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Erika Bálint

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University of Amsterdam

Kansas State University

Dr.Yousery Sherif

Mansoura University

Achmad Syahrani

Universitas Airlangga

Viacheslav Kuleshov

Stockholm University

Professor Dr. Loutfy H . Madkour

Al-Baha University, Kingdom of Saudi Arabia

Ain Shams University

FOREST RESEARCH INSTITUTE, DEHRADUN

Carlos Luna Criado

Universidad Autónoma de Nuevo León

International Journal for Pharmaceutical Research Scholars (IJPRS)

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Papers by Erika Bálint

Microwave-assisted alcoholysis of dialkyl phosphites by ethylene glycol and ethanolamine

by György Balogh and Erika Bálint

Pure and Applied Chemistry, 2014

ABSTRACT

Cyclic Phosphinates by the Alkylation of a Thermally Unstable 1-Hydroxy-1,2- Dihydrophosphinine 1-Oxide and A 3-Hydroxy-3-Phosphabicyclo[3.1.0]Hexane 3-Oxide

by György Balogh and Erika Bálint

Phosphorus, Sulfur, and Silicon and the Related Elements, 2012

1-alkoxy-1,2-dihydrophosphinine oxides 4 may be prepared by the reaction of 1-hydroxy-1,2-dihydro... more 1-alkoxy-1,2-dihydrophosphinine oxides 4 may be prepared by the reaction of 1-hydroxy-1,2-dihydrophosphinine 1-oxide 3 with alkyl halides. The best results were obtained in boiling acetone in the presence of K2CO3. The outcome of the alkylation of 3-hydroxy-6,6-dichloro-3-phosphabicyclo[3.1.0]hexane 3-oxide 5 was dependent on temperature. Butylation at 56 °C in acetone using K2CO3 afforded mainly the expected phosphinate 6, but an increase in the temperature led to opening of the cyclopropane ring, resulting in the formation of 1-butoxy-1,2-dihydrophosphinine oxide 4a as the major product.

The Synthesis of N,N -Bis(dialkoxyphosphinoylmethyl)- and N,N -Bis(diphenylphosphinoylmethyl)glycine Esters by the Microwave-Assisted Double Kabachnik-Fields Reaction

by Eszter Fazekas and Erika Bálint

Heteroatom Chemistry, 2013

The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity o... more The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity of a dialkyl phosphite or diphenylphosphine oxide afforded the title compounds as new bis(phospha-Mannich) products under microwave (MW) conditions at 100 • C. The dialkoxyphosphinoylmethyl derivatives were synthesized under solvent-free conditions, whereas the diphenylphosphinoylmethyl derivatives were synthesized in acetonitrile solution. Comparative thermal experiments showed the beneficial role of MW in respect of efficiency. C 2013 Wiley Periodicals, Inc. Heteroatom Chem. 00:1-6, 2013; View this article online at wileyonlinelibrary.com.

N-Benzyl and N-aryl bis(phospha-Mannich adducts): Synthesis and catalytic activity of the related bidentate chelate platinum complexes in hydroformylation

by Eszter Fazekas and Erika Bálint

Journal of Organometallic Chemistry, 2012

The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and aryl... more The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and arylamines, two equivalents of paraformaldehyde and the pP(O)H reagent, such as dialkyl phosphites, ethyl phenyl-H-phosphinate and diphenylphosphine oxide gave the bis(pP(O)CH 2 )amine derivatives in good yields. The bis(diphenylphosphinoxido) derivatives were converted to the corresponding ring platinum complexes after deoxygenation whose catalytic activity was tested in the hydroformylation of styrene. Crystal structure analysis of one of the complexes reveals interesting correlations between complex structure and solvent inclusion.

Synthesis and Utilization of the Bis( > P(O)CH2)amine Derivatives Obtained by the Double Kabachnik–Fields Reaction with Cyclohexylamine; Quantum Chemical and X-Ray Study of the Related Bidentate Chelate Platinum Complexes

by Eszter Fazekas and Erika Bálint

Current Organic Chemistry, 2012

The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and aryl... more The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and arylamines, two equivalents of paraformaldehyde and the pP(O)H reagent, such as dialkyl phosphites, ethyl phenyl-H-phosphinate and diphenylphosphine oxide gave the bis(pP(O)CH 2 )amine derivatives in good yields. The bis(diphenylphosphinoxido) derivatives were converted to the corresponding ring platinum complexes after deoxygenation whose catalytic activity was tested in the hydroformylation of styrene. Crystal structure analysis of one of the complexes reveals interesting correlations between complex structure and solvent inclusion.

Microwave-Assisted Synthesis of Organophosphorus Compounds

by Eszter Fazekas, Judit Takács, and Erika Bálint

Phosphorus, Sulfur, and Silicon and the Related Elements, 2013

ABSTRACT Kabachnik-Fields reactions of a variety of amines, phospha-Michael additions to maleimid... more

ChemInform Abstract: The Synthesis of N,N-Bis(dialkoxyphosphinoylmethyl)- and N,N-Bis(diphenylphosphinoylmethyl)glycine Esters by the Microwave-Assisted Double Kabachnik-Fields Reaction

by Eszter Fazekas and Erika Bálint

ChemInform, 2014

Synthesis of N,N -Bis(dialkoxyphosphinoylmethyl)- and N,N -Bis(diphenylphosphinoylmethyl)-β- and γ-amino acid Derivatives by the Microwave-Assisted Double Kabachnik-Fields Reaction

by Eszter Fazekas and Erika Bálint

Heteroatom Chemistry, 2014

The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity o... more The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity of a dialkyl phosphite or diphenylphosphine oxide afforded the title compounds as new bis(phospha-Mannich) products under microwave (MW) conditions at 100 • C. The dialkoxyphosphinoylmethyl derivatives were synthesized under solvent-free conditions, whereas the diphenylphosphinoylmethyl derivatives were synthesized in acetonitrile solution. Comparative thermal experiments showed the beneficial role of MW in respect of efficiency. C 2013 Wiley Periodicals, Inc. Heteroatom Chem. 00:1-6, 2013; View this article online at wileyonlinelibrary.com.

Microwave-assisted phospha-Michael addition of dialkyl phosphites, a phenyl-H-phosphinate and diphenylphosphine oxide to maleic derivatives

by Erika Bálint and Judit Takács

Heteroatom Chemistry

A series of new >P(O)-substituted succinic derivatives was synthesized by the microwave-assisted ... more A series of new >P(O)-substituted succinic derivatives was synthesized by the microwave-assisted phospha-Michael addition of dialkyl phosphites, ethyl phenyl-H-phosphinate, and diphenylphosphine oxide to N-phenyl and N-methyl maleimide, as well as to maleic acid anhydride. C 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:235-240, 2012; View this article online at wileyonlinelibrary.com.

The Addition of Dialkyl Phosphites and Diphenylphosphine Oxide on the Triple Bond of Dimethyl Acetylenedicarboxylate under Solvent-Free and Microwave Conditions

by Erika Bálint and Judit Takács

Current Organic Synthesis, 2014

ABSTRACT The addition of dialkyl phosphites or diphenylphosphine oxide to the triple bond of dial... more ABSTRACT The addition of dialkyl phosphites or diphenylphosphine oxide to the triple bond of dialkyl acetylenedicarboxylate may result in mono- and/or bisadducts. The ratio of the products may be influenced by the molar ratio of the reactants and the conditions (temperature of microwave irradiation and reaction time). Stereospecific 3JPP couplings were utilized in the assignments to the meso and racemic forms of the bisadducts. The bis(dialkylphosphonyl)-succinates were formed as a mixture of the corresponding meso form and racemate, while bis(diphenylphosphinoyl)-succinate was obtained as a racemate. The 31P–12CH–13CH–31P spin system of bis(dialkylphosphonyl)-succinates was subjected to a detailed NMR analysis supported by simulation.

Green Chemical Tools in Organophosphorus Chemistry—Organophosphorus Tools in Green Chemistry

by R. Tóth, Erika Bálint, Nóra Zs. Kis, and István Molnár

Phosphorus Sulfur and Silicon and The Related Elements, 2011

A variety of reactions including esterifications, alkylations, additions, cycloadditions, fragmen... more A variety of reactions including esterifications, alkylations, additions, cycloadditions, fragmentations, and condensations were carried out under microwave MW-assisted and solventless conditions, occasionally in ionic liquids (ILs). In a few cases, MW was synergic with phase transfer catalysis or could substitute it. A variety of P(III) ligands were developed and converted to Pt(II) complexes that can be used as catalysts. Finally, phosphorylations and the Kabachnik–Fields reaction were monitored and optimized by an on-line method, in situ Fourier transform IR spectroscopy.

Solid–Liquid Phase Alkylation of N-Heterocycles: Microwave-Assisted Synthesis as an Environmentally Friendly Alternative

Synthetic Communications - SYN COMMUN, 2010

The solid–liquid phase alkylation of a variety of five-membered N-heterocycles (carbazole, imidaz... more The solid–liquid phase alkylation of a variety of five-membered N-heterocycles (carbazole, imidazole, benzimidazole, and indole-3-carbaldehyde) was carried out under different conditions. The use of alkali carbonate in dimethylformamide or in MeCN (in the latter case, in the presence of a phase-transfer catalyst) is a suitable method to prepare the corresponding N-alkylated products in an efficient way. In most cases, the solventless, microwave-assisted reaction is an environmentally friendly alternative to traditional methods.

2,3-Bisphosphonosuccinic acid hexamethyl ester [(CH 3 O) 2 (O)P-CH-COOCH 3 ] 2 - NMR-spectroscopic studies of ABX and [AM 3 R 3 X] 2 +Z 6 spin systems

Phosphorus, Sulfur, and Silicon and the Related Elements, 2014

ABSTRACT Addition of dimethyl phosphite to the triple bond of dimethylacetylene-dicarboxylate by ... more ABSTRACT Addition of dimethyl phosphite to the triple bond of dimethylacetylene-dicarboxylate by conventional routes or assisted by microwaves leads predominantly to the meso form of 2,3-bisphosphonosuccinic acid hexamethyl ester [(CH3O)2(O)P-CH-COOCH3]2. Molecular structure and dominant rotamer were deduced from multinuclear 31P{1H}-, 13C{1H}-, 1H-, 1H{31P}-NMR studies on ABX and [AM3R3X]2+Z6 spin systems. Vicinal coupling constants 3JPP, 3JPH, and 3JHH were used as stereochemically relevant parameters to deduce rotamer preferences via Karplus-type relationships.

Microwave-Assisted Esterification of Phosphinic Acids by Alcohols, Phenols, and Alkyl Halogenides

Phosphorus, Sulfur, and Silicon and the Related Elements, 2011

Page 1. 1802 Current Organic Chemistry, 2011, 15, 1802-1810 1385-2728/11 $58.00+.00 © 2011 Bentha... more

Synthesis and Utilization of the Bis( > P(O)CH2)amine Derivatives Obtained by the Double Kabachnik–Fields Reaction with Cyclohexylamine; Quantum Chemical and X-Ray Study of the Related Bidentate Chelate Platinum Complexes

by Erika Bálint and Eszter Fazekas

Current Organic Chemistry, 2012

The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and aryl... more The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and arylamines, two equivalents of paraformaldehyde and the pP(O)H reagent, such as dialkyl phosphites, ethyl phenyl-H-phosphinate and diphenylphosphine oxide gave the bis(pP(O)CH 2 )amine derivatives in good yields. The bis(diphenylphosphinoxido) derivatives were converted to the corresponding ring platinum complexes after deoxygenation whose catalytic activity was tested in the hydroformylation of styrene. Crystal structure analysis of one of the complexes reveals interesting correlations between complex structure and solvent inclusion.

Alkylating esterification of 1-hydroxy-3-phospholene oxides under solventless MW conditions

Heteroatom Chemistry, 2010

α-Aminophosphonates and α-Aminophosphine Oxides by the Microwave-Assisted Kabachnik-Fields Reactions of 3-Amino-6-methyl-2 H -pyran-2-ones

by Judit Takács and Erika Bálint

Heteroatom Chemistry, 2013

The microwave-assisted Kabachnik-Fields reaction of a series of 3-amino-6-methyl-2H-pyran-2-ones,... more The microwave-assisted Kabachnik-Fields reaction of a series of 3-amino-6-methyl-2H-pyran-2-ones, paraformaldehyde, and dialkyl phosphites or diphenylphosphine oxide led to αaminophosphonates or α-aminophosphine oxides, respectively. The α-aminophosphonates were obtained under solvent-free conditions, whereas the αaminophosphine oxides in acetonitrile. The novel products were characterized by NMR and mass Correspondence to: György Keglevich;

Microwave-assisted phospha-michael addition of dialkyl phosphites, a phenyl-H-phosphinate, and diphenylphosphine oxide to maleic derivatives

by Judit Takács and Erika Bálint

Heteroatom Chemistry, 2012

A series of new >P(O)-substituted succinic derivatives was synthesized by the microwave-assisted ... more A series of new >P(O)-substituted succinic derivatives was synthesized by the microwave-assisted phospha-Michael addition of dialkyl phosphites, ethyl phenyl-H-phosphinate, and diphenylphosphine oxide to N-phenyl and N-methyl maleimide, as well as to maleic acid anhydride. C 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:235-240, 2012; View this article online at wileyonlinelibrary.com.

The Addition of Dialkyl Phosphites and Diphenylphosphine Oxide on the Triple Bond of Dimethyl Acetylenedicarboxylate under Solvent-Free and Microwave Conditions

by Judit Takács and Erika Bálint

Current Organic Synthesis, 2014

ABSTRACT The addition of dialkyl phosphites or diphenylphosphine oxide to the triple bond of dial... more ABSTRACT The addition of dialkyl phosphites or diphenylphosphine oxide to the triple bond of dialkyl acetylenedicarboxylate may result in mono- and/or bisadducts. The ratio of the products may be influenced by the molar ratio of the reactants and the conditions (temperature of microwave irradiation and reaction time). Stereospecific 3JPP couplings were utilized in the assignments to the meso and racemic forms of the bisadducts. The bis(dialkylphosphonyl)-succinates were formed as a mixture of the corresponding meso form and racemate, while bis(diphenylphosphinoyl)-succinate was obtained as a racemate. The 31P–12CH–13CH–31P spin system of bis(dialkylphosphonyl)-succinates was subjected to a detailed NMR analysis supported by simulation.

ChemInform Abstract: α-Aminophosphonates and α-Aminophosphine Oxides by the Microwave-Assisted Kabachnik-Fields Reactions of 3-Amino-6-methyl-2H-pyran-2-ones

by Judit Takács and Erika Bálint

ChemInform, 2013

The microwave-assisted Kabachnik-Fields reaction of a series of 3-amino-6-methyl-2H-pyran-2-ones,... more The microwave-assisted Kabachnik-Fields reaction of a series of 3-amino-6-methyl-2H-pyran-2-ones, paraformaldehyde, and dialkyl phosphites or diphenylphosphine oxide led to αaminophosphonates or α-aminophosphine oxides, respectively. The α-aminophosphonates were obtained under solvent-free conditions, whereas the αaminophosphine oxides in acetonitrile. The novel products were characterized by NMR and mass Correspondence to: György Keglevich;

Microwave-assisted alcoholysis of dialkyl phosphites by ethylene glycol and ethanolamine

by György Balogh and Erika Bálint

Pure and Applied Chemistry, 2014

ABSTRACT

Cyclic Phosphinates by the Alkylation of a Thermally Unstable 1-Hydroxy-1,2- Dihydrophosphinine 1-Oxide and A 3-Hydroxy-3-Phosphabicyclo[3.1.0]Hexane 3-Oxide

by György Balogh and Erika Bálint

Phosphorus, Sulfur, and Silicon and the Related Elements, 2012

1-alkoxy-1,2-dihydrophosphinine oxides 4 may be prepared by the reaction of 1-hydroxy-1,2-dihydro... more 1-alkoxy-1,2-dihydrophosphinine oxides 4 may be prepared by the reaction of 1-hydroxy-1,2-dihydrophosphinine 1-oxide 3 with alkyl halides. The best results were obtained in boiling acetone in the presence of K2CO3. The outcome of the alkylation of 3-hydroxy-6,6-dichloro-3-phosphabicyclo[3.1.0]hexane 3-oxide 5 was dependent on temperature. Butylation at 56 °C in acetone using K2CO3 afforded mainly the expected phosphinate 6, but an increase in the temperature led to opening of the cyclopropane ring, resulting in the formation of 1-butoxy-1,2-dihydrophosphinine oxide 4a as the major product.

The Synthesis of N,N -Bis(dialkoxyphosphinoylmethyl)- and N,N -Bis(diphenylphosphinoylmethyl)glycine Esters by the Microwave-Assisted Double Kabachnik-Fields Reaction

by Eszter Fazekas and Erika Bálint

Heteroatom Chemistry, 2013

The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity o... more The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity of a dialkyl phosphite or diphenylphosphine oxide afforded the title compounds as new bis(phospha-Mannich) products under microwave (MW) conditions at 100 • C. The dialkoxyphosphinoylmethyl derivatives were synthesized under solvent-free conditions, whereas the diphenylphosphinoylmethyl derivatives were synthesized in acetonitrile solution. Comparative thermal experiments showed the beneficial role of MW in respect of efficiency. C 2013 Wiley Periodicals, Inc. Heteroatom Chem. 00:1-6, 2013; View this article online at wileyonlinelibrary.com.

N-Benzyl and N-aryl bis(phospha-Mannich adducts): Synthesis and catalytic activity of the related bidentate chelate platinum complexes in hydroformylation

by Eszter Fazekas and Erika Bálint

Journal of Organometallic Chemistry, 2012

The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and aryl... more The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and arylamines, two equivalents of paraformaldehyde and the pP(O)H reagent, such as dialkyl phosphites, ethyl phenyl-H-phosphinate and diphenylphosphine oxide gave the bis(pP(O)CH 2 )amine derivatives in good yields. The bis(diphenylphosphinoxido) derivatives were converted to the corresponding ring platinum complexes after deoxygenation whose catalytic activity was tested in the hydroformylation of styrene. Crystal structure analysis of one of the complexes reveals interesting correlations between complex structure and solvent inclusion.

Synthesis and Utilization of the Bis( > P(O)CH2)amine Derivatives Obtained by the Double Kabachnik–Fields Reaction with Cyclohexylamine; Quantum Chemical and X-Ray Study of the Related Bidentate Chelate Platinum Complexes

by Eszter Fazekas and Erika Bálint

Current Organic Chemistry, 2012

The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and aryl... more The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and arylamines, two equivalents of paraformaldehyde and the pP(O)H reagent, such as dialkyl phosphites, ethyl phenyl-H-phosphinate and diphenylphosphine oxide gave the bis(pP(O)CH 2 )amine derivatives in good yields. The bis(diphenylphosphinoxido) derivatives were converted to the corresponding ring platinum complexes after deoxygenation whose catalytic activity was tested in the hydroformylation of styrene. Crystal structure analysis of one of the complexes reveals interesting correlations between complex structure and solvent inclusion.

Microwave-Assisted Synthesis of Organophosphorus Compounds

by Eszter Fazekas, Judit Takács, and Erika Bálint

Phosphorus, Sulfur, and Silicon and the Related Elements, 2013

ABSTRACT Kabachnik-Fields reactions of a variety of amines, phospha-Michael additions to maleimid... more

ChemInform Abstract: The Synthesis of N,N-Bis(dialkoxyphosphinoylmethyl)- and N,N-Bis(diphenylphosphinoylmethyl)glycine Esters by the Microwave-Assisted Double Kabachnik-Fields Reaction

by Eszter Fazekas and Erika Bálint

ChemInform, 2014

Synthesis of N,N -Bis(dialkoxyphosphinoylmethyl)- and N,N -Bis(diphenylphosphinoylmethyl)-β- and γ-amino acid Derivatives by the Microwave-Assisted Double Kabachnik-Fields Reaction

by Eszter Fazekas and Erika Bálint

Heteroatom Chemistry, 2014

The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity o... more The condensation of a glycine ester, two equivalents of paraformaldehyde, and the same quantity of a dialkyl phosphite or diphenylphosphine oxide afforded the title compounds as new bis(phospha-Mannich) products under microwave (MW) conditions at 100 • C. The dialkoxyphosphinoylmethyl derivatives were synthesized under solvent-free conditions, whereas the diphenylphosphinoylmethyl derivatives were synthesized in acetonitrile solution. Comparative thermal experiments showed the beneficial role of MW in respect of efficiency. C 2013 Wiley Periodicals, Inc. Heteroatom Chem. 00:1-6, 2013; View this article online at wileyonlinelibrary.com.

Microwave-assisted phospha-Michael addition of dialkyl phosphites, a phenyl-H-phosphinate and diphenylphosphine oxide to maleic derivatives

by Erika Bálint and Judit Takács

Heteroatom Chemistry

A series of new >P(O)-substituted succinic derivatives was synthesized by the microwave-assisted ... more A series of new >P(O)-substituted succinic derivatives was synthesized by the microwave-assisted phospha-Michael addition of dialkyl phosphites, ethyl phenyl-H-phosphinate, and diphenylphosphine oxide to N-phenyl and N-methyl maleimide, as well as to maleic acid anhydride. C 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:235-240, 2012; View this article online at wileyonlinelibrary.com.

The Addition of Dialkyl Phosphites and Diphenylphosphine Oxide on the Triple Bond of Dimethyl Acetylenedicarboxylate under Solvent-Free and Microwave Conditions

by Erika Bálint and Judit Takács

Current Organic Synthesis, 2014

ABSTRACT The addition of dialkyl phosphites or diphenylphosphine oxide to the triple bond of dial... more ABSTRACT The addition of dialkyl phosphites or diphenylphosphine oxide to the triple bond of dialkyl acetylenedicarboxylate may result in mono- and/or bisadducts. The ratio of the products may be influenced by the molar ratio of the reactants and the conditions (temperature of microwave irradiation and reaction time). Stereospecific 3JPP couplings were utilized in the assignments to the meso and racemic forms of the bisadducts. The bis(dialkylphosphonyl)-succinates were formed as a mixture of the corresponding meso form and racemate, while bis(diphenylphosphinoyl)-succinate was obtained as a racemate. The 31P–12CH–13CH–31P spin system of bis(dialkylphosphonyl)-succinates was subjected to a detailed NMR analysis supported by simulation.

Green Chemical Tools in Organophosphorus Chemistry—Organophosphorus Tools in Green Chemistry

by R. Tóth, Erika Bálint, Nóra Zs. Kis, and István Molnár

Phosphorus Sulfur and Silicon and The Related Elements, 2011

A variety of reactions including esterifications, alkylations, additions, cycloadditions, fragmen... more A variety of reactions including esterifications, alkylations, additions, cycloadditions, fragmentations, and condensations were carried out under microwave MW-assisted and solventless conditions, occasionally in ionic liquids (ILs). In a few cases, MW was synergic with phase transfer catalysis or could substitute it. A variety of P(III) ligands were developed and converted to Pt(II) complexes that can be used as catalysts. Finally, phosphorylations and the Kabachnik–Fields reaction were monitored and optimized by an on-line method, in situ Fourier transform IR spectroscopy.

Solid–Liquid Phase Alkylation of N-Heterocycles: Microwave-Assisted Synthesis as an Environmentally Friendly Alternative

Synthetic Communications - SYN COMMUN, 2010

The solid–liquid phase alkylation of a variety of five-membered N-heterocycles (carbazole, imidaz... more The solid–liquid phase alkylation of a variety of five-membered N-heterocycles (carbazole, imidazole, benzimidazole, and indole-3-carbaldehyde) was carried out under different conditions. The use of alkali carbonate in dimethylformamide or in MeCN (in the latter case, in the presence of a phase-transfer catalyst) is a suitable method to prepare the corresponding N-alkylated products in an efficient way. In most cases, the solventless, microwave-assisted reaction is an environmentally friendly alternative to traditional methods.

2,3-Bisphosphonosuccinic acid hexamethyl ester [(CH 3 O) 2 (O)P-CH-COOCH 3 ] 2 - NMR-spectroscopic studies of ABX and [AM 3 R 3 X] 2 +Z 6 spin systems

Phosphorus, Sulfur, and Silicon and the Related Elements, 2014

ABSTRACT Addition of dimethyl phosphite to the triple bond of dimethylacetylene-dicarboxylate by ... more ABSTRACT Addition of dimethyl phosphite to the triple bond of dimethylacetylene-dicarboxylate by conventional routes or assisted by microwaves leads predominantly to the meso form of 2,3-bisphosphonosuccinic acid hexamethyl ester [(CH3O)2(O)P-CH-COOCH3]2. Molecular structure and dominant rotamer were deduced from multinuclear 31P{1H}-, 13C{1H}-, 1H-, 1H{31P}-NMR studies on ABX and [AM3R3X]2+Z6 spin systems. Vicinal coupling constants 3JPP, 3JPH, and 3JHH were used as stereochemically relevant parameters to deduce rotamer preferences via Karplus-type relationships.

Microwave-Assisted Esterification of Phosphinic Acids by Alcohols, Phenols, and Alkyl Halogenides

Phosphorus, Sulfur, and Silicon and the Related Elements, 2011

Page 1. 1802 Current Organic Chemistry, 2011, 15, 1802-1810 1385-2728/11 $58.00+.00 © 2011 Bentha... more

Synthesis and Utilization of the Bis( > P(O)CH2)amine Derivatives Obtained by the Double Kabachnik–Fields Reaction with Cyclohexylamine; Quantum Chemical and X-Ray Study of the Related Bidentate Chelate Platinum Complexes

by Erika Bálint and Eszter Fazekas

Current Organic Chemistry, 2012

The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and aryl... more The microwave-assisted double KabachnikeFields (phospha-Mannich) reaction of benzylamine and arylamines, two equivalents of paraformaldehyde and the pP(O)H reagent, such as dialkyl phosphites, ethyl phenyl-H-phosphinate and diphenylphosphine oxide gave the bis(pP(O)CH 2 )amine derivatives in good yields. The bis(diphenylphosphinoxido) derivatives were converted to the corresponding ring platinum complexes after deoxygenation whose catalytic activity was tested in the hydroformylation of styrene. Crystal structure analysis of one of the complexes reveals interesting correlations between complex structure and solvent inclusion.

Alkylating esterification of 1-hydroxy-3-phospholene oxides under solventless MW conditions

Heteroatom Chemistry, 2010

α-Aminophosphonates and α-Aminophosphine Oxides by the Microwave-Assisted Kabachnik-Fields Reactions of 3-Amino-6-methyl-2 H -pyran-2-ones

by Judit Takács and Erika Bálint

Heteroatom Chemistry, 2013

The microwave-assisted Kabachnik-Fields reaction of a series of 3-amino-6-methyl-2H-pyran-2-ones,... more The microwave-assisted Kabachnik-Fields reaction of a series of 3-amino-6-methyl-2H-pyran-2-ones, paraformaldehyde, and dialkyl phosphites or diphenylphosphine oxide led to αaminophosphonates or α-aminophosphine oxides, respectively. The α-aminophosphonates were obtained under solvent-free conditions, whereas the αaminophosphine oxides in acetonitrile. The novel products were characterized by NMR and mass Correspondence to: György Keglevich;

Microwave-assisted phospha-michael addition of dialkyl phosphites, a phenyl-H-phosphinate, and diphenylphosphine oxide to maleic derivatives

by Judit Takács and Erika Bálint

Heteroatom Chemistry, 2012

A series of new >P(O)-substituted succinic derivatives was synthesized by the microwave-assisted ... more A series of new >P(O)-substituted succinic derivatives was synthesized by the microwave-assisted phospha-Michael addition of dialkyl phosphites, ethyl phenyl-H-phosphinate, and diphenylphosphine oxide to N-phenyl and N-methyl maleimide, as well as to maleic acid anhydride. C 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:235-240, 2012; View this article online at wileyonlinelibrary.com.

The Addition of Dialkyl Phosphites and Diphenylphosphine Oxide on the Triple Bond of Dimethyl Acetylenedicarboxylate under Solvent-Free and Microwave Conditions

by Judit Takács and Erika Bálint

Current Organic Synthesis, 2014

ABSTRACT The addition of dialkyl phosphites or diphenylphosphine oxide to the triple bond of dial... more ABSTRACT The addition of dialkyl phosphites or diphenylphosphine oxide to the triple bond of dialkyl acetylenedicarboxylate may result in mono- and/or bisadducts. The ratio of the products may be influenced by the molar ratio of the reactants and the conditions (temperature of microwave irradiation and reaction time). Stereospecific 3JPP couplings were utilized in the assignments to the meso and racemic forms of the bisadducts. The bis(dialkylphosphonyl)-succinates were formed as a mixture of the corresponding meso form and racemate, while bis(diphenylphosphinoyl)-succinate was obtained as a racemate. The 31P–12CH–13CH–31P spin system of bis(dialkylphosphonyl)-succinates was subjected to a detailed NMR analysis supported by simulation.

ChemInform Abstract: α-Aminophosphonates and α-Aminophosphine Oxides by the Microwave-Assisted Kabachnik-Fields Reactions of 3-Amino-6-methyl-2H-pyran-2-ones

by Judit Takács and Erika Bálint

ChemInform, 2013

The microwave-assisted Kabachnik-Fields reaction of a series of 3-amino-6-methyl-2H-pyran-2-ones,... more The microwave-assisted Kabachnik-Fields reaction of a series of 3-amino-6-methyl-2H-pyran-2-ones, paraformaldehyde, and dialkyl phosphites or diphenylphosphine oxide led to αaminophosphonates or α-aminophosphine oxides, respectively. The α-aminophosphonates were obtained under solvent-free conditions, whereas the αaminophosphine oxides in acetonitrile. The novel products were characterized by NMR and mass Correspondence to: György Keglevich;