Stem cells offer an amazing potential for tooth homeostasis, repair, and regeneration. Manipulati... more Stem cells offer an amazing potential for tooth homeostasis, repair, and regeneration. Manipulating dental stem cells in situ and expanding them ex vivo by using specific signaling molecules is an exciting outcome. Nevertheless, stem cell based tooth repair is not devoid of challenges that need to be solved prior to any clinical application. For example, it is crucial to identify the different types of dental stem/ progenitor cells and their niches in teeth in order to understand the mechanisms that support stem cell survival. This knowledge will guarantee the success of stem-cell-based therapeutic approaches in dentistry.
International Journal of Science and Research (IJSR), Dec 5, 2017
Background: Active smoking has effects on bacterial binding to epithelial cells, expression of ho... more Background: Active smoking has effects on bacterial binding to epithelial cells, expression of host cell antigens that act as receptors for some species and passive exposure to water-soluble components of cigarette smoke on bacterial binding. Passive coating of mucosal surfaces with components of cigarette smoke might enhance binding of potentially pathogenic bacteria. Aim: Our study is to evaluate the differences in the microflora of healthy individuals & those having potentially malignant disorders. Methods: Total 80 patients were seen including 20 smokers, 20 chewers , 20 smokers as well as chewers and 20 control(non users) were neither smoker nor tobacco chewer. Three swab samples were collected of each patient i.e. one for anaerobic in Robertson cooked meat medium (enrichment medium) and streaked on BHI Agar, one for aerobic which was applied on blood agar and Mac Conkey agar and one sample for fungal culture which was applied on Sabouraud's dextrose agar. Confirmatory biochemical test were done for aerobic and anaerobic cultures and for fungal, chrome agar test were done. Results: In leukoplakia, the mean of Candida glabrata was lower whereas of other microorganisms were same. In Oral submucous fibrosis, the mean of all the microorganisms were same. In other white lesions, Candida glabrata was significantly lower in other white lesions whereas other microorganisms were same in mean count. Discussion: Our study shows no significant difference in the levels of microorganisms amongst chewers, smokers, chewers as well as smokers who did not have any clinical lesion, and even non-users of tobacco. This suggests the intricate role of these microorganisms in the development of Oral potential malignant disorders. Conclusion: Our findings also led us to suppose that the microbes are related to lesions per say and not to the etiologic factors.
Oral submucous fibrosis (OSMF) is a well-recognized, potentially malignant condition of the oral ... more Oral submucous fibrosis (OSMF) is a well-recognized, potentially malignant condition of the oral cavity that can affect any part of the oral mucosa. It is strongly associated with a risk of oral cancer, although the biology underlying this association is still unresolved. The purpose of this paper is to show the histopathological prototypical illustration of OSMF turning into oral squamous cell carcinoma.
Stem cells offer an amazing potential for tooth homeostasis, repair, and regeneration. Manipulati... more Stem cells offer an amazing potential for tooth homeostasis, repair, and regeneration. Manipulating dental stem cells in situ and expanding them ex vivo by using specific signaling molecules is an exciting outcome. Nevertheless, stem cell based tooth repair is not devoid of challenges that need to be solved prior to any clinical application. For example, it is crucial to identify the different types of dental stem/ progenitor cells and their niches in teeth in order to understand the mechanisms that support stem cell survival. This knowledge will guarantee the success of stem-cell-based therapeutic approaches in dentistry.
International Journal of Science and Research (IJSR), Dec 5, 2017
Background: Active smoking has effects on bacterial binding to epithelial cells, expression of ho... more Background: Active smoking has effects on bacterial binding to epithelial cells, expression of host cell antigens that act as receptors for some species and passive exposure to water-soluble components of cigarette smoke on bacterial binding. Passive coating of mucosal surfaces with components of cigarette smoke might enhance binding of potentially pathogenic bacteria. Aim: Our study is to evaluate the differences in the microflora of healthy individuals & those having potentially malignant disorders. Methods: Total 80 patients were seen including 20 smokers, 20 chewers , 20 smokers as well as chewers and 20 control(non users) were neither smoker nor tobacco chewer. Three swab samples were collected of each patient i.e. one for anaerobic in Robertson cooked meat medium (enrichment medium) and streaked on BHI Agar, one for aerobic which was applied on blood agar and Mac Conkey agar and one sample for fungal culture which was applied on Sabouraud's dextrose agar. Confirmatory biochemical test were done for aerobic and anaerobic cultures and for fungal, chrome agar test were done. Results: In leukoplakia, the mean of Candida glabrata was lower whereas of other microorganisms were same. In Oral submucous fibrosis, the mean of all the microorganisms were same. In other white lesions, Candida glabrata was significantly lower in other white lesions whereas other microorganisms were same in mean count. Discussion: Our study shows no significant difference in the levels of microorganisms amongst chewers, smokers, chewers as well as smokers who did not have any clinical lesion, and even non-users of tobacco. This suggests the intricate role of these microorganisms in the development of Oral potential malignant disorders. Conclusion: Our findings also led us to suppose that the microbes are related to lesions per say and not to the etiologic factors.
Oral submucous fibrosis (OSMF) is a well-recognized, potentially malignant condition of the oral ... more Oral submucous fibrosis (OSMF) is a well-recognized, potentially malignant condition of the oral cavity that can affect any part of the oral mucosa. It is strongly associated with a risk of oral cancer, although the biology underlying this association is still unresolved. The purpose of this paper is to show the histopathological prototypical illustration of OSMF turning into oral squamous cell carcinoma.
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Papers by Esha Singh