A revelação do nome divino em Ex 3,14 indica que ele deve ser lido, interpretado e analisado a pa... more A revelação do nome divino em Ex 3,14 indica que ele deve ser lido, interpretado e analisado a partir da hipótese documentária, da revelação divina, da teologia e da tipologia presentes no nome yehwāh, da importância do Nome no Antigo Oriente, da revelação do nome no Evangelho de João, da saída do Egito, dos temas da Páscoa, da Lei, da Aliança e da formação de um povo sacerdotal. Sem uma compreensão prévia e interpretação crítica a partir desses aspectos se compromete (ou pode se comprometer) o alcance e o significado do estudo de Ex 3,14 para a exegese e a hermenêutica cristã contemporânea. O presente artigo desenvolve o argumento a partir do nome divino yhwh e da hipótese documentária clássica, que impulsionou o estudo sobre o nome divino.
VOLUME 1 -NÚMERO 1 Dossiê Especial Sistemas de justiça e interlocuções em prol de grupos vulneráv... more VOLUME 1 -NÚMERO 1 Dossiê Especial Sistemas de justiça e interlocuções em prol de grupos vulneráveis Em “A transversalidade dos crimes de femicídio/feminicídio no Brasil e em Portugal”, LourdesMaria Bandeira e Maria José Magalhães apresentam o feminicídio e os discursos que acompanham essa prática delituosa de violência de gênero em face das mulheres, a partir da análise comparativa do enquadramento midiático de crimes, assim definidos e noticiados em Goiás, Brasília e Portugal, entre os anos de 2016 e 2017. A partir dos cenários construídos ou ressignificados em periódicos, desenvolvem as categorias de aniquilamento simbólico, propriedade ou pertencimento sexual eterrorismo patriarcal ou crime de misoginia, que estariam representadas nas notícias sobre esses delitos. Gabriel Ignacio Anitua Marsan, no artigo “A Defensoria Pública como garantia de acesso à justiça”, apresenta estudo sobre o papel do defensor público criminal, ao tecer ilações sobre a conceituação do órgão e a concretização da atividade desempenhada pelo órgão, com considerações filosóficas a respeito da atividade defensorial e de como este órgão, opção política de uma determinada conformação social, possui potencialidade para ofertar um atendimentoadequado aos acusados. Antônio Carlos Fontes Cintra, em “A transcendência dos direitos humanos”, desenvolveuma reflexão teórica sobre a concepção de direitos humanos no mundo ocidental e suas raízes, buscando sua justificação como uma ontologia axiológica, atributiva de significado na medida em que alcança uma compreensão metafísica, transcendental. O intento de situar o acesso à justiça a partir de uma guinada paradigmática, democrática epara além da inafastabilidade de jurisdição, como concepção abrangente e ampliativa de respostas viáveis e efetivas do Estado no resolução de conflitos, é ofertado por Fernando Antônio CalmonReis, em “Da nova concepção teórica do acesso à justiça: o Judiciário como ultima ratio”. No artigo “O papel da tradução e da interpretação para grupos vulneráveis no acesso à justiça”, Silvana Aguiar dos Santos e Aline Vanessa Poltronieri-Gessner realizam uma interlocução, partindo das normas que respaldam a tradução e a interpretação no acesso à Justiça para gruposlinguisticamente vulneráveis, bem como apresentam levantamento quantitativo que situa a temáticano cenário de produção acadêmica no âmbito jurídico. Denise Paranhos e Aline Albuquerque, em “Direitos Humanos dos pacientes Testemunhas de Jeová e a transfusão de sangue compulsória em decisões judiciais no Brasil”, problematizama temática relativa às decisões envolvendo transfusão de sangue para pacientes Testemunhas de Jeová, no âmbito de decisões proferidas pelo Poder Judiciário brasileiro, comparado com oreferencial dos direitos humanos dos pacientes e do posicionamento da Corte Europeia de Direitos Humanos. No artigo “Planos de educação: a litigância estratégica da sociedade civil e da Defensoria Pública do Estado do Paraná na Comissão Interamericana de Direitos Humanos”, Ananda HadahRodrigues Puchta, Camille Vieira da Costa e Helena de Souza Rocha apresentam uma reflexão acerca da litigância estratégica em direitos humanos, com pretensão de respaldar a atuação de atores sociais no debate internacional de planos de educação, com objetivos pragmáticos. No artigo “Disputas semânticas sobre igualdade e família(s)”, Sarah Flister Nogueira busca compreender como estratégias discursivas e moralidades são mobilizadas como artefatos teórico-argumentativos para alguns julgados e projetos de lei sobre o (não) reconhecimento dasconjugalidades que escapam à heteronormatividade, realçando a relevância de se compreender a polissemia de termos como “família” e “igualdade”, em seus variados contextos. Em “Defensoria Pública e curadoria especial no Superior Tribunal de Justiça: a obrigatoriedade de recolhimento das custas de preparo como requisito de admissibilidade do recurso especial”,Pericles Batista da Silva apresenta, a partir de considerações jurídico-dogmáticas, a questão daobrigatoriedade de recolhimento das custas de preparo como requisito de admissibilidade dorecurso especial no Superior Tribunal de Justiça, na hipótese em que a Defensoria Pública atua em sua função institucional de curadora especial. Ao situar o Núcleo de Direitos Humanos da Defensoria Pública do Distrito Federal, instituído em 2017, Brenda Aíssa Martins Henrique, no texto intitulado “O redimensionamento da atuação da Defensoria Pública: a tutela de direitos humanos no âmbito da Defensoria Pública do Distrito Federal”, resgata os objetivos do órgão e o desenho institucional que se molda para atuação em áreas estratégicas à proteção de indivíduos e grupos vulneráveis, no concreto caso de instituição e operacionalização de um núcleo temático. No artigo “As decisões judiciais do caso comunidade LGBT (Defensoria Pública do Estado de São Paulo) versus Levy Fidélix e PRTB: uma análise empírico-retórica dos discursos”, Vitor Nunes Lages, utilizando-se da…
ABSTRACT The present study was designed to evaluate whether tissue preparation by glutaraldehyde ... more ABSTRACT The present study was designed to evaluate whether tissue preparation by glutaraldehyde and glycol methacrylate (G/GMA) improves the diagnostic assessment of testicular biopsies from azoospermic men when compared to the standard tissue preparation using Bouin’s solution and paraffin. We prospectively included a total of 21 testicular biopsies of sexually mature men aged 29–50 years with infertility and azoospermia. One testicular biopsy fragment from each patient was processed by the G/GMA method, whereas another tissue fragment was contemporarily processed by the conventional Bouin/paraffin (B/P) method. The G/GMA method provided better resolution of cytological details of the seminiferous epithelium, changing the final diagnosis in four cases. The medians of Bergmann’s spermatogenesis scores were 0.25 (interquartile range 0.04–0.88) for B/P preparations and 0.79 (interquartile range 0.17–0.96) for G/GMA preparations. Both techniques allowed accurate prediction of sperm recovery from the biopsies (B/P, area under the receiver operating characteristics [ROC] curve 0.88, 95% confidence interval [CI] 0.75–1.00; G/GMA, area under the ROC curve 0.94, 95% CI 0.86–1.00). We conclude that human testicular biopsy preparation with G/GMA improved image resolution under light microscopy and produced more reliable results for the evaluation of spermatogenesis in comparison with B/P, allowing a more precise fertility-oriented diagnosis in azoospermic men. Abbreviations: B/P: Bouin/paraffin; GMA: glycol methacrylate; G/GMA: glutaraldehyde and glycol methacrylate; ICSI: intracytoplasmic sperm injection; OA: obstructive azoospermia; NOA: nonobstructive azoospermia; TESE: testicular sperm extraction.
A industria couro-calcadista que opera com peles caprina e ovina esta em franca expansao no Brasi... more A industria couro-calcadista que opera com peles caprina e ovina esta em franca expansao no Brasil. Entretanto, a oferta de peles nao tem atendido a demanda dos curtumes brasileiros, cuja capacidade instalada e suficiente para curtir o dobro das peles ovinas e caprinas atualmente processadas. Em consequencia, o Pais tem recorrido a continuas importacoes de materia-prima para a manutencao de seu parque industrial. Os cenarios atuais sao favoraveis as atividades da caprinocultura e ovinocultura nas diferentes regioes do Pais. Os precos dos produtos derivados dos couros das duas especies sao crescentes, estimulando a adesao de novos empresarios a atividade. O presente trabalho apresenta, de forma clara e objetiva, o panorama da competitividade do Pais no tocante a industrializacao e ao mercado das peles oriundas dos pequenos ruminantes
The purpose of this study was to identify the biopsychosocial and spiritual effects of crack use ... more The purpose of this study was to identify the biopsychosocial and spiritual effects of crack use during pregnancy. This is a descriptive study with qualitat...
We study under the standpoint of integrable complex analytic 1-forms (complex analytic foliations... more We study under the standpoint of integrable complex analytic 1-forms (complex analytic foliations), a class of second order ordinary differential equations with periodic coefficients. More precisely, we study Hill's equations of motion of the moon, which are related to the dynamics of the system Sun-Earth-Moon. We associate to the {\em complex Hill equation} an integrable complex analytic one-form in dimension three. This defines a {\it Hill foliation}. The existence of first integral for a Hill foliation is then studied. The simple cases correspond to the existence of rational or Liouvillian first integrals. We then prove the existence of a {\it Bessel type} first integral in a more general case. We construct a standard two dimensional model for the foliation which we call {\it Hill fundamental form}. This plane foliation is then studied also under the standpoint of reduction of singularities and existence of first integral. For the more general case of the Hill equation, we pr...
Among the various aspects of health promotion and lifestyle adaptation to the postmenopausal peri... more Among the various aspects of health promotion and lifestyle adaptation to the postmenopausal period, nutritional habits are essential because they concern all women, can be modified, and impact both longevity and quality of life. In this narrative review, we discuss the current evidence on the association between dietary patterns and clinical endpoints in postmenopausal women, such as body composition, bone mass, and risk markers for cardiovascular disease. Current evidence suggests that low-fat, plant-based diets are associated with beneficial effects on body composition, but further studies are needed to confirm these results in postmenopausal women. The Mediterranean diet pattern along with other healthy habits may help the primary prevention of bone, metabolic, and cardiovascular diseases in the postmenopausal period. It consists on the use of healthy foods that have anti-inflammatory and antioxidant properties, and is associated with a small but significant decrease in blood pr...
Journal of Endometriosis and Pelvic Pain Disorders, 2020
Objective: Angiotensin-converting-enzyme 2 (ACE2), the cell surface receptor for severe acute res... more Objective: Angiotensin-converting-enzyme 2 (ACE2), the cell surface receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is found in a variety of reproductive tissues. The present study evaluated whether uterine fibroids and normal myometrium express ACE2 and, if so, at which tissue compartments. Methods: We included 13 premenopausal women (age range 33–50 years, median 40 years) with uterine fibroids undergoing elective hysterectomy or myomectomy. Samples of leiomyoma ( n = 12) and normal myometrial tissue ( n = 8) were analyzed by immunohistochemistry for protein localization or by real time PCR for mRNA detection. Results: In normal myometrium, ACE2 immunoreactivity was localized in smooth muscle fibers, arteriolar walls, and endothelial cells. In uterine leiomyoma, ACE2 staining was more intense in smooth muscle cells than in the extracellular matrix, and was also present in vascular endothelium. ACE2 mRNA was detected in myometrium as well as in fibroid sa...
Neosporosis is a disease caused by the obligate intracellular protozoa of the genus, Neospora. Ne... more Neosporosis is a disease caused by the obligate intracellular protozoa of the genus, Neospora. Neospora caninum causes neosporosis in domestic and wild animals. This disease is well known in cattle but it has been reported also in sheep. The prevalence of neosporosis in sheep has varied from 0.6% in New Zealand to 30.8% in Brazil. There are also reports of neosporosis in goats. A recent study showed that 11.5% of 26 aborted goat fetuses were infected with N. caninum. The control of neosporosis in sheep and goats involves mainly farm-management, and infected cattle, sheep and goats must be slaughtered. Diagnosis of N. caninum is carried out by serological exam, parasitological test and also by PCR (Polymerase Chain Reaction).
ABSTRACT ABSTRACT: : : : : This is a descriptive exploratory qualitative study, aiming at analyzi... more ABSTRACT ABSTRACT: : : : : This is a descriptive exploratory qualitative study, aiming at analyzing male participation in prenatal and childbirth. Semi-structured interviews were used to obtain discourse samples of nine men residing in the city of Catu, Bahia, Brazil, within the area of the Family Health Unit, where their pregnant partners went through prenatal in 2005. Men's participation was analyzed from the following thematic nucleus: pregnancy planning, acknowledgement of partners' prenatal assistance; participation in prenatal and childbirth; and conceptions of paternity . Reports have shown that the majority of pregnancies was not planned; they still indicate that those men participated neither of those appointments nor of the childbirth. Conclusions show that reproductive responsibility reflects socially built cultural standards, which contribute to the distancing of men from reproductive issues.
Non-continuous location traces inferred from Call Detail Records (CDR) at population scale are in... more Non-continuous location traces inferred from Call Detail Records (CDR) at population scale are increasingly becoming available for research and show great potential for automated detection of meaningful places. Yet, a majority of Home Detection Algorithms (HDAs) suffer from "blind" deployment of criteria to define homes and from limited possibilities for validation. In this paper, we investigate the performance and capabilities of five popular criteria for home detection based on a very large mobile phone dataset from France (~18 million users, 6 months). Furthermore, we construct a data-driven framework to assess the spatial uncertainty related to the application of HDAs. Our findings appropriate spatial uncertainty in HDA and, in extension, for detection of meaningful places. We show how spatial uncertainties on the individuals' level can be assessed in absence of ground truth annotation, how they relate to traditional, high-level validation practices and how they ca...
A região do Brasil Central presenciou expressivo desenvolvimento agrícola a partir da década de 8... more A região do Brasil Central presenciou expressivo desenvolvimento agrícola a partir da década de 80. Embora presente em muitas propriedades que exploram a pecuária, a criação de pequenos ruminantes carece de indicações tecnológicas baseadas em experimentações científicas, que amparem os produtores nas tomadas de decisões relativas a iniciar a atividade de ovinocultura de corte. Raça, pasto, número de matrizes e área necessária estão entre os maiores questionamentos.
Animals must balance needs to approach threats for risk assessment and to avoid danger. The dorsa... more Animals must balance needs to approach threats for risk assessment and to avoid danger. The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how it represents states associated with threat approach and avoidance. We identified a dPAG threatavoidance ensemble in mice that showed higher activity farther from threats such as the open arms of the elevated plus maze and a predator. These cells were also more active during threat avoidance behaviors such as escape and freezing, even though these behaviors have antagonistic motor output. Conversely, the threat approach ensemble was more active during risk assessment behaviors and near threats. Furthermore, unsupervised methods showed that avoidance/approach states were encoded with shared activity patterns across threats. Lastly, the relative number of cells in each ensemble predicted threat avoidance across mice. Thus, dPAG ensembles dynamically encode threat approach and avoidance states, providing a flex...
Polycystic ovary syndrome (PCOS) is a chronic dysfunction associated with obesity and metabolic d... more Polycystic ovary syndrome (PCOS) is a chronic dysfunction associated with obesity and metabolic disorders that can be ameliorated by treatment with metformin. Brown adipose tissue (BAT) has been recently identified in adult humans, and irisin is a myokine that induces BAT formation. The aim of this randomized controlled trial was to evaluate whether a short term treatment with metformin alters BAT activity and plasma irisin levels in women with PCOS. The participants were randomly assigned to receive metformin (1500 mg/day, n=21) or placebo (n=24) during 60 days. BAT activity was assessed by 18F-FDG positron emission tomography-computed tomography (PET-CT) and plasma irisin levels were measured by enzyme immunoassay. The groups were similar in age, body measures, metabolic profile and PCOS phenotypes. BAT activity did not change significantly in the women treated with metformin (median Δ SUVmax=–0.06 g/ml, interquartile interval –2.81 to 0.24 g/ml, p=0.484, Wilcoxon’s test) or place...
Angiotensin (Ang)-(1-7) is an active peptide formed from Ang I or Ang-(1-9) by multiple proteolyt... more Angiotensin (Ang)-(1-7) is an active peptide formed from Ang I or Ang-(1-9) by multiple proteolytic steps involving angiotensin-converting enzyme (ACE) 1 and other peptidases, or by a single cleavage of Ang II catalyzed chiefly by ACE2. The effects of Ang-(1-7) are mediated by the G protein-coupled receptor Mas (or Mas1), encoded by the protooncogene MAS. The reproductive system expresses ACE2 quite abundantly and therefore is able to generate Ang-(1-7) using precursor peptides produced locally or taken from circulation. In several mammalian species, Ang-(1-7) stimulates ovarian follicle growth, oocyte maturation and ovulation. The peptide is found in human endometrium, mostly during the secretory phase of menstrual cycle when the uterus is receptive to embryo implantation. Rat models and human observational studies suggest that Ang-(1-7) is part of the maternal adaptive response to pregnancy and its deficiency is associated with poor circulation in the placental bed. Knockout mice ...
The process of freezing/thawing causes structural and functional damage to sperm samples, which c... more The process of freezing/thawing causes structural and functional damage to sperm samples, which can be mitigated by seminal plasma proteins. This study investigated the proposition that seminal protein measurements using a urinary dipstick prior to freezing could help predict the post-thaw recovery of live spermatozoa. This was a prospective study including 149 men undergoing semen analysis due to male and/or female infertility. The seminal samples were analysed according to World Health Organisation standards and protein concentrations were measured using a commercially available urinary dipstick following quantitative validation. The median live sperm recovery rates were 79%, 81% and 94%, respectively, in samples with protein concentrations of 1.0 g/L (þ/þþ), 3.0 g/L (þþþ) and !20.0 g/L (þþþþ) measured in fresh specimen dipstick analysis (p < 0.05) indicating that the probability of recovering at least 50% of frozen spermatozoa increased progressively with higher protein concentrations in the fresh sample (chi-square for linear association ¼ 7.17. p ¼ 0.007). In conclusion, fresh seminal protein concentration levels assessed with a dipstick test correlate with the proportion of live spermatozoa recovered from cryopreserved samples. This simple, low-cost test may add prognostic information to baseline semen analysis prior to sperm banking.
This study aimed to evaluate the production performance, quantitative carcass characteristics, an... more This study aimed to evaluate the production performance, quantitative carcass characteristics, and economic viability of lambs of genetic group Pantaneiro finished under four production systems: 1) Stockpiled Brachiaria brizantha cv piatã pasture; 2) Consortium of sorghum intercropped with Brachiaria brizantha cv piatã; 3) Feedlot based on sorghum silage and 2% body weight energy-protein supplementation, 4) Feedlot based on sorghum silage and 4% body weight energy-protein supplementation. Were used one hundred Pantaneiro lambs with an average body weight of 17.85 ± 2.50 kg and at 70 ± 15 days of age, approximately. The average final body weight and total body weight gain of the animals finished on the consortium of sorghum intercropped with Brachiaria brizantha cv piatã were higher than those obtained with feedlot based on sorghum silage and 2% body weight energy-protein supplementation. However, when this system were compared with sorghum silage and 4% body weight energy-protein su...
A revelação do nome divino em Ex 3,14 indica que ele deve ser lido, interpretado e analisado a pa... more A revelação do nome divino em Ex 3,14 indica que ele deve ser lido, interpretado e analisado a partir da hipótese documentária, da revelação divina, da teologia e da tipologia presentes no nome yehwāh, da importância do Nome no Antigo Oriente, da revelação do nome no Evangelho de João, da saída do Egito, dos temas da Páscoa, da Lei, da Aliança e da formação de um povo sacerdotal. Sem uma compreensão prévia e interpretação crítica a partir desses aspectos se compromete (ou pode se comprometer) o alcance e o significado do estudo de Ex 3,14 para a exegese e a hermenêutica cristã contemporânea. O presente artigo desenvolve o argumento a partir do nome divino yhwh e da hipótese documentária clássica, que impulsionou o estudo sobre o nome divino.
VOLUME 1 -NÚMERO 1 Dossiê Especial Sistemas de justiça e interlocuções em prol de grupos vulneráv... more VOLUME 1 -NÚMERO 1 Dossiê Especial Sistemas de justiça e interlocuções em prol de grupos vulneráveis Em “A transversalidade dos crimes de femicídio/feminicídio no Brasil e em Portugal”, LourdesMaria Bandeira e Maria José Magalhães apresentam o feminicídio e os discursos que acompanham essa prática delituosa de violência de gênero em face das mulheres, a partir da análise comparativa do enquadramento midiático de crimes, assim definidos e noticiados em Goiás, Brasília e Portugal, entre os anos de 2016 e 2017. A partir dos cenários construídos ou ressignificados em periódicos, desenvolvem as categorias de aniquilamento simbólico, propriedade ou pertencimento sexual eterrorismo patriarcal ou crime de misoginia, que estariam representadas nas notícias sobre esses delitos. Gabriel Ignacio Anitua Marsan, no artigo “A Defensoria Pública como garantia de acesso à justiça”, apresenta estudo sobre o papel do defensor público criminal, ao tecer ilações sobre a conceituação do órgão e a concretização da atividade desempenhada pelo órgão, com considerações filosóficas a respeito da atividade defensorial e de como este órgão, opção política de uma determinada conformação social, possui potencialidade para ofertar um atendimentoadequado aos acusados. Antônio Carlos Fontes Cintra, em “A transcendência dos direitos humanos”, desenvolveuma reflexão teórica sobre a concepção de direitos humanos no mundo ocidental e suas raízes, buscando sua justificação como uma ontologia axiológica, atributiva de significado na medida em que alcança uma compreensão metafísica, transcendental. O intento de situar o acesso à justiça a partir de uma guinada paradigmática, democrática epara além da inafastabilidade de jurisdição, como concepção abrangente e ampliativa de respostas viáveis e efetivas do Estado no resolução de conflitos, é ofertado por Fernando Antônio CalmonReis, em “Da nova concepção teórica do acesso à justiça: o Judiciário como ultima ratio”. No artigo “O papel da tradução e da interpretação para grupos vulneráveis no acesso à justiça”, Silvana Aguiar dos Santos e Aline Vanessa Poltronieri-Gessner realizam uma interlocução, partindo das normas que respaldam a tradução e a interpretação no acesso à Justiça para gruposlinguisticamente vulneráveis, bem como apresentam levantamento quantitativo que situa a temáticano cenário de produção acadêmica no âmbito jurídico. Denise Paranhos e Aline Albuquerque, em “Direitos Humanos dos pacientes Testemunhas de Jeová e a transfusão de sangue compulsória em decisões judiciais no Brasil”, problematizama temática relativa às decisões envolvendo transfusão de sangue para pacientes Testemunhas de Jeová, no âmbito de decisões proferidas pelo Poder Judiciário brasileiro, comparado com oreferencial dos direitos humanos dos pacientes e do posicionamento da Corte Europeia de Direitos Humanos. No artigo “Planos de educação: a litigância estratégica da sociedade civil e da Defensoria Pública do Estado do Paraná na Comissão Interamericana de Direitos Humanos”, Ananda HadahRodrigues Puchta, Camille Vieira da Costa e Helena de Souza Rocha apresentam uma reflexão acerca da litigância estratégica em direitos humanos, com pretensão de respaldar a atuação de atores sociais no debate internacional de planos de educação, com objetivos pragmáticos. No artigo “Disputas semânticas sobre igualdade e família(s)”, Sarah Flister Nogueira busca compreender como estratégias discursivas e moralidades são mobilizadas como artefatos teórico-argumentativos para alguns julgados e projetos de lei sobre o (não) reconhecimento dasconjugalidades que escapam à heteronormatividade, realçando a relevância de se compreender a polissemia de termos como “família” e “igualdade”, em seus variados contextos. Em “Defensoria Pública e curadoria especial no Superior Tribunal de Justiça: a obrigatoriedade de recolhimento das custas de preparo como requisito de admissibilidade do recurso especial”,Pericles Batista da Silva apresenta, a partir de considerações jurídico-dogmáticas, a questão daobrigatoriedade de recolhimento das custas de preparo como requisito de admissibilidade dorecurso especial no Superior Tribunal de Justiça, na hipótese em que a Defensoria Pública atua em sua função institucional de curadora especial. Ao situar o Núcleo de Direitos Humanos da Defensoria Pública do Distrito Federal, instituído em 2017, Brenda Aíssa Martins Henrique, no texto intitulado “O redimensionamento da atuação da Defensoria Pública: a tutela de direitos humanos no âmbito da Defensoria Pública do Distrito Federal”, resgata os objetivos do órgão e o desenho institucional que se molda para atuação em áreas estratégicas à proteção de indivíduos e grupos vulneráveis, no concreto caso de instituição e operacionalização de um núcleo temático. No artigo “As decisões judiciais do caso comunidade LGBT (Defensoria Pública do Estado de São Paulo) versus Levy Fidélix e PRTB: uma análise empírico-retórica dos discursos”, Vitor Nunes Lages, utilizando-se da…
ABSTRACT The present study was designed to evaluate whether tissue preparation by glutaraldehyde ... more ABSTRACT The present study was designed to evaluate whether tissue preparation by glutaraldehyde and glycol methacrylate (G/GMA) improves the diagnostic assessment of testicular biopsies from azoospermic men when compared to the standard tissue preparation using Bouin’s solution and paraffin. We prospectively included a total of 21 testicular biopsies of sexually mature men aged 29–50 years with infertility and azoospermia. One testicular biopsy fragment from each patient was processed by the G/GMA method, whereas another tissue fragment was contemporarily processed by the conventional Bouin/paraffin (B/P) method. The G/GMA method provided better resolution of cytological details of the seminiferous epithelium, changing the final diagnosis in four cases. The medians of Bergmann’s spermatogenesis scores were 0.25 (interquartile range 0.04–0.88) for B/P preparations and 0.79 (interquartile range 0.17–0.96) for G/GMA preparations. Both techniques allowed accurate prediction of sperm recovery from the biopsies (B/P, area under the receiver operating characteristics [ROC] curve 0.88, 95% confidence interval [CI] 0.75–1.00; G/GMA, area under the ROC curve 0.94, 95% CI 0.86–1.00). We conclude that human testicular biopsy preparation with G/GMA improved image resolution under light microscopy and produced more reliable results for the evaluation of spermatogenesis in comparison with B/P, allowing a more precise fertility-oriented diagnosis in azoospermic men. Abbreviations: B/P: Bouin/paraffin; GMA: glycol methacrylate; G/GMA: glutaraldehyde and glycol methacrylate; ICSI: intracytoplasmic sperm injection; OA: obstructive azoospermia; NOA: nonobstructive azoospermia; TESE: testicular sperm extraction.
A industria couro-calcadista que opera com peles caprina e ovina esta em franca expansao no Brasi... more A industria couro-calcadista que opera com peles caprina e ovina esta em franca expansao no Brasil. Entretanto, a oferta de peles nao tem atendido a demanda dos curtumes brasileiros, cuja capacidade instalada e suficiente para curtir o dobro das peles ovinas e caprinas atualmente processadas. Em consequencia, o Pais tem recorrido a continuas importacoes de materia-prima para a manutencao de seu parque industrial. Os cenarios atuais sao favoraveis as atividades da caprinocultura e ovinocultura nas diferentes regioes do Pais. Os precos dos produtos derivados dos couros das duas especies sao crescentes, estimulando a adesao de novos empresarios a atividade. O presente trabalho apresenta, de forma clara e objetiva, o panorama da competitividade do Pais no tocante a industrializacao e ao mercado das peles oriundas dos pequenos ruminantes
The purpose of this study was to identify the biopsychosocial and spiritual effects of crack use ... more The purpose of this study was to identify the biopsychosocial and spiritual effects of crack use during pregnancy. This is a descriptive study with qualitat...
We study under the standpoint of integrable complex analytic 1-forms (complex analytic foliations... more We study under the standpoint of integrable complex analytic 1-forms (complex analytic foliations), a class of second order ordinary differential equations with periodic coefficients. More precisely, we study Hill's equations of motion of the moon, which are related to the dynamics of the system Sun-Earth-Moon. We associate to the {\em complex Hill equation} an integrable complex analytic one-form in dimension three. This defines a {\it Hill foliation}. The existence of first integral for a Hill foliation is then studied. The simple cases correspond to the existence of rational or Liouvillian first integrals. We then prove the existence of a {\it Bessel type} first integral in a more general case. We construct a standard two dimensional model for the foliation which we call {\it Hill fundamental form}. This plane foliation is then studied also under the standpoint of reduction of singularities and existence of first integral. For the more general case of the Hill equation, we pr...
Among the various aspects of health promotion and lifestyle adaptation to the postmenopausal peri... more Among the various aspects of health promotion and lifestyle adaptation to the postmenopausal period, nutritional habits are essential because they concern all women, can be modified, and impact both longevity and quality of life. In this narrative review, we discuss the current evidence on the association between dietary patterns and clinical endpoints in postmenopausal women, such as body composition, bone mass, and risk markers for cardiovascular disease. Current evidence suggests that low-fat, plant-based diets are associated with beneficial effects on body composition, but further studies are needed to confirm these results in postmenopausal women. The Mediterranean diet pattern along with other healthy habits may help the primary prevention of bone, metabolic, and cardiovascular diseases in the postmenopausal period. It consists on the use of healthy foods that have anti-inflammatory and antioxidant properties, and is associated with a small but significant decrease in blood pr...
Journal of Endometriosis and Pelvic Pain Disorders, 2020
Objective: Angiotensin-converting-enzyme 2 (ACE2), the cell surface receptor for severe acute res... more Objective: Angiotensin-converting-enzyme 2 (ACE2), the cell surface receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is found in a variety of reproductive tissues. The present study evaluated whether uterine fibroids and normal myometrium express ACE2 and, if so, at which tissue compartments. Methods: We included 13 premenopausal women (age range 33–50 years, median 40 years) with uterine fibroids undergoing elective hysterectomy or myomectomy. Samples of leiomyoma ( n = 12) and normal myometrial tissue ( n = 8) were analyzed by immunohistochemistry for protein localization or by real time PCR for mRNA detection. Results: In normal myometrium, ACE2 immunoreactivity was localized in smooth muscle fibers, arteriolar walls, and endothelial cells. In uterine leiomyoma, ACE2 staining was more intense in smooth muscle cells than in the extracellular matrix, and was also present in vascular endothelium. ACE2 mRNA was detected in myometrium as well as in fibroid sa...
Neosporosis is a disease caused by the obligate intracellular protozoa of the genus, Neospora. Ne... more Neosporosis is a disease caused by the obligate intracellular protozoa of the genus, Neospora. Neospora caninum causes neosporosis in domestic and wild animals. This disease is well known in cattle but it has been reported also in sheep. The prevalence of neosporosis in sheep has varied from 0.6% in New Zealand to 30.8% in Brazil. There are also reports of neosporosis in goats. A recent study showed that 11.5% of 26 aborted goat fetuses were infected with N. caninum. The control of neosporosis in sheep and goats involves mainly farm-management, and infected cattle, sheep and goats must be slaughtered. Diagnosis of N. caninum is carried out by serological exam, parasitological test and also by PCR (Polymerase Chain Reaction).
ABSTRACT ABSTRACT: : : : : This is a descriptive exploratory qualitative study, aiming at analyzi... more ABSTRACT ABSTRACT: : : : : This is a descriptive exploratory qualitative study, aiming at analyzing male participation in prenatal and childbirth. Semi-structured interviews were used to obtain discourse samples of nine men residing in the city of Catu, Bahia, Brazil, within the area of the Family Health Unit, where their pregnant partners went through prenatal in 2005. Men's participation was analyzed from the following thematic nucleus: pregnancy planning, acknowledgement of partners' prenatal assistance; participation in prenatal and childbirth; and conceptions of paternity . Reports have shown that the majority of pregnancies was not planned; they still indicate that those men participated neither of those appointments nor of the childbirth. Conclusions show that reproductive responsibility reflects socially built cultural standards, which contribute to the distancing of men from reproductive issues.
Non-continuous location traces inferred from Call Detail Records (CDR) at population scale are in... more Non-continuous location traces inferred from Call Detail Records (CDR) at population scale are increasingly becoming available for research and show great potential for automated detection of meaningful places. Yet, a majority of Home Detection Algorithms (HDAs) suffer from "blind" deployment of criteria to define homes and from limited possibilities for validation. In this paper, we investigate the performance and capabilities of five popular criteria for home detection based on a very large mobile phone dataset from France (~18 million users, 6 months). Furthermore, we construct a data-driven framework to assess the spatial uncertainty related to the application of HDAs. Our findings appropriate spatial uncertainty in HDA and, in extension, for detection of meaningful places. We show how spatial uncertainties on the individuals' level can be assessed in absence of ground truth annotation, how they relate to traditional, high-level validation practices and how they ca...
A região do Brasil Central presenciou expressivo desenvolvimento agrícola a partir da década de 8... more A região do Brasil Central presenciou expressivo desenvolvimento agrícola a partir da década de 80. Embora presente em muitas propriedades que exploram a pecuária, a criação de pequenos ruminantes carece de indicações tecnológicas baseadas em experimentações científicas, que amparem os produtores nas tomadas de decisões relativas a iniciar a atividade de ovinocultura de corte. Raça, pasto, número de matrizes e área necessária estão entre os maiores questionamentos.
Animals must balance needs to approach threats for risk assessment and to avoid danger. The dorsa... more Animals must balance needs to approach threats for risk assessment and to avoid danger. The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how it represents states associated with threat approach and avoidance. We identified a dPAG threatavoidance ensemble in mice that showed higher activity farther from threats such as the open arms of the elevated plus maze and a predator. These cells were also more active during threat avoidance behaviors such as escape and freezing, even though these behaviors have antagonistic motor output. Conversely, the threat approach ensemble was more active during risk assessment behaviors and near threats. Furthermore, unsupervised methods showed that avoidance/approach states were encoded with shared activity patterns across threats. Lastly, the relative number of cells in each ensemble predicted threat avoidance across mice. Thus, dPAG ensembles dynamically encode threat approach and avoidance states, providing a flex...
Polycystic ovary syndrome (PCOS) is a chronic dysfunction associated with obesity and metabolic d... more Polycystic ovary syndrome (PCOS) is a chronic dysfunction associated with obesity and metabolic disorders that can be ameliorated by treatment with metformin. Brown adipose tissue (BAT) has been recently identified in adult humans, and irisin is a myokine that induces BAT formation. The aim of this randomized controlled trial was to evaluate whether a short term treatment with metformin alters BAT activity and plasma irisin levels in women with PCOS. The participants were randomly assigned to receive metformin (1500 mg/day, n=21) or placebo (n=24) during 60 days. BAT activity was assessed by 18F-FDG positron emission tomography-computed tomography (PET-CT) and plasma irisin levels were measured by enzyme immunoassay. The groups were similar in age, body measures, metabolic profile and PCOS phenotypes. BAT activity did not change significantly in the women treated with metformin (median Δ SUVmax=–0.06 g/ml, interquartile interval –2.81 to 0.24 g/ml, p=0.484, Wilcoxon’s test) or place...
Angiotensin (Ang)-(1-7) is an active peptide formed from Ang I or Ang-(1-9) by multiple proteolyt... more Angiotensin (Ang)-(1-7) is an active peptide formed from Ang I or Ang-(1-9) by multiple proteolytic steps involving angiotensin-converting enzyme (ACE) 1 and other peptidases, or by a single cleavage of Ang II catalyzed chiefly by ACE2. The effects of Ang-(1-7) are mediated by the G protein-coupled receptor Mas (or Mas1), encoded by the protooncogene MAS. The reproductive system expresses ACE2 quite abundantly and therefore is able to generate Ang-(1-7) using precursor peptides produced locally or taken from circulation. In several mammalian species, Ang-(1-7) stimulates ovarian follicle growth, oocyte maturation and ovulation. The peptide is found in human endometrium, mostly during the secretory phase of menstrual cycle when the uterus is receptive to embryo implantation. Rat models and human observational studies suggest that Ang-(1-7) is part of the maternal adaptive response to pregnancy and its deficiency is associated with poor circulation in the placental bed. Knockout mice ...
The process of freezing/thawing causes structural and functional damage to sperm samples, which c... more The process of freezing/thawing causes structural and functional damage to sperm samples, which can be mitigated by seminal plasma proteins. This study investigated the proposition that seminal protein measurements using a urinary dipstick prior to freezing could help predict the post-thaw recovery of live spermatozoa. This was a prospective study including 149 men undergoing semen analysis due to male and/or female infertility. The seminal samples were analysed according to World Health Organisation standards and protein concentrations were measured using a commercially available urinary dipstick following quantitative validation. The median live sperm recovery rates were 79%, 81% and 94%, respectively, in samples with protein concentrations of 1.0 g/L (þ/þþ), 3.0 g/L (þþþ) and !20.0 g/L (þþþþ) measured in fresh specimen dipstick analysis (p < 0.05) indicating that the probability of recovering at least 50% of frozen spermatozoa increased progressively with higher protein concentrations in the fresh sample (chi-square for linear association ¼ 7.17. p ¼ 0.007). In conclusion, fresh seminal protein concentration levels assessed with a dipstick test correlate with the proportion of live spermatozoa recovered from cryopreserved samples. This simple, low-cost test may add prognostic information to baseline semen analysis prior to sperm banking.
This study aimed to evaluate the production performance, quantitative carcass characteristics, an... more This study aimed to evaluate the production performance, quantitative carcass characteristics, and economic viability of lambs of genetic group Pantaneiro finished under four production systems: 1) Stockpiled Brachiaria brizantha cv piatã pasture; 2) Consortium of sorghum intercropped with Brachiaria brizantha cv piatã; 3) Feedlot based on sorghum silage and 2% body weight energy-protein supplementation, 4) Feedlot based on sorghum silage and 4% body weight energy-protein supplementation. Were used one hundred Pantaneiro lambs with an average body weight of 17.85 ± 2.50 kg and at 70 ± 15 days of age, approximately. The average final body weight and total body weight gain of the animals finished on the consortium of sorghum intercropped with Brachiaria brizantha cv piatã were higher than those obtained with feedlot based on sorghum silage and 2% body weight energy-protein supplementation. However, when this system were compared with sorghum silage and 4% body weight energy-protein su...
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Papers by Fernando Reis