Linkage studies have indicated that a gene on chromosome arm 17q, designated BRCAI, confers susce... more Linkage studies have indicated that a gene on chromosome arm 17q, designated BRCAI, confers susceptibility to familial breast and ovarian cancer. To investigate the possible involvement of the BRCAI gene in sporadic breast cancer we have analysed loss of heterozygosity (LOH) in a panel of 100 sporadic primary breast tumours using 10 PCR-based polymorphic markers from 17q12–21. Allele losses were detected in 40 of 100 tumours informative for at least one of the markers analysed. Of these 40 deleted tumours, 27 showed partial or interstitial loss on 17q. The pattern of LOH in the tumours with partial or interstitial LOH revealed three putative distinct deleted regions on 17q12–21. The first lies on the proximal long arm between D17S250 and THRAI; the second one lies between D17S776 and D17S579, the region containing the BRCAI gene; and the third is telomeric to D17S733. The most frequently deleted region overlaps with the minimal region containing the BRCAI gene, suggesting that this gene might also be associated with the development or progression of a proportion of sporadic breast tumours.
This work deals with reconfigurable computation platforms for high speed simulation of physical p... more This work deals with reconfigurable computation platforms for high speed simulation of physical phenomena, based on numerical models of algebraic linear systems. This type of simulation is of extreme importance in research centers as CENPES/Petrobrs, that develops applications of geophysical processing for prospection of oil and gas. Currently, these applications are implemented on PCs conventional clusters. A new approach for this type of problem is presented here, based on reconfigurable computer systems using Field Programmable Gate Arrays technology (FPGA) and its implications regarding the hardware/software partitioning, operating system, memory connections, communication and device drivers. Such technologies make possible appreciable profits in terms of performance -electric power and processing speed when compared to the conventional clusters. This solution also promotes cost reduction when applied to massive computation and high complexity large data applications, normally used in scientific computation.
ABSTRACT This work presents the development of a dynamically reconfigurable computing platform ta... more ABSTRACT This work presents the development of a dynamically reconfigurable computing platform targeting Virtex-II devices under control of a host system based on the Nios II soft-core processor from Altera. The platform, called Aquarius, controls the system by means of the ...
Resumo Este trabalho apresenta o desenvolvimento de uma plataforma computacional dinamicamente re... more Resumo Este trabalho apresenta o desenvolvimento de uma plataforma computacional dinamicamente reconfigurável. A plataforma, chamada Aquarius, utiliza um sistema operacional (SO) µCLinux embarcado. Através deste sistema operacional, um módulo ( ...
Linkage studies have indicated that a gene on chromosome arm 17q, designated BRCAI, confers susce... more Linkage studies have indicated that a gene on chromosome arm 17q, designated BRCAI, confers susceptibility to familial breast and ovarian cancer. To investigate the possible involvement of the BRCAI gene in sporadic breast cancer we have analysed loss of heterozygosity (LOH) in a panel of 100 sporadic primary breast tumours using 10 PCR-based polymorphic markers from 17q12–21. Allele losses were detected in 40 of 100 tumours informative for at least one of the markers analysed. Of these 40 deleted tumours, 27 showed partial or interstitial loss on 17q. The pattern of LOH in the tumours with partial or interstitial LOH revealed three putative distinct deleted regions on 17q12–21. The first lies on the proximal long arm between D17S250 and THRAI; the second one lies between D17S776 and D17S579, the region containing the BRCAI gene; and the third is telomeric to D17S733. The most frequently deleted region overlaps with the minimal region containing the BRCAI gene, suggesting that this gene might also be associated with the development or progression of a proportion of sporadic breast tumours.
This work deals with reconfigurable computation platforms for high speed simulation of physical p... more This work deals with reconfigurable computation platforms for high speed simulation of physical phenomena, based on numerical models of algebraic linear systems. This type of simulation is of extreme importance in research centers as CENPES/Petrobrs, that develops applications of geophysical processing for prospection of oil and gas. Currently, these applications are implemented on PCs conventional clusters. A new approach for this type of problem is presented here, based on reconfigurable computer systems using Field Programmable Gate Arrays technology (FPGA) and its implications regarding the hardware/software partitioning, operating system, memory connections, communication and device drivers. Such technologies make possible appreciable profits in terms of performance -electric power and processing speed when compared to the conventional clusters. This solution also promotes cost reduction when applied to massive computation and high complexity large data applications, normally used in scientific computation.
ABSTRACT This work presents the development of a dynamically reconfigurable computing platform ta... more ABSTRACT This work presents the development of a dynamically reconfigurable computing platform targeting Virtex-II devices under control of a host system based on the Nios II soft-core processor from Altera. The platform, called Aquarius, controls the system by means of the ...
Resumo Este trabalho apresenta o desenvolvimento de uma plataforma computacional dinamicamente re... more Resumo Este trabalho apresenta o desenvolvimento de uma plataforma computacional dinamicamente reconfigurável. A plataforma, chamada Aquarius, utiliza um sistema operacional (SO) µCLinux embarcado. Através deste sistema operacional, um módulo ( ...
Uploads
Papers by Edson Barbosa