The biodegradable poly(ε-caprolactone) (PCL) and ethylcellulose (EC) and blend polymers were test... more The biodegradable poly(ε-caprolactone) (PCL) and ethylcellulose (EC) and blend polymers were tested for encapsulation of procaine hydrochloride (PR.HCl). The PCL and PCL blend EC microspheres were prepared by emulsion solvent evaporation method and the microcapsules were investigated using an image analyzer. The aim of this work is the evaluation of microencapsulation PCL and (PCL,EC) blend using the same weight to form the carrier polymer. It can be seen that the presence of ethylcellulose in formulation, decreases the rate of drug loaded percentage from microspheres but the higher molecular weight of PCL microparticles used for preparation of microspheres it led to rapid release. The drug release test of the (PCL,EC) and PCL microspheres in buffer solutions was characterized by UV-visible spectroscopy, the microsphers were characterized for drug content, percentage yield, particle size and by FTIR spectroscopy, DSC and DRX.
We present in this work the preparation of several formulations based on biocompatible biodegrada... more We present in this work the preparation of several formulations based on biocompatible biodegradable polymers: polycaprolactone (PCL) and poly (lacticco-glycolic) acid (PLGA) loaded with Erythromycin(ERYT) antibiotic. These biocompatible materials were used to prepare microspheres with and without immobilized ERYT via the simple evaporation method and simple emulsion. The particle size was determined by scanning electron microscopy and the absence of the interaction with ERYT was confirmed via X-ray diffraction and infrared spectroscopy. The release kinetics of ERYT were studied and then, ERYT loaded PCL and PLGA blends microspheres were used for the inhibition of gram-positive S. aureus strain. The microbial activity was carried out by the agar diffusion disc method. The results show that PCL/PLGA blend and only PCL inhibited the bacteria strain by ERYT present in kinetic aliquots with the complementary effect of the polymers. A numerical model was proposed for modeling the kinetics reported in our study.
The biodegradable poly(ε-caprolactone) (PCL) and ethylcellulose (EC) and blend polymers were test... more The biodegradable poly(ε-caprolactone) (PCL) and ethylcellulose (EC) and blend polymers were tested for encapsulation of procaine hydrochloride (PR.HCl). The PCL and PCL blend EC microspheres were prepared by emulsion solvent evaporation method and the microcapsules were investigated using an image analyzer. The aim of this work is the evaluation of microencapsulation PCL and (PCL,EC) blend using the same weight to form the carrier polymer. It can be seen that the presence of ethylcellulose in formulation, decreases the rate of drug loaded percentage from microspheres but the higher molecular weight of PCL microparticles used for preparation of microspheres it led to rapid release. The drug release test of the (PCL,EC) and PCL microspheres in buffer solutions was characterized by UV-visible spectroscopy, the microsphers were characterized for drug content, percentage yield, particle size and by FTIR spectroscopy, DSC and DRX.
We present in this work the preparation of several formulations based on biocompatible biodegrada... more We present in this work the preparation of several formulations based on biocompatible biodegradable polymers: polycaprolactone (PCL) and poly (lacticco-glycolic) acid (PLGA) loaded with Erythromycin(ERYT) antibiotic. These biocompatible materials were used to prepare microspheres with and without immobilized ERYT via the simple evaporation method and simple emulsion. The particle size was determined by scanning electron microscopy and the absence of the interaction with ERYT was confirmed via X-ray diffraction and infrared spectroscopy. The release kinetics of ERYT were studied and then, ERYT loaded PCL and PLGA blends microspheres were used for the inhibition of gram-positive S. aureus strain. The microbial activity was carried out by the agar diffusion disc method. The results show that PCL/PLGA blend and only PCL inhibited the bacteria strain by ERYT present in kinetic aliquots with the complementary effect of the polymers. A numerical model was proposed for modeling the kinetics reported in our study.
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Papers by Fatima Bennabi