Papers by Jose F E L I P E souza
Clinical Pharmacokinetics, 2009
Etravirine is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) developed ... more Etravirine is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) developed for the treatment of HIV-1 infection. It has a high genetic barrier to the emergence of viral resistance, and maintains its antiviral activity in the presence of common NNRTI mutations. The pharmacokinetics of etravirine in HIV-infected patients at the recommended dosage of 200 mg twice daily demonstrates moderate intersubject variability and no time dependency. Due to substantially lower exposures when taken on an empty stomach, etravirine should be administered following a meal. The drug is highly protein bound (99.9%) to albumin and alpha(1)-acid glycoprotein and shows a relatively long elimination half-life of 30-40 hours. Etravirine is metabolized by cytochrome P450 (CYP) 3A, 2C9 and 2C19; the metabolites are subsequently glucuronidated by uridine diphosphate glucuronosyltransferase. Renal elimination of etravirine is negligible. Etravirine has the potential for interactions by inducing CYP3A and inhibiting CYP2C9 and 2C19; it is a mild inhibitor of P-glycoprotein but not a substrate. The drug interaction profile of etravirine has been well characterized and is manageable. No dosage adjustments are needed in patients with renal impairment or mild to moderate hepatic impairment. Race, sex, bodyweight and age do not affect the pharmacokinetics of etravirine. In the two phase III trials DUET-1 and DUET-2, no relationship was demonstrated between the pharmacokinetics of etravirine and the primary efficacy endpoint of viral load below 50 copies/mL or the safety profile of etravirine.
ANÁLISE DAS PSICOPATOLOGIAS COM ÊNFASE EM DEPRESSÃO , 2020
The present study addresses a research on the theme psychopathologies with emphasis on depress... more The present study addresses a research on the theme psychopathologies with emphasis on depression it will focus on analyzing depression from the of a psychoanalyst perspective who mainly uses the techniques and concepts to work the conflicts and desires of people according to the father's theories of psychoanalysis and neurologist physician Sigmund Freud (1856-1939). His curiosity led him to know and explore the human psyche, leading him to know the depths of the human mind. As a result of his work, a new science was created linked to others such as neuroscience, psychology, and other philosophical disciplines. The main concept of psychoanalysis allowed a huge understanding of the individual through the "unconscious" until then never studied. In Freud's perspective, more important than knowing what is accessible to us what is conscious, is knowing what is beyond what we can know in a given state of affairs. The psychoanalysis is an area of independent knowledge that has emerged as an alternative way to deal with psychic suffering and to understand the mental functioning of the human being. Their notions and theoretical hypotheses are constructed and articulated in order to create models for the understanding of psychic phenomena that populate the clinic and everyday life. Psychoanalysis has its own organizing principle, its own truth. Understanding its creation and development involves epistemological issues, relationships with other areas of knowledge and their contextualization through history.
Freud had the sensitivity and receptivity to listen to the hysteric's speech and to learn what he had to teach him. By listening to the hysteric, Freud created psychoanalysis, its theory, its practice, its therapeutic method, and its ethics. He had the capacity to recognize ignorance and powerlessness in the face of an immense number of situations, in the face of suffering, he launched himself in search of new instruments, new techniques, new concepts.
Grammar exercises with answer.
Uploads
Papers by Jose F E L I P E souza
Freud had the sensitivity and receptivity to listen to the hysteric's speech and to learn what he had to teach him. By listening to the hysteric, Freud created psychoanalysis, its theory, its practice, its therapeutic method, and its ethics. He had the capacity to recognize ignorance and powerlessness in the face of an immense number of situations, in the face of suffering, he launched himself in search of new instruments, new techniques, new concepts.
Freud had the sensitivity and receptivity to listen to the hysteric's speech and to learn what he had to teach him. By listening to the hysteric, Freud created psychoanalysis, its theory, its practice, its therapeutic method, and its ethics. He had the capacity to recognize ignorance and powerlessness in the face of an immense number of situations, in the face of suffering, he launched himself in search of new instruments, new techniques, new concepts.