Advances in asthma clinical assessment help in categorizing patients based on their clinical seve... more Advances in asthma clinical assessment help in categorizing patients based on their clinical severity. Eosinophilia is a common laboratory finding in asthmatics. This paper explores the correlation between the clinical severity of asthmatic children and the degree of total peripheral eosinophil count (TPEC). Eighty asthmatic children referred to pediatric and allergy clinics were selected. Their clinical severity levels were assessed using the recent Global Strategy for Asthma Management and Prevention guidelines. Absolute TPEC was performed for all cases by the Cell-Dyne 3500 automated hematology counter. Correlation between clinical severity and TPEC was measured and their means in each severity group were compared for any significant association. Asthmatic children aged between 6 months and 15 years (mean = 5.9 years; 67.5% male) were studied. The clinical severity of their bronchial asthma was divided into four groups: intermittent (6, or 7.5%), mild-persistent (48, or 60%), moderate persistent (20, or 25%), and severe-persistent (6, or 7.5%). TPEC for the groups ranged between 10 and 2100 cells/mm3 (mean = 581.7 cells) and showed a very significant positive correlation with increased asthma severity (R = 0.61, p<0.001). A high linear trend of TPEC within each clinical group was found (F = 51.3, p<0.0001), and the means among each group also showed a significant increase as asthma severity level increased (F = 19.98, p<0.001). The study documents a significant positive correlation between the clinical severity of bronchial asthma and eosinophil counts. The authors advocate the use of this simple and sensitive laboratory test as a significant adjunct objective technique in the assessment of asthma severity and management.
Stool analysis plays an important role in pre-employment tests for the screening of intestinal pa... more Stool analysis plays an important role in pre-employment tests for the screening of intestinal parasites in new workers. to explore the spectrum of intestinal parasites in stool samples of workers and their families during the pre-employment tests over a one-year period at King Abdulaziz University Hospital (KAUH). Subjects were selected sequentially from routine single stool analysis forms labeled for pre-employment tests. Stool specimens were examined using the formalin ether technique at the parasitology laboratory at KAUH. Two hundred and ninety two different stool samples of the workers and their families were studied. Their ages ranged from 3 to 72 year old (mean 32 Ā± 8.5 SD) and females formed 58.6% of the number. Intestinal parasites were detected in 161 workers (55%). The prevalence of intestinal parasites in Saudi workers was significantly lower than non-Saudi nationals, 15.8% versus 57.9% (p<0.001). Of all the positive cases, pathogenic intestinal parasites were found ...
To investigate the association between some demographic factors and the levels of severity among ... more To investigate the association between some demographic factors and the levels of severity among asthmatic children. One hundred and twenty five asthmatic children aged between 6 months and 15 years were studied in pediatric and asthma clinics at King AbdulAziz University Hospital (KAUH). The assessment of clinical severity was based on the global strategy guidelines for asthma assessment and management. Subjects were grouped by age: infants (ā¤1 year), toddlers (1-3 years), preschool or kindergarten (3-6 years), school (6-12 years), and adolescents (12-15 years). Demographic data (age and sex) were analyzed for any statistical significance. Boys were 80 (64%) and predominated in all age groups except in infants. 10(8%) were infants, 22(17.6%) toddlers, 26 (20.8%) preschool or kindergarten, 49 (39.2%) school, and 18 (14.4%) adolescent. The levels of severity of asthma were intermittent 11 (8.8%), mild persistent 74 (59.2%), moderate persistent 33 (26.4%), and severe persistent 7 (5.6...
To explore the associated diseases with positive anti-double stranded (ds) DNA other than systemi... more To explore the associated diseases with positive anti-double stranded (ds) DNA other than systemic lupus erythematosus (SLE), and to determine an association if any, between its level in non-SLE causes. This is a retrospective review of all patients with positive anti-dsDNA assay (more than 200 IU/ml) tested for any underlying etiology from January to December 2007 at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia. Two hundred and twelve patients with anti-dsDNA antibody testing were evaluated. Of these, 124 patients had SLE (58.5%), while 88 patients (41.5%) had other diseases. Representing non-SLE diseases were: rheumatological disorders in 29 patients (33%), infections in 11 (12%), and malignancy in 6 patients (7%). Strong positive results (>800 IU/ml) were found in only 8 patients (4%) with diagnoses of antiphospholipid antibody syndrome, tuberculosis, osteomylitis, thymoma, lymphoma, sarcoidosis, and 2 autoimmune hepatitis patients. There was a statisti...
Advances in asthma clinical assessment help in categorizing patients based on their clinical seve... more Advances in asthma clinical assessment help in categorizing patients based on their clinical severity. Eosinophilia is a common laboratory finding in asthmatics. This paper explores the correlation between the clinical severity of asthmatic children and the degree of total peripheral eosinophil count (TPEC). Eighty asthmatic children referred to pediatric and allergy clinics were selected. Their clinical severity levels were assessed using the recent Global Strategy for Asthma Management and Prevention guidelines. Absolute TPEC was performed for all cases by the Cell-Dyne 3500 automated hematology counter. Correlation between clinical severity and TPEC was measured and their means in each severity group were compared for any significant association. Asthmatic children aged between 6 months and 15 years (mean = 5.9 years; 67.5% male) were studied. The clinical severity of their bronchial asthma was divided into four groups: intermittent (6, or 7.5%), mild-persistent (48, or 60%), moderate persistent (20, or 25%), and severe-persistent (6, or 7.5%). TPEC for the groups ranged between 10 and 2100 cells/mm3 (mean = 581.7 cells) and showed a very significant positive correlation with increased asthma severity (R = 0.61, p&lt;0.001). A high linear trend of TPEC within each clinical group was found (F = 51.3, p&lt;0.0001), and the means among each group also showed a significant increase as asthma severity level increased (F = 19.98, p&lt;0.001). The study documents a significant positive correlation between the clinical severity of bronchial asthma and eosinophil counts. The authors advocate the use of this simple and sensitive laboratory test as a significant adjunct objective technique in the assessment of asthma severity and management.
Discrepancy in asthmatic assessment by symptoms and peak flow rate (PFR) is a frequent dilemma. C... more Discrepancy in asthmatic assessment by symptoms and peak flow rate (PFR) is a frequent dilemma. Currently, total peripheral eosinophil count (TPEC) is under study for asthma evaluation. To explore the correlation between TPEC and asthma severity assessed by symptoms alone versus symptoms and PFR. Adults asthmatics were selected from the Asthma Clinic. Severity assessment was based on two methods: symptoms alone or symptoms and PFR. Expiratory PFR was recorded by a Wright peak flow meter. Severity levels included mild intermittent, mild persistent, moderate persistent, and severe persistent. Total peripheral eosinophil count was performed on a Celldyn-3500 counter. Data was analyzed for statistical significance. Sixty asthmatics aged 15 to 70 years (mean = 34 years), of which 68.3% were female, were studied. Severity levels differed between the two assessment methods in 45% of the cases and showed a predominance of the moderate persistent type. Total peripheral eosinophil count ranged between 22 and 2470 cells/mm3 (mean = 520 +/- SD = 393) and eosinophilia was found in 50% of the cases. Total peripheral eosinophil count showed a high positive correlation with increased asthma severity level assessed by history alone (r = 0.460, P &lt; .001); more than by history and PFR (r = 0.328, P &lt; .05). The discrepancy between symptoms and PFR is confirmed by these results. A reliable objective parameter in asthma assessment is a continuous challenge. This study advocates the possible supplementation of TPEC as another objective parameter that might help in selecting the appropriate severity level in asthmatics.
submit your manuscript | www.dovepress.com Dovepress 61 S h o rt r E P o rt open access to scient... more submit your manuscript | www.dovepress.com Dovepress 61 S h o rt r E P o rt open access to scientific and medical research open Access Full text Article
... Koshak, Emad 1 ; Almehdar, Hussein 2 ; Gheith, Tarek 3 ; Abdelreheim, Magdy 4. ... House dust... more ... Koshak, Emad 1 ; Almehdar, Hussein 2 ; Gheith, Tarek 3 ; Abdelreheim, Magdy 4. ... House dust collected from different houses at KSA was put on culture media plates containing a mixture ofcharcoal, gypsum and water, which was then dried and wood excelsior with crushed ...
Advances in asthma clinical assessment help in categorizing patients based on their clinical seve... more Advances in asthma clinical assessment help in categorizing patients based on their clinical severity. Eosinophilia is a common laboratory finding in asthmatics. This paper explores the correlation between the clinical severity of asthmatic children and the degree of total peripheral eosinophil count (TPEC). Eighty asthmatic children referred to pediatric and allergy clinics were selected. Their clinical severity levels were assessed using the recent Global Strategy for Asthma Management and Prevention guidelines. Absolute TPEC was performed for all cases by the Cell-Dyne 3500 automated hematology counter. Correlation between clinical severity and TPEC was measured and their means in each severity group were compared for any significant association. Asthmatic children aged between 6 months and 15 years (mean = 5.9 years; 67.5% male) were studied. The clinical severity of their bronchial asthma was divided into four groups: intermittent (6, or 7.5%), mild-persistent (48, or 60%), moderate persistent (20, or 25%), and severe-persistent (6, or 7.5%). TPEC for the groups ranged between 10 and 2100 cells/mm3 (mean = 581.7 cells) and showed a very significant positive correlation with increased asthma severity (R = 0.61, p&lt;0.001). A high linear trend of TPEC within each clinical group was found (F = 51.3, p&lt;0.0001), and the means among each group also showed a significant increase as asthma severity level increased (F = 19.98, p&lt;0.001). The study documents a significant positive correlation between the clinical severity of bronchial asthma and eosinophil counts. The authors advocate the use of this simple and sensitive laboratory test as a significant adjunct objective technique in the assessment of asthma severity and management.
Stool analysis plays an important role in pre-employment tests for the screening of intestinal pa... more Stool analysis plays an important role in pre-employment tests for the screening of intestinal parasites in new workers. to explore the spectrum of intestinal parasites in stool samples of workers and their families during the pre-employment tests over a one-year period at King Abdulaziz University Hospital (KAUH). Subjects were selected sequentially from routine single stool analysis forms labeled for pre-employment tests. Stool specimens were examined using the formalin ether technique at the parasitology laboratory at KAUH. Two hundred and ninety two different stool samples of the workers and their families were studied. Their ages ranged from 3 to 72 year old (mean 32 Ā± 8.5 SD) and females formed 58.6% of the number. Intestinal parasites were detected in 161 workers (55%). The prevalence of intestinal parasites in Saudi workers was significantly lower than non-Saudi nationals, 15.8% versus 57.9% (p<0.001). Of all the positive cases, pathogenic intestinal parasites were found ...
To investigate the association between some demographic factors and the levels of severity among ... more To investigate the association between some demographic factors and the levels of severity among asthmatic children. One hundred and twenty five asthmatic children aged between 6 months and 15 years were studied in pediatric and asthma clinics at King AbdulAziz University Hospital (KAUH). The assessment of clinical severity was based on the global strategy guidelines for asthma assessment and management. Subjects were grouped by age: infants (ā¤1 year), toddlers (1-3 years), preschool or kindergarten (3-6 years), school (6-12 years), and adolescents (12-15 years). Demographic data (age and sex) were analyzed for any statistical significance. Boys were 80 (64%) and predominated in all age groups except in infants. 10(8%) were infants, 22(17.6%) toddlers, 26 (20.8%) preschool or kindergarten, 49 (39.2%) school, and 18 (14.4%) adolescent. The levels of severity of asthma were intermittent 11 (8.8%), mild persistent 74 (59.2%), moderate persistent 33 (26.4%), and severe persistent 7 (5.6...
To explore the associated diseases with positive anti-double stranded (ds) DNA other than systemi... more To explore the associated diseases with positive anti-double stranded (ds) DNA other than systemic lupus erythematosus (SLE), and to determine an association if any, between its level in non-SLE causes. This is a retrospective review of all patients with positive anti-dsDNA assay (more than 200 IU/ml) tested for any underlying etiology from January to December 2007 at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia. Two hundred and twelve patients with anti-dsDNA antibody testing were evaluated. Of these, 124 patients had SLE (58.5%), while 88 patients (41.5%) had other diseases. Representing non-SLE diseases were: rheumatological disorders in 29 patients (33%), infections in 11 (12%), and malignancy in 6 patients (7%). Strong positive results (>800 IU/ml) were found in only 8 patients (4%) with diagnoses of antiphospholipid antibody syndrome, tuberculosis, osteomylitis, thymoma, lymphoma, sarcoidosis, and 2 autoimmune hepatitis patients. There was a statisti...
Advances in asthma clinical assessment help in categorizing patients based on their clinical seve... more Advances in asthma clinical assessment help in categorizing patients based on their clinical severity. Eosinophilia is a common laboratory finding in asthmatics. This paper explores the correlation between the clinical severity of asthmatic children and the degree of total peripheral eosinophil count (TPEC). Eighty asthmatic children referred to pediatric and allergy clinics were selected. Their clinical severity levels were assessed using the recent Global Strategy for Asthma Management and Prevention guidelines. Absolute TPEC was performed for all cases by the Cell-Dyne 3500 automated hematology counter. Correlation between clinical severity and TPEC was measured and their means in each severity group were compared for any significant association. Asthmatic children aged between 6 months and 15 years (mean = 5.9 years; 67.5% male) were studied. The clinical severity of their bronchial asthma was divided into four groups: intermittent (6, or 7.5%), mild-persistent (48, or 60%), moderate persistent (20, or 25%), and severe-persistent (6, or 7.5%). TPEC for the groups ranged between 10 and 2100 cells/mm3 (mean = 581.7 cells) and showed a very significant positive correlation with increased asthma severity (R = 0.61, p&lt;0.001). A high linear trend of TPEC within each clinical group was found (F = 51.3, p&lt;0.0001), and the means among each group also showed a significant increase as asthma severity level increased (F = 19.98, p&lt;0.001). The study documents a significant positive correlation between the clinical severity of bronchial asthma and eosinophil counts. The authors advocate the use of this simple and sensitive laboratory test as a significant adjunct objective technique in the assessment of asthma severity and management.
Discrepancy in asthmatic assessment by symptoms and peak flow rate (PFR) is a frequent dilemma. C... more Discrepancy in asthmatic assessment by symptoms and peak flow rate (PFR) is a frequent dilemma. Currently, total peripheral eosinophil count (TPEC) is under study for asthma evaluation. To explore the correlation between TPEC and asthma severity assessed by symptoms alone versus symptoms and PFR. Adults asthmatics were selected from the Asthma Clinic. Severity assessment was based on two methods: symptoms alone or symptoms and PFR. Expiratory PFR was recorded by a Wright peak flow meter. Severity levels included mild intermittent, mild persistent, moderate persistent, and severe persistent. Total peripheral eosinophil count was performed on a Celldyn-3500 counter. Data was analyzed for statistical significance. Sixty asthmatics aged 15 to 70 years (mean = 34 years), of which 68.3% were female, were studied. Severity levels differed between the two assessment methods in 45% of the cases and showed a predominance of the moderate persistent type. Total peripheral eosinophil count ranged between 22 and 2470 cells/mm3 (mean = 520 +/- SD = 393) and eosinophilia was found in 50% of the cases. Total peripheral eosinophil count showed a high positive correlation with increased asthma severity level assessed by history alone (r = 0.460, P &lt; .001); more than by history and PFR (r = 0.328, P &lt; .05). The discrepancy between symptoms and PFR is confirmed by these results. A reliable objective parameter in asthma assessment is a continuous challenge. This study advocates the possible supplementation of TPEC as another objective parameter that might help in selecting the appropriate severity level in asthmatics.
submit your manuscript | www.dovepress.com Dovepress 61 S h o rt r E P o rt open access to scient... more submit your manuscript | www.dovepress.com Dovepress 61 S h o rt r E P o rt open access to scientific and medical research open Access Full text Article
... Koshak, Emad 1 ; Almehdar, Hussein 2 ; Gheith, Tarek 3 ; Abdelreheim, Magdy 4. ... House dust... more ... Koshak, Emad 1 ; Almehdar, Hussein 2 ; Gheith, Tarek 3 ; Abdelreheim, Magdy 4. ... House dust collected from different houses at KSA was put on culture media plates containing a mixture ofcharcoal, gypsum and water, which was then dried and wood excelsior with crushed ...
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