The purpose of this study was to investigate the potential of pectin extracted from orange waste ... more The purpose of this study was to investigate the potential of pectin extracted from orange waste by acid hydrolysis and prepared Pectin/ hydroxyethyl cellulose (HEC)/ZnO nanoparticles (ZnO-NPs) biofilm for food packaging applications. The pectin/HEC/ZnO biofilms were prepared in an aqueous solution at room temperature using solvent casting method and characterized by different techniques such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), and scanning electron microscope (SEM). Also, thermal gravimetric analysis (TGA), mechanical properties, and water vapor permeability-WVP were evaluated. Moreover, its antimicrobial activity against Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica Typhimiurium) and two Gram positive bacteria (Listeria monocytogenes and Staphylococcus aureus), and also has antifungal activity against Candida albicans was assessed. The obtained results display that the water vapor permeability (WVP) indicated a reduction in permeability with increased ZnO concentration, with WVPs ranging from 2.55 × 10 -12 to 4.28 × 10 -12 gm/pas.m 2 , which indicates that our pectin/HEC/ZnO bionanocomposite biofilm could efficiently decrease moisture transfer, thereby potentially extending the shelf-life of packaged food products. Furthermore, the results showed enhanced tensile strength and flexibility in the biofilms with the addition of 1% ZnO nanoparticles from 1.2 to 2.6 MPa and 4.5 to 13 MPa respectively. The WVP indicated a reduction in permeability with increased ZnO concentration, with WVPs ranging from 2.55 × 10 -12 to 4.28 × 10 -12 gm/pas.m 2 . The antimicrobial activity against pathogens such as Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica Typhimurium, Listeria monocytogenes, Staphylococcus aureus, and Candida albicans was significant, with a 99.96% reduction in E. coli counts at a biofilm concentration of 200 mg/mL. Furthermore, the current study revealed that the synthesized bionanocomposite biofilms had excellent qualities such as transparency, flexibility, low cost, and being environmentally friendly. The pectin/ HEC/ZnO bionanocomposite was found to be an ideal biofilm for food packaging due to its safety and affordability, which is able to prolong food shelf-life.
Bulletin of the National Research Centre, Jan 4, 2024
Background The second most common cancer in the world is breast cancer. Chemotherapy is used to t... more Background The second most common cancer in the world is breast cancer. Chemotherapy is used to treat breast cancer, but instances of multidrug resistance, targets that are not selective, and physicochemical issues raise doubts about its efficacy. So, the exploration of chemopreventive agents from efficient natural sources has been required. The chia and quinoa seeds have health-promoting activities that include cardio-protective, antidiabetic, and anticancer effects. Given the paramount importance of their oils and their potential bioactivities, this work aimed to assess the repressive effect of their oil nanocapsules against mammary tumors in rats. Rat models of chemically induced mammary tumors were gavaged with chia and quinoa nanocapsules for one month. The repressive effect of nanocapsules was studied by quantifying TNF-α, assessing the gene expression of proto-oncogenes (PIK3CA and MYC) using qRT-PCR, and analyzing the cell cycle in mammary tissue. The studies clarified that the inhibition of tumors in response to quinoa and chia nanocapsules was associated with a reduction in TNF-α levels, proliferation capability, and motivation for apoptosis. Furthermore, quinoa and chia nanocapsule management repressed the activation of the MYC and PIK3CA genes. As well as nanocapsules modulated the liver enzymes and kidney function alterations induced in mammary tumor animals. Meanwhile, both oils' nanocapsules do not have an impact on the liver and kidneys of healthy rats. The findings indicate that quinoa and chia nanocapsules are safe and can reduce tumor growth, suggesting a potential natural therapeutic target for breast cancer treatment.
Zagazig Journal of Agricultural Research, Aug 31, 2023
The fruits of white mulberry are widespread fruit in Egypt and are eaten by most people with acce... more The fruits of white mulberry are widespread fruit in Egypt and are eaten by most people with acceptable taste, so we tried in this research to show the chemical composition of the fruits and the effectiveness of white mulberry as an antioxidant and also know the quality of the polysaccharide that is found in white mulberry and study the properties of sugar many in terms of the quality of the structural units involved in the composition and effective groups of its molecular weight and also its ability as an antioxidant and to achieve this purpose we have collected the fruits of white mulberry from The local market of the city of Zagazig was washed and dried and then grinding and storage in appropriate conditions of temperature (4°C) and the chemical composition of moisture, total ash, crude protein, crude fat, fiber and carbohydrates was estimated by the difference and the results were as follows as a percentage of the dry sample of white mulberry fruits (12.02 -14.42 -21 -4.83 -15 -59.75) respectively. Total phenols and total flavonoids were estimated through two types of extracts, aqueous extract and alcoholic extract to determine the effectiveness of white mulberry fruiting as an antioxidant, where the results were (23.5-13.9 mg gallic acid/gram total phenolat extract aqueous and alcoholic extract respectively As for the total flavonoids, the results were (1.43 -2.54 mg Quercetin /gram aqueous and alcoholic extract, respectively, and finally. The antioxidant activity of white mulberry fruits was estimated by DPPH method and the results obtained were (6.66 -1.97 mg vitamin C/gram aqueous and alcoholic extract respectively. The sugar was separated from many white mulberry fruits and purified and it became clear from the results to obtain two types of sugar many in the fruits of white mulberry differ in molecular weight and also in the type of structural units involved in the composition where the molecular weight sugar was reached 1.25 x 10 4 -5.29 x 10 4 Dalton and called them fraction 1 and fraction 2 respectively The quality of monosaccharide was glucose -Mannose -Arabenose -fructose -Mannuronic acid in fractions WMP1 or fraction WMP2 It contains the following structural units (glucose -galactose -arabinose -manuuronic acid acid) Through the results obtained from the HPLC device, the quality of the effective groups in polysaccharide fractions in white mulberry fruits was also identified through the infrared spectrum, which showed peaks appear in 1728 -1619.2 -3345.6 cm -1 for samples Which indicates the presence of the CH 2 group and the C=O group hydroxyl group, respectively. Through the results obtained, we can say that the consumption of white mulberry fruits provides the human body with natural antioxidant compounds and also a high content of protein, salts and total carbohydrates.
Featured Application: The bio-based food additives obtained from upcycling grapefruit peels can b... more Featured Application: The bio-based food additives obtained from upcycling grapefruit peels can be used mainly in the food industry as natural antioxidant and antimicrobial alternatives. Additionally, these ingredients also show anti-inflammatory potential, underscoring their potential as a nutraceutical.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Nigella sativa L. is an annual herb of the Ranunculaceae family. The seeds called black cumin see... more Nigella sativa L. is an annual herb of the Ranunculaceae family. The seeds called black cumin seed which contains 34-39% oil. Its oil has many purposes in traditional medicine and food industries. Black seed oil is a significant source of essential fatty acids, tocopherols, phytosterols, phenolics, essential oils, and other bioactive compounds. Thymoquinone (TQ) is one of the potent active compounds in the essential oil fraction of black seed oil with many health beneficial properties. Black seed oil is getting much attention either used alone or in combination with other vegetable oils. Providing information about the black seeds originating from different parts of the world, their oil composition and the effect of deferent extraction methods on the oil quality is of great value. Environmental condition, maturity stage and storage conditions have also significant effects on the oil properties.
Salvia has been used since ancient times in folk medicine and many pharmaceutical industries. Sal... more Salvia has been used since ancient times in folk medicine and many pharmaceutical industries. Salvia langiera Poir herbs, growing wild in Egyptian desert, are among nine endemic wild species native to Egypt. The essential oil of Wild Egyptian Salvia langiera has not been previously investigated in Egypt. The aim of the present study was to assess the composition and antimicrobial activity of the essential oil of Salvia langiera plant growing wild in Egyptian desert. The plant materials were collected from wild population growing in sandy soils near El-Sallum region (41 km eastern of Sallum). The essential oil of the air-dried aerial parts of plant was extracted by hydrodistillation and analyzed by Gas Chromatography-Mass Spectrometry (GC/MS). The essential oil composition of Salvia langiera was characterized by a high percentage of oxygenated sesquiterpene (26.44%). The major constituents were Spathulenol (5.90%), Carotol (5.36 %) and cis, trans farnesol (5.34%) followed by caryophyllene oxide (3.96%) and Globulol (2.20%). Oxygenated monoterpene (3.65 %) were Camphor (1.28%), -Thujone (1.23%) and Linalool (1.14%). -Pinene (2.17%) and Sabinene (1.12%) were the monoterpene hydrocarbons while sesquiterpene hydrocarbons were -Muurolene (1.68%). Other important constituents n-alkane (6.32 %), aliphatic alcohols (9.73%) and fatty acids (21.97%) were present in considerable amounts. On the other hand the essential oil of Salvia langiera was more active against Saccharomyces cereviseae, intermediate sensitive with Bacillus megaterium, while it was the least against Bacillus subtilis.
Nutrition is a key factor for growth and development of plants. Among the main nutrients is calci... more Nutrition is a key factor for growth and development of plants. Among the main nutrients is calcium (Ca). Calcium, uptaken as Ca 2+ , is essential element for the growth of the plants and fruit development, and it is important in the resistance of the plants to diseases due to with base in the protection of the cell wall. Ca plays important biochemical functions and supports many metabolic processes, in addition to activating several enzymatic systems, thus contributing to the proper development of plants. Ca fundamental role in the stability of the membrane and cell integrity. Among all organs, the leaves contain the highest concentration, Ca abundant in the leaves may be due to the formation of calcium pectate in the middle lamella of cells. As calcium is not mobile in the phloem, it cannot be retranslocated from old shoot tissues to young tissues, and its xylem transport into organs that do not have a high transpiration rate is low, Calcium is an element associated with the transport of N and interaction with potassium (K) and phosphorus (P). Abiotic stress often leads to an increase of free calcium in the cytoplasm of cells, which leads to gene expression which activates biochemical responses that allow the plant to adapt to adverse conditions of various kinds. Thus, the Ca is involved in the regulatory mechanisms that will enable the plant to make adjustments under adverse conditions such as high temperature, chilling, water stress and
Introduction: Obesity is the major pathogenesis of the non-alcoholic fatty liver disease (NAFLD).... more Introduction: Obesity is the major pathogenesis of the non-alcoholic fatty liver disease (NAFLD). The combination of low-level laser therapy (LLLT) and Mediterranean diet (MD) is a new approach for improving liver function. Methods: 60 obese older adults (65-75 years old) with NAFLD were randomly assigned equally to two groups: a study group and a control group. The study group received LLLT and MD, while the control group followed MD only. These findings evaluated the changes in the level of liver enzymes, serum lipid profile, and anthropometric measurements (body mass index [BMI] and waist circumference [WC]) after 12 weeks of intervention. Results: Both study and control groups showed a significant reduction in the levels of liver enzymes, serum lipid profile, BMI, and WC (P<0.001 and P <0.01 respectively); however, the study group showed more significant results compared to the control group (P<0.01). Conclusion: LLLT and MD may be considered as a treatment approach for...
Alzheimer’s disease (AD) and Parkinson's disease (PD) are notorious neurodegenerative disease... more Alzheimer’s disease (AD) and Parkinson's disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among different events, amyloid β peptide (Aβ) induced toxicity is a well‐established pathway of neuronal cell death, which plays a vital function in AD. Glutamate, the major excitatory transmitter, acts as a neurotoxin when present in excess at the synapses; this latter mechanism is termed excitotoxicity. It is hypothesised that glutamate-induced excitotoxicity contributes to the pathogenesis of AD and PD. No cure for AD and PD is currently available and the currently approved drugs available to treat these diseases have limited effectiveness and pose adverse effects. Indeed, plants have been a major source for the discovery of novel pharmacologically active compou...
Journal of Genetic Engineering and Biotechnology, 2020
BackgroundThe multidrug resistance (MDR) of cancer cells is a major obstacle to cancer treatment.... more BackgroundThe multidrug resistance (MDR) of cancer cells is a major obstacle to cancer treatment. Glutathione S-transferase Pi (GSTP1-1) catalyzes the conjugation of glutathione with anticancer drugs and therefore reduces their efficacy. Phenolic compounds have the potential to inhibit GST P1-1 activity, which is a promising goal to overcome MDR and increase the efficacy of chemotherapy.ResultsThree fractions (dichloromethane, ethyl acetate, andn-butanol) were prepared fromTamarindus indicaseeds to determine their phenolic and flavonoid properties as well as their antioxidant/pro-oxidant properties. Then-butanol fraction displayed the highest levels of phenol ( 378 ± 11.7 mg gallic acid equivalent/g DW) and flavonoids (83 ± 6.0 mg rutin equivalent/g DW). Inhibiting effects on purified GSTP1-1 activity in human erythrocytes (eGST), placenta (pGST), and hGSTP1-1 have been studied. Then-butanol fraction was the most effective in inhibiting eGST, hGSTP1-1, and pGST with IC50values of 3....
The food industries are interested in developing functional products due to their popularity with... more The food industries are interested in developing functional products due to their popularity within nutritional and healthy circles. Functional fruit-based beverages represent one of the fast-growing markets due to the high concentrations of bioactive compounds (BCs), which can be health promoters. Hence, functional beverages based on citrus fruits are a potential way to take advantage of their nutritional and bioactive properties that could attract the interest of consumers. In order to ensure microbial and quality stability, the beverages are subjected to preservation treatment; however, the application of high temperatures leads to the loss of thermolabile BCs. Nowadays, innovative processing technologies (IPT) such as pulsed electric field (PEF), high-pressure processing (HPP), ultrasound processing (US), ohmic heating (OH), and microwave (MW) are a promising alternative due to their efficiency and low impact on juice BCs. The available literature concerning the effects of these...
The purpose of this study was to investigate the potential of pectin extracted from orange waste ... more The purpose of this study was to investigate the potential of pectin extracted from orange waste by acid hydrolysis and prepared Pectin/ hydroxyethyl cellulose (HEC)/ZnO nanoparticles (ZnO-NPs) biofilm for food packaging applications. The pectin/HEC/ZnO biofilms were prepared in an aqueous solution at room temperature using solvent casting method and characterized by different techniques such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), and scanning electron microscope (SEM). Also, thermal gravimetric analysis (TGA), mechanical properties, and water vapor permeability-WVP were evaluated. Moreover, its antimicrobial activity against Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica Typhimiurium) and two Gram positive bacteria (Listeria monocytogenes and Staphylococcus aureus), and also has antifungal activity against Candida albicans was assessed. The obtained results display that the water vapor permeability (WVP) indicated a reduction in permeability with increased ZnO concentration, with WVPs ranging from 2.55 × 10 -12 to 4.28 × 10 -12 gm/pas.m 2 , which indicates that our pectin/HEC/ZnO bionanocomposite biofilm could efficiently decrease moisture transfer, thereby potentially extending the shelf-life of packaged food products. Furthermore, the results showed enhanced tensile strength and flexibility in the biofilms with the addition of 1% ZnO nanoparticles from 1.2 to 2.6 MPa and 4.5 to 13 MPa respectively. The WVP indicated a reduction in permeability with increased ZnO concentration, with WVPs ranging from 2.55 × 10 -12 to 4.28 × 10 -12 gm/pas.m 2 . The antimicrobial activity against pathogens such as Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica Typhimurium, Listeria monocytogenes, Staphylococcus aureus, and Candida albicans was significant, with a 99.96% reduction in E. coli counts at a biofilm concentration of 200 mg/mL. Furthermore, the current study revealed that the synthesized bionanocomposite biofilms had excellent qualities such as transparency, flexibility, low cost, and being environmentally friendly. The pectin/ HEC/ZnO bionanocomposite was found to be an ideal biofilm for food packaging due to its safety and affordability, which is able to prolong food shelf-life.
Bulletin of the National Research Centre, Jan 4, 2024
Background The second most common cancer in the world is breast cancer. Chemotherapy is used to t... more Background The second most common cancer in the world is breast cancer. Chemotherapy is used to treat breast cancer, but instances of multidrug resistance, targets that are not selective, and physicochemical issues raise doubts about its efficacy. So, the exploration of chemopreventive agents from efficient natural sources has been required. The chia and quinoa seeds have health-promoting activities that include cardio-protective, antidiabetic, and anticancer effects. Given the paramount importance of their oils and their potential bioactivities, this work aimed to assess the repressive effect of their oil nanocapsules against mammary tumors in rats. Rat models of chemically induced mammary tumors were gavaged with chia and quinoa nanocapsules for one month. The repressive effect of nanocapsules was studied by quantifying TNF-α, assessing the gene expression of proto-oncogenes (PIK3CA and MYC) using qRT-PCR, and analyzing the cell cycle in mammary tissue. The studies clarified that the inhibition of tumors in response to quinoa and chia nanocapsules was associated with a reduction in TNF-α levels, proliferation capability, and motivation for apoptosis. Furthermore, quinoa and chia nanocapsule management repressed the activation of the MYC and PIK3CA genes. As well as nanocapsules modulated the liver enzymes and kidney function alterations induced in mammary tumor animals. Meanwhile, both oils' nanocapsules do not have an impact on the liver and kidneys of healthy rats. The findings indicate that quinoa and chia nanocapsules are safe and can reduce tumor growth, suggesting a potential natural therapeutic target for breast cancer treatment.
Zagazig Journal of Agricultural Research, Aug 31, 2023
The fruits of white mulberry are widespread fruit in Egypt and are eaten by most people with acce... more The fruits of white mulberry are widespread fruit in Egypt and are eaten by most people with acceptable taste, so we tried in this research to show the chemical composition of the fruits and the effectiveness of white mulberry as an antioxidant and also know the quality of the polysaccharide that is found in white mulberry and study the properties of sugar many in terms of the quality of the structural units involved in the composition and effective groups of its molecular weight and also its ability as an antioxidant and to achieve this purpose we have collected the fruits of white mulberry from The local market of the city of Zagazig was washed and dried and then grinding and storage in appropriate conditions of temperature (4°C) and the chemical composition of moisture, total ash, crude protein, crude fat, fiber and carbohydrates was estimated by the difference and the results were as follows as a percentage of the dry sample of white mulberry fruits (12.02 -14.42 -21 -4.83 -15 -59.75) respectively. Total phenols and total flavonoids were estimated through two types of extracts, aqueous extract and alcoholic extract to determine the effectiveness of white mulberry fruiting as an antioxidant, where the results were (23.5-13.9 mg gallic acid/gram total phenolat extract aqueous and alcoholic extract respectively As for the total flavonoids, the results were (1.43 -2.54 mg Quercetin /gram aqueous and alcoholic extract, respectively, and finally. The antioxidant activity of white mulberry fruits was estimated by DPPH method and the results obtained were (6.66 -1.97 mg vitamin C/gram aqueous and alcoholic extract respectively. The sugar was separated from many white mulberry fruits and purified and it became clear from the results to obtain two types of sugar many in the fruits of white mulberry differ in molecular weight and also in the type of structural units involved in the composition where the molecular weight sugar was reached 1.25 x 10 4 -5.29 x 10 4 Dalton and called them fraction 1 and fraction 2 respectively The quality of monosaccharide was glucose -Mannose -Arabenose -fructose -Mannuronic acid in fractions WMP1 or fraction WMP2 It contains the following structural units (glucose -galactose -arabinose -manuuronic acid acid) Through the results obtained from the HPLC device, the quality of the effective groups in polysaccharide fractions in white mulberry fruits was also identified through the infrared spectrum, which showed peaks appear in 1728 -1619.2 -3345.6 cm -1 for samples Which indicates the presence of the CH 2 group and the C=O group hydroxyl group, respectively. Through the results obtained, we can say that the consumption of white mulberry fruits provides the human body with natural antioxidant compounds and also a high content of protein, salts and total carbohydrates.
Featured Application: The bio-based food additives obtained from upcycling grapefruit peels can b... more Featured Application: The bio-based food additives obtained from upcycling grapefruit peels can be used mainly in the food industry as natural antioxidant and antimicrobial alternatives. Additionally, these ingredients also show anti-inflammatory potential, underscoring their potential as a nutraceutical.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Nigella sativa L. is an annual herb of the Ranunculaceae family. The seeds called black cumin see... more Nigella sativa L. is an annual herb of the Ranunculaceae family. The seeds called black cumin seed which contains 34-39% oil. Its oil has many purposes in traditional medicine and food industries. Black seed oil is a significant source of essential fatty acids, tocopherols, phytosterols, phenolics, essential oils, and other bioactive compounds. Thymoquinone (TQ) is one of the potent active compounds in the essential oil fraction of black seed oil with many health beneficial properties. Black seed oil is getting much attention either used alone or in combination with other vegetable oils. Providing information about the black seeds originating from different parts of the world, their oil composition and the effect of deferent extraction methods on the oil quality is of great value. Environmental condition, maturity stage and storage conditions have also significant effects on the oil properties.
Salvia has been used since ancient times in folk medicine and many pharmaceutical industries. Sal... more Salvia has been used since ancient times in folk medicine and many pharmaceutical industries. Salvia langiera Poir herbs, growing wild in Egyptian desert, are among nine endemic wild species native to Egypt. The essential oil of Wild Egyptian Salvia langiera has not been previously investigated in Egypt. The aim of the present study was to assess the composition and antimicrobial activity of the essential oil of Salvia langiera plant growing wild in Egyptian desert. The plant materials were collected from wild population growing in sandy soils near El-Sallum region (41 km eastern of Sallum). The essential oil of the air-dried aerial parts of plant was extracted by hydrodistillation and analyzed by Gas Chromatography-Mass Spectrometry (GC/MS). The essential oil composition of Salvia langiera was characterized by a high percentage of oxygenated sesquiterpene (26.44%). The major constituents were Spathulenol (5.90%), Carotol (5.36 %) and cis, trans farnesol (5.34%) followed by caryophyllene oxide (3.96%) and Globulol (2.20%). Oxygenated monoterpene (3.65 %) were Camphor (1.28%), -Thujone (1.23%) and Linalool (1.14%). -Pinene (2.17%) and Sabinene (1.12%) were the monoterpene hydrocarbons while sesquiterpene hydrocarbons were -Muurolene (1.68%). Other important constituents n-alkane (6.32 %), aliphatic alcohols (9.73%) and fatty acids (21.97%) were present in considerable amounts. On the other hand the essential oil of Salvia langiera was more active against Saccharomyces cereviseae, intermediate sensitive with Bacillus megaterium, while it was the least against Bacillus subtilis.
Nutrition is a key factor for growth and development of plants. Among the main nutrients is calci... more Nutrition is a key factor for growth and development of plants. Among the main nutrients is calcium (Ca). Calcium, uptaken as Ca 2+ , is essential element for the growth of the plants and fruit development, and it is important in the resistance of the plants to diseases due to with base in the protection of the cell wall. Ca plays important biochemical functions and supports many metabolic processes, in addition to activating several enzymatic systems, thus contributing to the proper development of plants. Ca fundamental role in the stability of the membrane and cell integrity. Among all organs, the leaves contain the highest concentration, Ca abundant in the leaves may be due to the formation of calcium pectate in the middle lamella of cells. As calcium is not mobile in the phloem, it cannot be retranslocated from old shoot tissues to young tissues, and its xylem transport into organs that do not have a high transpiration rate is low, Calcium is an element associated with the transport of N and interaction with potassium (K) and phosphorus (P). Abiotic stress often leads to an increase of free calcium in the cytoplasm of cells, which leads to gene expression which activates biochemical responses that allow the plant to adapt to adverse conditions of various kinds. Thus, the Ca is involved in the regulatory mechanisms that will enable the plant to make adjustments under adverse conditions such as high temperature, chilling, water stress and
Introduction: Obesity is the major pathogenesis of the non-alcoholic fatty liver disease (NAFLD).... more Introduction: Obesity is the major pathogenesis of the non-alcoholic fatty liver disease (NAFLD). The combination of low-level laser therapy (LLLT) and Mediterranean diet (MD) is a new approach for improving liver function. Methods: 60 obese older adults (65-75 years old) with NAFLD were randomly assigned equally to two groups: a study group and a control group. The study group received LLLT and MD, while the control group followed MD only. These findings evaluated the changes in the level of liver enzymes, serum lipid profile, and anthropometric measurements (body mass index [BMI] and waist circumference [WC]) after 12 weeks of intervention. Results: Both study and control groups showed a significant reduction in the levels of liver enzymes, serum lipid profile, BMI, and WC (P<0.001 and P <0.01 respectively); however, the study group showed more significant results compared to the control group (P<0.01). Conclusion: LLLT and MD may be considered as a treatment approach for...
Alzheimer’s disease (AD) and Parkinson's disease (PD) are notorious neurodegenerative disease... more Alzheimer’s disease (AD) and Parkinson's disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among different events, amyloid β peptide (Aβ) induced toxicity is a well‐established pathway of neuronal cell death, which plays a vital function in AD. Glutamate, the major excitatory transmitter, acts as a neurotoxin when present in excess at the synapses; this latter mechanism is termed excitotoxicity. It is hypothesised that glutamate-induced excitotoxicity contributes to the pathogenesis of AD and PD. No cure for AD and PD is currently available and the currently approved drugs available to treat these diseases have limited effectiveness and pose adverse effects. Indeed, plants have been a major source for the discovery of novel pharmacologically active compou...
Journal of Genetic Engineering and Biotechnology, 2020
BackgroundThe multidrug resistance (MDR) of cancer cells is a major obstacle to cancer treatment.... more BackgroundThe multidrug resistance (MDR) of cancer cells is a major obstacle to cancer treatment. Glutathione S-transferase Pi (GSTP1-1) catalyzes the conjugation of glutathione with anticancer drugs and therefore reduces their efficacy. Phenolic compounds have the potential to inhibit GST P1-1 activity, which is a promising goal to overcome MDR and increase the efficacy of chemotherapy.ResultsThree fractions (dichloromethane, ethyl acetate, andn-butanol) were prepared fromTamarindus indicaseeds to determine their phenolic and flavonoid properties as well as their antioxidant/pro-oxidant properties. Then-butanol fraction displayed the highest levels of phenol ( 378 ± 11.7 mg gallic acid equivalent/g DW) and flavonoids (83 ± 6.0 mg rutin equivalent/g DW). Inhibiting effects on purified GSTP1-1 activity in human erythrocytes (eGST), placenta (pGST), and hGSTP1-1 have been studied. Then-butanol fraction was the most effective in inhibiting eGST, hGSTP1-1, and pGST with IC50values of 3....
The food industries are interested in developing functional products due to their popularity with... more The food industries are interested in developing functional products due to their popularity within nutritional and healthy circles. Functional fruit-based beverages represent one of the fast-growing markets due to the high concentrations of bioactive compounds (BCs), which can be health promoters. Hence, functional beverages based on citrus fruits are a potential way to take advantage of their nutritional and bioactive properties that could attract the interest of consumers. In order to ensure microbial and quality stability, the beverages are subjected to preservation treatment; however, the application of high temperatures leads to the loss of thermolabile BCs. Nowadays, innovative processing technologies (IPT) such as pulsed electric field (PEF), high-pressure processing (HPP), ultrasound processing (US), ohmic heating (OH), and microwave (MW) are a promising alternative due to their efficiency and low impact on juice BCs. The available literature concerning the effects of these...
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