Papers by Fernanda Altamirano
Autoimmunity Reviews, 2006
HSCT provides the opportunity to replace a damaged tissue. It is the most important treatment for... more HSCT provides the opportunity to replace a damaged tissue. It is the most important treatment for high risk hematologic malignant and non malignant disorders. An important challenge in the identification of matched donors/patients is the HLA diversity. The Mexican Bone Marrow Registry (DONORMO) has nowadays > 5000 donors. The prevalent alleles are Amerindian, Mediterranean (Semitic and Spanish genes) and African. In theory, it is possible to find 11% of 6/6 A-B-DR low resolution matches for 70% of patients with Mexican ancestry. We contributed with 39 unrelated, cord blood and autologous HSCT for patients with malignant, genetic and autoimmune disorders. Overall disease survival was 50% (2-7 years) depending on the initial diagnosis, conditioning, disease evolution or other factors. Clinical studies using autologous and unrelated HSC are performed on patients with refractory autoimmune diseases producing mixed results: mainly, T1D, RA, MS, SLE. Improvement has been observed in skin damage and quality of life in SLE and systemic sclerosis. Disease stabilization in 2/3 of MS patients. However, in RA and T1D, initial benefits have been followed by eventual relapse. With growing clinical experience and protocol improvement, treatment-related mortality is decreasing. Proof efficacy will be achieved by comparing HSCT with standard therapy in autoimmunity.
El objetivo del presente trabajo es realizar un recorrido histórico por las principales corriente... more El objetivo del presente trabajo es realizar un recorrido histórico por las principales corrientes de pensamiento que han caracterizado a la teoría crítica desde su nacimiento en el seno de la Escuela de Frankfurt hasta el presente. En primer lugar, el autor retrata la etapa clásica de la teoría crítica a partir de las investigaciones realizadas por Horkheimer, Marcuse y Adorno. Luego analiza la inclusión de la dimensión normativa como objeto de estudio por parte de Neumann y Kirchheimer y la influencia de la teoría discursiva de Habermas en el desarrollo de la teoría crítica. Por último, se enuncian las principales objeciones que realizan los críticos jurídicos a la filosofía legal positivista, especialmente en lo que concierne al Derecho Internacional Público y se exponen las propuestas de los nuevos enfoques críticos.
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Papers by Fernanda Altamirano