PAPASH syndrome is a rare autoinflammatory syndrome consisting of four essential components: pyog... more PAPASH syndrome is a rare autoinflammatory syndrome consisting of four essential components: pyogenic arthritis (PA), pyoderma gangrenosum (PG), acne (A), and suppurative hidradenitis (SH). The true etiology is unknown, yet genetic analysis has shown associations with PSTPIP1 mutations, which ultimately lead to elevations in interleukin-1 activity. Herein, we report a case of painful ulcers in a 47-year-old Syrian male located on the legs and swelling of both ankles, with a bad condition and hyperthermia. He also had a history of acne, suppurative hidradenitis, fistulas, and abscesses in the buttock area. The results of skin biopsy, laboratory testing, joint aspiration, and poor responding to antibiotic treatment excluded the infective nature of the case. To our knowledge, this was the first case of PAPASH syndrome diagnosed in Syria.
The trigeminal trophic syndrome (TTS) is a rare form of cutaneous ulceration characterized by ane... more The trigeminal trophic syndrome (TTS) is a rare form of cutaneous ulceration characterized by anesthesia, paresthesia and a secondary persistent facial ulceration. It is uncommon in children. However, we report an unusual case of TTS in a 5- year-old child with Moebius syndrome ,extending over the right nostril and then the other nostril was infected. The diagnosis of TTS was based on clinical history, tissue biopsy and serologic evaluation. The ulcer was treated with multiple antibiotics with no improvement. We describe this case because of very few pediatric cases of TTS published in the past , and to increase the awareness of this syndrome among dermatologists.
The trigeminal trophic syndrome (TTS) is a rare form of cutaneous ulceration characterized by ane... more The trigeminal trophic syndrome (TTS) is a rare form of cutaneous ulceration characterized by anesthesia, paresthesia and a secondary persistent facial ulceration. It is uncommon in children. However, we report an unusual case of TTS in a 5- year-old child with Moebius syndrome ,extending over the right nostril and then the other nostril was infected. The diagnosis of TTS was based on clinical history, tissue biopsy and serologic evaluation. The ulcer was treated with multiple antibiotics with no improvement. We describe this case because of very few pediatric cases of TTS published in the past , and to increase the awareness of this syndrome among dermatologists.
PAPASH syndrome is a rare autoinflammatory syndrome consisting of four essential components: pyog... more PAPASH syndrome is a rare autoinflammatory syndrome consisting of four essential components: pyogenic arthritis (PA), pyoderma gangrenosum (PG), acne (A), and suppurative hidradenitis (SH). The true etiology is unknown, yet genetic analysis has shown associations with PSTPIP1 mutations, which ultimately lead to elevations in interleukin-1 activity. Herein, we report a case of painful ulcers in a 47-year-old Syrian male located on the legs and swelling of both ankles, with a bad condition and hyperthermia. He also had a history of acne, suppurative hidradenitis, fistulas, and abscesses in the buttock area. The results of skin biopsy, laboratory testing, joint aspiration, and poor responding to antibiotic treatment excluded the infective nature of the case. To our knowledge, this was the first case of PAPASH syndrome diagnosed in Syria.
The trigeminal trophic syndrome (TTS) is a rare form of cutaneous ulceration characterized by ane... more The trigeminal trophic syndrome (TTS) is a rare form of cutaneous ulceration characterized by anesthesia, paresthesia and a secondary persistent facial ulceration. It is uncommon in children. However, we report an unusual case of TTS in a 5- year-old child with Moebius syndrome ,extending over the right nostril and then the other nostril was infected. The diagnosis of TTS was based on clinical history, tissue biopsy and serologic evaluation. The ulcer was treated with multiple antibiotics with no improvement. We describe this case because of very few pediatric cases of TTS published in the past , and to increase the awareness of this syndrome among dermatologists.
The trigeminal trophic syndrome (TTS) is a rare form of cutaneous ulceration characterized by ane... more The trigeminal trophic syndrome (TTS) is a rare form of cutaneous ulceration characterized by anesthesia, paresthesia and a secondary persistent facial ulceration. It is uncommon in children. However, we report an unusual case of TTS in a 5- year-old child with Moebius syndrome ,extending over the right nostril and then the other nostril was infected. The diagnosis of TTS was based on clinical history, tissue biopsy and serologic evaluation. The ulcer was treated with multiple antibiotics with no improvement. We describe this case because of very few pediatric cases of TTS published in the past , and to increase the awareness of this syndrome among dermatologists.
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Papers by Heba Fawal
(PA), pyoderma gangrenosum (PG), acne (A), and suppurative hidradenitis (SH). The true etiology is unknown, yet
genetic analysis has shown associations with PSTPIP1 mutations, which ultimately lead to elevations in interleukin-1
activity. Herein, we report a case of painful ulcers in a 47-year-old Syrian male located on the legs and swelling of both
ankles, with a bad condition and hyperthermia. He also had a history of acne, suppurative hidradenitis, fistulas, and
abscesses in the buttock area. The results of skin biopsy, laboratory testing, joint aspiration, and poor responding to
antibiotic treatment excluded the infective nature of the case. To our knowledge, this was the first case of PAPASH
syndrome diagnosed in Syria.
(PA), pyoderma gangrenosum (PG), acne (A), and suppurative hidradenitis (SH). The true etiology is unknown, yet
genetic analysis has shown associations with PSTPIP1 mutations, which ultimately lead to elevations in interleukin-1
activity. Herein, we report a case of painful ulcers in a 47-year-old Syrian male located on the legs and swelling of both
ankles, with a bad condition and hyperthermia. He also had a history of acne, suppurative hidradenitis, fistulas, and
abscesses in the buttock area. The results of skin biopsy, laboratory testing, joint aspiration, and poor responding to
antibiotic treatment excluded the infective nature of the case. To our knowledge, this was the first case of PAPASH
syndrome diagnosed in Syria.