Papers by Farah Hosseinian
Journal of Functional Foods, 2016
environmental studies that assessed the abundance of microplastics in different water columns [8]... more environmental studies that assessed the abundance of microplastics in different water columns [8]. Release of nanoplastics from drinking water bottles was characterized by SEM, XPS, SPES and µ-Raman Analysis [9]. Spherical organic nanoparticles from bottled water were collected effectively through a tangential flow ultrafiltration system [10]. Polyethylene terephthalate nanoplastics collected from commercially bottled drinking water were detected with an average mean size of 88 nm; their concentration was estimated to be 10 8 particles/mL by nanoparticle tracking analysis [11]. A new study has reported the levels of micro-and nano-particles released in carbonated beverage bottles range from 68 to 4.7×10 8 particles/L, potentially posing health risks to humans. Polypropylene bottles released more particles than polyethylene terephthalate and polyethylene bottles [12]. The occurrence of micro-and nano-plastics (with particle diameters from 0.7 to 20 μm) in plastic bottled water has been assessed, and the median concentration was 359 ng L −1. Polyethylene was the most detected polymer, while polyethylene terephthalate was found at the highest concentrations [13]. The content of microplastic and nanoplastic particles in raw water, tap water, and drinking water was analyzed. Plastic particles were found in all water samples, with an average abundance ranging from 204 to 336 particles/L in raw water, from 22 to 33 particles/L in tap water, and from 25 to 73 particles/L in drinking water [14]. Pyrolysis gas chromatography-mass spectrometry
Journal of oleo science, 2024
for edible and other industrial applications 5. In fact, growing population of the world leads to... more for edible and other industrial applications 5. In fact, growing population of the world leads to the higher demand for edible oils which required introduction of alternative unconventional sources of vegetables oils 1. Currently, the focus of the food industry is to recover and exploited the valuable by-products from agricultural waste biomass 6. Triacylglycerols are the major components of vegetable oils 95-98 , while phospholipids, phenolic compounds and unsaponifiable lipids such as sterols, tocochromanols and n-alkanes are the minor components. Other than health benefits, the minor constituents of vegetable oils determine the quality of the oil and provide a valuable marker for oil authentication 7, 8. The n-alkane profile could be used to distinguish between different vegetable oils and recent method has been developed for the determination of these minor compounds 9. Therefore, the n-alkane com-Abstract: Although peach kernels are rich in oil, there is a lack of information about its chemical and biological properties. Therefore, the purpose of this study was to determine the lipid profile, antioxidant capacity, and trypsin inhibitory propriety of peach oil extracted from two varieties (sweet cap and O'Henry) cultivated in Tunisia. The investigated peach kernel oil contains significant amount of unsaponifiable (2.1±0.5-2.8±0.2% of oil) and phenolic compounds (45.8±0.92-74.6±1.3 mg GAE/g of oil). Its n-alkane profile was characterized by the predominance of tetracosane n-C24 (47.24%) followed by tricosane n-C23 (34.43%). An important total tocopherol content (1192.83±3.1 mg/kg oil) has been found in sweet cap cultivar. Although rich in polyphenols and tocopherols, the tested oil did not display an inhibitory effect on trypsin. However, all peach oil samples showed effective antioxidant capacity and the highest values (86.34±1.3% and 603.50±2.6 μmol TE/g oil for DPPH test and ORAC assay, respectively) were observed for sweet cap oil. Peach oil has an excellent potential for application in the food and pharmaceutical industries as source of naturally-occurring bioactive substances.
Authorea (Authorea), Feb 21, 2023
The aim of this paper was to investigate effects of inulin and ultrasonic homogenization on parti... more The aim of this paper was to investigate effects of inulin and ultrasonic homogenization on particle size distribution and microstructure of oil-in-water emulsion gels stabilized by psyllium husk were investigated. The emulsion gel was assessed their utility in meat puree prepared for people with dysphagia. The results showed that increasing inulin percentage resulted in reduced particle size and improved emulsion stability with the optimum at 20% w/w inclusion. Ultrasonic homogenization further enhanced the emulsion stability by reducing the size of emulsion droplet and improving encapsulation of emulsion droplet. Increasing inulin concentrations in the emulsion gels added into purees also corresponded with decreasing total expressible fluid (TEF). The stability of puree against the action of carbohydrate-hydrolyzing enzymes (α-amylase and α-glucosidase) was improved with the addition of emulsion gels. Therefore, these developed emulsion gels could be beneficial in formulating modified-texture food prepare for people with dysphagia.
Although 5-n-alkylresorcinols can be isolated from a wide array of sources, alkylresorcinols (ARs... more Although 5-n-alkylresorcinols can be isolated from a wide array of sources, alkylresorcinols (ARs) in edible food sources are of the greatest advantage. The abundance of ARs in wholegrain cereals and their exclusive presence in the bran fraction, allows for ARs to be an excellent candidate as biomarkers of wholegrain intake. The role of ARs as biomarkers is extremely important for validation of the disease preventative properties and health benefits resulting from the inclusion of whole grains in the diet. Numerous studies on the pharmacokinetics of ARs in in vivo and in vitro have determined that levels of whole grains consumed in the diet correlate with levels of intact ARs measured in the faeces as well as AR metabolites extracted from urine samples of these individuals. Recently, it has been suggested that ARs can also be used as long-term biomarkers of whole grain intake. A small percentage of ARs consumed from whole grains often reside in the adipose tissue and accumulated proportions correlate with long term intake. In addition to the role of ARs as biomarkers, these phenolic lipids owe to their amphiphillic structure their varying degree of biological effects. ARs possess antimicrobial, antioxidant, and cytotoxic activity, as well as inhibitory or stimulatory effects on enzymes, and stabilizing or disruptive effects on the phospholipid bilayer of cell membranes. These effects are dependent on the chain length, degree of saturation, chain or ring constituents, and the concentration of AR homologues present; these factors affect their hydrogen donating capacity, amphiphillic or lipophilic nature, polarity, hydrophobicity, binding capacity, as well as their ease of integration and interaction with enzymes, proteins and membranes. The ability of ARs to reduce or inhibit triglyceride accumulation, tumour cell formation, thromboxane synthesis, and enhance liposome stability, makes them suitable for respective applications of obesity, cancer, and cardiovascular disease prevention (CVD), as well as liposomal drug delivery. However, future research, particularly that of in vivo studies, need to be conducted on the biological effects and health benefits of ARs before their potential application can be employed. Furthermore, a common trend is evident in studies on the bioactivity of ARs such that homologs of 15 to 17 carbon chains have more pronounced biological effects than their shorter and longer chain counterparts; Thus, emphasis should be placed on these chain lengths for future in vivo studies
Natural Product Research, Aug 8, 2016
Jatropha curcas seed shells are the by-product obtained during oil extraction process. Recently, ... more Jatropha curcas seed shells are the by-product obtained during oil extraction process. Recently, its chemical composition has gained attention since its potential applications. The aim of this study was to identify phenolic compounds profile from a non-toxic J. curcas shell from Mexico, besides, evaluate J. curcas shell methanolic extract (JcSME) antioxidant activity. Free, conjugate and bound phenolics were fractionated and quantified (606.7, 193.32 and 909.59 μg/g shell, respectively) and thirteen individual phenolic compounds were detected by HPLC. The radical-scavenging activity of JcSME was similar to Trolox and ascorbic acid by DPPH assay while by ABTS assay it was similar to BHT. Effective antioxidant capacity by ORAC was found (426.44 ± 53.39 μmol Trolox equivalents/g shell). The Mexican non-toxic J. curcas shell is rich in phenolic compounds with high antioxidant activity; hence, it could be considerate as a good source of natural antioxidants.
Authorea (Authorea), Feb 21, 2023
Although 5-n-alkylresorcinols can be isolated from a wide array of sources, alkylresorcinols (ARs... more Although 5-n-alkylresorcinols can be isolated from a wide array of sources, alkylresorcinols (ARs) in edible food sources are of the greatest advantage. The abundance of ARs in wholegrain cereals and their exclusive presence in the bran fraction, allows for ARs to be an excellent candidate as biomarkers of wholegrain intake. The role of ARs as biomarkers is extremely important for validation of the disease preventative properties and health benefits resulting from the inclusion of whole grains in the diet. Numerous studies on the pharmacokinetics of ARs in in vivo and in vitro have determined that levels of whole grains consumed in the diet correlate with levels of intact ARs measured in the faeces as well as AR metabolites extracted from urine samples of these individuals. Recently, it has been suggested that ARs can also be used as long-term biomarkers of whole grain intake. A small percentage of ARs consumed from whole grains often reside in the adipose tissue and accumulated proportions correlate with long term intake. In addition to the role of ARs as biomarkers, these phenolic lipids owe to their amphiphillic structure their varying degree of biological effects. ARs possess antimicrobial, antioxidant, and cytotoxic activity, as well as inhibitory or stimulatory effects on enzymes, and stabilizing or disruptive effects on the phospholipid bilayer of cell membranes. These effects are dependent on the chain length, degree of saturation, chain or ring constituents, and the concentration of AR homologues present; these factors affect their hydrogen donating capacity, amphiphillic or lipophilic nature, polarity, hydrophobicity, binding capacity, as well as their ease of integration and interaction with enzymes, proteins and membranes. The ability of ARs to reduce or inhibit triglyceride accumulation, tumour cell formation, thromboxane synthesis, and enhance liposome stability, makes them suitable for respective applications of obesity, cancer, and cardiovascular disease prevention (CVD), as well as liposomal drug delivery. However, future research, particularly that of in vivo studies, need to be conducted on the biological effects and health benefits of ARs before their potential application can be employed. Furthermore, a common trend is evident in studies on the bioactivity of ARs such that homologs of 15 to 17 carbon chains have more pronounced biological effects than their shorter and longer chain counterparts; Thus, emphasis should be placed on these chain lengths for future in vivo studies
Nutrition, 2009
Moderate consumption of wine, beer, whisky or liqueur is known to be beneficial for improving hea... more Moderate consumption of wine, beer, whisky or liqueur is known to be beneficial for improving health because of the radical scavenging action of antioxidants present in them. Thus, antioxidant and aroma properties of anthograin liqueur made from purple wheat grain were evaluated for the added-value processing purpose of that grain. Anthograin liqueur showed the highest 2,2-diphenyl-1-picryhydrazyl (DPPH) free radical scavenging activity, total phenolic content (TPC) and oxygen radical absorbance capacity (ORAC) in comparison with three control samples Canadian iceberg vodka (CIV), Hiram walker special old rye whisky (HWSORW) and Wiser's De Luxe Canadian whisky (WDLCW). Only anthograin liqueur contained anthocyanins and its total anthocyanin content (TAC) was 81 mg/l. In lipid-soluble phase, TPC and ORAC were 241.1 and 998.6 mg/l for anthograin liqueur, 40.0 and 93.6 mg/l d for WDLCW, 23.1 and 63.6 mg/l for HWSORW, and 1.1 and 12.4 mg/l for CIV, respectively. In water-soluble phase, TPC and ORAC were 685.5 and 1467.7 mg/l for anthograin liqueur, 29.0 and 96.0 mg/l for WDLCW, 36.4 and 99.2 mg/l for HWSORW, and 2.0 and 42.8 mg/l for CIV, respectively. Eight types of phenolic acids in anthograin liqueur, four types of phenolic acids in WDLCW and three types of phenolic acids in HWSORW were found and no phenolic acid was detectable in CIV. Total phenolic acids in anthograin liqueur, WDLCW and HWSORW were 28.8, 10.3 and 5.7 mg/l, respectively. Similarity in aroma quality was found between anthograin liqueur and CIV by using the electronic nose. Purple wheat grain may have potential as a novel material for liqueur brewing.
Free Radical Biology and Medicine
The lignans derived from flaxseed possess a number of pharmacological properties, both in vitro a... more The lignans derived from flaxseed possess a number of pharmacological properties, both in vitro and in vivo. The ability of these lignans to reduce oxidative stress likely contributes to many of these biological properties. However, it is likely that flaxseed-derived lignans also provide pharmacological activity as a result of their interactions with specific receptors and enzymes within these biological systems. In order to better understand the therapeutic role that flaxseed and flaxseed lignans may play, further studies into the mechanisms of action is warranted. A better understanding of the pharmacology of flaxseed lignans will ultimately lead to appropriate recommendations for their therapeutic use, either as stand-alone therapies or as adjuvants with other pharmaceutical or natural products
Journal of the Science of Food and Agriculture, 2011
ABSTRACT BACKGROUND:In this study the chemical composition, antioxidant activities and cytotoxic ... more ABSTRACT BACKGROUND:In this study the chemical composition, antioxidant activities and cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) and Morinda citrifolia (mengkudu) were determined. RESULTS: Thirty-eight compounds in nutmeg oil and six compounds in mengkudu oil were identified by gas chromatography– mass spectrometry. The free radical scavenging activity of nutmeg oil was superior of that mengkudu oil. The MTT assay of nutmeg oil on human colorectal carcinoma (HCT-116) and human breast carcinoma (MCF-7) cell lines showed IC50 values of 78.61 and 66.45 μgmL−1, respectively. The mengkudu oil exhibited IC50 values of 91.46 and 78.15 μgmL−1 for HCT-116 and MCF-7, respectively. CONCLUSION: The results showed that nutmeg oil can be developed as potent anti-cancer and antioxidant drugs. �
Nutrients
The microbiota gut–brain axis (mGBA) is an important contributor to mental health and neurologica... more The microbiota gut–brain axis (mGBA) is an important contributor to mental health and neurological and mood disorders. Lipopolysaccharides (LPS) are endotoxins that are components of Gram-negative bacteria cell walls and have been widely shown to induce both systemic and neuro-inflammation. Flaxseed (Linum usitatissimum) is an oilseed rich in fibre, n3-poly-unsaturated fatty acid (alpha-linolenic acid (ALA)), and lignan, secoisolariciresinol diglucoside, which all can induce beneficial effects across varying aspects of the mGBA. The objective of this study was to determine the potential for dietary supplementation with flaxseed or flaxseed oil to attenuate LPS-induced inflammation through modulation of the mGBA. In this study, 72 5-week-old male C57Bl/6 mice were fed one of three isocaloric diets for 3 weeks: (1) AIN-93G basal diet (BD), (2) BD + 10% flaxseed (FS), or (3) BD + 4% FS oil (FO). Mice were then injected with LPS (1 mg/kg i.p) or saline (n = 12/group) and samples were co...
Sustainable Agriculture Research
Bioconversion is an important avenue for finding value from biomass waste produced by the agricul... more Bioconversion is an important avenue for finding value from biomass waste produced by the agricultural industry. One avenue of conversion is the development of upcycling byproducts and waste from food processing to value-added products. This includes degradable biomaterials which have real potential to reduce waste, improving economic, social and environmental impacts. As such, this research paper was focused on exploring two avenues of bioconversion from waste products of tomato skin, hemp meal and hops vines: identification of phytochemicals and the development of bioplastic. Combined to these researches, the effect of Ultrasound as a green technology was studied in both contexts. It was found that Ultrasound treatment reduced extraction time for saponin and phenolic acid from tomato skin, hemp meal and/or hops vines from 24h to 30 min. However, Ultrasound Assisted Extraction (UAE) was shown to affect the phenolic acid and saponin profiles of certain extracts. Ultrasound treatment...
Molecules
Gas chromatography (GC) techniques for analyzing and determining the cannabinoid profile in canna... more Gas chromatography (GC) techniques for analyzing and determining the cannabinoid profile in cannabis (Cannabis sativa L.) are widely used in standard laboratories; however, these methods may mislabel the profile when used under rapid conditions. Our study aimed to highlight this problem and optimize GC column conditions and mass spectrometry (MS) parameters to accurately identify cannabinoids in both standards and forensic samples. The method was validated for linearity, selectivity, and precision. It was observed that when tetrahydrocannabinol (Δ9-THC) and cannabidiolic acid (CBD-A) were examined using rapid GC conditions, the resulting derivatives generated identical retention times. Wider chromatographic conditions were applied. The linear range for each compound ranged from 0.02 μg/mL to 37.50 μg/mL. The R2 values ranged from 0.996 to 0.999. The LOQ values ranged from 0.33 μg/mL to 5.83 μg/mL, and the LOD values ranged from 0.11 μg/mL to 1.92 μg/mL. The precision values ranged f...
Journal of Food Biochemistry
Farnworth, 2004). Before the advent of pasteurization and refrigeration, the quick spoilage of ra... more Farnworth, 2004). Before the advent of pasteurization and refrigeration, the quick spoilage of raw milk limited its uses (Ross et al. 2002). e initial fermented milks were probably discovered by accident, when unprotected raw milk was inoculated by environmental bacteria and yeasts. Although many of these contaminating microorganisms caused spoilage, others lowered the pH of milk, changed its viscosity, and protected the fermented milk from spoilage organisms through their production of antimicrobial peptides. us, initially, fermenting milk was seen as a way to prolong the shelf life of milk (Ross et al. 2002).
International Journal of Molecular Sciences
Nanoparticles (NPs) are increasingly used in a wide variety of applications and products; however... more Nanoparticles (NPs) are increasingly used in a wide variety of applications and products; however, NPs may affect stress response pathways and interact with proteins in biological systems. This review article will provide an overview of the beneficial and detrimental effects of NPs on stress response pathways with a focus on NP–protein interactions. Depending upon the particular NP, experimental model system, and dose and exposure conditions, the introduction of NPs may have either positive or negative effects. Cellular processes such as the development of oxidative stress, the initiation of the inflammatory response, mitochondrial function, detoxification, and alterations to signaling pathways are all affected by the introduction of NPs. In terms of tissue-specific effects, the local microenvironment can have a profound effect on whether an NP is beneficial or harmful to cells. Interactions of NPs with metal-binding proteins (zinc, copper, iron and calcium) affect both their struct...
Plant foods for human nutrition (Dordrecht, Netherlands), 2012
The objectives of this study were to: (i) define the optimum concentration of triticale bran (TB)... more The objectives of this study were to: (i) define the optimum concentration of triticale bran (TB) that can be incorporated in yogurt, (ii) evaluate the prebiotic effects of TB on microbial viability, pH and total titratable acidity (TTA) in yogurt across 28 days of cold storage, and (iii) measure the oxygen radical absorbance capacity (ORAC) of water-extractable polysaccharides (WEP) in TB. Lactobacillus bulgaricus and Streptococcus thermophilus were used as starter cultures. Lactobacillus acidophilus and Bifidobacterium lactis were used as probiotics. A concentration of 4% TB in yogurt was determined to be the maximum amount that could be added without causing synersis. By day 7, the number of bacteria greatly increased in yogurt samples containing TB and maintained higher viable bacteria counts at the end of the cold storage period, in comparison to controls (P ≤ 0.05). Confirming this data was the lower pH levels and higher TTA values of TB yogurt samples exhibited throughout 28 ...
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Papers by Farah Hosseinian