Une femme, âgee de 73 ans, ancienne documentaliste, consultait a veille de Noel. Ses antecedents ... more Une femme, âgee de 73 ans, ancienne documentaliste, consultait a veille de Noel. Ses antecedents comportaient une constipation hronique, une hepatite virale guerie, une hypertension arterielle, ne insuffisance veineuse, un syndrome de Raynaud, une presyacousie, une depression severe avec beaucoup d’insomnies, un ancer du sein droit en remission et une keratoconjonctivite bilaerale recidivante. Son pere et sa sœur avaient deja fait plusieurs entatives de suicide. Un de ses fils, geriatre de profession, avait fait n burn-out et l’autre etait depressif. Elle avait rec u 20 ans auparavant une anticoagulation curative et ne corticotherapie generale pour une nevrite optique anterieure roite et des arthralgies etiquetees « maladie de Horton ». Elle avait te hospitalisee quelques mois apres cet episode pour une aggraation de la nevrite optique qui semblait d’allure inflammatoire. es lesions cutanees erythemato-papuleuses non prurigineuses
A morning lymphocytosis has been observed in patients under methylprednisolone (mPDN) treatment. ... more A morning lymphocytosis has been observed in patients under methylprednisolone (mPDN) treatment. We here determine prospectively the timing and magnitude of mPDN-induced lymphocytosis and study the effects of concomitant beta-blockers administration on lymphocyte count (L). L was measured before and 24 to 72 hours after initiating mPDN treatment in 20 patients with immune-mediated inflammatory disorders (IMID). After one week, patients with increased L were divided in two groups receiving, in addition to mPDN, either propranolol or a placebo; L was determined 4 days later. Lymphocyte subpopulations and mPDN plasma levels were determined in subsets of the patients. Values are expressed as median with 25%-75% interquartile range. A 73.4 % (37-305) increase of L was observed in 18/20 patients as soon as 48 (48-72) hours after initiating mPDN (32 mg; 16-32). Lymphocytosis (L ≥4,000/µL) was observed in 7 patients and hyperlymphocytosis (L ≥ 5,000/µL) in 4 of them. No significant changes ...
Scientific fraud represents, to varying degrees, an increasingly important part of medical litera... more Scientific fraud represents, to varying degrees, an increasingly important part of medical literature and is estimated to make up nearly 20% of this literature. The increase in the number of articles accessible in preprint without peer review during the COVID-19 pandemic has led to an increase in the accessibility of fraudulent articles. In recent years, the viral increase in the number of predatory journals has contributed to polluting the scientific literature with articles whose content is unverifiable. Given the international nature of biomedical research, there is an urgent need to define unequivocally what is considered scientific fraud. In order to counter scientific misconduct, national and supranational procedures should be implemented to inform researchers at the beginning of their medical and biomedical training. Ethics commissions should implement local procedures for monitoring ongoing research. Finally, the fight against predatory journals requires information for rese...
audience: researcher, professional, student, popularizationTrop fréquemment, l’expérimentation an... more audience: researcher, professional, student, popularizationTrop fréquemment, l’expérimentation animale est présentée comme une pratique archaïque. Elle a bien changé. Et 100 % des patients traités le sont grâce aux concepts et techniques développés grâce à elle
23rd Annual Scientific Meeting of the European Society for Clinical Investigation (Athens, Greece... more 23rd Annual Scientific Meeting of the European Society for Clinical Investigation (Athens, Greece, April 1989)info:eu-repo/semantics/publishe
Le syndrome de Sjogren (SS) est une maladie auto-immunitaire caracterisee par une infiltration ly... more Le syndrome de Sjogren (SS) est une maladie auto-immunitaire caracterisee par une infiltration lymphocytaire des glandes exocrines menant le plus souvent, a une xerophtalmie et a une xerostomie. La physiopathologie de la maladie est complexe et malgre les progres realises, il existe beaucoup de questions a repondre. Classiquement, le syndrome sec qui caracterise la maladie resulterait d’un double processus ou dans un premier temps, la glande serait envahie par des cellules lymphoplasmocytaires puis secondairement detruite. Des avancees recentes dans la physiopathologie de la maladie ont demontre le role de nouvelles molecules, Aquaporine 5 (AQP5) et anticorps muscariniques, qui peuvent contribuer au syndrome sec. Dans ce travail, nous avons etudie des marqueurs diagnostiques de la maladie. Nous avons montre que 2 alarmines, HMGB1 et S100A8/A9 sont augmentes mais ne presentent pas de correlation avec le score d’activite de la maladie. Utilisant differents modeles animaux de SS, nous ...
Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is import... more Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.
Recent studies suggest the use of topical nitroglycerin (NTG) application in systemic sclerosis (... more Recent studies suggest the use of topical nitroglycerin (NTG) application in systemic sclerosis (SSc)-associated Raynaud phenomenon (RP). With the current study, we aimed to characterize for the first time the microvascular response to a NTG patch (Trinipatch® 5 mg/24 h) applied to the hand dorsum in patients with SSc using Laser Doppler imaging (LDI) at baseline and following a cold challenge. The study included 21 patients with SSc and 13 controls. Blood flow was evaluated by LDI at the level of the fingertips and metacarpus. Microvascular morphology was evaluated by nailfold capillaroscopy (NC). LDI revealed decreased fingertip baseline perfusion and a stronger vasoconstrictor response to a cold challenge in patients with SSc versus control. Metacarpal application of a NTG patch led to an increase in blood flow and hand temperature in patients with SSc. Furthermore, NTG administration led to a faster reperfusion after cold challenge. Correlation analyses revealed that the magnitu...
(2020) Eosinophilia Associated With CD3 − CD4 + T Cells: Characterization and Outcome of a Single... more (2020) Eosinophilia Associated With CD3 − CD4 + T Cells: Characterization and Outcome of a Single-Center Cohort of 26 Patients.
Le raisonnement clinique à l'ère du numérique Comment formaliser la supervision de l'apprentissag... more Le raisonnement clinique à l'ère du numérique Comment formaliser la supervision de l'apprentissage du raisonnement clinique [How to formalize the supervision of learning of clinical reasoning]
American Journal of Physiology-Renal Physiology, 1987
In single cortical collecting tubules (CCT) of the rabbit, guanosine 5'-triphosphate (GTP) in... more In single cortical collecting tubules (CCT) of the rabbit, guanosine 5'-triphosphate (GTP) increased the arginine vasopressin (AVP)-stimulated adenylate cyclase (AC) by 60% (P less than 0.05). In contrast, guanosine 5' O-(2-thio)-diphosphate (GDP-beta S), a competitive inhibitor of GTP action on the stimulatory guanine regulatory protein (Ns), reduced the AVP-stimulated AC activity by 72% (P less than 0.001), indicating the presence of endogenous GTP in the cells under study. That inhibitory effect was reversed by the addition of GTP to the incubation medium. In isolated perfused CCT, cholera toxin (CT) induced a significant increase in water permeability in the absence of AVP. In contrast, Bordetella pertussis toxin (BPT) did not modify the low AVP-independent water permeability. Lithium, an inhibitor of the hydrosmotic action of AVP, also inhibits the hydrosmotic action of CT by 70% (P less than 0.05) but not that of forskolin. The conclusions of the present study are Ns i...
Abscesses of the psoas muscle are due to a hematogenous dissemination, to the spread of infection... more Abscesses of the psoas muscle are due to a hematogenous dissemination, to the spread of infection from adjacent intestinal structures, to osteomyelitis of the spine or to tuberculous infection of a disc space. In contrast, psoas abscesses related to the urological tract have only been described on exception. The present report focuses on a right psoas abscess which developed 27 years after a nephrectomy. The infectious process resulted from the spread of an acute vesical infection through the residual ureter. Analysis of 4 other cases reported in the literature allows us to delineate the clinical features of psoas abscesses of urological origin.
Une femme, âgee de 73 ans, ancienne documentaliste, consultait a veille de Noel. Ses antecedents ... more Une femme, âgee de 73 ans, ancienne documentaliste, consultait a veille de Noel. Ses antecedents comportaient une constipation hronique, une hepatite virale guerie, une hypertension arterielle, ne insuffisance veineuse, un syndrome de Raynaud, une presyacousie, une depression severe avec beaucoup d’insomnies, un ancer du sein droit en remission et une keratoconjonctivite bilaerale recidivante. Son pere et sa sœur avaient deja fait plusieurs entatives de suicide. Un de ses fils, geriatre de profession, avait fait n burn-out et l’autre etait depressif. Elle avait rec u 20 ans auparavant une anticoagulation curative et ne corticotherapie generale pour une nevrite optique anterieure roite et des arthralgies etiquetees « maladie de Horton ». Elle avait te hospitalisee quelques mois apres cet episode pour une aggraation de la nevrite optique qui semblait d’allure inflammatoire. es lesions cutanees erythemato-papuleuses non prurigineuses
A morning lymphocytosis has been observed in patients under methylprednisolone (mPDN) treatment. ... more A morning lymphocytosis has been observed in patients under methylprednisolone (mPDN) treatment. We here determine prospectively the timing and magnitude of mPDN-induced lymphocytosis and study the effects of concomitant beta-blockers administration on lymphocyte count (L). L was measured before and 24 to 72 hours after initiating mPDN treatment in 20 patients with immune-mediated inflammatory disorders (IMID). After one week, patients with increased L were divided in two groups receiving, in addition to mPDN, either propranolol or a placebo; L was determined 4 days later. Lymphocyte subpopulations and mPDN plasma levels were determined in subsets of the patients. Values are expressed as median with 25%-75% interquartile range. A 73.4 % (37-305) increase of L was observed in 18/20 patients as soon as 48 (48-72) hours after initiating mPDN (32 mg; 16-32). Lymphocytosis (L ≥4,000/µL) was observed in 7 patients and hyperlymphocytosis (L ≥ 5,000/µL) in 4 of them. No significant changes ...
Scientific fraud represents, to varying degrees, an increasingly important part of medical litera... more Scientific fraud represents, to varying degrees, an increasingly important part of medical literature and is estimated to make up nearly 20% of this literature. The increase in the number of articles accessible in preprint without peer review during the COVID-19 pandemic has led to an increase in the accessibility of fraudulent articles. In recent years, the viral increase in the number of predatory journals has contributed to polluting the scientific literature with articles whose content is unverifiable. Given the international nature of biomedical research, there is an urgent need to define unequivocally what is considered scientific fraud. In order to counter scientific misconduct, national and supranational procedures should be implemented to inform researchers at the beginning of their medical and biomedical training. Ethics commissions should implement local procedures for monitoring ongoing research. Finally, the fight against predatory journals requires information for rese...
audience: researcher, professional, student, popularizationTrop fréquemment, l’expérimentation an... more audience: researcher, professional, student, popularizationTrop fréquemment, l’expérimentation animale est présentée comme une pratique archaïque. Elle a bien changé. Et 100 % des patients traités le sont grâce aux concepts et techniques développés grâce à elle
23rd Annual Scientific Meeting of the European Society for Clinical Investigation (Athens, Greece... more 23rd Annual Scientific Meeting of the European Society for Clinical Investigation (Athens, Greece, April 1989)info:eu-repo/semantics/publishe
Le syndrome de Sjogren (SS) est une maladie auto-immunitaire caracterisee par une infiltration ly... more Le syndrome de Sjogren (SS) est une maladie auto-immunitaire caracterisee par une infiltration lymphocytaire des glandes exocrines menant le plus souvent, a une xerophtalmie et a une xerostomie. La physiopathologie de la maladie est complexe et malgre les progres realises, il existe beaucoup de questions a repondre. Classiquement, le syndrome sec qui caracterise la maladie resulterait d’un double processus ou dans un premier temps, la glande serait envahie par des cellules lymphoplasmocytaires puis secondairement detruite. Des avancees recentes dans la physiopathologie de la maladie ont demontre le role de nouvelles molecules, Aquaporine 5 (AQP5) et anticorps muscariniques, qui peuvent contribuer au syndrome sec. Dans ce travail, nous avons etudie des marqueurs diagnostiques de la maladie. Nous avons montre que 2 alarmines, HMGB1 et S100A8/A9 sont augmentes mais ne presentent pas de correlation avec le score d’activite de la maladie. Utilisant differents modeles animaux de SS, nous ...
Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is import... more Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.
Recent studies suggest the use of topical nitroglycerin (NTG) application in systemic sclerosis (... more Recent studies suggest the use of topical nitroglycerin (NTG) application in systemic sclerosis (SSc)-associated Raynaud phenomenon (RP). With the current study, we aimed to characterize for the first time the microvascular response to a NTG patch (Trinipatch® 5 mg/24 h) applied to the hand dorsum in patients with SSc using Laser Doppler imaging (LDI) at baseline and following a cold challenge. The study included 21 patients with SSc and 13 controls. Blood flow was evaluated by LDI at the level of the fingertips and metacarpus. Microvascular morphology was evaluated by nailfold capillaroscopy (NC). LDI revealed decreased fingertip baseline perfusion and a stronger vasoconstrictor response to a cold challenge in patients with SSc versus control. Metacarpal application of a NTG patch led to an increase in blood flow and hand temperature in patients with SSc. Furthermore, NTG administration led to a faster reperfusion after cold challenge. Correlation analyses revealed that the magnitu...
(2020) Eosinophilia Associated With CD3 − CD4 + T Cells: Characterization and Outcome of a Single... more (2020) Eosinophilia Associated With CD3 − CD4 + T Cells: Characterization and Outcome of a Single-Center Cohort of 26 Patients.
Le raisonnement clinique à l'ère du numérique Comment formaliser la supervision de l'apprentissag... more Le raisonnement clinique à l'ère du numérique Comment formaliser la supervision de l'apprentissage du raisonnement clinique [How to formalize the supervision of learning of clinical reasoning]
American Journal of Physiology-Renal Physiology, 1987
In single cortical collecting tubules (CCT) of the rabbit, guanosine 5'-triphosphate (GTP) in... more In single cortical collecting tubules (CCT) of the rabbit, guanosine 5'-triphosphate (GTP) increased the arginine vasopressin (AVP)-stimulated adenylate cyclase (AC) by 60% (P less than 0.05). In contrast, guanosine 5' O-(2-thio)-diphosphate (GDP-beta S), a competitive inhibitor of GTP action on the stimulatory guanine regulatory protein (Ns), reduced the AVP-stimulated AC activity by 72% (P less than 0.001), indicating the presence of endogenous GTP in the cells under study. That inhibitory effect was reversed by the addition of GTP to the incubation medium. In isolated perfused CCT, cholera toxin (CT) induced a significant increase in water permeability in the absence of AVP. In contrast, Bordetella pertussis toxin (BPT) did not modify the low AVP-independent water permeability. Lithium, an inhibitor of the hydrosmotic action of AVP, also inhibits the hydrosmotic action of CT by 70% (P less than 0.05) but not that of forskolin. The conclusions of the present study are Ns i...
Abscesses of the psoas muscle are due to a hematogenous dissemination, to the spread of infection... more Abscesses of the psoas muscle are due to a hematogenous dissemination, to the spread of infection from adjacent intestinal structures, to osteomyelitis of the spine or to tuberculous infection of a disc space. In contrast, psoas abscesses related to the urological tract have only been described on exception. The present report focuses on a right psoas abscess which developed 27 years after a nephrectomy. The infectious process resulted from the spread of an acute vesical infection through the residual ureter. Analysis of 4 other cases reported in the literature allows us to delineate the clinical features of psoas abscesses of urological origin.
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Papers by Elie Cogan