-glucosidase and pancreatic alpha-amylase inhibitor, on gastric emptying of solid meals of varying nutrient composition and plasma responses of gut hormones. Gastric emptying was determined with scintigraphy in healthy subjects, and all studies were performed with and without 100 mg of acarbose, in random order, at least 1 wk apart. Acarbose did not alter the emptying of a carbohydrate-free meal, but it delayed emptying of a mixed meal and a carbohydrate-free meal given 2 h after sucrose ingestion. In meal groups with carbohydrates, acarbose attenuated responses of plasma insulin and glucose-dependent insulinotropic polypeptide (GIP) while augmenting responses of CCK, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY). With mixed meal + acarbose, area under the curve (AUC) of gastric emptying was positively correlated with integrated plasma response of GLP-1 (r = 0.68, P < 0.02). With the carbohydrate-free meal after sucrose and ...
A 31-year-old male patient with a biopsy-proven cutaneous malignant melanoma located in the inter... more A 31-year-old male patient with a biopsy-proven cutaneous malignant melanoma located in the interscapular area was referred to lymphoscintigraphy for preoperative sentinel lymph node mapping. Anterior and posterior planar images showed 3 hot spots suggesting left axillary sentinel nodes. Herein, we reported the contribution of preoperative SPECT/CT-guided sentinel lymph node excision on accurate staging, management, prognostic evaluation, and determination of the proper surgical positioning preoperatively.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India, 2014
A 60-year-old male who underwent left upper lobectomy because of recently diagnosed lung cancer w... more A 60-year-old male who underwent left upper lobectomy because of recently diagnosed lung cancer was admitted to the nuclear medicine department. A whole body fluorodeoxyglucose positron emission tomography/computed tomography (CT) that was performed for staging purposes, revealed an intense hypermetabolism in left vocal cord region corresponding with hyperdense mass-like material on CT scan.
Contrast-enhanced CT or MRI are used as a gold standard imaging modalities in the detection and c... more Contrast-enhanced CT or MRI are used as a gold standard imaging modalities in the detection and characterization of renal masses. On the other hand, the role of FDG PET/CT in evaluating primary or metastatic cancers of the kidney is limited due to the excretion of FDG through urinary tract. We reported the FDG PET/CT of a lung cancer patient with multiple metastases in both kidneys which were missed in previous PET/CT, and underestimated on sequential diagnostic abdominal CT study. None declared.
Vascular endothelial growth factor (VEGF) is a prognostic factor in breast cancer. One of the mec... more Vascular endothelial growth factor (VEGF) is a prognostic factor in breast cancer. One of the mechanisms of extra-skeletal uptake of Tc-99m-methylenediphosphonate (MDP) is suggested to be tumor vascularity. We studied the correlation between MDP uptake and VEGF and compared the diagnostic accuracy of mammography versus MDP-scintimammography (MDP-S). Fifty-four patients with suspicion of breast cancer were evaluated. Breast images were collected 5-10 minutes after injection of Tc-99m-MDP prior to biopsy. Tissue slides were stained using a rabbit-polyclonal anti-VEGF. MDP-S showed a diagnostic accuracy of 83.3% in BIRADS category 4 lesions. Four out of 23 benign lesions were false-positive. The tumor to background (TM/BG) ratio of early images of MDP-S was correlated with VEGF staining (p: 0.014) and with tumor size (p: 0.006). Early images of Tc-99m-MDP-S may satisfactorily identify cancers with increased neovascularization. MDP-S seems to be an accurate imaging modality, especially ...
Mastoid region recurrence is a rare entity either or at the time of recurrence. This paper presen... more Mastoid region recurrence is a rare entity either or at the time of recurrence. This paper presents a patient with an isolated mastoid recurrence following definitive treatment and discusses the therapeutic approach which may help in the treatment of such cases.
Revista Española de Medicina Nuclear e Imagen Molecular, 2014
Breast cancer lung metastases incidentally detected on bone SPECT/CT: A rare finding that might b... more Breast cancer lung metastases incidentally detected on bone SPECT/CT: A rare finding that might be missed on whole body scan Metástasis pulmonares de un cáncer de mama detectadas incidentalmente en SPECT/TC óseo: hallazgo infrecuente que puede pasar desapercibido en un rastreo corporal
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