Papers by Eleftherios Ferekidis
Oto-Rhino-Laryngologia Nova, 2001
Eber, A.M.; Paul, C. (Strasbourg) 20 Difficultés liées au développement d'une échelle de handicap... more Eber, A.M.; Paul, C. (Strasbourg) 20 Difficultés liées au développement d'une échelle de handicap vestibulaire Erni, C.; Guyot, J.-P. (Genève) 25 Consultation conjointe médico-psychologique pour les patients souffrant d'acouphènes
Skull Base Surgery, Mar 22, 2007
Diabetes Therapy, Mar 10, 2023
Aims: Malignant external otitis (MEO) is a special type of external otitis associated with extens... more Aims: Malignant external otitis (MEO) is a special type of external otitis associated with extensive inflammation and osteomyelitis. It is believed to originate from the external auditory meatus and advance regionally to the soft tissues and the bone, eventually involving the skull base. Pseudomonas aeruginosa and diabetes mellitus are factors commonly involved in the pathogenesis of MEO. Although its treatment has changed considerably during the last decades, morbidity and mortality of the disease remain high. Our aim was to review basic aspects of MEO, a disease unknown until 1968, which attracts great interest among Ears, Nose and Throat (ENT), diabetes and infectious diseases specialists. In this narrative review we mainly include relevant papers written in English or with an English abstract. We searched PubMed and Google Scholar, using the keywords malignant external otitis, malignant otitis externa, necrotizing external otitis, skull base osteomyelitis, diabetes mellitus and surgery up to July 2022. Some of the most recent articles, with specific references to earlier articles and a book reference regarding the pathophysiology, diagnosis and treatment of MEO and its relationship to diabetes mellitus, were included. Conclusion: MEO is not an uncommon disease and is principally treated by ENT surgeons. Nevertheless, diabetes specialists should be aware of the disease presentation and management, since they will often encounter patients with undiagnosed MEO or will need to manage glucose levels in patients hospitalized with the disease.
PubMed, Apr 1, 1979
The reconstructive use of bipedicled chest flap in cancer surgery of the neck is described. This ... more The reconstructive use of bipedicled chest flap in cancer surgery of the neck is described. This flaps have been found extremely useful in cases of surgical treatment of postlaryngectomy tracheal stomal recurrences.
PubMed, 1980
The use of a local flap for a reconstruction of very large defects of the auricular and parotid a... more The use of a local flap for a reconstruction of very large defects of the auricular and parotid area is described. This flap combines the advantage of a local and a regional flap, it is safe in use, easy to design, it permits a simultaneous radical neck dissection to be performed, it does not leave a secondary defect and it is convenient for the patient.
Rossiiskaya rinologiya, 2017
Background: Skin grafting of mucosal cavities is an old practice. We present some historical clue... more Background: Skin grafting of mucosal cavities is an old practice. We present some historical clues and a new indication for replacing nasal mucosa with free split-thickness skin graft for intractable polyposis. Material and methods. Fifteen patients suffering from recurrent nasal polyps underwent replacement of the mucosa of the sphenoethmoidal vault with a skin graft derived from their thigh under general anesthesia. Results. The graft take was successful in the vast majority of the patients and resulted in sufficient control of nasal polyps, free upper airways, and great improvement in the quality of life with only limited pharmaceutical support, reduced morbidity and minor side effects. Conclusion. Skin grafting of mucosal cavities is a time honored practice. We propose a new indication for the nasal cavity which we believe it will prove very effective in the control of nasal polyps. In this case it may become one of the commonest uses of skin grafting.
Skull Base Surgery, Mar 22, 2007
Aim: To explore the human papilloma virus's association with the clinical course of cholestea... more Aim: To explore the human papilloma virus's association with the clinical course of cholesteatomas and correlate the surgical findings with the histological features. Material and Methods: The present study assessed 79 patients with cholesteatoma. Fifty-one patients had surgically aggressive cholesteatoma. This is defined as the cholesteatoma that does not maintain its cystic form and erodes the middle ear ossicles, inner ear, the adjacent bone, and sometimes even the surrounding soft tissues. Twenty-eight of the 79 patients in the present study had simple (nonsurgically aggressive cholesteatoma). This is defined as the cholesteatoma that, usually following retraction, is located in the attic, or, in fewer cases, shows a limited expansion to the mastoid antrum, widens it and maintains its cystic form. All patients underwent mastoid surgery and the cholesteatoma specimens were sent for histological examination. Results: The clinical course of the cholesteatomas had a statistically significant association (p < 0.001) with the “aggressive” nature found in surgery suggesting that clinical history correlates well with surgical findings. All specimens of patients with surgically aggressive cholesteatoma had characteristic papillary hyperplasia of the epithelium and marked koilocytosis, suggesting papillomavirus-induced lesions. In contrast, none of the specimens of the patients with simple (nonaggressive) cholesteatoma had papillary hyperplasia and there was no marked koilocytosis as only scarce koilocytes could be found occasionally. This difference was statistically significant (p < 0.001). Conclusion: Papillomaviruses may be involved in the pathogenesis and clinical course of cholesteatomas and their involvement seems to be related with a more aggressive course.
Journal of Otolaryngology-ENT Research, 2016
The treatment of nasal polyps is many times hard for the patient with difficult operations undert... more The treatment of nasal polyps is many times hard for the patient with difficult operations undertaken and intense and protracted medical regimens ordered. In this setting we designed and perform a new surgical technique involving skin grafting. Fifteen patients of both sexes with multiple surgical attempts in the past were operated using the dermoplasty technique. The mucosa of the lamina papyracea, the fovea ethmoidalis, and the lateral surface of the middle concha were replaced by a skin graft. Results: With the exception of the first two cases, the rest of the patients report a beneficial effect of the method in the quality of their life. Until now this group of patients retains both nasal cavities functional with only limited pharmaceutical support. This novel use of dermoplasty in the nasal cavity displays a great potential towards an effective treatment of recalcitrant nasal polyposis and deserves the attention of the rhinological society.
European Archives of Oto-rhino-laryngology, 1977
La Prensa Medica, 2016
Evolutions in our Practice on the Management of the Chronic Ear Diseases through the Years Chroni... more Evolutions in our Practice on the Management of the Chronic Ear Diseases through the Years Chronic ear disease is characterized by long standing or recurrent infection of the middle ear. It is usually manifested with permanent or periodical pus drainage from the ear canal and associated with a wide variety of clinical findings that might include a single eardrum perforation of various size, hypertrophy of the middle ear mucosal lining and in some cases the formation of a skin cyst, named ‘’cholesteatoma’’.
Rhinology, 1999
Intrasphenoidal encephalocele is a rare clinical entity. In the international literature only 16 ... more Intrasphenoidal encephalocele is a rare clinical entity. In the international literature only 16 cases have been reported up today, with female predominance. Clinically they manifest at middle and advanced ages (40-67 years), when spontaneous CSF rhinorrhoea or recurrent meningitis occurs. We present our case, a 46 years old female, who had CSF rhinorrhoea from the right vestibule for 10 months. The diagnosis was based on the history and the high-resolution brain and skull base CT-scanning in conjunction with opaque fluid injection in the subarachnoidal space through a lumbar puncture. She was successfully treated with an operation, through an endonasal trans-ethmoid microendoscopic approach, using the Draf and Stammberger technique. We discuss the pathogenesis of the intrasphenoidal encephalocele, the existence of small occult defects in the skull base, which cause, at the middle and advanced ages, CSF fistula with spontaneous CSF rhinorrhoea and/or recurrent meningitis. Finally we...
Archives of oto-rhino-laryngology, 1979
termedi/irund Endothelzellen sowie eine Vergr6gerung der Mitochondrien in der Stria vascularis be... more termedi/irund Endothelzellen sowie eine Vergr6gerung der Mitochondrien in der Stria vascularis beschrieben. Auch dieser rnorphologische Befund deutet auf eine St6rung des F1/jssigkeitstransportes lain. Da die Na+-K+-stimulierte ATPase in einer im einzelnen noch nicht aufgekl~irten Weise f/Jr die Aufrechterhaltung der Asymmetric der Ionen-Konzentrationen in der Endolymphe verantwortlich ist, scheint die Hemmung des Transportenzyms zur Deutung der erworbenen Innenohrschwerh6rigkeit bei Niereninsuffizienz yon Bedeutung.
Skull Base Surgery, Mar 22, 2007
Skull Base Surgery, Mar 22, 2007
Skull Base Surgery, Mar 22, 2007
Skull Base Surgery, Mar 22, 2007
Skull Base Surgery, Mar 22, 2007
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Papers by Eleftherios Ferekidis